Month: November 2022

Falck, J. R.; Sun, Lumin; Lee, Sang Gyeong; Heckmann, Bertrand; Mioskowski, Charles; Karara, Armando; Capdevila, Jorge published the artcile< Enantiospecific synthesis of 17- and 18-hydroxyeicosatetraenoic acids, cytochrome P450 arachidonate metabolites>, Synthetic Route of 617-55-0, the main research area is hydroxyeicosatetraenoate stereoselective preparation; eicosatetraenoate hydroxy stereoselective preparation; cuprate addition bromobutanediol tosylate.

The title bioactive eicosanoids were prepared from di-Me L-malate by a convergent strategy exploiting the differential reactivity of ethereal dialkylcuprates towards tosylate vs. bromide in the intermediate I.

Tetrahedron Letters published new progress about Addition reaction, regioselective. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Synthetic Route of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fairweather, Jon K.; Stick, Robert V.; Tilbrook, D. Matthew G. published the artcile< The asymmetric dihydroxylation of some alkenyl 2-acetylamino-2-deoxy-β-D-glucopyranosides: the preparation of optically pure epoxides as putative inhibitors of chitinases>, Product Details of C19H34O2, the main research area is aminodeoxyglucopyranoside epoxide preparation potential chitinase inhibitor; alkenyl aminodeoxyglucopyranoside asym hydroxylation.

Various alkenyl 2-acetylamino-2-deoxy-β-D-glucopyranosides have been subjected to the Sharpless asym. dihydroxylation protocol to yield the corresponding diols, albeit with somewhat disappointing stereoselectivity. An alternative, more traditional approach has yielded the optically pure epoxyalkyl 2-acetylamino-2-deoxy-β-D-glucopyranosides as putative inhibitors of chitinases. As well, an epoxypropyl chito-bioside and -trioside have been prepared, each as mixtures of two diastereoisomers.

Australian Journal of Chemistry published new progress about Dihydroxylation, stereoselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Apath, Daniel; Moyo, Mambo; Shumba, Munyaradzi published the artcile< TiO2 nanoparticles decorated graphene nanoribbons for voltammetric determination of an Anti-HIV drug nevirapine>, Product Details of C19H34O2, the main research area is nevirapine graphene titanium oxide nanoparticle nanoribbon voltammetry HIV.

In the present study, electrochem. behavior of nevirapine on a glassy carbon electrode (GCE) modified with TiO2 nanoparticles decorated graphene nanoribbons was investigated. Characterization of different components used for modifications was achieved using Fourier transform IR spectroscopy (FT-IR) and SEM (SEM). The electrochem. behavior of nevirapine on the modified electrodes was examined using cyclic voltammetry (CV), electrochem. impedance spectroscopy (EIS), chronoamperometry (CA), and differential pulse voltammetry (DPV). A considerable oxidation potential decrease of +352 mV for nevirapine in 0.1 M phosphate-buffered saline (PBS), pH 11.0, was achieved due to synergy offered by graphene nanoribbons and TiO2 compared to graphene nanoribbons (+252 mV) and TiO2 (-37 mV), all with respect to the glassy carbon electrode. Under optimized conditions, DPV gave linear calibrations over the range of 0.020-0.14μM. The detection limit was calculated as 0.043μM. The developed sensor was used for determination of nevirapine in a pharmaceutical formulation successfully.

Journal of Chemistry published new progress about Additive manufacturing. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Bin; Thayumanavan, S. published the artcile< Substituent Effects on the pH Sensitivity of Acetals and Ketals and Their Correlation with Encapsulation Stability in Polymeric Nanogels>, Recommanded Product: Perfluorophenyl acrylate, the main research area is pH sensitivity acetal ketal encapsulation stability polymeric nanogel.

The effect of structural variations in acetal- and ketal-based linkers upon their degradation kinetics is studied through the design, synthesis, and study of six series of mols., comprising a total of 18 different mols. Through this systematic study, the structural fine-tuning of the linkers allows access to variations in kinetics of degradation of >6 orders of magnitude. Hammett correlations show that the ρ value for the hydrolysis of benzylidene acetals is ∼-4.06, which is comparable to an SN1-like process. There is a strong, developing pos. charge at the benzylic position in the transition state during the degradation of acetals. This pos. charged transition state is consistent with the relative degradation rates of acetals vs. ketals (correlated to stabilities of 1°, 2°, and 3° carboxonium ion type intermediates) and the observed effect of proximal electron-withdrawing groups upon the degradation rates. Following this, the authors studied whether the degradation kinetics study correlates with pH-sensitive variations in the host-guest characteristics of polymeric nanogels that contains these acetal or ketal moieties as crosslinking functionalities. Indeed, the trends observed in the small mol. degradation have clear correlations with the encapsulation stability of guest mols. within these polymeric nanogels. The implications of this fundamental study extend to a broad range of applications, well beyond the polymeric nanogel examples studied here.

Journal of the American Chemical Society published new progress about Acetals Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), PROC (Process), RACT (Reactant or Reagent). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Recommanded Product: Perfluorophenyl acrylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Martinez-Pardo, Pablo; Lavios, Adrian; Sanz-Marco, Amparo; Vila, Carlos; Pedro, Jose R.; Blay, Gonzalo published the artcile< Enantioselective Synthesis of Functionalized Diazaspirocycles from 4-Benzylideneisoxazol-5(4H)-one Derivatives and Isocyanoacetate Esters>, Computed Properties of 112-63-0, the main research area is isocyanoacetate methylidene isoxazolone silver oxide squaramide enantioselective diastereoselective cycloaddition; spiro pyrrolidine isoxazolone preparation.

Enantioenriched spirocyclic compounds bearing three contiguous stereocenters and high functionalization were obtained through a formal [3+2] cycloaddition reaction catalyzed by a cooperative system. The spiro compounds were synthesized from 4-arylideneisoxazol-5-ones and isocyanoacetate esters using a bifunctional squaramide/Bronsted base organocatalyst derived from a Cinchona alkaloid and silver oxide as Lewis acid. This method afforded two out of the four possible diastereomers with good yields and high enantiomeric excess for both diastereomers.

Advanced Synthesis & Catalysis published new progress about [3+2] Cycloaddition reaction catalysts (stereoselective). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sefkow, M. published the artcile< Synthesis of (+)-wikstromol by double alkylation of malic acid>, SDS of cas: 617-55-0, the main research area is lactone lignan wikstromol preparation stereoselective benzylation malic acid derivative.

The synthesis of (+)-wikstromol (I) in six steps, based on two stereoselective benzylations of unnatural malic acid derivatives, is presented. The influence of the alkyl ester on yield and selectivity in the alkylation of malic acid esters is examined

Tetrahedron: Asymmetry published new progress about Benzylation (stereoselective). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, SDS of cas: 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Turco, Rosa; Di Serio, Martino published the artcile< Sustainable synthesis of epoxidized Cynara C. seed oil>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Cardoon seed oil epoxidation hydrogen peroxide phys chem property.

The use of non-edible vegetable oils to produce oleochems. has been attracting more attention in recent years. Cardoon seed oil, derived from the Cynara C. plant, growing in marginal and contaminated lands, represents a non-edible alternative to soybean oil to obtain plasticizers through epoxidation reaction. The use of hydrogen peroxide as oxidant and in the presence of a heterogeneous catalyst allows overcoming the limits of epoxidation with peracids. γ-Alumina has been shown to have an active catalyst epoxidation reaction with hydrogen peroxide, mainly using acetonitrile as solvent. However, the use of acetonitrile as solvent is widely debated due to its hazardous character and health issues. For these reasons, the influence of solvent on the reaction was studied in this work to find a more environmentally friendly and stable solvent. The study showed that the epoxidation reaction takes place also in the absence of solvent although with lower selectivity. The type of solvent influences both the epoxidation and decomposition reactions of hydrogen peroxide. γ-Valerolactone was found to be the most promising solvent for cardoon oil epoxidation reaction. This finding represents a noteworthy novelty in the field of epoxidation of vegetable oils with hydrogen peroxide, opening the way to greener and cleaner process. Finally, an optimization study showed that the most effective molar ratio between hydrogen peroxide and double bonds for better selectivity was 4.5 and the need to use the highest possible initial concentration of hydrogen peroxide (approx. 60 weight%).

Catalysts published new progress about Artichoke. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cooper, G.; Irwin, W. J. published the artcile< 1-styrylimidazoles>, Application In Synthesis of 112-63-0, the main research area is styrylimidazole; imidazole styryl; benzimidazole styryl; dehydration hydroxyphenylethylimidazole.

Addnl. data considered in abstracting and indexing are available from a source cited in the original document. Styrene oxide reacted with imidazole, its 2-methyl, 2-phenyl, and 4,5-diphenyl derivatives and benzimidazole in DMF in the presence of catalytic quantities of K at room temperature to give 45-98% of the corresponding 1-(2-hydroxy-2-phenylethyl)imidazole, which on heating with SOCl2 and KOH were dehydrated to give 51-90% trans-1-styrylimidazoles.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tian, Yi; Zhang, Ruoqi; Zhao, Wenguang; Wen, Sha; Xiang, Yanping; Liu, Xianxiang published the artcile< A New Sulfonic Acid-Functionalized Organic Polymer Catalyst for the Synthesis of Biomass-Derived Alkyl Levulinates>, HPLC of Formula: 112-63-0, the main research area is sulfonate functionalized organic polymer catalyst biomass alkyl levulinate.

Alkyl levulinates are important biobased chems. with great fuel-blending properties and good reactivity. In this work, a new functionalized nitrogen-containing organic polymer bearing sulfonic acid groups (PDVTA-SO3H) was successfully prepared and studied for the esterification of levulinic acid with alcs. to produce alkyl levulinates. The results showed that this sulfonic acid-functionalized organic polymer possessed high catalytic activity, and the yield of Bu levulinate reached 97.4% under the mild conditions. PDVTA-SO3H exhibited strong acidic sites and high stability, and would be well expected to be a potential candidate better than some com. sulfonic solid catalysts for alkyl levulinates production The catalyst had been reused without any treatment for five times and the results proved its potential for industrial applications.

Catalysis Letters published new progress about Biomass. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ni, Haiwei; Ruan, Guojing; Sun, Cheng; Yang, Xuan; Miao, Zhenyan; Li, Jifei; Chen, Ying; Qin, Hai; Liu, Yichen; Zheng, Lufeng; Xing, Yingying; Xi, Tao; Li, Xiaoman published the artcile< Tanshinone IIA inhibits gastric cancer cell stemness through inducing ferroptosis>, Application In Synthesis of 347174-05-4, the main research area is tanshinone IIA gastric cancer cell stemness ferroptosis; SLC7A11; Tanshinone IIA; ferroptosis; gastric cancer; stemness.

Tanshinone IIA is the active constituent extracted from Salvia Miltiorrhza. Numerous studies have shown that Tanshinone IIA could inhibit tumor proliferation and metastasis, including gastric cancer. However, the effect of Tanshinone IIA on gastric cancer cell stemness stays unclear. Here, we found that Tanshinone IIA could reduce gastric cancer cell stemness through detecting spheroid-forming, flow cytometry anal., and the expression of stemness markers (OCT3/4, ALDH1A1, and CD44). Mechanistically, Tanshinone IIA increased the level of lipid peroxides and decreased glutathione level in gastric cancer cells, both of which are the markers of ferroptosis. Similarly, ferroptosis inducers (erastin, sulfasalazine, and sorafenib) reduced gastric cancer cell stemness. Addnl., the inhibitory effects of Tanshinone IIA on GC cell stemness were reversed by ferroptosis inhibitor (Fer-1) or overexpression of SLC7A11, which is a critical ferroptosis inhibitor. Therefore, we revealed that Tanshinone IIA inhibited the stemness of gastric cancer cells partly through inducing ferroptosis.

Environmental Toxicology published new progress about CD44 antigens Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Application In Synthesis of 347174-05-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics