On-Chip Neo-Glycopeptide Synthesis for Multivalent Glycan Presentation was written by Mende, Marco;Tsouka, Alexandra;Heidepriem, Jasmin;Paris, Grigori;Mattes, Daniela S.;Eickelmann, Stephan;Bordoni, Vittorio;Wawrzinek, Robert;Fuchsberger, Felix F.;Seeberger, Peter H.;Rademacher, Christoph;Delbianco, Martina;Mallagaray, Alvaro;Loeffler, Felix F.. And the article was included in Chemistry – A European Journal in 2020.Related Products of 604-69-3 The following contents are mentioned in the article:
Single glycan-protein interactions are often weak, such that glycan binding partners commonly use multiple, spatially defined binding sites to enhance binding avidity and specificity. Current array technologies usually neglect defined multivalent display. Laser-based array synthesis technol. allows for flexible and rapid on-surface synthesis of different peptides. By combining this technique with click chem., neo-glycopeptides were produced directly on a functionalized glass slide in the microarray format. D. and spatial distribution of carbohydrates can be tuned, resulting in well-defined glycan structures for multivalent display. The two lectins Con A and langerin were probed with different glycans on multivalent scaffolds, revealing strong spacing-, d.-, and ligand-dependent binding. In addition, the authors could also measure the surface dissociation constant This approach allows for a rapid generation, screening, and optimization of a multitude of multivalent scaffolds for glycan binding. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Related Products of 604-69-3).
(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Related Products of 604-69-3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics