Month: November 2022

Zeyen, Thomas; Potthoff, Anna-Laura; Nemeth, Robert; Heiland, Dieter H.; Burger, Michael C.; Steinbach, Joachim P.; Hau, Peter; Tabatabai, Ghazaleh; Glas, Martin; Schlegel, Uwe; Grauer, Oliver; Krex, Dietmar; Schnell, Oliver; Goldbrunner, Roland; Sabel, Michael; Thon, Niklas; Delev, Daniel; Clusmann, Hans; Seidel, Clemens; Gueresir, Erdem; Schmid, Matthias; Schuss, Patrick; Giordano, Frank A.; Radbruch, Alexander; Becker, Albert; Weller, Johannes; Schaub, Christina; Vatter, Hartmut; Schilling, Judith; Winkler, Frank; Herrlinger, Ulrich; Schneider, Matthias published the artcile< Phase I/II trial of meclofenamate in progressive MGMT-methylated glioblastoma under temozolomide second-line therapy-the MecMeth/NOA-24 trial>, HPLC of Formula: 112-63-0, the main research area is meclofenamate MGMT temozolomide glioblastoma therapy progression; Glioblastoma; Meclofenamate; Relapse; Second-line therapy; Temozolomide.

Glioblastoma is the most frequent and malignant primary brain tumor. Even in the subgroup with O-6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and favorable response to first-line therapy, survival after relapse is short (12 mo). Standard therapy for recurrent MGMT-methylated glioblastoma is not standardized and may consist of re-resection, re-irradiation, and chemotherapy with temozolomide (TMZ), lomustine (CCNU), or a combination thereof. Preclin. results show that meclofenamate (MFA), originally developed as a nonsteroidal anti-inflammatory drug (NSAID) and registered in the USA, sensitizes glioblastoma cells to temozolomide-induced toxicity via inhibition of gap junction-mediated intercellular cytosolic traffic and demolishment of tumor microtube (TM)-based network morphol. In this study, combined MFA/TMZ therapy will be administered (orally) in patients with first relapse of MGMT-methylated glioblastoma. A phase I component (6-12 patients, 2 dose levels of MFA + standard dose TMZ) evaluates safety and feasibility and determines the dose for the randomized phase II component (2 x 30 patients) with progression-free survival as the primary endpoint. This study is set up to assess toxicity and first indications of efficacy of MFA repurposed in the setting of a very difficult-to-treat recurrent tumor. The trial is a logical next step after the identification of the role of resistance-providing TMs in glioblastoma, and results will be crucial for further trials targeting TMs. In case of favorable results, MFA may constitute the first clin. feasible TM-targeted drug and therefore might bridge the idea of a TM-targeted therapeutic approach from basic insights into clin. reality.

Trials published new progress about Clinical trials, phase I. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kowalczyk, Dorota; Albrecht, Lukasz published the artcile< Vinylogous Nucleophiles Bearing the Endocyclic Double Bond in the Allylic Alkylation with Morita-Baylis-Hillman Carbonates>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is coumarin methyl carbonate Morita Baylis Hillman chiral allylic alkylation; homoallylic coumarin stereoselective preparation.

This study demonstrates that vinylogous transfer of nucleophilicity in the allylic alkylation with Morita-Baylis-Hillman carbonates can be accomplished through the endocyclic double bond in 3-cyano-4-methylcoumarins. The developed reaction provides a straightforward access to functionalized coumarin derivativesI (EWG = CO2Me, CO2Et, CO2Bu-t, CN; R1 = Ph, 4-CF3C6H4, 4-BrC6H4, etc.; R2 = H, 6-Cl, 6-Br, etc.) of biol. and synthetic relevance. Target, highly functionalized products have been chemoselectively and efficiently obtained in very high yield (up to 98%) and with excellent enantioselectivity (up to 99.5:0.5 er).

Advanced Synthesis & Catalysis published new progress about Allylic alkylation catalysts, stereoselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Aparna, P.; Kothari, Seema; Banerji, Kalyan K. published the artcile< Kinetics and mechanism of oxidation of hydroxy acids by pyridinium hydrobromide perbromide>, Application In Synthesis of 112-63-0, the main research area is oxidation hydroxy acid pyridinium hydrobromide perbromide.

The oxidation of glycolic, lactic, mandelic and malic acids by pyridinium hydrobromide perbromide (PHPB) in acetic acid-water mixture (3:7, volume/volume) gives oxo acids. The reaction is first-order each in PHPB and the hydroxy acid. Addition of pyridinium hydrobromide does not affect the rate, indicating that PHPB itself is the reactive oxidizing species. The oxidation of α-deuteriomandelic acid shows the presence of a primary kinetic isotope effect (kH/kD = 5.07). The reaction does not exhibit a solvent isotope effect [k(H2O)/k(D2O) = 1.01]. The rate decreases with an increase in acetic acid content in the solvent mixture A mechanism involving hydride ion transfer to the oxidant is proposed.

Indian Journal of Chemistry, Section A: Inorganic, Bio-inorganic, Physical, Theoretical & Analytical Chemistry published new progress about Isotope effect. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hu, Yaofang; Tang, Gang; Luo, Yunjun; Chi, Shumeng; Li, Xiaoyu published the artcile< Glycidyl azide polymer-based polyurethane vitrimers with disulfide chain extenders>, Computed Properties of 112-63-0, the main research area is glycidyl azide polyol based polyurethane vitrimer property.

The glycidyl azide polymer (GAP) is an important type of energetic polymer and is considered to be the most promising candidate for polymeric binders for next generation solid propellants. However, the most outstanding obstacle for the wide application of GAP is its low mech. properties, which is usually overcome by incorporating it into polyurethanes (PUs) as a soft segment. Herein, we report the preparation of a series of GAP-based PU vitrimers (GAPUVs), with GAP, 2-hydroxyethyl disulfide (HEDS), and trimethylolpropane (TMP) as the soft segment, chain extender and crosslinker, resp. The crosslinking d. and composition of the resultant thermosetting GAPUVs were optimized to significantly improve the mech. properties, which were clearly superior to their linear counterparts and most examples from the literature. More interestingly, the incorporation of dynamic disulfide bonds in the network not only endowed the GAPUVs with decent mech. properties, but also marked healing ability upon mild heating and thermo-reprocessability. This allowed the fabrication of healable composites from GAPUVs and aluminum powders, with a healing efficiency above 95%. Addnl., the thermo-exchangeable disulfide linkage in the GAPUVs allowed the full recovery of the loaded fillers by simply heating the composite in a solvent.

Polymer Chemistry published new progress about Crosslink density. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Krysan, Damian J. published the artcile< A dramatic reversal of facial selectivity in the Sharpless asymmetric dihydroxylation of a sterically hindered 3-methylidene-benzofuran>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is benzofuran asym dihydroxylation catalyst; dihydroquinine catalyst asym osmylation; dihydroquinidine catalyst asym osmylation; osmylation asym catalyst dihydroquinine dihydroquinidine.

Reversal of π-facial selectivity in the osmium-catalyzed asym. dihydroxylation (AD) of an exocyclic olefin I was reported. Switching from a phthalazine-linked ligand (DHQ2PHAL or DHQD2PHAL) to a pyrimidine-linked ligand (DHQ2PYR or DHQD2PYR) led to the opposite enantiomer using the same pseudo-enantiomer of the cinchona alkaloid.

Tetrahedron Letters published new progress about Dihydroxylation catalysts, stereoselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hong, Zhongyang; Zhang, Xianzheng; Zhang, Tianjing; Hu, Ling; Liu, Ruijin; Wang, Pan; Wang, Han; Yu, Qianqian; Mei, Dan; Xue, Ziyang; Zhang, Feng; Zhang, Lingling published the artcile< The ROS/GRK2/HIF-1α/NLRP3 pathway mediates pyroptosis of fibroblast-like synoviocytes and the regulation of monomer derivatives of paeoniflorin>, SDS of cas: 112-63-0, the main research area is .

Hypoxia is an important factor in the development of synovitis in rheumatoid arthritis (RA). The previous study of the research group found that monomeric derivatives of paeoniflorin (MDP) can alleviate joint inflammation in adjuvant-induced arthritis (AA) rats by inhibiting macrophage pyroptosis. This study revealed increased levels of hypoxia-inducible factor- (HIF-) 1α and N-terminal p30 fragment of GSDMD (GSDMD-N) in fibroblast-like synoviocytes (FLS) of RA patients and AA rats, while MDP significantly inhibited their expression. Subsequently, FLS were exposed to a hypoxic environment or treated with cobalt ion in vitro. Western blot and immunofluorescence anal. showed increased expression of G protein-coupled receptor kinase 2 (GRK2), HIF-1α, nucleotide-binding oligomerization segment-like receptor family 3 (NLRP3), ASC, caspase-1, cleavedcaspase- 1, and GSDMD-N. Electron microscopy revealed FLS pyroptosis after exposure in hypoxia. Next, corresponding shRNAs were transferred into FLS to knock down hypoxia-inducible factor- (HIF-) 1α, and in turn, NLRP3 and western blot results confirmed the same. The enhanced level of GSDMD was reversed under hypoxia by inhibiting NLRP3 expression. Knockdown and overexpression of GRK2 in FLS revealed GRK2 to be a pos. regulator of HIF-1α. Levels of GRK2 and HIF-1α were inhibited by eliminating excess reactive oxygen species (ROS). Furthermore, MDP reduced FLS pyroptosis through targeted inhibition of GRK2 phosphorylation. According to these findings, hypoxia induces FLS pyroptosis through the ROS/GRK2/HIF-1α/NLRP3 pathway, while MDP regulates this pathway to reduce FLS pyroptosis.

Oxidative Medicine and Cellular Longevity published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zeng, Ruiming; Chen, Ying; Zhang, Li; Tan, Jianbo published the artcile< R-RAFT or Z-RAFT? Well-Defined Star Block Copolymer Nano-Objects Prepared by RAFT-Mediated Polymerization-Induced Self-Assembly>, COA of Formula: C19H34O2, the main research area is RAFT polymerization copolymer nanoobject polymerization.

Reversible addition-fragmentation chain transfer (RAFT)-mediated polymerization-induced self-assembly (PISA) has served as a versatile platform for the large-scale preparation of block copolymer nano-objects with a diverse set of morphologies. However, almost all PISA formulations are focused on the syntheses of linear block copolymers rather than star block copolymers. Owing to the asym. structure of the RAFT agent, herein, we report a direct comparison between Z-RAFT (the nonfragmenting group attached to the core) and R-RAFT (the fragmenting group attached to the core) strategies for preparing well-defined star block copolymer nano-objects via RAFT-mediated PISA. We showed that the Z-RAFT strategy is a more suitable strategy for the preparation of star block copolymer nano-objects without compromising the control over the mol. weight and morphol. A binary mixture of Z-type and R-type tetrafunctional macro-RAFT agents was used to control the morphologies of star block copolymer assemblies. The effect of numbers of the RAFT group on polymerization kinetics and morphologies of block copolymer nano-objects was also investigated in detail. Finally, (ABC)4 four-arm star triblock copolymer vesicles were prepared by seeded RAFT dispersion polymerization of solvophobic and solvophilic monomers using (AB)4 four-arm star diblock copolymer vesicles as seeds. This research not only expands the scope for preparing well-defined star block copolymer nano-objects but also provides important insights into the effect of the polymer architecture on RAFT-mediated PISA.

Macromolecules (Washington, DC, United States) published new progress about Binary mixtures. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Maki, Toshikatsu; Ishihara, Kazuaki; Yamamoto, Hisashi published the artcile< N-Alkyl-4-boronopyridinium Halides versus Boric Acid as Catalysts for the Esterification of α-Hydroxycarboxylic Acids>, Product Details of C6H10O5, the main research area is boric boronic acid catalyst condensation hydroxycarboxylic acid alc; resin bound boronic acid catalyst condensation hydroxycarboxylic acid alc; alpha beta hydroxy ester chemoselective preparation; hydroxybenzoate ester chemoselective preparation; amide preparation; chemoselective condensation alpha beta hydroxy carboxylic hydroxybenzoic acid alc; boronic boric acid catalyst chemoselective condensation hydroxyacid alc; alkyl boronopyridinium halide boric acid catalyst condensation hydroxyacid alc.

α- And β-hydroxycarboxylic and ortho-hydroxybenzoic acids undergo condensation reactions with alcs. in the presence of either boronic acids such as 4-borono-1-methylpyridinium iodide (I) or in the presence of boric acid to yield α-hydroxy or ortho-benzoate esters chemoselectively. When excess alcs. are used to prepare the hydroxyesters, I is the more effective catalyst of those tested, while for esterifications using less than three equivalent of the alc. boric acid is a more effective catalyst. Resin-bound 1-benzyl-4-boronopyridinium chloride is recycled nine times as a catalyst for the dehydrative esterification of mandelic acid in isobutanol to give iso-Bu mandelate in 95-99% conversion. Esterification of α-hydroxy acids with alcs. in the presence of boric acid is preferred to esterification of carboxylic acids; for example, esterification of 2-methyl-2-hydroxypropanoic acid and benzoic acid with one equivalent of 1-octanol in the presence of boric acid yields octyl 2-hydroxy-2-methylpropanoate in 90% and octyl benzoate in 1% yield. I also acts as a catalyst for the condensation of amines and carboxylic acids to give amides; condensation of 5-amino-1-pentanol and benzenebutanoic acid in anisole in the presence of I yields Ph(CH2)3CONH(CH2)5OH (II) in 82% yield; condensation of II with 2-hydroxy-2-methylpropanoic acid in toluene in the presence of boric acid provides Ph(CH2)3CONH(CH2)5OCOC(OH)Me2 in 91% yield.

Organic Letters published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Product Details of C6H10O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nakamura, Shinsuke; Mukudai, Yoshiki; Chikuda, Junichiro; Zhang, Meilin; Shigemori, Hideyuki; Yazawa, Kazunaga; Kondo, Seiji; Shimane, Toshikazu; Shirota, Tatsuo published the artcile< Combinational anti-tumor effects of chemicals from Paeonia lutea leaf extract in oral squamous cell carcinoma cells>, HPLC of Formula: 112-63-0, the main research area is Paeonia lutea leaf extract antitumor oral squamous cell carcinoma; Gallic acid methyl ester; Paeonia lutea; paeoniflorin; pentagalloyl glucose; squamous cell carcinoma.

We identified chem. components that exhibited antitumor activity against oral squamous cell carcinoma (OSCC) cells and examined their effective concentrations and additive and/or synergistic effects in combinational usage on the proliferation, apoptosis and cell cycle of OSCC cells. Using high-performance liquid chromatog., NMR spectroscopy and electrospray ionization-mass spectrometry, we identified the main chem. components of the methanol extracts from Paeonia lutea. We investigated the pharmaceutical effects of those components on the proliferation, apoptosis, and cell cycle of an OSCC cell line, SAS, using the tetrazolium salt 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) and caspase assays, as well as flow cytometry cell cycle anal. We also examined the effects of those components on the mitogen-activated protein kinase signal transduction pathway by western blotting. Finally, the effects on normal human epidermal keratinocyte cells were also examined in similar experiments Three chems. have been identified in P. lutea leaves using high performance liquid chromatog.: gallic acid Me ester (GAME), pentagalloyl glucose (PGG) and paeoniflorin (PF). Both GAME and PGG significantly suppressed cell proliferation, and their combined effects were synergistic, while the effect of PF was minimal. However, those chems. did not induce apoptosis. Cell cycle and western blotting anal. showed that the suppressive effects on cell proliferation resulted from G2 arrest and the suppression of phosphorylation of Akt/PKB. No effect was identified on normal human epidermal keratinocyte cells. These results indicate that GAME and PGG are the main chem. components of P. lutea leaves that have potential anti-cancer therapeutic effects.

Anticancer Research published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lin, Yuanbin; Liang, Chungen published the artcile< Convenient synthetic procedures for 2-bromothiophene>, Application In Synthesis of 112-63-0, the main research area is bromothiophene preparation; thiophene bromination pyridine hydrobromide perbromide.

The reaction of thiophene with pyridine hydrobromide perbromide in 48% hydrobromic acid and tetrachloromethane gives 90.4% 2-bromothiophene.

Xiangtan Daxue Ziran Kexue Xuebao published new progress about Bromination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics