ω-(5-Phenyl-2H-tetrazol-2-yl)alkyl-substituted hydrazides and related compounds as inhibitors of amine oxidase copper containing 3 (AOC3) was written by Galster, Florian;Postges, Timo;Hanekamp, Walburga;Lehr, Matthias. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2022.Electric Literature of C13H10O3 The following contents are mentioned in the article:
Recently, 6-(5-phenyl-2H-tetrazol-2-yl)hexan-1-amine was found to be a tight-binding substrate of AOC3. To obtain novel inhibitors of the enzyme, the amino group of this substrate was replaced with functional groups that occur in known AOC3 inhibitors, such as hydrazide or glycine amide moieties. In addition, derivatives of the compounds I [R = NHNH2, OEt, NH(CH2)2NH2, NH(CH2)3NH2, 3-(tert-butoxycarbonylamino)propylamino; n = 1, 2, 5, 6, etc.], II [R2 = HNC(O)CH2NH2, HNC(O)OPh, 2-(aminomethyl)imidazol-1-yl, etc.] obtained in this way were prepared The obtained hydrazide I [R = NHNH2; n = 6] which proved to be the most effective, was subjected to further structural modifications. Selected hydrazides I [R = NHNH2; n = 1, 6] were evaluated for selectivity toward some other amine oxidases. This study involved multiple reactions and reactants, such as Diphenyl carbonate (cas: 102-09-0Electric Literature of C13H10O3).
Diphenyl carbonate (cas: 102-09-0) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Electric Literature of C13H10O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics