Gu, Hai-ning published the artcileStudy on new process of synthesizing levofloxacin, Safety of Ethyl 3-(dimethylamino)acrylate, the publication is Gaoxiao Huaxue Gongcheng Xuebao (2005), 19(5), 708-711, database is CAplus.
New process for preparing the fluoroquinolone antibacterial drug levofloxacin was described. The object compound was prepared from 2,3,4,5-tetrafluorobenzoic acid, via acyl chlorination, Et N,N-dimethylamino-acrylate coupling, S-(+)-2-aminopropanol displacement, cyclization, hydrolysis, and finally N-methylpiperazine condensation, the total yield is 52.3%. Comparing to the old process conventionally used at present, the application of the new starting material Et N, N-dimethylamino-acrylate can curtail three reaction steps, they are the di-Et malonate condensation, partial hydrolysis decarboxylation and triethylorthoformate condensation. New process has many advantages, such as simple procedure, short reaction period, high optical purity, cheaper raw material, higher yield. So it should have a good prospect for industrial application.
Gaoxiao Huaxue Gongcheng Xuebao published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Safety of Ethyl 3-(dimethylamino)acrylate.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics