Hay, Michael B. published the artcilePalladium-catalyzed synthesis of tetrahydrofurans from γ-hydroxy terminal alkenes: Scope, limitations, and stereoselectivity, Application of Ethyltert-butylacetate, the publication is Journal of Organic Chemistry (2005), 70(8), 3099-3107, database is CAplus and MEDLINE.
A stereoselective synthesis of substituted tetrahydrofurans, e.g., I, by Pd-catalyzed reactions of aryl and vinyl bromides with γ-hydroxy terminal alkenes is described. This transformation afforded trans-2,5- and trans-2,3-disubstituted tetrahydrofurans with good diastereomeric ratio. This methodol. also provided access to bicyclic and spirocyclic THF derivatives in good yield diastereomeric ratio. The scope and limitations of these transformations are discussed in detail, as are the effect of substrate sterics and electronics on yield and stereoselectivity. A proposed mechanism of these transformations is presented along with a model that rationalizes the stereochem. outcome of the reactions.
Journal of Organic Chemistry published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Application of Ethyltert-butylacetate.
Referemce:
https://en.wikipedia.org/wiki/Ester,
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