Tran, Van T. published the artcileActivation of diverse carbon-heteroatom and carbon-carbon bonds via palladium(II)-catalyzed β-X elimination, Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one, the publication is Nature Chemistry (2018), 10(11), 1126-1133, database is CAplus and MEDLINE.
γ-Substituted N-(8-quinolinyl) alkanecarboxamides and cycloalkanecarboxamides such as I underwent regioselective substitution reactions with nucleophiles such as 1-methyl- and 1,2-dimethylindoles in the presence of Pd(OAc)2 and 1-adamantanecarboxylic acid (1-AdCO2H) to yield substitution products such as II (R = H, Me). The substitutions occurred using elimination reactions of the β-palladated carboxamides as a key step; a β-palladation product was isolated and its structure determined by X-ray crystallog. The substitution reactions occurred at alkyl C(sp3)-oxygen, nitrogen, carbon, fluorine and sulfur bonds with high regioselectivity. The method was used for substitution reactions of γ-substituted amino acids such as the 8-aminoquinolinyl amide of L-methionine and its sulfoxide to give functionalized amino acids in 60-98% ee. Unstrained 8-aminoquinolinyl heterocyclylalkanecarboxamides underwent regioselective γ-substitution reactions with ring opening if a heteroatom was in the γ-position; if the heteroatom was in an appropriate position, lactonization and lactamization reactions also occurred with loss of the aminoquinoline moieties.
Nature Chemistry published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C18H28B2O4, Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics