Month: November 2022

Liu, Xiaofeng; Liu, Huibiao; Zhou, Weidong; Zheng, Haiyan; Yin, Xiaodong; Li, Yuliang; Guo, Yanbing; Zhu, Mei; Ouyang, Canbin; Zhu, Daoben; Xia, Andong published the artcile< Thermoreversible Covalent Self-Assembly of Oligo(p-phenylenevinylene) Bridged Gold Nanoparticles>, Related Products of 112-63-0, the main research area is gold nanoparticle oligophenylenevinylene bridge thermoreversible Diels Alder assembly preparation; fluorescence gold nanoparticle oligophenylenevinylene bridge; organic inorganic hybrid gold nanoparticle oligophenylenevinylene bridge preparation fluorescence.

Organic-inorganic hybrids were fabricated through mild Diels-Alder crosslinking between maleimide bearing oligo(p-phenylenevinylene) (OPV) and furan functionalized Au nanoparticles with diameter smaller than 2 nm. The OPV ligands afford strong reaction ability toward furan group due to their maleimide moieties. These small Au nanoparticles form close-packed homogeneous hybrids with well-defined interfaces by incorporating OPV ligands in solutions Covalent assembly and disassembly of Au nanoparticles can be achieved by repeated thermal stimuli on as-obtained hybrids, which can be monitored by fluorescence changes of OPVs and surface plasmon resonance absorption. Also, the dramatic photophys. properties and assembly behavior of these hybrids allow this procedure to be performed as a smart assay for monitoring the process of the Diels-Alder reaction.

Langmuir published new progress about Diels-Alder reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Weringa, W. D. published the artcile< Mass spectra of spiroalkanones with five-and six-membered rings>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is mass spectra spiroalkanone.

The mass spectral fragmentations of 3 spiroundecanones and 4 dispirohexadecanones with 6-membered rings, and of 2 spirononanones with 5-membered rings are recorded and discussed. The fragmentation patterns for the spiro[4.4]nonanones and the spiro[5.5]undecanones were determined by using specific D labeling and in some cases the measurement of metastable transitions by the defocusing technique. The most important fragment ions in the spectra of 4 dispirohexadecanones could be explained by assuming the same types of fragmentation as found for the monospiro ketones. The composition of the fragment ions was checked by high resolution mass measurements.

Organic Mass Spectrometry published new progress about Mass spectra. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gu, Yuanyun; Zhang, Zhen; Wang, Yan-En; Dai, Ziteng; Yuan, Yaqi; Xiong, Dan; Li, Jie; Walsh, Patrick J.; Mao, Jianyou published the artcile< Benzylic Aroylation of Toluenes Mediated by a LiN(SiMe3)2/Cs+ System>, Related Products of 2557-13-3, the main research area is aryl acetophenone preparation; methyl benzoate Weinreb amide toluene benzylic aroylation.

Chemoselective deprotonative functionalization of benzylic C-H bonds is challenging, because the arene ring contains multiple aromatic C(sp2)-H bonds, which can be competitively deprotonated and lead to selectivity issues. Recently it was found that bimetallic [MN(SiMe3)2 M = Li, Na]/Cs+ combinations exhibit excellent benzylic selectivity. Herein, is reported the first deprotonative addition of toluenes to Weinreb amides mediated by LiN(SiMe3)2/CsF for the synthesis of a diverse array of 2-arylacetophenones. Surprisingly, simple Me benzoates also react with toluenes under similar conditions to form 2-arylacetophenones without double addition to give tertiary alc. products. This finding greatly increases the practicality and impact of this chem. Some challenging substrates with respect to benzylic deprotonations, such as fluoro and methoxy substituted toluenes, are selectively transformed to 2-aryl acetophenones. The value of benzylic deprotonation of 3-fluorotoluene is demonstrated by the synthesis of a key intermediate in the preparation of Polmacoxib.

Journal of Organic Chemistry published new progress about Acetophenones Role: SPN (Synthetic Preparation), PREP (Preparation) (2-aryl). 2557-13-3 belongs to class esters-buliding-blocks, and the molecular formula is C9H7F3O2, Related Products of 2557-13-3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nunno, Vincenzo Di; Franceschi, Enrico; Gatto, Lidia; Brandes, Alba Ariela published the artcile< BET inhibitors: the promise of a new generation of immunotherapy in glioblastoma>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is glioblastoma BET inhibitor immunotherapy; BET; BET inhibitors; BRD; glioblastoma; immunotherapy.

The clin. evaluation of immune checkpoint inhibitors in patients with glioblastoma (GBM) has resulted in another failed attempt to change the clin. course of one of the most fatal diseases known. Unfortunately, no drugs have shown clin. efficacy in advanced/relapsed disease. As a consequence, no therapeutic approaches have modified the standard of care represented by surgery followed by radiation therapy with concurrent and adjuvant temozolomide. The inhibition of BET proteins can lead to reduced activity of H3K27Ac, resulting in restored activity of different immune cells. Although Phase I studies showed a safety profile of these agents, their clin. effect on GBM is unknown. The interaction between microenvironment and tumor cells offers novel possible targets for GBM treatment. Nonetheless, BET inhibitors are currently under investigation as single agents, and there are no studies reporting the toxicity profile and efficacy of combinations of BET inhibitors and immune checkpoint inhibitors or other systemic agents.

Immunotherapy published new progress about Bromodomain and extra-terminal domain-containing protein inhibitors. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kelley, Elizabeth H.; Jamison, Timothy F. published the artcile< Synthesis of the EFG Framework of Tamulamides A and B>, Recommanded Product: (2R,3R,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate, the main research area is tamulamide A B EFG ring system synthesis reductive etherification.

Synthesis of the fused polycyclic ether motif comprising the EFG rings of the marine ladder polyethers tamulamides A and B has been achieved via two different etherification strategies. Ultimately, a reductive etherification approach proved most successful due to tolerance of the G ring substitution and provided the EFG 6,7,6 ring system I in 58% yield.

Organic Letters published new progress about Etherification (reductive). 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Recommanded Product: (2R,3R,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

de Goede, Paul; Wuest, Rob C. I.; Schomakers, Bauke V.; Denis, Simone; Vaz, Frederic M.; Pras-Raves, Mia L.; van Weeghel, Michel; Yi, Chun-Xia; Kalsbeek, Andries; Houtkooper, Riekelt H. published the artcile< Time-restricted feeding during the inactive phase abolishes the daily rhythm in mitochondrial respiration in rat skeletal muscle>, Category: esters-buliding-blocks, the main research area is Bmal1 Ucp3 Mfn1 type 2 diabetes mellitus; lipidomics; metabolomics; mitochondrial respiration; soleus muscle; time-restricted feeding.

Shift-workers show an increased incidence of type 2 diabetes mellitus (T2DM). A possible mechanism is the disruption of the circadian timing of glucose homeostasis. Skeletal muscle mitochondrial function is modulated by the mol. clock. We used time-restricted feeding (TRF) during the inactive phase to investigate how mistimed feeding affects muscle mitochondrial metabolism Rats on an ad libitum (AL) diet were compared to those that could eat only during the light (inactive) or dark (active) phase. Mitochondrial respiration, metabolic gene expressions, and metabolite concentrations were determined in the soleus muscle. Rats on AL feeding or dark-fed TRF showed a clear daily rhythm in muscle mitochondrial respiration. This rhythm in mitochondrial oxidative phosphorylation capacity was abolished in light-fed TRF animals and overall 24h respiration was lower. The expression of several genes involved in mitochondrial biogenesis and the fission/fusion machinery was altered in light-fed animals. Metabolomics anal. indicated that light-fed animals had lost rhythmic levels of α-ketoglutarate and citric acid. Contrastingly, lipidomics showed that light-fed animals abundantly gained rhythmicity in levels of triglycerides. Furthermore, while the RER shifted entirely with the food intake in the light-fed animals, many measured metabolic parameters (e.g., activity and mitochondrial respiration) did not strictly align with the shifted timing of food intake, resulting in a mismatch between expected metabolic supply/demand (as dictated by the circadian timing system and light/dark-cycle) and the actual metabolic supply/demand (as dictated by the timing of food intake). These data suggest that shift-work impairs mitochondrial metabolism and causes metabolic inflexibility, which can predispose to T2DM.

FASEB Journal published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (Bmal1). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mori, Yoshihiro; Shinoda, Hiroyuki; Nakano, Taku; Kitagawa, Taiji published the artcile< Laser photolysis of pyrenesulfonate and pyrenetetrasulfonate via two-photon ionization in aqueous and reverse micellar solutions>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is laser photolysis pyrenesulfonate two photon ionization; pyrenetetrasulfonate laser photolysis two photon ionization.

We investigated the laser photolysis of tetrasodium 1,3,6,8-pyrene-tetrasulfonate (Na4PS4) and sodium 1-pyrenesulfonate (NaPS) in aqueous and reverse micellar solutions The photoproducts as well as their yields were found to strongly depend on the reaction parameters such as pH, dissolved gases and the size of water pool. The primary reaction in aqueous solution was commonly presented by laser-induced formation of the cation radicals followed by hydroxylation of them. In the case of PS44-, pyranine was efficiently and highly selectively formed, possibly via desulfonation of the cation radical, P√+S44-, followed by the hydroxylation. On the other hand, from PS-, hydroxypyrenesulfonate (PSOH) was initially formed in alk. solution and desulfonation occurred secondarily, leading to the formation of hydroxypyrene. These photoreactions were markedly suppressed within a small water pool of the reverse micelle. As the size of water pool increased similar photochem. reactions occurred depending on the dissolved gases. The observed micellar effects could be explained based on the pH of water pool and the nature of the cation radicals in it.

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about Two-photon ionization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Koller, Georg published the artcile< A synthesis of derivatives of 1,8-naphthyridine>, SDS of cas: 112-63-0, the main research area is .

K. learned of Seide’s work (C. A. 21, 586) only after the completion of his own investigation. Me α-aminonicotinate (1.5 g.) with Na in alc. and CH2(CO2Et)2 gives 1.26 g. Me 2,4-dihydroxy-1,8-naphthyridine-3-carboxylate, (the Et ester grouping in the CH2(CO2Et)2 being replaced by Me by the MeOH set free in the reaction), sinters in an evacuated tube on rapid heating at 236°, turns brown and carbonizes at higher temperatures, is strongly acid, dissolves in dilute Na2CO3, gives a distinct brown color with FeCl3 in alc.; heated a long time with dilute KOH it gives 2,4-dihydroxy-1,8-naphthyridine, sandy crystalline powder, gives a distinct yellow color with FeCl3 in alc., is strongly acid, dissolves clear in carbonates, slowly in dilute HCl, converted by POCl3 + PCl5 into the 2,4-dichloro compound, m. 125-6°; chloroaurate, yellow, sinters 200° (decomposition) in an evacuated tube, m. 210-2°.

Berichte der Deutschen Chemischen Gesellschaft [Abteilung] B: Abhandlungen published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guo, Song; Liu, Na; Ding, Wei; Pang, Xiaoyan; Ding, Zhiwen; Chen, Yongfang published the artcile< Graphene oxide modified waterborne polyurethane-based dye with high color-fastness performance>, COA of Formula: C19H34O2, the main research area is graphene oxide waterborne polyurethane dye color fastness.

Graphene oxide (GO) was incorporated into waterborne polyurethane-based polymeric dyes to prepare GO modified polymeric dyes for further improving the performances of waterborne polyurethane-based dyes. Structure properties of the prepared polymeric dyes were analyzed using FTIR and UV-Vis spectrophotometers. The fastnesses to dry-wet rubbing, thermal migration, light, and the mech. properties of the GO modified polymeric dye films were further investigated. The introduction of GO might lower the tensile strength and the elongation at break of polymeric dye films. Meanwhile, the color of modified polymeric dye films turned to be darker as the GO dosage increased. Moreover, most of the above-mentioned properties could be enhanced considerably. In particular, the dry-wet rubbing and thermal migration fastness of modified polymeric dye films could be enhanced up to grade 5. This suggests that the GO modified waterborne polyurethane-based dye has the potential to be used in leather finishing coloring with high performance.

Journal of Applied Polymer Science published new progress about Color. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Climans, Seth A.; Mason, Warren P.; Grunfeld, Eva; Chan, Kelvin published the artcile< Clinical features of glioma patients who develop pneumocystis pneumonia with temozolomide chemoradiotherapy>, Electric Literature of 112-63-0, the main research area is Glioma; Pneumocystis pneumonia; Temozolomide.

Abstract: Introduction: The treatment of glioma with temozolomide chemoradiotherapy predisposes patients to pneumocystis pneumonia (PCP). Because PCP is a rare outcome, very little is known about specific clin. risk factors for its development in patients with glioma. Methods: We performed a population-based retrospective cohort study of glioma patients undergoing temozolomide chemoradiotherapy 2005 to 2019 in Ontario, Canada. We compared clin. features of patients who did not vs. did develop PCP within one year of chemoradiotherapy. We examined the overall survival of patients by PCP status. Results: There were 5130 patients with glioma treated with temozolomide chemoradiotherapy. Ultimately, 38 patients (0.74%) were diagnosed with PCP within 1 yr of chemoradiotherapy. Most (71%) infections occurred between 0-90 days and 29% occurred between 91-365 days. Median survival was 12.3 mo in patients who did not develop PCP and 8.6 mo in those who did develop PCP (P < 0.001). Trough 90-day lymphocyte counts were lower in the PCP group. When the lymphocytes fell below 0.19 x 109/L (or 0.25 x 109/L among patients without PCP prophylaxis), the risk of PCP was > 3.5%. Conclusions: Pneumocystis pneumonia is rare in glioma patients who receive temozolomide chemoradiotherapy. Infection is associated with shorter survival and the development of lymphopenia. Reserving PCP prophylaxis for patients whose lymphocyte counts drop below 0.25 x 109/L may be a reasonable strategy.

Journal of Neuro-Oncology published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics