Month: November 2022

Hong, Suk Bong; Raushel, Frank M. published the artcile< Inhibitors directed towards the binuclear metal center of phosphotriesterase>, COA of Formula: C19H34O2, the main research area is phosphotriesterase cadmium zinc phosphonate phosphoramidate.

The potential roles in binding and catalysis for the binuclear metal center found within bacterial phosphotriesterase were evaluated by characterization of the inhibitory properties of 26 substrate and product mimetics. Phosphonates bearing monofluoro, difluoro, or hydroxyl substituents at the methylene position were noncompetitive inhibitors with Ki values ranging from 0.6-9 mM vs. the substrate paraoxon. Phosphoramidates did not inhibit the enzyme. Di-Et phosphate and di-Et dithiophosphate inhibited the Cd-substituted enzyme with Ki values of 10 and 130 μM, resp. The most effective inhibitor for either the Cd or Zn substituted enzyme was found di-Et thiomethyl-phosphonate. The competitive inhibition constants for this compound were 60 nM and 2.8 μM for the Cd- and Zn-substituted enzyme, resp. The tight binding is attributed to chelation of both metal ions simultaneously.

Journal of Enzyme Inhibition published new progress about Metalloenzymes Role: BAC (Biological Activity or Effector, Except Adverse), BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Yachen; Gao, Mingxing; Li, Sai; Liu, Jun; Feng, Anchao; Zhang, Liqun published the artcile< Recyclable, self-healable and reshape vitrified poly-dimethylsiloxane composite filled with renewable cellulose nanocrystal>, Formula: C19H34O2, the main research area is recyclable self healable vitrified polysiloxane composite renewable cellulose nanocrystal.

Traditional thermoset polymeric materials pose an enormous burden on the environment due to permanent covalent crosslinks that make them difficult to reprocess or recycle. Herein, we describe the facile synthesis of recyclable, healable and reprocessable poly-dimethylsiloxane (PDMS)/cellulose nanocrystals (CNC) composites via engineering dynamic covalent bond (DCB) vinylogous urethane between the polymer-polymer and polymer-CNC. We successfully prepared the amine-modified CNC, evidenced by the anal. of FTIR, XPS and Element anal., and its surface morphol. as well as its size compared to the pristine one is not altered via XRD and TEM anal. The DCBs are constructed not only between polymer chains, but also on the interface between polymer and CNC. Interestingly, the macromol. cross-linker synthesized by RAFT polymerization significantly improves the mech. properties of PDMS-based CNC vitrimer, without affecting its recycling and reprocessing properties. Remarkably, DCB vinylogous urethane endows this vitrimer good self-healing, reprocessing and recycling and this DCB can be effectively reshaped by the catalyst-free transamination of the vinylogous urethane through hot pressing or welding. It is emphasized that this macromol. crosslinker containing β-keto acids obtained by RAFT polymerization can significantly broaden the application range for DCB vinylogous urethane. In general, this work could provide a facile approach to design and fabricate high performance renewable CNC based composites with excellent self-healing, reprocessing and recycling capabilities.

Polymer published new progress about Binding energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jamshaid, Sana; Devkota, Shreedhar; Lee, Yong Rok published the artcile< Catalyst- and Substituent-Controlled Regio- and Stereoselective Synthesis of Indolyl Acrylates by Lewis-Acid-Catalyzed Direct Functionalization of 3-Formylindoles with Diazo Esters>, Formula: C11H12O3, the main research area is hydroxy indolyl acrylate preparation diastereoselective regioselective; alkoxy oxoethoxy indolyl acrylate preparation diastereoselective regioselective; formylindole diazo ester addition reaction Lewis Acid catalyst.

A facile and efficient In(OTf)3- and BF3.OEt2-catalyzed direct transformation of 3-formylindoles I (R = Me, prop-2-en-1-yl, Ph, Bn, etc.; R1 = H, Me, Et, Ph; R2 = H, Ph, OBn; R3 = H, Me, Ph, naphthalen-2-yl, etc.; R4 = H, Me, Br, Cl, F; R5 = H, Me; R4R5 = -(CH2)3-, -CH=CH-CH=CH-) with diazo esters N2=CHC(O)OR6 (R6 = Et, allyl, Bn, cyclohexyl, etc.) has been developed for synthesizing diverse and functionalized indolyl acrylates II, III and IV. This one-pot protocol furnishes various (Z)-α-hydroxy-β-indolyl acrylates II, (E)-β-(2-alkoxy-2-oxoethoxy)-α-indolyl acrylates III, and (Z)-3-hydroxy-2-indolyl acrylates IV by a catalyst- and substituent-controlled, regio- and stereoselective cascade reaction. The protocol has several advantages, including low loading of the catalyst, mild reaction conditions, broad scope, and high functional group tolerance. The synthesized compounds II, III and IV can be further converted into diversely functionalized materials.

Organic Letters published new progress about C-H bond activation. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Formula: C11H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ganesa, Sachita; Sule, Amrita; Sundaram, Ranjini K.; Bindra, Ranjit S. published the artcile< Mismatch repair proteins play a role in ATR activation upon temozolomide treatment in MGMT-methylated glioblastoma>, Computed Properties of 112-63-0, the main research area is glioblastoma MGMT mismatch repair proteins temozolomide.

The methylation status of the O6-methylguanine methyltransferase (MGMT) gene promoter has been widely accepted as a prognostic biomarker for treatment with the alkylator, temozolomide (TMZ). In the absence of promoter methylation, the MGMT enzyme removes O6-methylguanine (O6-meG) lesions. In the setting of MGMT-promoter methylation (MGMT-), the O6-meG lesion activates the mismatch repair (MMR) pathway which functions to remove the damage. Our group reported that loss of MGMT expression via MGMT promoter silencing modulates activation of ataxia telangiectasia and RAD3 related protein (ATR) in response to TMZ treatment, which is associated with synergistic tumor-cell killing. Whether or not MMR proteins are involved in ATR activation in MGMT-cells upon alkylation damage remains poorly understood. To investigate the function of MMR in ATR activation, we created isogenic cell lines with knockdowns of the individual human MMR proteins MutS homolog 2 (MSH2), MutS homolog 6 (MSH6), MutS homolog 3 (MSH3), MutL homolog 1 (MLH1), and PMS1 homolog 2 (PMS2). Here, we demonstrate that MSH2, MSH6, MLH1 and PMS2, specifically, are involved in the activation of the ATR axis after TMZ exposure, whereas MSH3 is likely not. This study elucidates a potential mechanistic understanding of how the MMR system is involved in ATR activation by TMZ in glioblastoma cells, which is important for targeting MMR-mutated cancers.

Scientific Reports published new progress about Alkylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Soba, David; Arrese-Igor, Cesar; Aranjuelo, Iker published the artcile< Additive effects of heatwave and water stresses on soybean seed yield is caused by impaired carbon assimilation at pod formation but not at flowering>, Electric Literature of 112-63-0, the main research area is soybean seed heatwave water stress carbon pod flowering; C and N metabolism; Heatwave; Interacting stresses; Nodule; Soybean; Water stress.

Heatwave (HW) combined with water stress (WS) are critical environmental factors neg. affecting crop development. This study aimed to quantify the individual and combined effects of HW and WS during early reproductive stages on leaf and nodule functioning and their relation with final soybean seed yield (SY). For this purpose, during flowering (R2) and pod formation (R4) soybean (Glycine max L. Merr.) plants were exposed to different temperature (ambient[25°C] vs. HW[40°C]) and water availability (full capacity vs. WS[20% field capacity]). HW, WS and their combined impact on yield depended on the phenol. stage at which stress was applied being more affected at R4. For gas exchange, WS severely impaired photosynthetic machinery, especially when combined with HS. Impaired photoassimilate supply at flowering caused flower abortion and a significant reduction in final SY due to interacting stresses and WS. On the other hand, at pod formation (R4), decreased leaf performance caused additive effect on SY by decreasing pod setting and seed size with combined stresses. At the nodule level, WS (alone or in combination with HW) caused nodule impairment, which was reflected by lower leaf N. Such response was linked with a poor malate supply to bacteroids and feed-back inhibition caused by nitrogenous compounds accumulation. In summary, our study noted that soybean sensitivity to interacting heat and water stresses was highly conditioned by the phenol. stage at which it occurs with, R4 stage being the critical moment. To our knowledge this is the first soybean work integrating combined stresses at early reproductive stages.

Plant Science (Shannon, Ireland) published new progress about Anthocyanins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yu, Shaomei; Zhang, Ying published the artcile< Effects of lactic acid bacteria on nitrite degradation during pickle fermentation>, Reference of 112-63-0, the main research area is pickle nitrite fermentation lactic acid bacteria.

Two strains with nitrite degradation ability were obtained from Kimchi. According to morphol., Gram-stain, physiol. tests, the isolates were identified primarily as Lactobacillus brevis and Lactobacillus plantarum, resp. Comparing the nitrite degradation rate of two strains, the strain L. plantarum Z1 with higher degradation rate was utilized to investigate effects on sodium nitrite degradation (NaNO2) during pickle fermentation The strain L. plantarum Z1 was inoculated to 200mL MRS medium including 120μg/mL NaNO2 with inoculum of 1% after culturing at 30°C for 18 h. Several experiments that involved different temperature, pH, substrate concentration were carried out. Nitrite degradation ability of L. plantarum Z1 was estimated from detection of the residue concentration of NaNO2. The optimal conditions for nitrite degradation were: growing temperature at 30°C, initial pH at 5.5 and substrate concentration of 400μg/mL. Under these conditions, the nitrite degradation efficiency was up to 96% with residue of 4.8μg/mL which is below the content of National Standards The ability to degrade sodium nitrite provided a tool for LAB (Lactic acid bacteria) application to improve their industrial performance.

Advanced Materials Research (Durnten-Zurich, Switzerland) published new progress about Fermentation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yu, Xiao-Ye; Chen, Jia-Rong; Wang, Peng-Zi; Yang, Meng-Nan; Liang, Dong; Xiao, Wen-Jing published the artcile< Visible-Light-Driven Iminyl Radical-Mediated C-C Single Bond Cleavage/Radical Addition Cascade of Oxime Esters>, Application of C19H34O2, the main research area is iminyl radical light carbon bond cleavage cascade oxime ester; N-centered radicals; heterocycles; iminyl radicals; nitriles; photoredox catalysis.

A room-temperature, visible-light-driven N-centered iminyl radical-mediated and redox-neutral C-C single bond cleavage/radical addition cascade reaction of oxime esters and unsaturated systems was accomplished. The strategy tolerates a wide range of O-acyl oximes and unsaturated systems, such as alkenes, silyl enol ethers, alkynes, and isonitrile, enabling highly selective formation of various chem. bonds. This method thus provides an efficient approach to various diversely substituted cyano-containing alkenes, ketones, carbocycles, and heterocycles.

Angewandte Chemie, International Edition published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

He, Benzhao; Zhang, Jing; Wang, Jia; Wu, Yongwei; Qin, Anjun; Tang, Ben Zhong published the artcile< Preparation of multifunctional hyperbranched poly(β-aminoacrylate)s by spontaneous amino-yne click polymerization>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is hyperbranched polyaminoacrylate aminoyne click polymerization.

A series of multifunctional hyperbranched poly(β-aminoacrylate)s (hb-PAAs) were synthesized using spontaneous amino-yne click polymn for the first time. Using the optimized polymerization conditions, soluble and thermally stable hb-PAAs with high weight-average mol. weights (Mw up to 18,290) were obtained in excellent yields (up to 99%). This click polymerization also can proceed in stereo- and regiospecific and anti-Markovnikov addition fashion, and 100% E-isomers were obtained. Moreover, introducing the aggregation-induced emission (AIE)-active tetraphenylethene moiety into polymer backbones endows the resultant polymers with unique AIE properties, and their nanoaggregates can be used for sensitive detection of explosives. This work not only enriches the family of hyperbranched polymers but also confirms the universality of the spontaneous amino-yne click polymerization

Macromolecules (Washington, DC, United States) published new progress about Aggregation-induced emission. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kitagawa, Haruaki; Kitagawa, Ranna; Tsuboi, Ririko; Hirose, Nanako; Thongthai, Pasiree; Sakai, Hirohiko; Ueda, Mayuka; Ono, Shunka; Sasaki, Jun-Ichi; Ooya, Tooru; Imazato, Satoshi published the artcile< Development of endodontic sealers containing antimicrobial-loaded polymer particles with long-term antibacterial effects>, Safety of 2-Ethyl-2-((methacryloyloxy)methyl)propane-1,3-diyl bis(2-methylacrylate), the main research area is antimicrobial polymer particle endodontic sealer antibacterial effect; Antibacterial; Antimicrobial; Cetylpyridinium chloride; Drug delivery; Endodontic filling; Infection control; PolyHEMA/TMPT particle; Resin; Sealer; Sustained release.

The objective of this study is to prepare new dental resins with a long-lasting antimicrobial activity. Specifically, this study evaluates an approach for controlling infection in root canals using sealers containing polyhydroxyethyl methacrylate trimethylolpropane trimethacrylate (polyHEMA/TMPT) particles loaded with cetylpyridinium chloride (CPC). In addition, the phys. properties of sealers containing CPC-loaded polyHEMA/TMPT particles (CLP) are determined PolyHEMA/TMPT particles with 10 (10%-CLP) and 25 weight% CPC (25%-CLP) with different particle sizes were fabricated and incorporated in HEMA-based sealers. CPC-release profiles were evaluated over 14 days of immersion in water, followed by 14 days of storage and 14 days of water immersion. The antibacterial activity of these sealers against Enterococcus faecalis in dentinal tubules was assessed using a root-canal-infection model. Their sealing abilities were evaluated by fluid filtration and phys. properties were tested according to the ISO 6876 standard The long-term antibacterial activity of the cured sealer containing 25%-CLP (∼21 μm particle diameter) was re-assessed after 1 yr of storage. After 28 days of immersion, 25%-CLP exhibited a higher and sustained CPC release unlike 10%-CLP. Residual bacteria in root dentinal tubules were eradicated by obturation with 25%-CLP-containing sealers. The incorporation of 25%-CLP (∼21 μm) had no adverse effects on the sealing ability and phys. properties of the sealer and resulted in long-term antibacterial activity. The incorporation of CPC-loaded particles in HEMA resins yielded endodontic sealers with long-term bactericidal activity against E. faecalis in root canals. These sealers can potentially be used to prevent recurrent apical periodontitis.

Dental Materials published new progress about Antibacterial agents. 3290-92-4 belongs to class esters-buliding-blocks, and the molecular formula is C18H26O6, Safety of 2-Ethyl-2-((methacryloyloxy)methyl)propane-1,3-diyl bis(2-methylacrylate).

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shah, Sanjit; Manzoor, Saima; Rothman, Yehudit; Hagen, Matthew; Pater, Luke; Golnik, Karl; Mahammedi, Abdelkader; Lin, Andrew L; Bhabhra, Ruchi; Forbes, Jonathan A; Sengupta, Soma published the artcile< Complete Response of a Patient With a Mismatch Repair Deficient Aggressive Pituitary Adenoma to Immune Checkpoint Inhibitor Therapy: A Case Report.>, COA of Formula: C19H34O2, the main research area is .

BACKGROUND AND IMPORTANCE: Aggressive pituitary adenomas (APAs) are pituitary tumors that are refractory to standard treatments and carry a poor prognosis. Current treatment guidelines are not standardized but combine surgical resection, radiation therapy, and chemotherapy. Temozolomide is the only chemotherapeutic agent with documented effectiveness and is recommended for APA in European Society of Endocrinology clinical guidelines. CLINICAL PRESENTATION: A 57-year-old man presented with visual deterioration and bitemporal hemianopsia. MRI of the brain demonstrated a sellar mass suspected to be pituitary macroadenoma with displacement of the stalk and optic nerve impingement. The patient underwent stereotactic endoscopic transsphenoidal resection of the mass. Postoperative MRI demonstrated gross total resection. Pathology revealed a sparsely granulated corticotroph adenoma with malignant transformation. Immunohistochemistry showed loss of expression of MLH1 and PMS2 in the tumor cells. Proton therapy was recommended given an elevated Ki67 index and p53 positivity. Before radiotherapy, there was no radiographic evidence of residual tumor. Temozolomide therapy was initiated after surveillance MRI showed recurrence at 16 months postoperatively. However, MRI demonstrated marked progression after 3 cycles. Next-generation sequencing using the MSK-IMPACT platform identified somatic mutations in MLH1 Y548lfs*9 and TP53 R337C . Immunotherapy with ipilimumab/nivolumab was initiated, and MRI demonstrated no residual tumor burden 34 months postoperatively. CONCLUSION: APA is a tumor with frequent recurrence and a short median expected length of survival. Here, we demonstrate the utility of immunotherapy in a single case report of APA, with complete resolution of recurrent APA and improved survival compared with life expectancy.

Neurosurgery published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics