Month: November 2022

Yang, Zan; Cao, Ting; Liu, Si; Li, An; Liu, Kun; Yang, Tao; Zhou, Congshan published the artcile< Transition-metal-free S-N bond formation: synthesis of 5-amino-1,2,4-thiadiazoles from isothiocyanates and amidines>, Application In Synthesis of 19241-24-8, the main research area is thiadiazole amino preparation regioselective green chem; amidine isothiocyanate tandem radical oxidative cyclization.

A novel and green method for the synthesis of 5-amino-1,2,4-thiadiazoles I (R1 = Me, cyclopropyl, 4-fluorophenyl, pyridin-3-yl, 1H-pyrazol-1-yl, etc.; R2 = tert-Bu, benzyl, naphth-1-yl, etc.) has been developed by the reaction of isothiocyanates R2N=C=S with amidines R1C(=NH)NH2.HCl. This protocol which is free of metal, catalyst and iodine involves O2 oxidative S-N bond formation for the synthesis of various 5-amino-1,2,4-thiadiazole derivatives I with excellent to good yields. High regioselectivity, mild reaction conditions, broad substrate scope and good functional group tolerance are the highlights of the report.

New Journal of Chemistry published new progress about Amidines Role: RCT (Reactant), RACT (Reactant or Reagent). 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Application In Synthesis of 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Wenzhi; Bie, Fusheng; Ma, Jie; Zhou, Fengyan; Szostak, Michal; Liu, Chengwei published the artcile< Palladium-Catalyzed Decarbonylative Borylation of Aryl Anhydrides>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is palladium catalyzed decarbonylative borylation aryl anhydride; arylboronate ester preparation.

A Pd-catalyzed base-free decarbonylative borylation of aryl anhydrides was developed. Catalyst system consisting of Pd(OAc)2/dppb enables readily available aryl anhydrides to be employed as electrophiles for the synthesis of versatile arylboronate esters via O-C(O) bond activation and decarbonylation. This method was characterized by an excellent functional group tolerance and broad substrate scope, using bench stable aryl anhydrides as aryl electrophiles in C-B bond formation. Mechanistic studies and functionalization of late-stage pharmaceutical mols. are disclosed.

Journal of Organic Chemistry published new progress about Anhydrides, aryl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xie, Yuchun; Liu, Zhihong; Guo, Juntao; Su, Xin; Zhao, Cun; Zhang, Chongyan; Qin, Qing; Dai, Dongliang; Zhao, Yanhong; Wang, Zhiying; Wang, Ruijun; Zhang, Yanjun; Su, Rui; Wang, Zhixin; Li, Jinquan published the artcile< MicroRNA-mRNA regulatory networking fine-tunes polyunsaturated fatty acid synthesis and metabolism in the inner mongolia cashmere goat>, Application In Synthesis of 112-63-0, the main research area is polyunsaturated fatty acid metabolism adipocytokine ACSL1 microRNA; ACSL1; cashmere goat; fatty acid; mRNA; microRNA.

Fatty acid composition is an important aspect of meat quality in ruminants. Improving the beneficial fatty acid level in cashmere goat meat is important to its economic value. To investigate microRNAs (miRNAs) and mRNAs that regulate or coregulate polyunsaturated fatty acid (PUFA) synthesis and metabolism in the Inner Mongolia cashmere goat, we used longissimus dorsi muscle (WLM) and biceps femoris muscle (WBM) for transcript-level sequencing. RT-qPCR was used to evaluate the expression of mRNAs and miRNAs associated with PUFA synthesis and metabolism The total PUFA content in the WBM was significantly higher than that in the WLM (P < 0.05). Our study is the first to systematically report miRNAs in cashmere goat meat. At the mRNA level, 20,375 genes were identified. ACSL1, CD36 and TECRL were at the center of a gene regulatory network and contributed significantly to the accumulation and metabolic regulation of fatty acids. At the miRNA level, 426 known miRNAs and 30 novel miRNAs were identified. KEGG anal. revealed that the miRNA target genes were involved mainly in the PPAR signaling pathway. The mRNA-miRNA coregulation anal. showed that ACSL1 was neg. targeted by nine miRNAs: chi-miR-10a-5p, chi-miR-10b- 5p, chi-miR-130b-5p, chi-miR-15a-5p_R-1, chi-miR-15b-5p, chi-miR-16a-5p, chi-miR- 16b-5p, chi-miR-181c-5p_R+1, and chi-miR-26b-5p. Finally, we speculated that the simultaneous silencing of ACSL1 by one or more of these nine miRNAs through PPAR signaling led to low ACSL1 expression in the WLM and, ultimately to high PUFA content in the WBM. Our study helps elucidate the metabolic regulation of fatty acids in Inner Mongolia cashmere goats. Frontiers in Genetics published new progress about Adipokines Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Ruifeng; Yu, Sijia; Zhao, Xiangxin; Chen, Yixuan; Yang, Bowen; Wu, Tianxiao; Hao, Chenzhou; Zhao, Dongmei; Cheng, Maosheng published the artcile< Design, synthesis, biological evaluation and molecular docking study of novel thieno[3,2-d]pyrimidine derivatives as potent FAK inhibitors>, Product Details of C19H34O2, the main research area is thienopyrimidine preparation FAK inhibition SAR antitumor docking cytotoxicity apoptosis; Apoptosis; FAK inhibitor; Migration; Structure-activity relationship; Thieno[3,2-d]pyrimidine.

A series of 2,7-disubstituted thieno[3,2-d]pyrimidine derivatives I [R1 = 2-methoxy, 3-acetyl, 3-methylsulfonyl, etc.], II [R2 = methylcarbamoyl, piperidine-3-carbonylamino, diethoxyphosphorylmethyl, etc.], III [R3 = H, Me, ethoxy, etc.; R4 = H, fluoro, methyl; R5 = H, fluoro] and IV [R6 = pyrrolidin-3-yl, tetrahydro-2H-pyran-4-yl, piperidin-3-ylmethyl, etc.] were synthesized and evaluated as novel focal adhesion kinase (FAK) inhibitors. The novel 2,7-disubstituted thieno[3,2-d]pyrimidine scaffold was designed as a new kinase inhibitor platform that mimics the bioactive conformation of the well-known diaminopyrimidine motif. Most of the compounds potently suppressed the enzymic activities of FAK and potently inhibited the proliferation of U-87MG, A-549 and MDA-MB-231 cancer cell lines. Among these derivatives, the optimized compound III [R3 = R5 = H, R4 = fluoro] potently inhibited the enzyme (IC50 = 28.2 nM) and displayed stronger potency than TAE-226 in U-87MG, A-549 and MDA-MB-231 cells, with IC50 values of 0.16, 0.27, and 0.19μM, resp. Compound III [R3 = R5 = H, R4 = fluoro] also exhibited relatively less cytotoxicity (IC50 = 3.32μM) toward a normal human cell line, HK2. According to the flow cytometry results, compound III [R3 = R5 = H, R4 = fluoro] induced the apoptosis of MDA-MB-231 cells in a dose-dependent manner and effectively arrested MDA-MB-231 cells in G0/G1 phase. Further investigations revealed that compound III [R3 = R5 = H, R4 = fluoro] potently suppressed the migration of MDA-MB-231 cells. Collectively, these data support the further development of compound III [R3 = R5 = H, R4 = fluoro] as a lead compound for FAK-targeted anticancer drug discovery.

European Journal of Medicinal Chemistry published new progress about Anilines Role: ADV (Adverse Effect, Including Toxicity), PAC (Pharmacological Activity), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Jianchun; Yang, Jieke; Zhu, Bingwen; Fan, Junming; Hu, Qiongdan; Wang, Li published the artcile< Tectorigenin protects against unilateral ureteral obstruction by inhibiting Smad3-mediated ferroptosis and fibrosis>, Electric Literature of 347174-05-4, the main research area is tectorigenin Smad unilateral ureteral obstruction ferroptosis fibrosis; Smad3; ferroptosis; fibrosis; tectorigenin.

Renal tubular epithelial cell (TEC) injury and fibrosis are the key factors of the pathogenesis of chronic kidney disease. Here, we reported that tectorigenin is effectively protected against obstructive nephropathy established by unilateral ureteral obstruction (UUO). In vivo, tectorigenin administration significantly alleviated the deteriorations of renal functions including blood urea nitrogen and creatinine. Meanwhile, results from the histol. suggested that renal injury characterized by tubular cell damage and fibrosis lesions of kidneys in UUO group were markedly attenuated following tectorigenin treatment. Mechanistically, we found that tectorigenin treatment greatly inhibited Smad3 phosphorylation, and the transcription and protein level of Nox4, a newly identified direct downstream mol. of Smad3 and a modulator of ferroptosis, while it indirectly restored the expression of glutathione peroxidase 4, a neg. regulator of ferroptosis. Consistent with in vivo studies, treatment with tectorigenin also suppressed the ferroptosis induced by erastin/RSL3 and fibrosis stimulated by transforming growth factor β1 (TGF-β1) in primary renal TECs. What is more, treatment with ferroptosis inhibitor, ferrostatin-1, also impeded TGF-β1 stimulated the profibrotic effects in TECs, indicating that tectorigenin may relieve fibrosis by inhibiting ferroptosis in TECs. In addition, tectorigenin treatment exhibited a similar tendency, which inhibited Smad3 activation, and the docking anal. revealed that tectorigenin docked well into the Smad3 binding cavity with strong binding affinity (-7.9 kcal/mol). Thus, this study deciphers the protective effect of tectorigenin against obstructive nephropathy through inhibiting Smad3-mediated ferroptosis and fibrosis.

Phytotherapy Research published new progress about Blood urea nitrogen. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Electric Literature of 347174-05-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

McErlean, Christopher S. P.; Willis, Anthony C. published the artcile< Application of an intramolecular Stetter reaction to access trans,syn,trans-fused pyrans>, Computed Properties of 112-63-0, the main research area is trans syn fused bicyclic pyranone preparation; crystal structure trans syn fused bicyclic pyranon.

The use of a com. available thiazolium salt facilitated an intramol. Stetter reaction between an aliphatic aldehyde and an acrylate unit, which delivered a trans,syn-fused bicyclic pyranone in high yield as a single diastereomer. The pyranone was used to synthesize a trans,syn,trans-fused polycyclic ether array and was ring expanded to give the corresponding oxepanone.

Synlett published new progress about Aliphatic aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lampros, Marios; Vlachos, Nikolaos; Voulgaris, Spyridon; Alexiou, George A. published the artcile< The Role of Hsp27 in Chemotherapy Resistance>, Application of C19H34O2, the main research area is review cancer Hsp27 chemotherapy resistance; Hsp27; cancer; chemotherapy.

A review. Heat shock protein (Hsp)-27 is a small-sized, ATP-independent, chaperone mol. that is overexpressed under conditions of cellular stress such as oxidative stress and heat shock, and protects proteins from unfolding, thus facilitating proteostasis and cellular survival. Despite its protective role in normal cell physiol., Hsp27 overexpression in various cancer cell lines is implicated in tumor initiation, progression, and metastasis through various mechanisms, including modulation of the SWH pathway, inhibition of apoptosis, promotion of EMT, adaptation of CSCs in the tumor microenvironment and induction of angiogenesis. Investigation of the role of Hsp27 in the resistance of various cancer cell types against doxorubicin, herceptin/trastuzumab, gemcitabine, 5-FU, temozolomide, and paclitaxel suggested that Hsp27 overexpression promotes cancer cell survival against the above-mentioned chemotherapeutic agents. Conversely, Hsp27 inhibition increased the efficacy of those chemotherapy drugs, both in vitro and in vivo. Although numerous signaling pathways and mol. mechanisms were implicated in that chemotherapy resistance, Hsp27 most commonly contributed to the upregulation of Akt/mTOR signaling cascade and inactivation of p53, thus inhibiting the chemotherapy-mediated induction of apoptosis. Blockage of Hsp27 could enhance the cytotoxic effect of well-established chemotherapeutic drugs, especially in difficult-to-treat cancer types, ultimately improving patients’ outcomes.

Biomedicines published new progress about Angiogenesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Abramova, Tatiana V.; Vasileva, Svetlana V.; Koroleva, Ludmila S.; Kasatkina, Nina S.; Silnikov, Vladimir N. published the artcile< Design and synthesis of dinucleotide 5'-triphosphates with expanded functionality>, Application of C19H34O2, the main research area is dinucleotide triphosphate preparation nucleoside.

The new approach to the synthesis of 5′-triphosphate derivatives of natural and modified dinucleotides with expanded functionality is reported. The strategy includes the combination of the solution phase synthesis of necessary dimers using the wide range of nucleic acids chem. methods and the subsequent introduction of the triphosphate residue. A number of the new potential substrates for the template dependent synthesis of nucleic acids with expanded functionality are obtained, namely, 5′-triphosphates of dinucleotides containing the functionally active groups in heterocyclic bases, in carbohydrate-phosphate backbone, and the groups mimicking the residues of natural amino acids. The abilities of the proposed synthetic route are also demonstrated by the synthesis of 5′-triphosphates of dinucleotides with modified carbohydrate-phosphate backbone.

Bioorganic & Medicinal Chemistry published new progress about Dinucleotides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reeves, W. Preston; Lu, Cuong V.; Schulmeier, Brian; Jonas, Lynette; Hatlevik, Oyvind published the artcile< Selective bromination of aromatic ethers with pyridinium hydrobromide perbromide>, Synthetic Route of 112-63-0, the main research area is bromination aromatic ether pyridinium hydrobromide perbromide.

In aqueous polar solvents, various aromatic ethers, e.g., anisole, 4-methylanisole, p-dimethoxybenzene, and 1-methoxynaphthalene, were selectively brominated using pyridinium hydrobromide perbromide.

Synthetic Communications published new progress about Aromatic ethers Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Miao, Yue; Zou, Qingfei; Wang, Qiuping; Gong, Jiashun; Tan, Chao; Peng, Chunxiu; Zhao, Chunyan; Li, Zelin published the artcile< Evaluation of the physiochemical and metabolite of different region coffee beans by using UHPLC-QE-MS untargeted-metabonomics approaches>, Application of C19H34O2, the main research area is coffee bean physiochem metabolite UHPLCQEMS untargeted metabonomics.

Coffee is one of the most important agricultural commodities and has the unique organoleptic characteristics such as strong but not bitter taste, fragrant, oily, and fruity. In this study, an untargeted metabolomics approach based on UHPLC-QE-MS was used to investigate the differences in terms of components of precursor metabolites in coffee beans from 18 producing regions worldwide. Fingerprint anal., principal component anal. and hierarchical clustering anal. revealed a neat separation among coffee beans. Compounds with high relevance to variance in the projection values in supervised multivariate anal. were selected as important metabolites for the discrimination of coffee samples. In total, 10 different families of compounds were considered as potential markers of the coffee beans: 3-hydroxycoumarin, 4,5-di-O-caffeoylquinic, cryptochlorogenic acid, palmitic amide, linoleamide, arachidic acid, petroselinic acid, trehalose, L-glutamic acid, L-malic acid. The findings presented herein serve as a suitable framework for the design of novel discrimination strategies in food origin tracing.

Food Bioscience published new progress about Bitterness. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics