Month: November 2022

Wang, Yuanhui; Hao, Liang; Bai, Minli published the artcile< Modeling the multi-step discharge and charge reaction mechanisms of non-aqueous Li-O2 batteries>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is charge discharge reaction lithium oxygen battery.

The modeling study plays a critical role in understanding the reaction mechanisms and predicting the performance of lithium-oxygen (Li-O2) batteries. Although several models have successfully captured the discharge behaviors of the Li-O2 batteries, modeling the charge behaviors of the Li-O2 batteries is a challenge due to lacking a thorough understanding of the related reaction processes. This work proposes a multi-step reversible discharge/charge model for the non-aqueous Li-O2 batteries. Both the surface and solution reaction pathways of lithium peroxide (Li2O2) are taken into account. The proposed model can predict the discharge behaviors well, and more importantly, can accurately capture the charge behaviors of the Li-O2 batteries by considering the following three aspects: the effect of Li2O2 morphol. on its decomposition potential, the evolution of interfacial resistance by Li2O2 film collapse, and the different desorption rates of absorbed lithium superoxide (LiO*2) in different electrolytes. Based on this model, the discharge/charge processes of the Li-O2 batteries using dimethoxyethane(DME), tetraethylene glycol di-Me ether (TEGDME) and DMSO (DMSO) electrolytes, as well as a redox mediator TEMPO, are simulated and verified. The Li2O2 formation/decomposition through the surface and solution pathways are dominated by the sp. surface area of the electrode and the potential, resp. The Li2O2 generated by the solution pathway is more difficult to be decomposed during charge. The use of redox mediator TEMPO lowers the discharge capacity of the Li-O2 batteries due to the weakened solution reaction, while remarkably reduces the reversible capacity loss. The desorption time constant of LiO*2 in electrolyte is a critical parameter that determines the degree of the reaction through the solution pathway, thus determining the discharge/charge cycling performance of the Li-O2 batteries with various electrolytes.

Applied Energy published new progress about Battery electrodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chiu, George; Li, Shengjian; Connolly, Peter J.; Pulito, Virginia; Liu, Jingchun; Middleton, Steven A. published the artcile< (Arylpiperazinyl)cyclohexylsufonamides: Discovery of α1a/1d-selective adrenergic receptor antagonists for the treatment of Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms (BPH/LUTS)>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is arylpiperazinyl cyclohexylsufonamide derivative preparation adrenergic receptor antagonist prostatic hyperplasia.

Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms (BPH/LUTS) can be effectively treated by α1-adrenergic receptor antagonists. Unfortunately, all currently marketed α1 blockers produced CV related side effects that are caused by the subtype nonselective nature of the drugs. To overcome this problem, it was postulated that a α1a/1d subtype selective antagonist would bring more benefit for the treatment of BPH/LUTS. In developing selective α1a/1d ligands, (arylpiperazinyl)cyclohexylsulfonamides were synthesized and their binding profiles against three cloned human α1-adrenergic receptor subtypes were evaluated. Many compounds show equal affinity for both α1a and α1d subtypes with good selectivity against the α1b subtype. They also overcome the problem of dopamine receptor affinity that previous analogs had exhibited.

Bioorganic & Medicinal Chemistry Letters published new progress about Benign prostatic hyperplasia. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gnanadoss, Lalitha; Vijayalakshmi, A. published the artcile< Steric effects in oxidation of primary alcohols by pyridinium hydrobromide perbromide>, Related Products of 112-63-0, the main research area is steric effect oxidation alc; oxidation alc bromide kinetics; pyridinium hydrobromide perbromide oxidation alc; LFER oxidation alc bromide; isokinetic temperature oxidation alc.

Kinetics of oxidation of a homologous series of nine primary alcs. was studied in 60 volume% aqueous AcOH using pyridinium hydrobromide perbromide as the oxidizing agent. The results were interpreted in terms of steric effects and a plot of log rate vs. υ, the steric parameter introduced by M. Charton (1975) is linear. A mechanism involving steric relief in the rate-determining step is proposed.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Chong; Sun, Dan; Zheng, Hong-Xiang; Wang, Guo-Bao; Liu, Wen-Shen; Cao, Yue; Tang, Ye-Tao; Qiu, Rong-Liang published the artcile< The limited exclusion and efficient translocation mediated by organic acids contribute to rare earth element hyperaccumulation in Phytolacca americana>, Reference of 112-63-0, the main research area is Phytolacca rare earth element translocation organic acid; Hyperaccumulator; Rhizosphere; Root exudate; Translocation; Yttrium.

Organic acids play an important role in metal tolerance, uptake, and translocation in hyperaccumulators. Phytolacca americana is a rare earth element (REE) hyperaccumulator, but the underlying mechanisms on REE tolerance and accumulation mediated by organic acids are poorly understood. Here, we reported for the first time the strategy of P. americana to enhance REE tolerance and accumulation through organic acids from root external secretion to internal biosynthesis. Different from the exclusion of heavy metal by organic acid in the typical plants, the results showed that oxalate secretion (0.3-0.6μmol h-1 g-1 root DW) induced by yttrium (Y) could not prevent Y from entering the roots, resulting in excess Y uptake by P. americana. Yttrium stress also stimulated the accumulation of malate and citrate by 1.4- and 2.0-folds in the root cortex. Exogenous malate and citrate promoted the redistribution of Y from the root cell walls to the shoot by 30% and 21%, resp. Based on comparative transcriptome anal., 6-fold up-regulation was observed in PaNIP1;2, whose homol. AtNIP1;2 is responsible for the transport of Al-malate in Arabidopsis. These results suggested that the promoted formation of Y-malate complexes within the roots potentially accelerated the transport of Y from P. americana roots to shoots through PaNIP1;2. Our study revealed the potential mechanism of organic acids in the external exclusion and internal detoxification and translocation of REE in P. americana roots, which provided a basis for improving the efficiency of REE phytoextraction

Science of the Total Environment published new progress about Arabidopsis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Potikha, L. M.; Kovtunenko, V. A.; Kisil, V. M. published the artcile< Condensed isoquinolines. Part 21. Condensation of o-bromomethylphenylacetonitrile with substituted anthranilic acids>, Formula: C19H34O2, the main research area is bromomethylbenzeneacetonitrile anthranilate cyclocondensation; isoquinoquinazolinone hydro preparation tautomerism.

The reaction of substituted anthranilic acids and esters with ortho-bromomethylphenylacetonitrile gives 2,3-disubstituted 7,12-dihydro-5H-isoquino[2,3-a]quinazolin-5-one hydrobromides. It was found that 7,12-dihydro-5H-isoquino[2,3-a]quinazolin-5-ones can exist in the two tautomeric imine and enamine forms. The tautomeric equilibrium position depends on the nature and position of the substituent in the quinazoline fragment. The borohydride reduction, oxidation, and reaction of the 7,12-dihydro-5H-isoquino[2,3-a]quinazolin-5-ones with electrophilic reagents was studied.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about Aromatic amino acids Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pulvirenti, Luca; Monforte, Francesca; Lo Presti, Francesca; Li Volti, Giovanni; Carota, Giuseppe; Sinatra, Fulvia; Bongiorno, Corrado; Mannino, Giovanni; Cambria, Maria Teresa; Condorelli, Guglielmo Guido published the artcile< Synthesis of MIL-Modified Fe3O4 Magnetic Nanoparticles for Enhancing Uptake and Efficiency of Temozolomide in Glioblastoma Treatment>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is enhancing Uptake Efficiency temozolomide Glioblastoma Treatment; Fe3O4; glioblastoma; magnetic nanoparticles; metal organic frameworks; temozolomide.

A nanometric hybrid system consisting of a Fe3O4 magnetic nanoparticles modified through the growth of Fe-based Metal-organic frameworks of the MIL (Materials Institute Lavoiser) was developed. The obtained system retains both the nanometer dimensions and the magnetic properties of the Fe3O4 nanoparticles and possesses increased the loading capability due to the highly porous Fe-MIL. It was tested to load, carry and release temozolomide (TMZ) for the treatment of glioblastoma multiforme one of the most aggressive and deadly human cancers. The chem. characterization of the hybrid system was performed through various complementary techniques: X-ray-diffraction, thermogravimetric anal., FT-IR and X-ray photoelectron spectroscopies. The nanomaterial showed low toxicity and an increased adsorption capacity compared to bare Fe3O4 magnetic nanoparticles (MNPs). It can load about 12 mg/g of TMZ and carry the drug into A172 cells without degradation Our exptl. data confirm that, after 48 h of treatment, the TMZ-loaded hybrid nanoparticles (15 and 20μg/mL) suppressed human glioblastoma cell viability much more effectively than the free drug. Finally, we found that the internalization of the MIL-modified system is more evident than bare MNPs at all the used concentrations both in the cytoplasm and in the nucleus suggesting that it can be capable of overcoming the blood-brain barrier and targeting brain tumors. In conclusion, these results indicate that this combined nanoparticle represents a highly promising drug delivery system for TMZ targeting into cancer cells.

International Journal of Molecular Sciences published new progress about Astrocytoma. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Wanfang; Lu, Bin; Xie, Xiaomin; Zhang, Zhaoguo published the artcile< Ru-Catalyzed Chemo- and Enantioselective Hydrogenation of β-Diketones Assisted by the Neighboring Heteroatoms>, Synthetic Route of 112-63-0, the main research area is diketone beta hydrogenation chemo enantioselective ruthenium catalyst.

A highly chemo- and enantioselective hydrogenation of β-diketones was achieved by using [Ru(benzene)(S)-SunPhosCl]Cl for consistency in THF. The neighboring heteroatoms played important roles in guaranteeing the reactivity and controlling the chemoselectivity. These results suggested a potential approach for the clean and facile synthesis of functionalized chiral β-hydroxy ketones, which could otherwise be prepared through much less step-economic transformations.

Organic Letters published new progress about Diketones, 1,3-diketones Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Inoo, Akane; Fukutsuka, Tomokazu; Miyahara, Yuto; Kondo, Yasuyuki; Yokoyama, Yuko; Miyazaki, Kohei; Abe, Takeshi published the artcile< Molecular structural influence of glymes on Co-intercalation behavior of solvated Li+ in graphite electrodes>, Quality Control of 112-63-0, the main research area is tetraglyme lithium graphite composite electrode ionic conductivity.

Solvated Li+ ions are intercalated into graphite in a dilute glyme-based solution and this reaction has attracted much attention for use in advanced lithium-ion batteries due to their high rate capability. In this study, Li+ co-intercalation behaviors in asym. glymes (CH3O(CH2CH2O)nC4H9, n = 2 or 3) were investigated and compared to those in sym. glymes (CH3O(CH2CH2O)nCH3, n = 1-4). Despite the large alkyl sidechains of asym. glymes, co-intercalation reactions of solvated Li+ proceeded as well as those in sym. glymes. In charge and discharge measurements, the reversible capacities in asym. glyme-based solutions were smaller than those in sym. glymes except for tetraglyme, which showed the lowest reversible capacity. There was no clear difference in the sandwich distances of glyme-Li-GICs calculated from X-ray diffraction patterns of both sym. and asym. glymes. Therefore, solvated Li+ ions with asym. glymes occupied more space in the graphite interlayer compared to sym. glymes, which resulted in smaller reversible capacities for asym. glymes. These results demonstrate the influence of solvent-related structures of GICs on reversible capacities for co-intercalation systems.

Journal of the Electrochemical Society published new progress about Composites. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shiraishi, Takaya; Sakaitani, Masahiro; Otsuguro, Satoko; Maenaka, Katsumi; Suzuki, Toshiharu; Nakaya, Tadashi published the artcile< Novel Notch signaling inhibitor NSI-1 suppresses nuclear translocation of the Notch intracellular domain>, COA of Formula: C19H34O2, the main research area is novel notch signaling inhibitor NSI nuclear translocation intracellular domain.

The Notch receptor serves a fundamental role in the regulation of cell fate determination through intracellular signal transmission. Mutation of the Notch receptor results in abnormal active signaling, leading to the development of diseases involving abnormal cell growth, including malignant tumors. Therefore, the Notch signaling pathway is a useful pharmacol. target for the treatment of cancer. In the present study, a compound screening system was designed to identify inhibitors of the Notch signaling targeting Notch intracellular domain (NICD). A total of 9,600 compounds were analyzed using the Michigan Cancer Foundation-7 (MCF7) human breast adenocarcinoma cell line and the SH-SY5Y human neuroblastoma cell line with the reporter assay system using an artificial protein encoding a partial Notch carboxyl-terminal fragment fused to the Gal4 DNA-binding domain. The mol. mechanism underlying the inhibition of Notch signaling by a hit compound was further validated using biochem. and cell biol. approaches. Using the screening system, a potential candidate, Notch signaling inhibitor-1 (NSI-1), was isolated which showed 50% inhibition at 6.1μM in an exogenous Notch signaling system. In addition, NSI-1 suppressed the nuclear translocation of NICD and endogenous gene expression of hairy and enhancer of split-1, indicating that NSI-1 specifically targets Notch. Notably, NSI-1 suppressed the cell viability of MCF7 cells and another human breast adenocarcinoma cell line, MDA-MB-231 exhibiting constitutive and high Notch signaling activity, whereas no significant effect was observed in the SH-SY5Y cells bearing a lower Notch signaling activity. NSI-1 significantly suppressed the viability of SH-SY5Y cells expressing exogenous human Notch1. These results indicate that NSI-1 is a novel Notch signaling inhibitor and suggest its potential as a useful drug for the treatment of diseases induced by constitutively active Notch signaling.

International Journal of Molecular Medicine published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lee, Hyojin; Jang, Kyoung Won published the artcile< Effect of puffing in the extraction of active ingredients from the roots of Paeonia lactiflora and Astragalus membranaceus>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Paeonia Astragalus puffing root polyphenol.

In Asia, the roots of Paeonia lactiflora and Astragalus membranaceus have been used as therapeutic agents for thousands of years. Once the medicinal plants are harvested, they are dried and their ingredients are extracted by heat-mediated reflux extraction However, the condensed structure of organic products (especially roots) limits the extraction of bioactive components. In this study, we assessed the effect of the puffing method (using high temperature and pressure) before the extraction process in relation to the profile and antioxidant capacity of active ingredients. We demonstrated that the addnl. puffing process before extraction methods improves the yield of polyphenol concentrations and antioxidant activities from the roots of P. lactiflora and A.membranaceus.

Natural Product Sciences published new progress about Astragalus membranaceus. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics