Well-defined, environment-friendly synthesis of polypeptides based on phosgene-free transformation of amino acids into urethane derivatives and their applications was written by Endo, Takeshi;Sudo, Atsushi. And the article was included in Polymer International in 2020.HPLC of Formula: 102-09-0 The following contents are mentioned in the article:
A review. In this study, both naturally occurring and artificial amino acids were successfully transformed into the corresponding urethane derivatives using di-Ph carbonate. The urethanes thus prepared could be efficiently cyclized into amino acid N-carboxyanhydrides (NCAs) without the requirement of phosgene. In addition, the presence of primary amines converted the urethane derivatives into NCAs and initiated the ring-opening polymerization of the in situ formed NCAs, allowing for the well-defined synthesis of polypeptides. These polypeptides contained initiating ends functionalized by an amine-derived residue and propagating ends bearing the reactive amino group. By precise control of the structures of the polypeptides, various polypeptide conjugates such as block copolymers and graft copolymers were successfully synthesized as designed, and their applications in antifouling coatings against proteins, drug delivery systems and biosensors were demonstrated. © 2019 Society of Chem. Industry. This study involved multiple reactions and reactants, such as Diphenyl carbonate (cas: 102-09-0HPLC of Formula: 102-09-0).
Diphenyl carbonate (cas: 102-09-0) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.HPLC of Formula: 102-09-0
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics