Degree of crosslinking in β-cyclodextrin-based nanosponges and their effect on piperine encapsulation was written by Guineo-Alvarado, Juan;Quilaqueo, Marcela;Hermosilla, Jeyson;Gonzalez, Sofia;Medina, Camila;Rolleri, Aldo;Lim, Loong-Tak;Rubilar, Monica. And the article was included in Food Chemistry in 2021.COA of Formula: C13H10O3 The following contents are mentioned in the article:
Piperine (PIP) is an alkaloid which is potent as a therapeutic agent. However, its applications are restricted by its poor water solubility Nanosponges (NS) derived from polymers are versatile carriers for poor water-soluble substances. The aim of this work was to synthesize β-cyclodextrin NS, by microwave-assisted fusion, for the encapsulation of PIP. Different formulations of NS were synthesized by varying the molar ratio of β-cyclodextrin:diphenyl carbonate (β-CD:DPC; 1:2, 1:6 and 1:10). NS specimens derived from 1:2, 1:6 and 1:10 β-CD:DPC molar ratios exhibited degree of substitution values of 0.345, 0.629 and 0.878, resp. The crystallinity of NS was enhanced by increasing di-Ph carbonate concentration A high degree of crosslinking in the NS increased the loading efficiency due to increased surface area available for bioactive inclusion. This study demonstrated the feasibility of synthesizing NS derived from β-cyclodextrin of high crystallinity for the encapsulation of PIP at high loading capacity. This study involved multiple reactions and reactants, such as Diphenyl carbonate (cas: 102-09-0COA of Formula: C13H10O3).
Diphenyl carbonate (cas: 102-09-0) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.COA of Formula: C13H10O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics