Month: November 2022

Zhou, Jie; Tan, Yong; Wang, Xudong; Zhu, Meihong published the artcile< Paeoniflorin attenuates DHEA-induced polycystic ovary syndrome via inactivation of TGF-β1/Smads signaling pathway in vivo>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is TGF-β1/Smads signaling pathway; ovarian fibrosis; paeoniflorin; polycystic ovary syndrome.

Polycystic ovarian syndrome (PCOS) is one of the most common reproductive endocrine disorders which are involved in complicated and unknown pathogenic mechanisms. Paeoniflorin (PAE) plays a significant anti-fibrotic role according to previous studies. The aim of the present study was to investigate the effect of PAE on ovarian fibrosis and its underlying mechanism in PCOS development. An animal model of PCOS was established by s.c. injection of 60mg/kg/d dehydroepiandrosterone (DHEA) for 35 consecutive days. Rats in PAE-L, PAE-M and PAE-H groups were administrated by gavage with PAE (20, 40, 80 mg/kg/d) for 4 wk. Our results indicated that DHEA-induced PCOS rats showed similar phenotypes with PCOS patients. PAE could significantly block the DHEA-induced decline of ovary weight and organ coefficient, shorten the prolonged diestrus period, and regulate the irregular estrous cycle of PCOS rats. Moreover, PAE regulated reproductive hormone levels and improved ovarian fibrosis induced by DHEA. PAE treatment could also reduce the expression levels of TGF-β1 and Smad3, and increase the expression levels of Smad7 and MMP2. In conclusion, PAE significantly attenuated the ovarian fibrosis in PCOS, which could be mediated by TGF-β1/Smads signaling pathway. Herein, PAE can be used for the treatment of ovarian fibrosis in PCOS progression.

Aging published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhao, Chengke; Hu, Zhenhua; Shi, Lanlan; Wang, Chen; Yue, Fengxia; Li, Suxiang; Zhang, Han; Lu, Fachuang published the artcile< Profiling of the formation of lignin-derived monomers and dimers from Eucalyptus alkali lignin>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Eucalyptus alkali lignin monomer dimer fraction chem pulping.

Lignin is a renewable and the most abundant aromatic source that can be used for extensive chems. and materials. Although approx. 50 million tons of lignin are produced annually as a byproduct of the pulp and paper industry, it is currently underutilized. It is important to know the structural features of tech. lignin when considering its application. In this work, we have demonstrated the formation of low-mol.-weight constituents from hardwood (Eucalyptus) lignin, which produces much more low-mol.-weight constituents than softwood (spruce) lignin, after a chem. pulping process, and analyzed the micromol. compositions in the alkali lignin after fractionation by dichloromethane (DCM) extraction By applying anal. methods (gel-permeation chromatog., 2D NMR and GC-MS) with the aid of evidence from authenticated compounds, a great treasure trove of lignin-derived phenolic compounds from Eucalyptus alkali lignin were disclosed. Except for some common monomeric products, as many as 15 new lignin-derived monomers and dimers including syringaglycerol, diarylmethane, 1,2-diarylethanes, 1,2-diarylethenes, (arylvinyl ether)-linked arylglycerol dimers and isomeric syringaresinols were identified in the DCM-soluble fraction. Regarding the formation and evolution of the Cα-condensed β-aryl ether structure, a novel route that is potentially responsible for the high content of β-1 diarylethenes and diarylethanes in the lignin low-mol.-weight fraction, in addition to the β-1 (spirodienone) pathway, was proposed. This work not only provides novel insights into the chem. transformation of S-G lignin during the alkali pulping process, but also discovered lignin-derived phenolic monomers and dimers that can potentially be used as raw materials in the chem. or pharmaceutical industries.

Green Chemistry published new progress about Bond energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Thomas, Aline M.; Yang, Ethan; Smith, Matthew D.; Chu, Chengyan; Calabresi, Peter A.; Glunde, Kristine; van Zijl, Peter C. M.; Bulte, Jeff W. M. published the artcile< CEST MRI and MALDI imaging reveal metabolic alterations in the cervical lymph nodes of EAE mice>, Synthetic Route of 112-63-0, the main research area is CEST MRI MALDI imaging cervical lymph node metabolic alteration; CEST MRI; Lymph nodes; Multiple sclerosis; Neuroinflammation.

Multiple sclerosis (MS) is a neurodegenerative disease, wherein aberrant immune cells target myelin-ensheathed nerves. Conventional magnetic resonance imaging (MRI) can be performed to monitor damage to the central nervous system that results from previous inflammation; however, these imaging biomarkers are not necessarily indicative of active, progressive stages of the disease. The immune cells responsible for MS are first activated and sensitized to myelin in lymph nodes (LNs). Here, we present a new strategy for monitoring active disease activity in MS, chem. exchange saturation transfer (CEST) MRI of LNs. We studied the potential utility of conventional (T2-weighted) and CEST MRI to monitor changes in these LNs during disease progression in an exptl. autoimmune encephalomyelitis (EAE) model. We found CEST signal changes corresponded temporally with disease activity. CEST signals at the 3.2 ppm frequency during the active stage of EAE correlated significantly with the cellular (flow cytometry) and metabolic (mass spectrometry imaging) composition of the LNs, as well as immune cell infiltration into brain and spinal cord tissue. Correlating primary metabolites as identified by matrix-assisted laser desorption/ionization (MALDI) imaging included alanine, lactate, leucine, malate, and phenylalanine. Taken together, we demonstrate the utility of CEST MRI signal changes in superficial cervical LNs as a complementary imaging biomarker for monitoring disease activity in MS. CEST MRI biomarkers corresponded to disease activity, correlated with immune activation (surface markers, antigen-stimulated proliferation), and correlated with LN metabolite levels.

Journal of Neuroinflammation published new progress about Antigen-presenting cell. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hussain, Nazar; Babu Tatina, Madhu; Mukherjee, Debaraj published the artcile< Cross dehydrogenative coupling of sugar enol ethers with terminal alkenes in the synthesis of pseudo-disaccharides, chiral oxadecalins and a conjugated triene>, Synthetic Route of 4098-06-0, the main research area is Diels Alder cycloaddition oxadecalin stereoselective dehydrogenative coupling disaccharide; maleic anhydride cycloaddition oxadecalin stereoselective dehydrogenative coupling disaccharide preparation; oxadecalin disaccharide dehydrogenative stereoselective coupling alkene triene.

An efficient strategy for the synthesis of C-2 and C-3 branched sugar dienes via cross dehydrogenative coupling of sugar enol ethers with terminal alkenes was developed. Both pyran and furan based enol ethers coupled smoothly with electron rich as well as deficient alkene sources yielding sugar dienes with complete E-stereoselectivity. This coupling reaction was applied successfully for the synthesis of orthogonally protected pseudo-C-saccharides as an alternative to olefin metathesis. Substrate scope was further enhanced by reacting exo-glycals with Me acrylate to generate C-5 branched sugars with moderate diastereoselectivity. These diene subunits were reacted with maleic anhydride under [4+2] cycloaddition conditions to generate highly functionalized chiral oxadecalin cores. Finally, utilizing this C-C bond formation, a sugar based conjugated triene was synthesized in excellent yield and selectivity.

Organic & Biomolecular Chemistry published new progress about Coupling reaction. 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Synthetic Route of 4098-06-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lakouraj, Moslem M.; Ghodrati, Keivan published the artcile< A facile and convenient method for the conversion of thioamides into amides using pyridinium hydrobromide perbromide>, Computed Properties of 112-63-0, the main research area is thioamide oxidation pyridinium hydrobromide perbromide; amide preparation.

Selective transformation of thioamides to their corresponding carbonyl compounds are performed in high to excellent yields under mild conditions using pyridinium hydrobromide perbromide as a mild and efficient reagent.

Monatshefte fuer Chemie published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Booth, Paul M.; Fox, Christina M. J.; Ley, Steven V. published the artcile< Preparation of acyltetronic acids using tert-butyl acetothioacetate: total synthesis of the fungal metabolites carolic, carlosic, and carlic acids>, Application In Synthesis of 617-55-0, the main research area is carolate total synthesis; carlosate total synthesis; carlate total synthesis; acetothioacetate dianion alkylation; oxoalkanethioate preparation transesterification; oxoacyloxylalkanoate preparation ring closure.

Dianions of MeCOCH2C(O)SCMe3 were allylated with a variety of electrophiles at the γ-C. Treatment of the products with 2-hydroxy esters in the presence of Ag (I) salts gave transesterified acetoacetate derivs in good yields. These acetoacetates were cyclized to acyltetronic acid derivs using Bu4NF in THF at room temperature Natural products carlosic (I) carolic (II; R = Me) and carlic acids (II; R = CH2CO2H) acids were prepared this way.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Cyclization. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Application In Synthesis of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nowak, Anna; Cybulska, Krystyna; Makuch, Edyta; Kucharski, Lukasz; Rozewicka-Czabanska, Monika; Prowans, Piotr; Czapla, Norbert; Bargiel, Piotr; Petriczko, Jan; Klimowicz, Adam published the artcile< In vitro human skin penetration, antioxidant and antimicrobial activity of ethanol-water extract of fireweed (Epilobium angustifolium L.)>, Formula: C19H34O2, the main research area is ethanol water human skin penetration antioxidant antimicrobial activity extract; Franz cell; antibacterial activity; antioxidants; herbal extract; phenolic acids; skin.

Epilobium angustifolium L. is applied as an antiseptic agent in the treatment of skin diseases. However, there is a lack of information on human skin penetration of active ingredients with antioxidative potential. It seems crucial because bacterial infections of skin and s.c. tissue are common and partly depend on oxidative stress. Therefore, we evaluated in vitro human skin penetration of fireweed ethanol-water extracts (FEEs) by determining antioxidant activity of these extracts before and after penetration study using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and Folin-Ciocalteu methods. Microbiol. tests of extracts were done. The qual. and quant. evaluation was performed using gas chromatog.-mass spectrometry (GC-MS) and high-performance liquid chromatog. (HPLC-UV) methods. The in vitro human skin penetration using the Franz diffusion chamber was assessed. The high antioxidant activity of FEEs was found. Gallic acid (GA), chlorogenic acid (ChA), 3,4-dihydroxybenzoic acid (3,4-DHB), 4-hydroxybenzoic acid (4-HB), and caffeic acid (CA) were identified in the extracts The antibacterial activities were found against Serratia lutea, S. marcescens, Bacillus subtilis, B. pseudomycoides, and B. thuringiensis and next Enterococcus faecalis, E. faecium, Streptococcus pneumoniae, Pseudomonas aeruginosa, and P. fluorescens strains. In vitro penetration studies showed the penetration of some phenolic acids and their accumulation in the skin. Our results confirm the importance of skin penetration studies to guarantee the efficacy of formulations containing E. angustifolium extracts

Molecules published new progress about Antimicrobial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shekari, Nafiseh; Vosough, Maryam; Tabar Heidar, Kourosh published the artcile< Chromatographic fingerprinting through chemometric techniques for herbal slimming pills: A way of adulterant identification>, HPLC of Formula: 112-63-0, the main research area is sibutramine amfepramone caffeine herbal slimming pill adulterant GC MS; Adulteration; Fingerprinting; GC–MS; Herbal slimming pills; MCR-ALS.

In the current study, gas chromatog.-mass spectrometry (GC-MS) fingerprinting of herbal slimming pills assisted by chemometric methods has been presented. Deconvolution of two-way chromatog. signals of nine herbal slimming pills into pure chromatog. and spectral patterns was performed. The peak clusters were resolved using multivariate curve resolution-alternating least squares (MCR-ALS) by employing appropriate constraints. It was revealed that more useful chem. information about the composition of the slimming pills can be obtained by employing sophisticated GC-MS method coupled with proper chemometric tools yielding the extended number of identified constituents. The thorough fingerprinting of the complex mixtures proved the presence of some toxic or carcinogen components, such as toluene, furfural, furfuryl alc., styrene, itaconic anhydride, citraconic anhydride, tri-Me phosphate, phenol, pyrocatechol, p-propenylanisole and pyrogallol. In addition, some samples were shown to be adulterated with undeclared ingredients, including stimulants, anorexiant and laxatives such as phenolphthalein, amfepramone, caffeine and sibutramine.

Forensic Science International published new progress about Adulterants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nikitas, Nikolaos F.; Triandafillidi, Ierasia; Kokotos, Christoforos G. published the artcile< Photo-organocatalytic synthesis of acetals from aldehydes>, Electric Literature of 34637-22-4, the main research area is aldehyde alc thioxanthenone catalyst photochem acetalization green chem; acetal preparation.

A mild and green photo-organocatalytic protocol for the highly efficient acetalization of aldehydes were developed. Utilizing thioxanthenone as the photocatalyst and inexpensive household lamps as the light source, a variety of aromatic and aliphatic aldehydes were converted into acyclic and cyclic acetals in high yields. The reaction mechanism was extensively studied.

Green Chemistry published new progress about Acetalization (photochem.). 34637-22-4 belongs to class esters-buliding-blocks, and the molecular formula is C11H15NO3, Electric Literature of 34637-22-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shahabuddin, Mohammad; Akutsu, Akira; Kimura, Takao; Karikomi, Michinori published the artcile< Synthesis of Helical Quinone Derivatives by Oxidative Coupling of Substituted 2-Hydroxybenzo[c]phenanthrenes>, Product Details of C19H34O2, the main research area is crystal mol structure bibenzo phenanthrylidene dione; hydroxybenzo phenanthrene electrocyclization oxidative aromatization coupling; helical quinone preparation electrocyclization oxidative aromatization coupling.

A concise synthesis of novel substituted quinone derivatives from com. available starting materials was developed. For this synthesis, classical photo-induced 6π-electrocyclization was utilized, followed by oxidative aromatization reaction, and subsequent oxidative coupling reactions in the presence of CuCl(OH)-TMEDA. The unique quinone derivatives were characterized by IR, 1H, and 13C NMR spectroscopies, and mass spectroscopic data anal. In some cases, the keto dimers were obtained as significant intermediates for the quinone synthesis.

Synthesis published new progress about Aromatization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics