Study on relation of dissolution of benorilate tablets with drug concentration in human plasma was written by Chen, Zongdai;Du, Kairong;Zeng, Jingze;Zhang, Da;Deng, Fu. And the article was included in Yaowu Fenxi Zazhi in 2002.Reference of 5003-48-5 The following contents are mentioned in the article:
The relation between dissolution of benorilate tablets and benorilate concentration in human plasma was analyzed. Sodium lauryl sulfate (1%) solution was used as the medium, and paddles method was used with sampling after 45 min. UV spectrophotometry was adapted for the determination of dissolution of benorilate tablets. The concentration of benorilate in human plasma was estimated by using a HPLC method which was developed to determine the hydrolytic products of benorilate paracetamol and salicylic acid. p-Dimethylaminobenzaldehyde was used as the internal standard The relationship between dissolution and concentration of benorilate in human plasma was treated statistically. A good relationship existed between the dissolution and pharmacokinetic parameters AUC, Cmax [r=0.968; 0.985 (n=5), r0.01,3=0.959]. The method could control the sample quality effectively. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Reference of 5003-48-5).
4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Reference of 5003-48-5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics