Month: November 2022

Ohashi, Tsutomu; Miyoshi, Fumihisa; Sawada, Yukie published the artcile< Studies on organic solid state reactions. I. Solid state bromination with sulfonium tribromide crystals>, Application of C19H34O2, the main research area is stilbene bromination stereochem methylthianium tribromide; ethane dibromo diphenyl; sulfonium tribromide bromination stilbene.

Sulfonium tribromides brominate (E)-PhCH:CHPh (I) effectively in the solid state. When a ground mixture of I and 1-methylthianium tribromide (II) in an agate mortar was stored in a thermostat at 30° for 2 d, meso-PhCHBrCHBrPh (III) was obtained quant. and stereoselectively (trans addition). Several other sulfonium tribromides also gave similar results, though the reaction times varied. Examination of the progress of the reaction of I and II by IR absorption spectrometry and powder x-ray diffraction indicated that the crystals of I gradually changed to those of III, while those of II changed to those of the sulfonium monobromide.

Nippon Kagaku Kaishi published new progress about Bromination, stereoselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Faulstich, Heinz; Zobeley, Suse; Bentrup, Ulla; Jockusch, Brigitte M. published the artcile< Biotinylphallotoxins: preparation and use as actin probes>, SDS of cas: 112-63-0, the main research area is electron microscopy actin filament biotinylphallotoxin; phalloidin derivative biotin preparation cytoskeleton.

The synthesis of four phalloidin derivatives conjugated with biotin is described. An aminomethyldithiolane derivative of ketophalloidin was used as a reactive starter compound, and biotin residues were coupled to this mol. either directly, separated by spacer chains comprised of one or two glycyl residues, or of a 12-atom long chain constructed from succinic acid and hexamethylenediamine. Although all products still displayed a high affinity for E-actin, as seen in competition experiments with [3H]demethylphalloidin, only the one with the longest spacer (BHPP) showed specific and high-affinity decoration of actin filaments in permeabilized cells, in conjunction with FITC-coupled avidin and fluorescence microscopy. Combined with gold-streptoavidin, BHPP decorated the actin filament system at the light and electron microscopic level faithfully and with satisfactory d. Actin filaments polymerized in vitro from purified protein were not as densely labeled as had been expected. However, in all these experiments the new phalloidin probe, when combined with avidin or streptoavidin, yielded clear and highly specific labeling of E-actin. Therefore, this system is useful to identify and localize actin unambiguously in microfilaments, independent of actin antibodies, and should facilitate double-label experiments on cystoskeletal components at the ultrastructural level.

Journal of Histochemistry and Cytochemistry published new progress about Avidins, conjugates Role: ANST (Analytical Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gao, Zhao; Chen, Ze; Han, Yifei; Wang, Feng published the artcile< Cyanostilbene-based vapo-fluorochromic supramolecular assemblies for reversible 3D code encryption>, Computed Properties of 112-63-0, the main research area is cyanostilbene preparation fluorescence vapochromism self assembly.

Scanning codes with the capability for stimuli-triggered decryption are urgently needed to prevent information leakage and counterfeiting. Compared to conventional 1D barcodes and 2D QR codes, 3D codes show promise in this field thanks to the presence of four different colors in the icon, with great information variability. Up to now, encrypted 3D code development has primarily focused on chem. reaction-based systems, leading to information decryption in an irreversible transformation manner. Herein, a novel and intelligent 3D code encryption system has been constructed with full reversibility and a fast response, taking advantage of the luminescent vapochromism of cyanostilbene-based supramol. assemblies. Information in the inkjet-printed 3D code is specifically decrypted through vapor fuming with chlorinated solvents, while it is reversibly encrypted upon removing the vapor. Hence, this study provides a novel and effective strategy for obtaining high-performance smart scanning codes.

Nanoscale Horizons published new progress about Aggregates. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tian, Dan-Dan; Wang, Min; Liu, An; Gao, Mei-Rong; Qiu, Chen; Yu, Wen; Wang, Wen-Ju; Zhang, Kun; Yang, Le; Jia, Yan-Yan; Yang, Chang-Bin; Wu, Yu-Mei published the artcile< Antidepressant Effect of Paeoniflorin Is Through Inhibiting Pyroptosis CASP-11/GSDMD Pathway>, Reference of 112-63-0, the main research area is depression neuroinflammation paeoniflorin reserpine CASP11 lipopolysaccharide ifenprodil CD68 GSDMD; Depression; GSDMD; Microglia; Neuroinflammation; Paeoniflorin; Pyroptosis.

We provide evidence that paeoniflorin, a monoterpene glycoside compound derived from Paeonia lactiflora, ameliorated reserpine-induced mouse depression-like behaviors, characterized as increased mobility time in tail suspension test and forced swimming test, as well as the abnormal alteration of synaptic plasticity in depressive hippocampus. We further demonstrated that PF administration inhibited the enhanced expression of GSDMD which mainly distributed in microglia, along with proteins involved in pyroptosis signaling transduction including caspase (CASP)-11, CASP-1, NLRP3, and interleukin (IL)-1β. PF prevented lipopolysaccharide and ATP induced pyroptosis in murine N9 microglia in vitro, evidenced by inhibiting the expression of CASP-11, NLRP3, CASP-1 cleavage, as well as IL-1β. VX-765, effective and selective inhibitor for CASP-1 activation, reduced expression of inflammasome and pyroptosis-associated proteins in over-activated N9 and also facilitated PF-mediated inhibition of pyroptosis synergistically. Collectively, data indicated that PF exerted antidepressant effects, alleviating neuroinflammation through inhibiting CASP-11-dependent pyroptosis signaling transduction induced by over-activated microglia in the hippocampus of mice treated with reserpine. GSDMD-mediated pyroptosis in activated microglia is previously unrecognized inflammatory mechanism of depression and represents unique therapeutic opportunity for mitigating depression given PF administration.

Molecular Neurobiology published new progress about Antidepressants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

de Falco, Bruna; Grauso, Laura; Fiore, Alberto; Bonanomi, Giuliano; Lanzotti, Virginia published the artcile< Metabolomics and chemometrics of seven aromatic plants: Carob, eucalyptus, laurel, mint, myrtle, rosemary and strawberry tree>, HPLC of Formula: 112-63-0, the main research area is Arbutus Ceratonia Eucalyptus Laurus Mentha chemometrics metabolomics; GC-MS; NMR; PCA; dendrogram; heatmap.

Arbutus unedo L. (strawberry tree), Ceratonia siliqua L. (carob), Eucalyptus camaldulensis Dehnh. (eucalyptus), Laurus nobilis L. (laurel), Mentha aquatica L. (water mint), Myrtus communis L. (common myrtle), and Rosmarinus officinalis L. (rosemary) are aromatic plants from the Mediterranean region whose parts and preparations are used for their nutritional properties and health benefits. To evaluate and compare the metabolites profile, total phenol content (TPC), and antioxidant activity of plant leaves for their future use. Gas chromatog.-mass spectrometry (GC-MS) was used for metabolomics. Data comparison was performed by chemometrics. Polar and apolar extracts were analyzed using untargeted GC-MS metabolomics followed by chemometrics (principal component anal., heatmap correlation and dendrogram) to identify, quantify and compare the major organic compounds in the plants. Addnl., NMR (NMR) spectroscopy was used for the laurel polar extract to identify D-gluco-L-glycero-3-octulose whose presence was unclear from the GC-MS data. TPC and antioxidant assays were performed using classical methods (Folin-Ciocalteu, 2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH)) and correlated to the phytochem. profiles. Forty-three metabolites were identified including amino acids, organic acids, carbohydrates, phenols, polyols, fatty acids, and alkanes. Eight metabolites (D-fructose, D-glucose, D-mannose, gallic acid, quinic acid, myo-inositol, palmitic and stearic acids) were in common between all species. D-Gluco-L-glycero-3-octulose (37.29 ± 1.19%), D-pinitol (31.33 ± 5.12%), and arbutin (1.30 ± 0.44%,) were characteristic compounds of laurel, carob, and strawberry tree, resp. Carob showed the highest values of TPC and antioxidant activity. GC-MS metabolomics and chemometrics analyses are fast and useful methods to determine and compare the metabolomics profiling of aromatic plants of food and industrial interest.

Phytochemical Analysis published new progress about Alkanes Role: ANT (Analyte), BSU (Biological Study, Unclassified), ANST (Analytical Study), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nickel, Mara C; Chaudhary, Rekha published the artcile< Temozolomide for Intracranial Melanoma.>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is .

There is no abstract available for this document.

American journal of therapeutics published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Das, Tamal Kanti; Biju, Akkattu T. published the artcile< A Method for the Analysis of Free Carbenes Present after NHC-Organocatalyzed Transformations>, Reference of 112-63-0, the main research area is azaheterocyclic carbene organocatalysis thione.

In N-heterocyclic carbene (NHC) based organocatalysis, usually, the free carbene is generated in situ by treatment of the azolium salt with a base. Described herein is a method for the anal. of the NHC present in the reaction flask after the NHC-organocatalyzed reaction. For this, the reaction mixture was treated with elemental sulfur after the reaction and the thus-formed thiourea/thione derivative was isolated. Common NHC-catalyzed transformations such as benzoin reactions, Stetter reactions, homoenolate annulation reactions, and reactions proceeding via the α,β-unsaturated acylazolium intermediate have been studied. The results indicate that after the reactions, 28-84 % of the initial carbenes exist in the free form.

European Journal of Organic Chemistry published new progress about Benzoin condensation reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yasmeen, Tahira; Arif, Muhammad Saleem; Shahzad, Sher Muhammad; Riaz, Muhammad; Tufail, Muhammad Ammar; Mubarik, Muhammad Salman; Ahmad, Aqeel; Ali, Shafaqat; Albasher, Gadah; Shakoor, Awais published the artcile< Abandoned agriculture soil can be recultivated by promoting biological phosphorus fertility when amended with nano-rock phosphate and suitable bacterial inoculant>, Synthetic Route of 112-63-0, the main research area is Zea nanorock phosphate agriculture soil phosphorus fertility rhizosphere; Maize, Nano-technology; Regenerative agriculture; Rhizosphere; Soil fertility.

In semi-arid regions, post-restoration vegetation recovery on abandoned agricultural lands often fails due to inherently low organic matter content and poor soil fertility conditions, including phosphorus (P). As such, amending these soils with controlled release P fertilizer, especially with suitable P solubilizing bacteria (PSB) may promote plant growth and productivity by stimulating biol. P fertility. To this aim, a pot study was performed to evaluate the agronomic potential of maize and soil biol. P pools, using encapsulated (ENRP) and non-encapsulated (NRP) nano-rock phosphate as the P fertilizer source, on reclaimed agricultural soil in the presence and absence of PSB inoculant. The experiment was setup following a 3 x 2 factorial arrangement with four replicates. Without PSB, NRP treatment showed marginal pos. effects on plant growth, P nutrition and P use efficiency (PUE) compared to control treatment. Although larger gains with NRP treatment were more noticeable under PSB inoculation, ENRP was the most convenient slow-release P fertilizer, increasing plant growth, P nutrition and grain yield compared to all treatments. Importantly, PSB inoculation with ENRP resulted in significantly higher increase in soil CaCl2-P (8.91 mg P kg soil-1), citrate-P (26.98 mg P kg soil-1), enzyme-P (18.98 mg P kg soil-1), resin-P (11.41 mg P kg soil-1), and microbial-P (18.94 mg P kg soil-1), when compared to all treatment combinations. Although a decrease in soil HCl-P content was observed with both types of P fertilizer, significant differences were found only with PSB inoculation. A significant increase in soil biol. P pools could be due to the higher specific area and crystalline structure of nano materials, providing increased number of active sites for PSB activity in the presence of biobased encapsulated shell. Furthermore, the increase in PSB abundance, higher root carboxylate secretions, and decreased rhizosphere pH in response to nano-structured P fertilizer, implies greater extension of rhizosphere promoting greater P mobilization and/or solubilization, particularly under PSB inoculated conditions. We conclude that cropping potential of abandoned agricultural lands can be enhanced by the use of nano-rock phosphate in combination with PSB inoculant, establishing a favorable micro-environment for higher plant growth and biochem. P fertility.

Ecotoxicology and Environmental Safety published new progress about Arable soils (Abandoned). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Wenchang; Wang, Yaxin; Zhang, Chenggang; Huang, Yongzhou; Yu, Jiaxian; Shi, Liang; Zhang, Peng; Yin, Yuping; Li, Ruidong; Tao, Kaixiong published the artcile< Maresin1 protect against ferroptosis-induced liver injury through ROS inhibition and Nrf2/HO-1/GPX4 activation>, Formula: C15H22N2O2, the main research area is liver injury maresin 1 ROS inhibition Nrf2 HO1 GPX4; Maresin1; Nrf2; ferroptosis; glutathione peroxidase 4; reactive oxygen species.

Drugs, viruses, and chem. poisons stimulating live in a short period of time can cause acute liver injury (ALI). ALI can further develop into serious liver diseases such as cirrhosis and liver cancer. Therefore, how to effectively prevent and treat ALI has become the focus of research. Numerous studies have reported Maresin1 (MaR1) has anti-inflammatory effect and protective functions on organs. In the present study, we used D-galactosamine/lipopolysaccharide (D-GalN/LPS) to establish an ALI model, explored the mechanism of liver cells death caused by D-GalN/LPS, and determined the effect of MaR1 on D-GalN/LPS-induced ALI. In vivo experiments, we found that MaR1 and ferrostatin-1 significantly alleviated D-GalN/LPSinduced ALI, reduced serum alanine transaminase and aspartate transaminase levels, and improved the survival rate of mice. Meanwhile, MaR1 inhibited hepatocyte death, inhibited tissue reactive oxygen species (ROS) expression, reduced malondialdehyde (MDA), reduced glutathione (GSH),GSH/oxidized glutathione (GSSG), and iron content induced byD-GalN/LPS in mice. In addition, MaR1 inhibited ferroptosis-induced liver injury through inhibiting the release of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and IL-6. Subsequently, western blot showed that MaR1 improved the expression of nuclear factor E2-related factor 2(Nrf2)/heme oxygenase-1 (HO-1)/glutathione peroxidase 4 (GPX4). In vitro experiments, we found that MaR1 inhibited LPS-induced and erastin-induced cell viability reduction Meanwhile, we found that MaR1 increased the MDA and GSH levels in cells. Western blot showed that MaR1 increased the expression level of Nrf2/HO-1/GPX4. Next, the Nrf2 was knocked down in HepG2 cells, and the results showed that the protective effect ofMaR1 significantly decreased. Finally, flow cytometry revealed that MaR1 inhibited ROS production and apoptosis. Overall, our study showed MaR1 inhibited ferroptosis-induced liver injury by inhibiting ROS production and Nrf2/HO-1/GPX4 activation.

Frontiers in Pharmacology published new progress about Apoptosis. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Formula: C15H22N2O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Erkang; Whitcomb, Luke A.; Chicco, Adam J.; Wilson, Jesse W. published the artcile< Transient absorption spectroscopy and imaging of redox in muscle mitochondria>, HPLC of Formula: 112-63-0, the main research area is muscle mitochondria imaging transient absorption spectroscopy.

Mitochondrial redox is an important indicator of cell metabolism and health, with implications in cancer, diabetes, aging, neurodegenerative diseases, and mitochondrial disease. The most common method to observe redox of individual cells and mitochondria is through fluorescence of NADH and FAD+, endogenous cofactors serve as electron transport inputs to the mitochondrial respiratory chain. Yet this leaves out redox within the respiratory chain itself. To a degree, the missing information can be filled in by exogenous fluorophores, but at the risk of disturbed mitochondrial permeability and respiration. Here we show that variations in respiratory chain redox can be detected up by visible-wavelength transient absorption microscopy (TAM). In TAM, the selection of pump and probe wavelengths can provide multiphoton imaging contrast between non-fluorescent mols. Here, we applied TAM with a pump at 520nm and probe at 450nm, 490nm, and 620nm to elicit redox contrast from mitochondrial respiratory chain hemeproteins. Experiments were performed with reduced and oxidized preparations of isolated mitochondria and whole muscle fibers, using mitochondrial fuels (malate, pyruvate, and succinate) to set up physiol. relevant oxidation levels. TAM images of muscle fibers were analyzed with multivariate curve resolution (MCR), revealing that the response at 620nm probe provides the best redox contrast and the most consistent response between whole cells and isolated mitochondria.

Biomedical Optics Express published new progress about Flash photolysis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics