Month: November 2022

Davison, Holly R.; Solano, Danielle M.; Phuan, Puay-Wah; Verkman, A. S.; Kurth, Mark J. published the artcile< Fluorinated ΔF508-CFTR correctors and potentiators for PET imaging>, Synthetic Route of 112-63-0, the main research area is fluorinated F508 CFTR corrector potentiator PET imaging.

19F-modified bithiazole correctors and phenylglycine potentiators of the ΔF508-CFTR chloride channel were synthesized and their function assayed in cells expressing human ΔF508-CFTR and a halide-sensitive fluorescent protein. Fluorine was incorporated into each scaffold using prosthetic groups for future biodistribution imaging studies using positron emission tomog. (PET). The ΔF508-CFTR corrector and potentiator potencies of the fluorinated analogs were comparable to or better than those of the original compounds

Bioorganic & Medicinal Chemistry Letters published new progress about Amidation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sun, Wei; Chen, Rong; Cheng, Xinjian; Marin, Luminita published the artcile< Bodipy-based chemosensors for highly sensitive and selective detection of Hg2+ ions>, Formula: C19H34O2, the main research area is bodipy chemosensor sensitive selective detection mercury ion.

Detection of heavy metals with high sensitivity and selectivity is of vital importance. In this study, we report the synthesis of small mol. chemosensors and the fabrication of corresponding macromol. fluorescent chemosensors. Boron dipyrrole methane (BODIPY)-derived chemosensors, BE and BB, were designed and synthesized first. Then, they were incorporated into polymeric derivatives to prepare macromol. fluorescent chemosensors. The small mol. sensors were highly sensitive and selective to Hg2+. Other ions and albumin did not exhibit clear interference to the sensing of Hg2+ ions. Once the macromol. chemosensors were formed, the recognition ability was preserved; moreover, the sensitivity was even enhanced by the “”mol. wire”” mechanism. The min. detection limits of four macromol. chemosensors, PBEP, PBEB, PBBP and PBBB, for Hg2+ reached 2.05 μM, 0.23 μM, 4.23 μM, and 0.15 μM, resp. Under natural light, the addition of Hg2+ led to significant color changes; also, they can be used as Hg2+-sensitive “”naked eye”” indicators in the natural environment.

New Journal of Chemistry published new progress about Sensors. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Marques Mota, Filipe; Kim, Yeonseo; Hong, Haeji; Yu, Subin; Lee, Sangheon; Kim, Dong Ha published the artcile< Revisiting Solvent-Dependent Roles of the Electrolyte Counteranion in Li-O2 Batteries upon CO2 Incorporation>, Application In Synthesis of 112-63-0, the main research area is revisiting solvent dependent roles electrolyte counteranion lithium oxygen battery.

Lithium-oxygen batteries are promising next-generation high-energy storage candidates. Replacing pure O2 with air and uncovering moisture and CO2-contamination effects on the O2 electrochem., however, represent necessary steps toward commercialization. Representatively, a CO2-induced shift toward Li2CO3 formation has been systematically disclosed in a number of electrolyte solvents. Here, we show that in tetraglyme only Li2CO3 is formed without Li2O2. Using explicit theor. calculations, we reveal that discharge is governed by the strong chelation effect induced by oxygen lone electron pairs of the glyme, which emphasizes the importance of assessing direct interat. interactions between Li+ and solvent mols. when determining preferred reaction pathways in these O2/CO2 systems. The choice of the electrolyte counteranion investigated here for the first time, however, has no apparent effect on the O2/CO2 electrochem., leading to Li2CO3. Galvanostatic results and product analysisnonetheless reveal that highly dissociated Li+ counteranions in tetraglyme favorably stabilize soluble peroxocarbonate reaction intermediates during discharge, whereas highly associated salts accelerate Li2CO3 precipitation, dramatically narrowing the cell capacity. Importantly, these observations are also distinct from prior conclusions from rationally designed electrolytes under pure O2 conditions and emphasize the need to revisit established correlations between uncovered counteranion···Li+···solvent interaction degrees and the balance between mechanistic pathways in practical Li-air devices.

ACS Applied Energy Materials published new progress about Battery electrolytes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ogawa, Toshihisa; Matsumoto, Keita; Yoshimura, Misa; Hatayama, Katsuo; Kitamura, Kunihiro; Kita, Yasuyuki published the artcile< Stereochemistry of the 2-hydroxy-1,2,3,4-tetrahydropyridine intermediate of Hantzsch cyclization>, Computed Properties of 60705-25-1, the main research area is crystal structure nitrophenyl hydroxytetrahydropyridine; mol structure nitrophenyl hydroxytetrahydropyridine; cyanoethyl aminocrotonate Hantzsch cyclization dialkoxymethylbenzylidene acetoacetate.

Hantzsch cyclization of cyanoethyl 3-aminocrotonate and (E,Z)-4-dialkoxymethyl-2-benzylideneacetoacetates (alkoxy = Me, Et) afforded 3,4-trans-2-hydroxy-1,2,3,4-tetrahydropyridines, e.g., I, in high stereoselectivity.

Tetrahedron Letters published new progress about Crystal structure. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Computed Properties of 60705-25-1.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lesuisse, D.; Albert, E.; Bouchoux, F.; Cerede, E.; Lefrancois, J.-M.; Levif, M.-O.; Tessier, S.; Tric, B.; Teutsch, G. published the artcile< Biphenyls as surrogates of the steroidal backbone. Part 1. Synthesis and estrogen receptor affinity of an original series of polysubstituted biphenyls>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is biphenyl polysubstituted preparation estrogen receptor affinity.

Substituted biphenyls were prepared and evaluated for their binding affinity for the estrogen receptor. Some of them demonstrated binding better than or equivalent to that of estradiol.

Bioorganic & Medicinal Chemistry Letters published new progress about Estrogen receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mziray, Sophia; Maganda, Betty A.; Mwamwitwa, Kissa; Fimbo, Adam M.; Kisenge, Seth; Sambu, Gerald; Mwalwisi, Yonah H.; Bitegeko, Adonis; Alphonce, Emmanuel; Khea, Akida; Shewiyo, Danstan H.; Kaale, Eliangiringa published the artcile< Quality of selected anti-retroviral medicines: Tanzania Mainland market as a case study>, Related Products of 112-63-0, the main research area is anti retroviral medicine quality Tanzania; Antiretroviral medicines; Falsified; Medicines quality; Patient information leaflet; Post market surveillance; Substandard.

Abstract: Background: Antiretroviral drugs (ARVs) have significantly reduced morbidity, mortality and improved the quality of life of people living with HIV infection. Poor quality ARVs may result in harmful consequences such as adverse drug reactions, treatment failure and development of drug resistant strains and sometimes death, which in turn may undermine the healthcare delivery system. To ensure optimal treatment outcomes, medicines quality control must be undertaken regularly. This study was aimed at evaluating the quality of ARVs circulating on the Tanzania Mainland market. Methods: This was a survey study. ARVs samples were collected in 20 regions of Tanzania Mainland, between 2012 and 2018. All sampled ARVs were subjected to screening testing using the Global Pharma Health Fund Mini-Lab kits. Sampled ARV′s that failed screening test or yielded doubtful results and 10 % (10 %) of all that complied with the screening test requirements were selected for full quality control testing. Quality control testing was conducted at the Tanzania Medicines and Medical Devices Authority (TMDA) laboratory a World Health Organization prequalified. Samples collected from the medicine distribution outlets were also, subjected to product information review. Results: A total of 2,630 samples were collected, of which 83.7 % (2200/2630) were from port of entry (POEs). All sampled ARVs were screened and conformed to the specifications, except of the fixed dose combination (FDC) lopinavir/ritonavir 0.27 % (7/2630) and lamivudine/zidovudine/nevirapine 0.27 % (7/2630) that failed the disintegration test. Out of the 100 samples selected for full quality control testing, 3 % of them failed to comply with the specifications, of which FDC stavudine/lamivudine/nevirapine failed disintegration and assay tests 2 % (2/100) and 1 % (1/100), resp. Samples failing the assay test had low content of stavudine (86.6 %) vs. specification limits (90 -110 %). Out of the 430 samples which were subjected to product information review, 25.6 % (110/430) failed to comply with the TMDA packaging and labeling requirements. Conclusions: The quality of majority of ARVs circulating on the Tanzania Mainland market was good, even so, significant deficiencies on labeling and packaging were observed These results call for continuous monitoring of quality of medicines circulating on the Tanzania Mainland market.

BMC Pharmacology and Toxicology published new progress about Fixed-dose combination drug delivery systems. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Park, Albert K; Waheed, Anem; Forst, Deborah A; Al-Samkari, Hanny published the artcile< Characterization and prognosis of temozolomide-induced aplastic anemia in patients with central nervous system malignancies.>, Electric Literature of 112-63-0, the main research area is CNS malignancy; aplastic anemia; bone marrow failure; pancytopenia; temozolomide.

BACKGROUND: Temozolomide-induced aplastic anemia (TIAA) is a rare but highly challenging complication of temozolomide (TMZ) therapy. Evidence describing prognosis, clinical characteristics, and treatment of this entity is very limited. METHODS: We performed a multicenter, 22-year observational cohort study of patients with central nervous system (CNS) malignancies treated with temozolomide who developed TIAA, retrospectively analyzing prognosis, complications, and recovery. TIAA was defined using adapted evidence-based severe aplastic anemia criteria incorporating profound cytopenias and a minimum duration (4 weeks) without hematologic recovery. RESULTS: Of 3821 patients with CNS malignancies receiving TMZ, 34 patients (0.89%) met criteria for TIAA. Onset was rapid, with 29 patients (85.3%) developing TIAA before completing a second TMZ cycle. 23 patients (67.6%) ultimately achieved a hematologic recovery. Patients without recovery were more likely to develop febrile neutropenia (72.7% vs. 30.4%, P = .03), infectious complications (45.5% vs. 8.7%, P = .02), require hospitalization (81.8% vs. 43.5%, P = .04), and die (100.0% vs. 60.9%, P = .02). Median overall survival from TIAA diagnosis was 752 days in patients achieving a partial hematologic recovery versus 28 days in those who did not (P < .0001). 29 patients (85.3%) received one or more hematopoietic growth factors; hematologic recovery rates were higher in patients receiving thrombopoietin receptor agonists (81.8% vs. 60.9%) but were not higher in patients receiving granulocyte colony-stimulating factors. CONCLUSIONS: TIAA occurs in <1% of patients receiving TMZ for CNS malignancies, but is highly morbid when it occurs and frequently fatal in the one-third of patients not achieving hematologic recovery. Thrombopoietin receptor agonists may improve the likelihood of a hematologic recovery. Neuro-oncology published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

He, Lu; Huang, Jun; Chen, Yuhui published the artcile< First-Order or Second-Order? Disproportionation of Lithium Superoxide in Li-O2 Batteries>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is lithium superoxide battery.

The disproportionation of LiO2 to Li2O2 is a key step in Li-O2 batteries, and it is regarded as a second-order reaction. However, its mechanism is not well addressed, and its kinetics is rarely studied due to the difficulties of quantifying the rate constants, particularly for high concentrations of superoxide (>10 mM). Here, we quantified the kinetic rate constant by a microkinetic model using a microelectrode tip with a thin diffusion layer and fast response. We report that the reaction order of LiO2 transitions from 1 at high concentrations of superoxide (~20 mM) to 2 at low concentrations of superoxide (~1 mM). LiO2 is chem. reduced by free superoxides to form Li2O2 and O2, instead of reacting with another LiO2 via a disproportionation step. This chem.-reduction mechanism explained the change of reaction order and the kinetics profile. As a rate-determining step, this step restricts the overall kinetics of the discharging process and should be the focus of future catalyst design.

Journal of Physical Chemistry Letters published new progress about Lithium-ion secondary batteries. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Anquetil, Celine; Salem, Joe-Elie; Lebrun-Vignes, Benedicte; Touhami, Sara; Desbois, Anne-Claire; Maalouf, Georgina; Domont, Fanny; Allenbach, Yves; Cacoub, Patrice; Bodaghi, Bahram; Saadoun, David published the artcile< Evolving spectrum of drug-induced uveitis at the era of immune checkpoint inhibitors results from the WHO's pharmacovigilance database>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is human drug induced uveitis ICI pharmacovigilance database; Drug induced-adverse event; Immune checkpoint inhibitors; Protein kinase inhibitors; Uveitis; Visual loss.

Drug-induced uveitis is a rare but sight-threatening condition. We seek to determine the spectrum of drug-induced uveitis at the era of immune checkpoint inhibitors (ICI). Retrospective pharmacovigilance study based on adverse drug reactions reported within VigiBase, the WHO international pharmacovigilance database. We included deduplicated individual case safety reports (ICSRs) reported as ‘uveitis’ at Preferred Term level according to the Medical Dictionary for Drug Regulatory Activities between 1967 and 04/28/2019. We performed a case/non-case anal. to study if suspected drug-induced uveitis were differentially reported for each suspected treatment compared to the full database. We excluded drugs with potential indication bias.1404 ICSRs corresponding to 37 drugs had a significant over-reporting signal with a median age of 57 [42-68] years and 45.7% of males. We identified five major groups of treatments: bisphosphonates (26.9%), non-antiviral anti-infectious drugs (25.4%), protein kinase inhibitors (15.5%), ICI (15.0%), and antiviral drugs (11.1%). Severe visual loss was reported in 12.1% of cases. ICI and protein kinase inhibitors were the most recently emerging signals. The time to onset between first infusion and uveitis was significantly different between groups ranging from 5 days [2-19] in the bisphosphonate group to 138.5 [47.25-263.75] in protein kinase inhibitors group (p < 0.0001). Anti-Programmed Cell death 1 represented more than 70% of ICI-induced uveitis. We identified Vogt-Koyanagi-Harada (VKH)-like syndrome as being associated with ICI use. The spectrum of drug-induced uveitis has changed with the evolution of pharmacopeia and the recent emergence of ICIs. VKH-like syndrome has been reported with ICI and protein kinase inhibitors therapy. Journal of Autoimmunity published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cai, Hongyun; Khanal, Hari Datta; Lee, Yong Rok published the artcile< Base-Promoted Direct Cascade Transformation of Chromones to Coumarins via Benzannulation and Transesterification>, Electric Literature of 94-02-0, the main research area is alkenyl chromone acetoacetate cesium carbonate promoter tandem benzannulation transesterification; acyl phenylcoumarin preparation.

A mild base-promoted reaction between 3-substituted chromones and β-keto esters for the easy access to various coumarins with structural diversity was described. This protocol provided highly functionalized 3-acyl-4-arylcoumarins in good-to-excellent yield via benzannulation and transesterification. A reaction mechanism containing Michael addition, 1,5-H shift and intramol. transesterification was proposed.

Asian Journal of Organic Chemistry published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Electric Literature of 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics