Month: November 2022

Koenig, Wilfried A.; Icheln, Detlef; Hardt, Ingo published the artcile< Unusual retention behavior of methyl lactate and methyl 2-hydroxybutyrate enantiomers on a modified cyclodextrin>, COA of Formula: C5H10O3, the main research area is methyl lactate enantiomer elution reversal GC; methyl hydroxybutyrate enantiomer elution behavior GC; gas chromatog enantiomer elution behavior; elution reversal enantiomer gas chromatog; cyclodextrin derivative stationary phase gas chromatog; butyryldipentyl cyclodextrin stationary phase gas chromatog; capillary gas chromatog elution reversal enantiomer.

Gas chromatog. elution behavior was investigated for Me lactate and Me 2-hydroxybutyrate enantiomers on a Pyrex capillary column coated with octakis(3-O-butyryl-2,6-di-O-pentyl)-γ cyclodextrin over the complete range of operating temperatures Elution order reversal was achieved for the Me lactate but not for the latter example.

Journal of High Resolution Chromatography published new progress about 73349-07-2. 73349-07-2 belongs to class esters-buliding-blocks, and the molecular formula is C5H10O3, COA of Formula: C5H10O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Qiu-yan; Huang, Jin-lin; Hou, Hai-sheng; Chen, Shao-chuan published the artcile< Influences of enhanced external counterpulsation on pulse wave velocity and vascular endothelial function in hypertensive patients complicated by impaired glucose tolerance>, Category: esters-buliding-blocks, the main research area is hypertension impaired glucose tolerance endothelin enhanced external counterpulsation.

The effects of enhanced external counterpulsation (EECP) on the pulse wave velocity and vascular endothelial function in hypertensive patients complicated by impaired glucose tolerance (IGT) were explored. Eighty hypertensive patients complicated by IGT were divided into treatment group (n = 44, conventional treatment + EECP) and control group (n = 36, conventional treatment). Both groups received conventional antihypertensive treatment, but EECP was added in the treatment group based on the conventional treatment. Blood pressure, pulse wave velocity, endothelin (ET) and nitric oxide (NO) were measured and compared between groups. Blood pressure in the two groups after treatment was dramatically reduced, but there was no significant difference between groups. The ba PWV of patients in treatment group (1602±214) vs. (1890±251) cm/s and control group (1704±221) vs. (1893±243) cm/s after treatment decreased significantly. The ET level of patients in the treatment group (63±21) vs. (90±24) ng/L and control group (75±20) vs. (90±24) ng/L also decreased significantly after treatment. However, NO level of patients in treatment group (79±17) vs. (51±19) mmol/L and control group (68±17) vs. (51±18) μmol/L increased significantly after treatment. However, the ba PWV, ET and NO of patients in treatment group improved more significantly compared with those in the control group. Enhanced external counterpulsation can improve the pulse wave velocity and vascular endothelial function in hypertensive patients complicated by impaired glucose tolerance.

Xinzang Zazhi published new progress about Blood triglycerides Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sawano, Takahiro; Ogihara, Kei; Sagawa, Jun; Ono, Masaki; Takeuchi, Ryo published the artcile< Iridium-Catalyzed Hydroalkylation of Aliphatic Alkenes with β-Ketoesters: Formal Hydroalkylation with Methyl Ketones>, Application of C11H12O3, the main research area is iridium catalyzed hydroalkylation alkene beta ketoester; ketone preparation one pot dealkoxycarbonylation hydroalkylated intermediate.

Transition-metal-catalyzed hydroalkylation of alkenes with 1,3-dicarbonyl compounds is a useful reaction to construct a C-C bond under neutral reaction conditions in a highly atom-economical manner. We found that hydroalkylation of aliphatic alkenes with β-ketoesters proceeded with the use of a cationic iridium complex and bidentate phosphine ligand to give selectively branched α-substituted β-ketoesters in high yields. The obtained hydroalkylated compounds can be converted to β-substituted ketones through one-pot Krapcho dealkoxycarbonylation.

Organic Letters published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Application of C11H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kandil, Heba; El-Sawy, Eslam R.; Awad, Hanem M.; E. El. Nashar, Doaa; Amin, Amal published the artcile< RAFT Terminated Hyperbranched Functionalized Nano Rice Husk Powder / EPDM Nanocomposite for Biomedical Applications>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is hyperbranched polymer modified rice husk EPDM nanocomposite cytotoxicity.

Modified nanosize rice husk powder (i.e. mod.nRHP; mod.nRHP-MA-RAFT-H)/ethylene propylene diene monomer (EPDM) nanocomposite was prepared by solvent casting method. The surface of nano rice husk (n-RHP) was treated with maleic anhydride (MA) to yield n-RHP-MA, then, aliphatic hyperbranched polyester (H) was end capped with RAFT agent to obtain H-RAFT. Afterward, H-RAFT-was successfully anchored onto nRHP-MA via RAFT polymerization technique to afford nRHP-MA-RAFT-H (mod.nRHP). The mech. and thermal properties were studied for nRHP-MA-RAFT-H (mod.nRHP)/EPDM nanocomposite with different loadings of mod.nRHP. The cytotoxicity activities of the prepared mod.nRHP/EPDM nanocomposites were investigated toward human cell lines in vitro.

Polymer-Plastics Technology and Materials published new progress about Adhesion, physical, interfacial. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Strelyaeva, Angelina V.; Larina, Olga A.; Antsyshkina, Alla M.; Kuznetsov, Roman M.; Bondar, Alina A.; Sorokin, Vladimir A. published the artcile< The study of external signs, microscopy and chemical composition of medicinal plant materials of Verinica beccabunga L. Herb>, HPLC of Formula: 112-63-0, the main research area is external sign microscopy chem composition Verinica beccabunga.

Veronica beccabunga L. belongs to the class dicotyledons, order Lamiáles, family Scrophulariaceae. Representatives of the genus Veronica have long been used in folk medicine as antiinflammatory, antibacterial, antiseptic, wound healing, hemostatic, choleretic and antispasmodic drugs. Widely studied species are Veronica officinalis and Veronica chamaedrys. Veronica beccabunga L., which is the object of our study, remains a poorly studied plant. The study of external signs, microscopy and chem. composition of medicinal plant materials of Veronica beccabunga L. herb. Chromato-mass spectrometry was used in the work. When describing external signs and microscopy, diagnostic signs of Veronica beccabunga were revealed. 27 compounds were identified by chromatog.-mass spectrometry. The maximum content falls on: Citronellol epoxide (R or S) (30.5%), Linolenic acid, Et ester (15.18), Di-Et succinate (12.17%), Et palmitate (6.43%), Phytol (4.89%), Acetaldehyde Et amyl acetal (3.94%), Dibenzylamine (3.01%), Oleamide (2.77%), 2-(1-Methylbutyl)oxirane (2.7%), Bu octyl phthalate(1.7%), Et 10-bromodecanoate (1.68), Valeric acid, 4-methyl-, Et ester (1.58), Glycoside detected : 1-Benzyl-1H-benzimidazole 3-oxide (0.76%). The revealed morphol. and anatomical signs of Veronica beccabunga herb can be used to diagnose this species and develop authenticity indicators for promising medicinal herbs. 27 compounds were identified by chromatographymass spectrometry. Using the method of simple normalization, the relative percentage of identified compounds was determined

Pharmacognosy Journal published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ren, Linjing; Ran, Maogang; Fang, Xuehong; Zhao, Ling; Yao, Qiuli published the artcile< An efficient synthesis of 1-arylvinylphosphonates via direct functionalization of C(sp3)-H bond>, Category: esters-buliding-blocks, the main research area is phosphonate arylvinyl preparation green chem; green chem tetrabutylammonium iodide catalyst benzylic phosphonate paraformaldehyde reaction.

The direct functionalization of the C(sp3)-H bond adjacent to the phosphonate group for the preparation of vinyl phosphonates was rarely developed. Herein, a simple and efficient tetrabutylammonium iodide catalyzed protocol for the preparation of vinyl phosphonates from benzylic phosphonates and paraformaldehyde is achieved under mild conditions in air. Moderate to high yields can be obtained for a broad scope of substrates.

Youji Huaxue published new progress about Green chemistry. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Smith, Hilton A.; Scrogham, Kenneth G.; Stump, Billy L. published the artcile< The kinetics of the acid-catalyzed hydrolysis of the methyl esters of cyclohexanedicarboxylic acids>, Formula: C19H34O2, the main research area is .

Isomeric cyclohexane dicarboxylic acids (I) were made by reduction of phthalic acids: cis-1,2 (II), m. 194°; trans-1,2 (III), m. 227.5-9.4°; cis-1,3 (IV), m. 167.2-8.2°; cis-1,4 (V), m. 170-2°; and trans-1,4 (VI), m. 312-13°. Di-Me esters made by acid-catalyzed esterification with MeOH were: II, b12 124.4°; III, m. 30.2-30.8°; V, b10 131°; and VI, m. 69°. IV di-Me ester, b10 130.6°, was made from the Ag salt and MeI, whereas trans-1,3-di-Me ester (VII), b20 140°, was made from H and 1,3-C6H4(CO2Me)2 with Adams Pt catalyst. Mono-Me derivative of II, m. 68.5-9.0°, was made similarly from 2-HO2CC6H4CO2Me and H. Mono-Me derivative of III, m. 94.5-95°, was made from the acid and MeOH. Mono-Me derivative of IV, m. 66.2-7.0°, was made from the acid chloride and MeOH. By treatment of the di-Me esters with 1 equivalent KOH, mono-Me derivative of V, m. 106.6-8.6°, mono-Me derivative of VI, m. 125.6-6.8°, and mono-Me derivative of trans-1,3-I were prepared Acid-catalyzed rate constants for these esters were determined at 25°, 35°, 45°, and 55° and the heats of activation calculated Me and di-Me esters of II and III hydrolyzed most slowly, those of IV and VI most rapidly, and those of V and VII at an intermediate rate.

Journal of Organic Chemistry published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Falck, J. R.; Sun, Lumin; Lee, Sang Gyeong; Heckmann, Bertrand; Mioskowski, Charles; Karara, Armando; Capdevila, Jorge published the artcile< Enantiospecific synthesis of 17- and 18-hydroxyeicosatetraenoic acids, cytochrome P450 arachidonate metabolites>, Synthetic Route of 617-55-0, the main research area is hydroxyeicosatetraenoate stereoselective preparation; eicosatetraenoate hydroxy stereoselective preparation; cuprate addition bromobutanediol tosylate.

The title bioactive eicosanoids were prepared from di-Me L-malate by a convergent strategy exploiting the differential reactivity of ethereal dialkylcuprates towards tosylate vs. bromide in the intermediate I.

Tetrahedron Letters published new progress about Addition reaction, regioselective. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Synthetic Route of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Larcher, Adele; Nocentini, Alessio; Supuran, Claudiu T.; Winum, Jean-Yves; van der Lee, Arie; Vasseur, Jean-Jacques; Laurencin, Danielle; Smietana, Michael published the artcile< Bis-benzoxaboroles: Design, Synthesis, and Biological Evaluation as Carbonic Anhydrase Inhibitors>, Application of C19H34O2, the main research area is dicarboxamide linked benzoxaborole preparation carbonic anhydrase inhibitor.

The synthesis, characterization, and biol. evaluation of a series of compounds incorporating two or three benzoxaborole moieties is reported. Three different synthetic strategies were used to explore within this series as much chem. space as possible, all starting from the 6-aminobenzoxaborole reagent: amide coupling, imine bond formation, and squarate coupling. Eleven new compounds were isolated in pure form, and single crystals were obtained for two of them. These compounds were then evaluated as carbonic anhydrase inhibitors against the cytosolic hCA I and II and the transmembrane hCA IV, IX, and XII isoforms. While the benzoxaborole scaffold has been recently introduced as a new chemotype for carbonic anhydrase inhibition, these new multivalent derivatives exhibited superior inhibitory activity against the tumor-associated isoform hCA IX. In particular, compared to monovalent 6-aminobenzoxaborole (KI = 813 nM) and 6-carboxybenzoxaborole (KI = 400 nM), derivative 2h characterized by a glutamic acid structural core and two benzoxaborole moieties was found to be more potent (KI = 64 nM) and more selective over human hCA II.

ACS Medicinal Chemistry Letters published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics