H2O2-Mediated Synthesis of 1,2,4-Thiadiazole Derivatives in Ethanol at Room Temperature was written by Cao, Xian-Ting;Zheng, Zuo-Ling;Liu, Jie;Hu, Yu-He;Yu, Hao-Yun;Cai, Shasha;Wang, Guannan. And the article was included in Advanced Synthesis & Catalysis in 2022.COA of Formula: C4H7NS The following contents are mentioned in the article:
Herein, the H2O2-mediated synthesis of 1,2,4-thiadiazole derivatives under metal-free conditions at room temperature with ethanol as the sole solvent was reported. Various substrates could undergo the reaction smoothly, providing the expected yields of the desired products. Moreover, the target products were obtained by filtration or extraction instead of column chromatog., which requires a large amount of organic solution and silica gel during purification The developed synthetic method can be potentially applied in the large-scale preparation of 1,2,4-thiadiazole derivatives as agrochems., pharmaceuticals, and functional materials. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8COA of Formula: C4H7NS).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.COA of Formula: C4H7NS
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics