Development of novel carbohydrate based compounds for better antipyretic activity was written by Grover, Parul;Singh, Jitender;Mehta, Lovekesh;Kapoor, Garima;Nagarajan, K.. And the article was included in International Journal of Pharmaceutical Sciences and Research in 2021.Synthetic Route of C16H22O11 The following contents are mentioned in the article:
Carbohydrate-based therapeutics are extremely potent, and many carbohydrate-based drugs are in the stage of preclin. or clin. trials. There is a growing interest in developing carbohydrate analogs for novel drug discovery as most of the recently used carbohydrate drugs display significant pharmacol. activities and low toxicity. Also, the search for an antipyretic drug is a never-ending challenge. This research aimed at the development and synthesis of a series of amide-linked sugars (PV1-PV20) by coupling brominated sugars with varying amino acids coupled with nicotinic acid (GP1-GP10). Characterization of the derivatives synthesized was done by IR and NMR Spectroscopy. These congeners were tested to analyze their antipyretic potential, and eight analogs out of twenty showed significant antipyretic activity. Thus, the carbohydrate-based amide derivatives show important action in obstruction and therapy of fever. Further work on these lines may play an important role in maintaining good health at a low cost. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Synthetic Route of C16H22O11).
(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Synthetic Route of C16H22O11
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics