Month: November 2022

Yan, Guoyi; Pu, Chunlan; Lan, Suke; Zhong, Xinxin; Zhou, Meng; Hou, Xueyan; Yang, Jie; Shan, Huifang; Zhao, Lifeng; Li, Rui published the artcile< Discovery of 4-phenyl-2H-benzo[b][1,4]oxazin-3(4H)-one derivatives as potent and orally active PI3K/mTOR dual inhibitors>, Quality Control of 112-63-0, the main research area is benzooxazinone preparation SAR PI3K mTOR dual inhibitor antitumor human; Cancer treatment; Dual inhibitor; PI3K/mTOR; Structural optimization.

PI3K/Akt/mTOR signaling pathway plays an important role in cancer cell growth and survival. In this study, a new class of mols. with skeleton of 4-phenyl-2H-benzo[b][1,4]oxazin-3(4H)-one I (X = H, F, Cl, etc.; R1 = 4-HOC6H4, 3-quinoline, 3-(4-fluoro-benzenesulfonamido)phenyl, etc.) II (R = i-Pr, cyclopropyl, Cy; R1 = 4-HOC6H4, 3-quinoline, 3-(4-fluoro-benzenesulfonamido)phenyl, etc.) were designed and synthesized targeting this pathway. Bioassays showed that, among all the mols., I (X = 4-OMe; R1 = 2-methoxy-3-(4-fluoro-benzenesulfonamido)pyrid-5-yl) was a pan-class I PI3K/mTOR inhibitor with an IC50 of 0.63 nM against PI3Kα. In a wide panel of protein kinases assays, no off-target interactions of I (X = 4-OMe; R1 = 2-methoxy-3-(4-fluoro-benzenesulfonamido)pyrid-5-yl) were identified. I (X = 4-OMe; R1 = 2-methoxy-3-(4-fluoro-benzenesulfonamido)pyrid-5-yl) was orally available, and displayed favorable pharmacokinetic parameters in mice (oral bioavailability of 24.1%). In addition, I (X = 4-OMe; R1 = 2-methoxy-3-(4-fluoro-benzenesulfonamido)pyrid-5-yl) demonstrated significant efficiency in Hela/A549 tumor xenograft models (TGI of 87.7% at dose of 50 mg/kg in Hela model) without causing significant weight loss and toxicity during 30 days treatment. Based on the bioassays, compound I (X = 4-OMe; R1 = 2-methoxy-3-(4-fluoro-benzenesulfonamido)pyrid-5-yl) could be used as an anti-cancer drug candidate.

European Journal of Medicinal Chemistry published new progress about Antiproliferative agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Martinez-Solorio, Dionicio; Jennings, Michael P. published the artcile< Chemoselective TBS deprotection of primary alcohols by means of pyridinium tribromide (Py·Br3) in MeOH>, COA of Formula: C19H34O2, the main research area is silyl ether deprotection pyridinium tribromide.

A catalytic amount of pyridinium tribromide in MeOH chemoselectively deprotects primary tert.-butyldimethylsilyl ethers in the presence of a variety of other protecting and common functional groups in modest to excellent yields when performed at 0 °C.

Tetrahedron Letters published new progress about Primary alcohols Role: SPN (Synthetic Preparation), PREP (Preparation) (tert.-butyldimethylsilyl). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ma, Junfu; Meng, Qingliang; Zhan, Junping; Wang, Huilian; Fan, Wei; Wang, Yanqi; Zhang, Sudan; Bian, Hua; Zheng, Fuzeng published the artcile< Paeoniflorin Suppresses Rheumatoid Arthritis Development via Modulating the Circ-FAM120A/miR-671-5p/MDM4 Axis>, Reference of 112-63-0, the main research area is paeoniflorin AMA microRNA MDM rheumatoid arthritis development; Circ-FAM120A; Paeoniflorin; Rheumatoid arthritis; mDM4; miR-671-5p.

Paeoniflorin is an active ingredient derived from Paeonia, which has an anti-inflammatory effect. However, the potential role and basis of paeoniflorin in rheumatoid arthritis (RA) are indistinct. Cell viability, cycle distribution, migration, and invasion were evaluated via Cell Counting Kit-8 (CCK-8), flow cytometry, and transwell assays. The contents of inflammatory cytokines were examined using ELISA (ELISA). RNA expression levels were determined via qRT-PCR and western blot. The targeting relationship between miR-671-5p and circ-FAM120A (hsa_circ_0003972) or murine double minute 4 (MDM4) was validated via dual-luciferase reporter assay. Paeoniflorin restrained proliferation, migration, invasion, and inflammation and accelerated cell cycle arrest in RA fibroblast-like synoviocytes (RA-FLSs). Circ-FAM120A was boosted in RA synovial tissues and RA-FLSs. Circ-FAM120A upregulation, miR-671-5p knockdown, or MDM4 augmentation reversed the repressive effect of paeoniflorin on RA-FLS progression. Moreover, paeoniflorin attenuated RA-FLS progression by regulating the circ-FAM120A/miR-671-5p/MDM4 axis. Paeoniflorin inhibited RA-FLS proliferation, mobility, and inflammation and triggered cell cycle arrest via mediating the circ-FAM120A/miR-671-5p/MDM4 pathway.

Inflammation published new progress about 3′-Untranslated region Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reimlinger, Hans; Vandewalle, Jan J. M.; King, Geoffrey S. D.; Lingier, Willy R. F.; Merenyi, Robert published the artcile< 1,5-Dipolar cyclizations. III. Condensed triazoles from conjugated nitrilimines. Structure and stability of the products from the reaction of N-acylated cyclic amidrazones with thionyl chloride>, Application of C19H34O2, the main research area is dipolar cyclizations; cyclizations dipolar; acyl amidrazones reaction thionyl chloride; amidrazones acyl reaction thionyl chloride; thionyl chloride reaction acyl amidrazones; triazolopyridines; pyridines triazolo; oxathiadiazoles; isoquinolines thiatriazolo structure; thiatriazoloisoquinolines structure; crystal structure thiatriazoloisoquinolines.

Treatment of 2-[2-(RCO-substituted)hydrazino]-5,6-(R1R2-disubstituted)pyridines with SOCl2 gave 5-(R-substituted)-3-[5,6-(R1R2-disubstituted)-2-pyridyl]-3H-1,2,3,4-oxathiadiazole S-oxides (I) [where R = Me, Ph, o-O2NC6H4, 2-pyridyl, or 4-pyridyl; and R1, R2 = H or (mono)Cl]. On thermolysis, I yielded the corresponding 3,5,6-(RR2R1-trisubstituted)-s-triazolo[4,3-a]pyridines (II). Reaction of 1-[2-(RCO-substituted)hydrazino]-3-(R1-substituted)isoquinolines with SOCl2 in HCONMe2-Et3N gave 2-(RCO-substituted)-5-(R1-substituted)-2H-1,2,3,5-thiatriazolo[4,5-a]isoquinoline S-oxides (III) (where R = Me, Ph, PhCC, or o-O2NC6H4 and R1 = H or Cl) or 5-(2-nitrophenyl)-3-(3-chloro-1-isoquinolyl)-3H-1,2,3,4-oxathiadiazole S-oxide (IV). III (R = Me, R1 = Cl) crystallizes in the triclinic space group P1 or P1 ̅with a = 11.528 ± 0.003, b = 8.054 ± 0.002, c = 7.258 ± 0.002 Å, α = 63.22 ± 0.02°, β = 85.26 ± 0.03°, γ = 74.38 ± 0.02°; d. (exptl.) = 1.621 ± 0.005 and d. (calculated) 1.616 for Z = 2. Ir data of III are reported.

Chemische Berichte published new progress about Hydrazidines Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Goerlitzer, Klaus; Bartke, Ulrich; Schmidt, Eckhardt published the artcile< Reaction of nifedipine with pyridinium bromide perbromide>, Formula: C19H34O2, the main research area is nifedipine pyridinium bromide perbromide; difuropyridinedione nitrophenyl.

The 1,4-dihydropyridine bislactone I was obtained in the title reaction. The pyridinium compound II and the brominated 1,4-dihydropyridine monolactones III (R = H, Me) were isolated from this reaction as byproducts. I is characterized by redox and photochem. reactions.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Lizhi; Liu, Zhong-Quan published the artcile< Molecular Oxygen-Mediated Minisci-Type Radical Alkylation of Heteroarenes with Boronic Acids>, Reference of 112-63-0, the main research area is alkyl heterocycle preparation; heteroarene alkylboronic acid Minisci radical alkylation.

The carbon-carbon bond formation via autoxidation of organoboronic acid using 1 atm of O2 is achieved in a simple, clean, and green fashion. The approach allows a tech. facile and environmentally benign access to structurally diverse heteroaromatics with medicinally privileged scaffolds. The strategy also displays its practicality and sustainability in the resynthesis of marketed drugs Crestor and pyrimethamine.

Organic Letters published new progress about Boronic acids Role: RCT (Reactant), RACT (Reactant or Reagent) (alkyl). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Khonkarov, Kh. Zh.; Sevbo, D. P.; Mikhailitsyn, F. S.; Veretennikova, N. L.; Lykova, T. I.; Lebedeva, M. N.; Lychko, N. D. published the artcile< Synthesis of salicylanilides containing quinoline moiety and study of their acute toxicity and anthelmintic activity>, Formula: C19H34O2, the main research area is salicylanilide quinoline preparation toxicity anthelmintic.

Salicylanilides containing a quinoline moiety were synthesized and examined for acute toxicity and antinematodal activity. All the compounds possess a low toxicity. In the trials on a nematodal model (Aspiculuris tetraptera, white mice), 2 compounds – I (X = Cl, G-1570; and X = Br, G-1575) – were highly effective.

Meditsinskaya Parazitologiya i Parazitarnye Bolezni published new progress about Acute toxicity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Feng, Wei; Huang, Tingting; Gao, Liqian; Yang, Xianfeng; Deng, Wenbin; Zhou, Rui; Liu, Hongjun published the artcile< Textile-supported silver nanoparticles as a highly efficient and recyclable heterogeneous catalyst for nitroaromatic reduction at room temperature>, Name: Methyl 2-(2-nitrophenyl)acetate, the main research area is nitroarom reduction silver nanoparticle textile support recyclable heterogeneous catalyst.

A novel textile-based nanosilver catalyst was prepared with a facile synthetic method. The textile-supported nanosilver (TsNS) proved to be an excellent heterogeneous catalyst for the reduction of nitroaroms. with a broad substrate scope. It can be recycled for up to 6 times without significantly compromising its catalytic efficacy. The TsNS catalyst was developed into a column reactor, demonstrating its practical application with the advantages of low cost, ease of operation and large scale synthesis capabilities. SEM (SEM) showed that there were few changes to the catalyst’s surface after the reaction. Besides, inductively coupled plasma (ICP) anal. showed that few silver particles leaked, and the interactions between the nitro groups of the nitroaroms. and the nanosilver particles were characterized by XPS, which lead to the proposal of a four-step mechanism for the reduction reaction.

RSC Advances published new progress about Aromatic amines Role: IMF (Industrial Manufacture), PREP (Preparation). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Name: Methyl 2-(2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Talluri, Siva Kumar; Sudalai, Arumugam published the artcile< NBS-Catalyzed Hydroamination and Hydroalkoxylation of Activated Styrenes>, Related Products of 112-63-0, the main research area is alc styrene derivative intermol hydroalkoxylation bromosuccinimide; styrene amine derivative intermol hydroamination bromosuccinimide; bromosuccinimide intermol hydroalkoxylation catalyst; benzylic ether derivative regioselective preparation; amine benzylic derivative derivative regioselective preparation.

N-Bromosuccinimide efficiently catalyzes the hydroamination and hydroalkoxylation of activated styrenes using tosylamides, carbamates, and alcs. as the nucleophiles to afford amino and ether derivatives, resp. Both the processes give good to excellent yields of the products with 100% regioselectivity (Markovnikov fashion).

Organic Letters published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hu, Jingyi; Huang, Hai; Che, Yuan; Ding, Chujie; Zhang, Lu; Wang, Yun; Hao, Haiping; Shen, Hong; Cao, Lijuan published the artcile< Qingchang Huashi Formula attenuates DSS-induced colitis in mice by restoring gut microbiota-metabolism homeostasis and goblet cell function>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is qingchang huashi formula colitis gut microbiota homeostasis; Goblet cell; Gut microbiota; Qingchang Huashi formula; Ulcerative colitis.

The aim of this study was to clearly define the effect of QHF and its components, Baitouweng (PBR) and Baizhi (ADR) on treating UC. Pharmacodynamic effects of QHF and single herb were evaluated in dextran sulfate sodium (DSS) induced acute or chronic colitis mice. The colorectal tissues were used to detect levels of IL-1β, IL-6 and TNF-α by ELISA or qRT-PCR. The expression of NLRP3, Caspase 1 and IL-1β were examined by western blotting. QHF significantly inhibited colitis, protected mice from the loss of body weight and colon shorten. We verified that while ADR was responsible for QHF s effect on maintaining gut microbiota homeostasis and metabolism, PBR was more prominent in keeping crypt stem cells proliferation and colonic goblet cells function. Moreover, we demonstrated that the alleviation of colitis by QHF was associated with the restoration of gut microbiota-metabolism homeostasis, protection of intestinal epithelial barrier and regulation of NLRP3/IL-1β pathway. The finding of the present study suggested that QHF is curative in DSS-induced colitis by restoring gut microbiota-metabolism homeostasis and goblet cells function. An optimized QHF was constituted by ADR and PBR, which showed comparable efficacy on colitis to that of QHF. Our work probed out the active constitutes as well as the relevant pharmacol. mechanisms of QHF, shedding light on potential new drug combination for the treatment of IBD.

Journal of Ethnopharmacology published new progress about Animal gene, IL1B Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics