Zhang, Sheng published the artcileDimethyl Itaconate Alleviates the Inflammatory Responses of Macrophages in Sepsis, Safety of Dimethyl itaconate, the publication is Inflammation (2021), 44(2), 549-557, database is CAplus and MEDLINE.
Sepsis is an inflammatory disease characterized by dysregulation of inflammation. Macrophage-mediated inflammation has been implicated in the pathophysiol. of sepsis. Itaconate is a metabolite produced in activated macrophages which has anti-inflammatory activities. In the present study, we investigated the potential effects of a cell-permeable itaconate derivative di-Me itaconate on inflammation in sepsis. We established a lipopolysaccharide (LPS)-induced septic mouse model and administered di-Me itaconate to the septic mice. The survival rate, serum level of pro-inflammatory cytokines, and lung pathol. were evaluated. We also administered di-Me itaconate to LPS-treated bone marrow-derived macrophages (BMDMs), and measured the cytokine production and Nrf2 expression. We also evaluated the effects of di-Me itaconate on Nrf2-deficient mice. Administration of di-Me itaconate enhanced survival rate, decreased serum level of TNF-α and IL-6, and ameliorated lung injury in septic mice. Di-Me itaconate also suppressed LPS-induced production of TNF-α, IL-6, and NOS2 in BMDMs. Di-Me itaconate activated Nrf2 and promoted the expression of Nrf2 and its downstream factor HO-1 and NQO-1. The regulatory activities of di-Me itaconate on inflammatory cytokine production, mouse survival rate were abolished in septic Nrf2-/- mice. Di-Me itaconate suppressed the inflammatory responses of macrophages in sepsis.
Inflammation published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C5H5NO3S, Safety of Dimethyl itaconate.
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https://en.wikipedia.org/wiki/Ester,
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