Month: November 2022

Huang, Yande; Yu, Jaehoon; Bentrude, Wesley G. published the artcile< Study of the Conformational Equilibria of 2-Z-3-Methyl-1,3,2-oxazaphosphorinanes. Steric and Stereoelectronic Influences on the Orientation of the Me2N Substituent on Three-Coordinate Phosphorus>, Electric Literature of 112-63-0, the main research area is conformation equilibrium oxazaphosphorinane steric stereoelectronic effect.

The conformations of a series of 1,3,2-oxazaphosphorinanes containing three-coordinate phosphorus I (R = OMe, (CF3)2CHO, NMe2, R1 = R2 = H, Me; R = same, R1 = CMe3, R2 = H) have been determined by the use of 1H, 31P, and 13C NMR spectroscopy. The rings were substituted at ring nitrogen, N(3), with a Me group to compare its effect on conformational energies with those of 1,3,2-oxazaphosphorinanes reported earlier that featured a larger substituent at N(3), Ph or i-Pr. Quite expectedly, like those rings previously studied with Ph or i-Pr at N(3), a MeO or (CF3)2CHO substituent at phosphorus has a strong preference to be axial on a chair-form ring I (R = OMe, (CF3)2CHO, R1 = R2 = H, Me) and cis-I (R = OMe, (CF3)2CHO, R1 = CMe3, R2 = H), or pseudoaxial on a ring in a twist/boat conformation, trans-I (R = OMe, R1 = CMe3, R2 = H). However, when Me2N is attached to phosphorus, the newly studied N(3)Me rings display a chair-chair conformational equilibrium, II ⇄ III, with the Me2N equatorial ring, III, mildly dominant. This contrasts with ratios of 17/83 and 20/80 for the corresponding N(3)Ph analogs. The observed change in the free energy of the equilibrium II ⇄ III, 1.2-1.3 kcal/mol, is ascribed to the dominant influence of a decrease in repulsion experienced in conformation III between the equatorial Me2NP and the smaller Me at N(3) (Me2N(eq)/N(3)Me destabilization) compared to that experienced with the N(3)Ph and N(3)-i-Pr analogs. This steric influence of N(3) substituents on the equilibrium II ⇄ III is opposite to that found for four-coordinate phosphorus containing 1,3,2-oxazaphosphorinanes in which Me2NP(ax)/N(3)Ph repulsions that destabilize II appear to be dominant.

Journal of Organic Chemistry published new progress about Equilibrium. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xie, Qinglong; Zhu, Huiyun; Xu, Pan; Xing, Kainan; Yu, Shangzhi; Liang, Xiaojiang; Ji, Weirong; Nie, Yong; Ji, Jianbing published the artcile< Transesterification of methyl oleate for sustainable production of biolubricant: Process optimization and kinetic study>, Product Details of C19H34O2, the main research area is biolubricant process optimization sustainable production methyl oleate transesterification.

Trimethylolpropane fatty acid triester (TFATE) is a promising biolubricant as an environmentally friendly substitute to conventional mineral-based lubricants. However, the issues of extensive energy consumption from vacuum maintenance and feedstock saponification caused by strong alk. catalysts exist in current TFATE-based biolubricant synthesis. Here, sustainable production of biolubricant was achieved with Me oleate (MO) from non-edible oil sources as the feedstock and moderate alk. K2CO3 as the catalyst. Nitrogen gas stripping method instead of vacuum was adopted for methanol removal. The effects of agitation speed, N2 flow rate, catalyst amount, MO to trimethylolpropane (TMP) molar ratio and temperature on MO conversion and TFATE selectivity were examined The TFATE selectivity reached 95.6% under the optimized conditions. Leaching tests indicated neglectable K2CO3 dissolution in reaction products. The kinetic parameters for the three consecutive transesterification reactions were calculated In addition, the synthesized biolubricants exhibit low acid value and volatility, moderate iodine value, superior thermal stability, and good rheol. and frictional properties.

Industrial Crops and Products published new progress about Acid number. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Naushad, Mu.; Ahamad, Tansir; Khan, Mohammad Rizwan published the artcile< Fabrication of magnetic nanoparticles supported ionic liquid catalyst for transesterification of vegetable oil to produce biodiesel>, Electric Literature of 112-63-0, the main research area is butylimidazole magnetic nanoparticle ionic liquid transesterification catalyst.

In the present study, we have fabricated novel magnetic ionic liquid based nanocomposites using 1-butylimidazole, 3-bromopropyl-trimethoxysilane and NiFe2O4 nanoparticles. NiFe2O4@-BMSIHSO4 was synthesized from NiFe2O4@-BMSI Br via ion-exchange process. The fabricated nanocomposites were characterized by various anal. techniques. The surface area was determined using N2 adsorption-desorption anal. and the BET surface area of NiFe2O4@BMSI Br and NiFe2O4@BMSI HSO4 was noted to be 89.21 and 87.21 m2/g, resp. The fabricated nanocomposites were used as catalyst for the transesterification of palm oil (VO) for the production of biodiesel. The results revealed that NiFe2O4@BMSI HSO4 exhibited better performance in terms of biodiesel yield; a maximum i.e. 86.4% yield was obtained using NiFe2O4@BMSI HSO4 while in the case of NiFe2O4@BMSI Br, about ∼74.6% yield was found with 5% weight/weight catalyst loading, 353 K and to CH3OH ratio of 1:12 in 8 h. The reusability of the catalyst results revealed that the catalytic activity of the catalysts still remained about 92.7% and 88.1% with NiFe2O4@BMSI HSO4 and NiFe2O4@BMSI Br, resp. after six cycles which may be accredited to the handling loss during the manipulation process.

Journal of Molecular Liquids published new progress about Ion exchange. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

D’Ambrosio, Valeria; di Bitonto, Luigi; Angelini, Antonella; Gallipoli, Agata; Braguglia, Camilla M.; Pastore, Carlo published the artcile< Lipid extraction from sewage sludge using green biosolvent for sustainable biodiesel production>, Formula: C19H34O2, the main research area is sewage sludge green biosolvent sustainable biodiesel production lipid extraction.

Sewage sludge is a type of urban waste generated as a byproduct of wastewater treatment in quantities ranging from 9 to 9.5 million tons (dry substance) in Europe. This waste can be considered a source of lipids, which can be converted into biofuels. Recovery of lipids from sludge is a critical step in the overall process, and the choice of the extracting solvent should satisfy efficiency as well as sustainability criteria. This study reports exptl. optimization of lipid extraction from sewage sludge using Et butyrate, a green bio-derivable solvent. Extraction conditions were optimized using the desirability function applied to the response surface methodol. anal. of a Box-Behnken factorial design of experimentals. By carrying out the extraction at 70°C for 7 h, using an amount of solvent equal to the wet sludge, and without using any acids, 93.7% of the starting lipids were recovered. The extracted lipids were then efficiently converted into biodiesel (fatty acid Me esters) through direct esterification promoted by AlCl3·6H2O (catalyst). Furthermore, the residual sludge obtained after the extraction, different to that obtained using hexane, was found to be anaerobically digestible without any inhibition.

Journal of Cleaner Production published new progress about Alkalinity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Werner, Maxim; Lyu, Chen; Stadlbauer, Birgit; Schrader, Isabel; Buchner, Alexander; Stepp, Herbert; Sroka, Ronald; Pohla, Heike published the artcile< The role of Shikonin in improving 5-aminolevulinic acid-based photodynamic therapy and chemotherapy on glioblastoma stem cells>, Computed Properties of 112-63-0, the main research area is Glioblastoma; Photodynamic therapy; Shikonin; Stem cells.

Glioblastoma multiforme is a malignant neoplasia with a median survival of less than two years and without satisfactory therapeutic options. The so-called glioblastoma stem cells escape the established radio- and chemotherapies and lead to tumor recurrence in most cases. The alkaloid Shikonin with its various anti stem cell properties and the interstitial photodynamic therapy with 5-aminolevulinic acid seem to be promising new options in the therapy of glioblastoma. In this study, in vitro investigations were performed to observe the influence of Shikonin on viability, proliferation, induction of apoptosis and the capability of forming tumor spheres in U-87 MG and the primary glioblastoma cell line GB14. The combined effect with the chemotherapeutic temozolomide and photodynamic treatment on the mRNA expression of glioma specific stem cell markers and further examined intracellular protoporphyrin IX accumulation under Shikonin treatment was analyzed. Shikonin effectively inhibited the capability of forming tumor spheres and enhanced temozolomide effectiveness in the reduction of proliferation and in the induction of apoptosis. Addnl., Shikonin increased the mRNA expression of the tumor suppressing Neurofibromatosis type 1 (NF1) gene and showed modulating effects on intracellular protoporphyrin IX.

Photodiagnosis and Photodynamic Therapy published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Selvakumar, N.; Azhagan, A. Malar; Srinivas, D.; Krishna, G. Gopi published the artcile< A direct synthesis of 2-arylpropenoic acid esters having nitro groups in the aromatic ring: a short synthesis of (±)-coerulescine and (±)-horsfiline>, Category: esters-buliding-blocks, the main research area is coerulescine synthesis; horsfiline synthesis; arylpropenoic acid ester nitro preparation; propenoic acid ester arylnitro preparation.

A short synthesis of 2-arylpropenoic acid esters that possess nitro groups in their Ph ring using common and less expensive reagents is described. The usefulness of this methodol. is substantiated by the efficient total syntheses of (±)-coerulescine (I) and (±)-horsfiline from the 2-arylpropenoic acid esters obtained.

Tetrahedron Letters published new progress about Nitro group. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sun, Lei; Wang, Hua; Yu, Shanshan; Zhang, Lin; Jiang, Jue; Zhou, Qi published the artcile< Herceptin induces ferroptosis and mitochondrial dysfunction in H9c2 cells>, Recommanded Product: Ethyl 3-amino-4-(cyclohexylamino)benzoate, the main research area is herceptin ferroptosis mitochondrial dysfunction heart failure; Herceptin; cardiotoxicity; ferroptosis; mitochondrial dysfunction.

Ferroptosis has been previously implicated in the pathol. progression of cardiomyopathy. Herceptin (trastuzumab), which targets HER2, is commonly applied for the treatment of HER2+ breast cancer. However, its clin. use is limited by its cardiotoxicity. Therefore, the present study aimed to investigate if targeting ferroptosis could protect against Herceptin-induced heart failure in an in vitro model of H9c2 cells after treatment of Herceptin, Herceptin + ferroptosis inhibitor ferrostatin-1 (Fer-1) or Herceptin + Deferoxamine. H9c2 cell viability was measured by MTT assay. Reactive oxygen species (ROS) levels were detected by measuring the fluorescence of DCFH-DA-A and MitoSOX Red. Glutathione (GSH)/oxidized glutathione (GSSG) ratio was measured using the GSH/GSSG Ratio Detection Assay kit. Mitochondrial membrane potential and ATP content were evaluated by JC-1 staining and bioluminescent assay kits, resp. Protein expressions of glutathione peroxidase 4, recombinant solute carrier family 7 member 11, mitochondrial optic atrophy1-1/2, mitofusin, Acyl-CoA synthetase long chain family member 4, cytochrome c, voltage-dependent anion-selective channel, dynamin-related protein, mitochondrial fission 1 protein and mitochondrial ferritin were evaluated by western blotting. It was found that Herceptin reduced H9c2 cell viability while increasing intracellular and mitochondrial ROS levels in a dose- and time-dependent manner. Furthermore, Herceptin decreased glutathione peroxidase (GPX) protein expression and the GSH/GSSG ratio in H9c2 cells in a dose- and time-dependent manner. The Fer-1 abolished this Herceptin-induced reduction in cell viability, GSH/GSSG ratio, mitochondrial membrane potential and ATP content. Fer-1 also reversed the suppressive effects of Herceptin on the protein expression levels of GPX4, recombinant solute carrier family 7 member 11, mitochondrial optic atrophy1-1/2 and mitofusin in H9c2 cells. Subsequently, Fer-1 was found to reverse the Herceptin-induced increase in mitochondrial ROS and iron levels in H9c2 cells, as well as the increased protein expression levels of Acyl-CoA synthetase long chain family member 4, cytochrome c, voltage-dependent anion-selective channel, dynamin-related protein, mitochondrial fission 1 protein and mitochondrial ferritin in H9c2 cells. However, compared with deferoxamine, an iron chelator, the effects of Fer-1 were less effective. Collectively, these findings provided insights into the pathogenic mechanism that underlie Herceptin-induced cardiomyopathy, which potentially provides a novel therapeutic target for the prevention of cardiotoxicity in HER2+ breast cancer treatment.

International Journal of Molecular Medicine published new progress about Antioxidant enzymes Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Recommanded Product: Ethyl 3-amino-4-(cyclohexylamino)benzoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gangane, Purushottam Shridhar; Pachpute, Tejas; Mahapatra, Debarshi Kar; Mahajan, Nilesh Manoharrao published the artcile< HPMC polymers and xanthan gum assisted development and characterization of stavudine extended release floating tablets>, HPLC of Formula: 112-63-0, the main research area is xanthan gum assisted development extended release floating tablet.

Stavudine has a low half-life of 0.8-1.5 h and therefore needs recurrent administration to sustain stable beneficial drug plasma levels. In order to enhance and preserve the stable drug level of stavudine for round the clock, gastroretentive systems (floating low-d. formulations that cause buoyancy on the gastric fluid in the stomach) may prove to be advantageous for releasing the drug content from the matrix tablet reservoirs for several hours. The current research endeavors towards formulating the stavudine floating tablet formulations (F1-F9) employing rate modifying polymers such as HPMC K15M, xanthan gum and HPMC K100M using multiple punch tablet compression machine containing 9 mm diameter, round flat-faced punches to form 80 mg tablet with a batch size of 100. The drug-polymer compatibility was investigated through Fourier-Transformed IR Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC). The stavudine floating tablet formulations were successfully fabricated. The pre-compression characteristics (tapped d., bulk d., Hausner’s ratio, Carr’s index and angle of repose) as well as postcompression characteristics (appearance, hardness, dimension, drug content, friability, swelling index, weight variation, in vitro drug release, in vitro buoyancy, accelerated stability and drug release kinetics for 90 days) of the formulations were comprehensively studied. This research study on stavudine will definitely open several new milestones for anti-retroviral pharmacotherapeutics in the upcoming future perspectives by enhancing the half-life of the drug employing the floating extended-release attributes.

Indian Journal of Pharmaceutical Education and Research published new progress about Artificial gastric juice. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Calter, Michael A.; Phillips, Ryan M.; Flaschenriem, Christine published the artcile< Catalytic, Asymmetric, ""Interrupted"" Feist-Benary Reactions>, Formula: C19H34O2, the main research area is hydroxydihydrofuran preparation catalytic asym interrupted Feist Benary.

Pyrimidine derivatives of the cinchona alkaloids function as excellent asym. catalysts for the interrupted Feist-Benary reaction. This reaction produces highly substituted hydroxydihydrofurans from simple starting materials under mild conditions. The asym. reaction gives high enantioselectivities with unsubstituted bromoketones and high enantio- and diastereoselectivities with substituted substrates. Mechanistic experiments suggest that the hydrobromide salt of the alkaloid derivative is the active catalyst for the reaction.

Journal of the American Chemical Society published new progress about Condensation reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jones, Matthew A.; Morton, James D.; Coxon, James M.; McNabb, Stephen B.; Lee, Hannah Y.-Y.; Aitken, Steven G.; Mehrtens, Janna M.; Robertson, Lucinda J. G.; Neffe, Axel T.; Miyamoto, Shigeru; Bickerstaffe, Roy; Gately, Karl; Wood, Jacqueline M.; Abell, Andrew D. published the artcile< Synthesis, biological evaluation and molecular modeling of N-heterocyclic dipeptide aldehydes as selective calpain inhibitors>, Name: Ethyl 5-formyl-1H-pyrrole-2-carboxylate, the main research area is peptide aldehyde preparation inhibitor calpain eye lens opacification; cDNA sequence Ovis calpain 1 2 catalytic subunit.

Ten N-heterocyclic dipeptide aldehydes (4-13) have been synthesized and evaluated as inhibitors of ovine calpain 1 (o-CAPN1) and ovine calpain 2 (o-CAPN2). N-(5-formylpyrrole-2-carbonyl)-L-valylleucinal (9; IC50 values of 290 and 25 nM against o-CAPN1 and o-CAPN2, resp.) was the most potent and selective o-CAPN2 inhibitor, displaying >11-fold selectivity. The amino acid sequences of o-CAPN1 and o-CAPN2 have been determined Because of the lack of available structural information on the ovine calpains, in silico homol. models of the active site cleft of o-CAPN1 and o-CAPN2 were developed based on human calpain 1 (h-CAPN1) X-ray crystal structure (PDB code 1ZCM). These models were used to rationalize the observed SAR for compounds 4-13 and the selectivity observed for 9. The o-CAPN2 selective inhibitor 9 (CAT0059) was assayed in an in vitro ovine lens culture system and shown to successfully protect the lens from calcium-induced opacification.

Bioorganic & Medicinal Chemistry published new progress about Aldehydes Role: PAC (Pharmacological Activity), SPN (Synthetic Preparation), BIOL (Biological Study), PREP (Preparation) (dipeptides). 7126-50-3 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO3, Name: Ethyl 5-formyl-1H-pyrrole-2-carboxylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics