Month: November 2022

Mardenborough, Leroy G.; Zhu, Xue Y.; Fan, Pincheng; Jacob, Melissa R.; Khan, Shabana I.; Walker, Larry A.; Ablordeppey, Seth Y. published the artcile< Identification of bis-quindolines as new antiinfective agents>, COA of Formula: C19H34O2, the main research area is bisquindoline preparation antiinfective agent SAR.

Several N-substituted quindolines were made to further evaluate the role of N-alkylation on the activity of indoloquinolines as antifungal agents. While N-5 substitution is required for these activities, N-10 alkylation alone leads to inactive products but is tolerated in the presence of N-5 alkyl groups. It was also discovered that bis-quindolines appear to have a more expanded antimicrobial spectrum and lower cytotoxicity than their monomeric counterparts.

Bioorganic & Medicinal Chemistry published new progress about Antimalarials. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guo, Haixin; Abe, Yuya; Qi, Xinhua; Smith, Richard Lee Jr published the artcile< Bifunctional carbon Ni/NiO nanofiber catalyst based on 5-sulfosalicylic acid for conversion of C5/C6 carbohydrates into ethyl levulinate>, Related Products of 112-63-0, the main research area is carbon nickel oxide catalyst sulfosalicylic acid carbohydrate ethyl levulinate.

A method was developed for preparing bifunctional carbon Ni/NiO nanofiber catalysts that promote efficient one-pot conversion of C5/C6 carbohydrates into levulinate esters in alc. solvents. The bifunctional catalysts were prepared via solvothermal carbonization of 5-sulfosalicylic acid/NiSO4 without the use of sulfuric acid or hydrogen gas and had fine particle sizes (d = 5 nm to 50 nm) and contained -NH2, -SO3H, -COOH and phenolic -OH functional groups. Under optimal conditions, the catalysts afforded 93% selectivity of Et levulinate in ethanol with the major intermediate being 2-(ethoxymethyl)furan, 4,5,5-triethoxypentan-2-one and major byproduct being 2,5,5-triethoxpentan-2-one. Cooperative activity of Lewis acidity, Bronsted acidity and functional group sites of the catalyst is demonstrated for multi-step reaction sequences of C5/C6 carbohydrates with one-pot conversions and alcs. (methanol, ethanol, 1-propanol, 1-butanol) that act as both solvent and hydrogen donor source in which the bifunctional catalyst was shown to be recyclable five times with no apparent change in conversion and ca. 5% change in selectivity.

Reaction Chemistry & Engineering published new progress about Carbon fibers Role: CAT (Catalyst Use), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Lianhong; Lewis, Iestyn R.; Davidsen, Steven K.; Summers, James B. published the artcile< Transition metal catalyzed synthesis of 5-azaindoles>, Application In Synthesis of 112-63-0, the main research area is azaindole preparation transition metal catalyzed.

In an effort to develop synthetic procedures for the preparation of 2-substituted 5-azaindoles, the synthesis and cyclization reactions of acetylenic aminopyridines was explored. A novel method for the synthesis of 2-substituted 5-azaindoles via a transition metal catalyzed reaction is described. For example coupling reaction of 3-iodo-4-(tert-butoxycarbonyl)aminopyridine with propyne in the presence of Pd(PPh3)2Cl2, Et3N, and CuI at room temperature gave quant. 3-propynyl-4-(tert-butoxycarbonyl)aminopyrine, cyclization of which with CuI in DMF at 80° gave 84% 1-(tert-butoxycarbonyl)-2-methyl-5-azaindole.

Tetrahedron Letters published new progress about Transition metals Role: CAT (Catalyst Use), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Majee, Debashis; Jakkampudi, Satish; Arman, Hadi D.; Zhao, John C.-G. published the artcile< Enantioselective Synthesis of Cyclohexenol Derivatives from γ-Aryl-Substituted Enals via an Organocatalyzed Three-Component Reaction>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is cyclohexenol preparation enantioselective diastereoselective; unsaturated aldehyde nitroalkene cinchona alkaloid squaramide catalyst.

A three-component reaction between γ-aryl-substituted α,β-unsaturated aldehydes and nitroalkenes was realized by using cinchona alkaloid-derived (thio)ureas and squaramides via the dienolate intermediates. This unprecedented 1,3- and 1,5-reactivity of dienolates of the γ-aryl-α,β-unsaturated aldehydes led to the formation of cyclohexenol derivatives I (R1 = Ph, 4-MeOC6H4, 4-FC6H4, etc.; R2 =Ph, 2-BrC6H4, 2-theinyl, etc.) with four contiguous stereogenic centers and a chiral substituent at C2 with good diastereoselectivities and high ee values. Such reactivities of the dienolates are totally different from those of the corresponding dienamine intermediates.

Organic Letters published new progress about Alkenes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhou, Xin-Yue; Zhang, Ming; Liu, Zhong; He, Jia-Hao; Wang, Xiao-Chen published the artcile< C3-Selective Trifluoromethylthiolation and Difluoromethylthiolation of Pyridines and Pyridine Drugs via Dihydropyridine Intermediates>, SDS of cas: 33402-75-4, the main research area is trifluoromethylthiopyridine preparation one pot regioselective; pyridine trifluoromethylthiolation difluoromethylthiolation hydroboration oxidative aromatization; difluoromethylthiopyridine preparation regioselective one pot.

Herein, authors report a method for unprecedented C3-selective C-H tri- and difluoromethylthiolation of pyridines. The method relies on borane-catalyzed pyridine hydroboration for generation of nucleophilic dihydropyridines; these intermediates react with trifluoromethylthio and difluoromethylthio electrophiles to form functionalized dihydropyridines, which then undergo oxidative aromatization. The method can be used for late-stage functionalization of pyridine drugs for the generation of new drug candidates.

Journal of the American Chemical Society published new progress about Aromatization. 33402-75-4 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO2, SDS of cas: 33402-75-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hu, Yunfei; Chen, Li; Zou, Canlin; He, Jiangtao; Feng, Luanqi; Wu, Jia-Qiang; Chen, Wen-Hua; Hu, Jinhui published the artcile< Access to 3-Amino-[1,2,4]-triazolo Pyridines and Related Heterocycles via Electrochemically Induced Desulfurative Cyclization>, Reference of 112-63-0, the main research area is hydrazinopyridine isothiocyanate tetrabutylammonium iodide catalyst desulfurative cyclization; amino triazolo pyridine electrochem preparation.

An efficient, one-pot approach was established for synthesizing a wide range of 3-amino-[1,2,4]-triazolo pyridines and related heterocycles from the electrochem. induced desulfurative cyclization of 2-hydrazinopyridines with isothiocyanates. The protocol allowed for the formation of C-N bonds under simple conditions without transition metals or external oxidants. The practicability of this strategy was demonstrated by its broad substrate scope, good functional group compatibility, and gram-scale synthesis. The late-stage modification of 3-amino-[1,2,4]-triazolo pyridines enabled to obtain several mols. with potent anticancer activity.

Organic Letters published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zheng, Long-Sheng; Yin, Congcong; Wang, Fangyuan; Chen, Gen-Qiang; Zhang, Xumu published the artcile< Enantioselective synthesis of cis-hexahydro-γ-carboline derivatives via Ir-catalyzed asymmetric hydrogenation>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is tetrahydropyridoindole carboxylate iridium ZhaoPhos catalyst diastereoselective enantioselective hydrogenation; hexahydropyridoindole carboxylate preparation.

A novel synthetic route was developed for the construction of a chiral cis-hexahydro-γ-carboline derivative through Ir/ZhaoPhos-catalyzed asym. hydrogenation of corresponding tetrahydro-γ-carboline with high yields (up to 99% yield), excellent diastereoselectivities (up to >99 : 1 dr) and enantioselectivities (up to 99% ee), and high substrate-to-catalyst ratios (up to 5000).

Chemical Communications (Cambridge, United Kingdom) published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kim, Jae-Hyun; Kim, Minsun; Hong, Sooyeon; Kim, Eun-Young; Lee, Hyangsook; Jung, Hyuk-Sang; Sohn, Youngjoo published the artcile< Albiflorin promotes osteoblast differentiation and healing of rat femoral fractures through enhancing BMP-2/Smad and Wnt/β-catenin signaling>, HPLC of Formula: 112-63-0, the main research area is Paeonia lactiflora albiflorin catenin osteoblast differentiation osteogenesis; Paeonia lactiflora; Wnt; albiflorin; bone morphogenetic protein 2; femoral fracture; osteoblast; runt-related transcription factor 2.

Fracture healing is related to osteogenic differentiation and mineralization. Recently, due to the unwanted side effects and clin. limitations of existing treatments, various natural productbased chem. studies have been actively conducted. Albiflorin is a major ingredient in Paeonia lactiflora, and this study investigated its ability to promote osteogenic differentiation and fracture healing. To demonstrate the effects of albiflorin on osteoblast differentiation and calcified nodules, alizarin red S staining and von Kossa staining were used in MC3T3-E1 cells. In addition, BMP-2/Smad and Wnt/β-catenin mechanisms known as osteoblast differentiation mechanisms were analyzed through RT-PCR and western blot. To investigate the effects of albiflorin on fracture healing, fractures were induced using a chainsaw in the femur of Sprague Dawley rats, and then albiflorin was i.p. administered. After 1, 2, and 3 wk, bone microstructure was analyzed using micro-CT. In addition, histol. anal. was performed by staining the fractured tissue, and the expression of osteogenic markers in serum was measured. The results demonstrated that albiflorin promoted osteoblastogenesis and the expression of RUNX2 by activating BMP-2/Smad and Wnt/β-catenin signaling in MC3T3-E1 cells. In addition, albiflorin upregulated the expression of various osteogenic genes, such as alk. phosphatase, OCN, bone sialoprotein, OPN, and OSN. In the femur fracture model, micro-CT anal. showed that albiflorin played a pos. role in the formation of callus in the early stage of fracture recovery, and histol. examination proved to induce the expression of osteogenic genes in femur tissue. In addition, the expression of bone-related genes in serum was also increased. This suggests that albiflorin promotes osteogenesis, bone calcification and bone formation, thereby promoting the healing of fractures in rats.

Frontiers in Pharmacology published new progress about Biomineralization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Becker, Heinrich; Soler, Marcos A.; Sharpless, K. Barry published the artcile< Selective asymmetric dihydroxylation of polyenes>, Category: esters-buliding-blocks, the main research area is asym dihydroxylation polyene; hydroxylation di asym polyene; stereochem dihydroxylation polyene; olefin poly asym dihydroxylation; osmylation asym polyene.

The asym. dihydroxylation procedure (AD) is applied to a variety of polyenes. In many cases excellent regioselectivities are obtained. The observed selectivities are rationalized in terms of electronic and/or steric effects inherent to the substrate, superimposed on the substrate’s favorable or unfavorable interactions with the binding pocket of the AD ligand. Surprisingly, for medium and large ring olefins with trans-double bonds outstanding enantioselectivities are realized using the pyrimidine ligands. A hexaol of D3 symmetry is prepared from all trans cyclododecatriene.

Tetrahedron published new progress about Alkenes, polyene alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ramos, Alicia Marcos; Beckers, Edwin H. A.; Offermans, Ton; Meskers, Stefan C. J.; Janssen, Rene A. J. published the artcile< Photoinduced Multistep Electron Transfer in an Oligoaniline-Oligo(p-phenylene Vinylene)-Perylene Diimide Molecular Array>, Reference of 112-63-0, the main research area is photoinduction multistep electron transfer oligoaniline oligophenylene vinylene perylene diimide.

Photoinduced multistep electron transfer has been studied in two sym. oligoaniline-oligo(p-phenylene vinylene)-perylene diimide-oligo(p-phenylene vinylene)-oligoaniline (OAn-OPV-PERY-OPV-OAn) multichromophore arrays with fluorescence and transient absorption spectroscopy in the femtosecond and nanosecond time domains. The arrays consist of a sym. donor(2)-donor(1)-acceptor-donor(1)-donor(2) arrangement, with two OAn-OPV segments coupled to a central PERY unit via a direct linkage (1) or a saturated spacer (2). Photoexcitation gives the OAn-OPV+•-PERY-•-OPV-OAn as the primary charge-separated state. For 1 the transfer is extremely fast (kCS > 1000 ns-1) in polar and apolar solvents, while the rate constants for recombination differ and are significantly higher in polar solvents than in apolar solvents because recombination occurs in the Marcus inverted region. Charge separation and charge recombination are slower in 2, because the saturated spacer reduces the electronic coupling between OPV donor and PERY acceptor. The primary OAn-OPV+•-PERY-•-OPV-OAn charge-separated state can rearrange in a charge-shift reaction to the OAn+•-OPV-PERY-•-OPV-OAn state. This charge shift is exergonic and competes with fast charge recombination. In polar solvents the efficiency of the charge shift is about 0.22 and 0.28 for 1 and 2, resp., and only weakly dependent on the polarity. In toluene the two charge-separated states are nearly isoenergetic for 1, and hence, no shift is observed in toluene. The OAn+•-OPV-PERY-•-OPV-OAn charge-separated state has a long lifetime as a result of the negligible interaction between the distant OAn+• and PERY-• redox sites and can be observed up to several microseconds.

Journal of Physical Chemistry A published new progress about Chromophores. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics