Yu, Tongyan published the artcileFacile synthesis of penta-substituted pyrroles and pyrrole-fused piperidin-4-ones via four component reactions of 2,3-diketoesters, anilines and enaminones, Recommanded Product: Ethyl 3-(dimethylamino)acrylate, the publication is Organic Chemistry Frontiers (2021), 8(20), 5716-5721, database is CAplus.
Herein, a novel BF3.Et2O mediated four component reaction of 2,3-diketoesters RC(O)C((OH)2)C(O)R1 (R = Me, 2-phenylethenyl, naphthalen-2-yl, thiophen-2-yl, etc.; R1 = OMe, OEt, (2-methylpropyl)oxidanyl, dimethylaminyl, OBn), anilines 4-R2C6H4NH2 (R2 = H, Me, Br, methoxycarbonyl, etc.) and enaminones R3C(O)CH=CHN(CH3)2 (R3 = OEt, Ph, furan-2-yl, etc.)/R4CH=CHC(O)CH=CHN(CH3)2 (R4 = Ph, 4-methoxyphenyl), providing highly functionalized pyrroles I and pyrrole-fused piperidin-4-ones II in moderate to good yields was presented. The key to success lies in the utilization of enaminone as the substrate and precise capture of the carbocation intermediate by anilines, allowing the amination to occur at the 5-position smoothly. This strategy is potentially applicable to diverse nucleophilic reagents. Moreover, an intramol. version of this strategy can be utilized to form fused heterocycles.
Organic Chemistry Frontiers published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C4H4N2O2, Recommanded Product: Ethyl 3-(dimethylamino)acrylate.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics