High-pressure liquid chromatographic evaluation of cyclic paracetamol-acetylsalicylate and its active metabolites with results of a comparative pharmacokinetic investigation in the rat was written by Marzo, A.;Quadro, G.;Treffner, E.;Ripamonti, M.;Meroni, G.;Lucarelli, C.. And the article was included in Arzneimittel-Forschung in 1990.Application In Synthesis of 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:
Like benorilate, its correlated open ester, MR 897 (I), a cyclic ester between acetylsalicylic acid and paracetamol, gives rise to acetylsalicylic acid, salicylic acid and paracetamol by enzymic hydrolysis. An anal. method was developed, which detects parent drugs and active metabolites, in order to compare the pharmacokinetic and metabolic behavior of the 2 products. The method was specifically validated for quant. anal. of salicylic acid and paracetamol, which are the main systemic metabolites of both MR 897 and benorilate. Extraction from rat plasma or tissue homogenate was carried out in 2 steps with Et2O and Et acetate. Recovery of the anal. substances ranged from 82.7% for paracetamol to 98.5% for salicylic acid. The results of a comparative pharmacokinetic investigation of MR 897 and benorilate in the rat confirm higher bioavailability and a more favorable plasma level profile with MR 897. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Application In Synthesis of 4-Acetamidophenyl 2-acetoxybenzoate).
4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Application In Synthesis of 4-Acetamidophenyl 2-acetoxybenzoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics