Synthesis of 2,5-substituted piperidines: transposition of 1,4-substitution pattern for the analgesic drug R6582 was written by Baens, Nicole P.;Compernolle, Frans;Toppet, Suzanne M.;Hoornaert, Georges J.. And the article was included in Tetrahedron in 1993.HPLC of Formula: 149437-67-2 The following contents are mentioned in the article:
Cis-5-(1,3-dihydro-2-oxo-2H-benzimidazol-1-yl)-2-p-fluorophenyl-1-methylpiperidine I R = H) and the analogous cis- and trans-1-benzylpiperidines II (R = Ph) were prepared Key steps in the synthesis were the α-chlorination of 1-methyl- and 1-benzyl-6-p-fluorophenyl-2-piperidinone, and nucleophilic substitution of the resulting cis and trans 3-chloro lactams. 1H NMR anal. for the epimeric 3,6-substituted lactam compounds revealed a preferred axial orientations for the 3-chloro substituent and an equatorial orientation for the 3-(oxobenzimidazolyl) group. For I, a conformational equilibrium was observed This was shifted to the [2ax,5eq] form for II (R = H). This study involved multiple reactions and reactants, such as Methyl 5-(4-fluorophenyl)-5-oxopentanoate (cas: 149437-67-2HPLC of Formula: 149437-67-2).
Methyl 5-(4-fluorophenyl)-5-oxopentanoate (cas: 149437-67-2) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.HPLC of Formula: 149437-67-2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics