Gordeev, Mikhail F. published the artcileNovel oxazolidinone-quinolone hybrid antimicrobials, Computed Properties of 924-99-2, the publication is Bioorganic & Medicinal Chemistry Letters (2003), 13(23), 4213-4216, database is CAplus and MEDLINE.
Antimicrobial compounds incorporating oxazolidinone and quinolone pharmacophore substructures have been synthesized and evaluated. Representative analogs I and II [racemic and 3-(S)-isomer] display an improved potency vs. linezolid against gram-pos. and fastidious gram-neg. pathogens. The compounds are also active against linezolid- and ciprofloxacin-resistant Staphylococcus aureus and Enterococcus faecium strains. The MOA for these new antimicrobials is consistent with a combination of protein synthesis and gyrase A/topoisomerase IV inhibition, with a structure-dependent degree of the contribution from each inhibitory mechanism.
Bioorganic & Medicinal Chemistry Letters published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Computed Properties of 924-99-2.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics