Month: November 2022

Lounasmaa, Mauri; Johansson, Carl J. published the artcile< Synthetic studies in the alkaloid field. IV. The sodium dithionite reduction of 1-[2-(3-indolyl)-ethyl]-3-methoxycarbonylpyridinium bromides>, Quality Control of 33402-75-4, the main research area is indoloquinolizine; reduction indolyl pyridinium dithionite; ring closure indolyl pyridine; alkaloid vallesiachotamine model.

Na dithionite reduction of the 1-[2-(3-indolyl)ethyl]-3-(methoxycarbonyl)pyridinium bromides I (R = H, Me, Pr) in NaHCO3-buffered medium gave 49-67% of the 1,4-dihydro derivatives II, whereas in unbuffered medium 58-62% of the indoloquinolizines III were formed. Acid-induced cyclization of II (R = H) gave 94% III (R = H) whereas II (R = Me, Pr) gave 91 and 86% resp. IV (R = Me, Pr). The stereochem. of the products were deduced from 13C NMR spectra. The use of Na dithionite reduction in the preparation of vallesiachotamine models is discussed.

Tetrahedron published new progress about Cyclization. 33402-75-4 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO2, Quality Control of 33402-75-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Oschmann, Bernd; Bresser, Dominic; Tahir, Muhammad Nawaz; Fischer, Karl; Tremel, Wolfgang; Passerini, Stefano; Zentel, Rudolf published the artcile< Polyacrylonitrile Block Copolymers for the Preparation of a Thin Carbon Coating Around TiO2 Nanorods for Advanced Lithium-Ion Batteries>, Safety of Perfluorophenyl acrylate, the main research area is polyacrylonitrile block copolymer carbon coating titania nanorod lithium battery; RAFT-polymerization; TiO2 nanorods; carbon coating; lithium-ion batteries; poly­acrylonitrile.

Herein, a new method for the realization of a thin and homogeneous carbonaceous particle coating, made by carbonizing RAFT polymerization derived block copolymers anchored on anatase TiO2 nanorods, is presented. These block copolymers consist of a short anchor block (based on dopamine) and a long, easily graphitizable block of polyacrylonitrile. The grafting of such block copolymers to TiO2 nanorods creates a polymer shell, which can be visualized by at. force microscopy (AFM). Thermal treatment at 700° converts the polyacrylonitrile block to partially graphitic structures (as determined by Raman spectroscopy), establishing a thin carbon coating (as determined by transmission electron microscopy, TEM, anal.). The carbon-coated TiO2 nanorods show improved electrochem. performance in terms of achievable specific capacity and, particularly, long-term cycling stability by reducing the average capacity fading per cycle from 0.252 mAh g-1 to only 0.075 mAh g-1.

Macromolecular Rapid Communications published new progress about Annealing (of polyacrylonitrile block). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Safety of Perfluorophenyl acrylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Liu; Lu, Pingan; Qu, Song published the artcile< Commentary: Kinesin Family Member C1 Increases Resistance of Glioblastoma to Temozolomide Through Promoting DNA Damage Repair.>, Application of C19H34O2, the main research area is DNA-PK; KIFC1; chemoresistance; neoplasms; normal tissue toxicity.

There is no abstract available for this document.

Cell transplantation published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tian, Haiping; Zhai, Wanchen; Sun, Ke; Zhu, Yunwen; Zhou, Hongli; Wan, Peng published the artcile< Chemical composition and potential bioactivities of essential oil from Quercus mongolica bark>, SDS of cas: 112-63-0, the main research area is Quercus bark essential oil pentadecanoic acid antioxidant anticoagulant.

The chem. composition and potential bioactivities of essential oil from Quercus mongolica bark (EOQMB) were researched for value-added utilization processing byproduct. The results of gas chromatog.-mass spectrometry (GC-MS) anal. showed that 30 components accounting for 98.42% were identified in EOQMB, with pentadecanoic acid the most abundant compound accounting for 34.90%, which was further confirmed by the Fourier transform IR observation. EOQMB exerts antioxidant activities, and the IC50 values for scavenging DPPH radical, ABTS radical, and hydroxyl radical were 8.48, 0.77, and 3.54 mg/mL, resp. The effects of EOQMB on prolonging activated partial thromboplastin time and thrombin time and on decreasing fibrinogen are similar to those of heparin, and the promising anticoagulant activities of EOQMB could be largely contributed by pentadecanoic acid. Herein, the present study uncovered that the waste Q. mongolica bark can serve as a new potential material in pharmaceutical products.

Arabian Journal of Chemistry published new progress about Anticoagulants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Park, Jaemin; Nam, Jiyun; Seo, Myungeun; Li, Sheng published the artcile< Side-Chain Density Driven Morphology Transition in Brush-Linear Diblock Copolymers>, Electric Literature of 71195-85-2, the main research area is side chain density morphol transition brush linear diblock copolymer.

We report the synthesis and self-assembly of brush-linear diblock copolymers with variable side-chain length and d. Poly(pentafluorophenyl acrylate-g-ethylene glycol)-b-polystyrene ((PPFPA-g-PEG)-b-PS) brush-linear diblock copolymers are prepared by sequential reversible addition-fragmentation chain transfer (RAFT) polymerization of PPFPA and PS, followed by postpolymn. reaction between the precursor PPFPA-b-PS diblock copolymer and amine-functionalized PEG. By controlling the PEG chain length and the degree of substitution, brush-linear diblock copolymers with different side-chain lengths and densities are obtained. The solid-state morphologies of the diblocks are then examined by small-angle X-ray scattering (SAXS). At low PEG side-chain d., the segregation of PEG and PS away from PPFPA leads to the formation of PEG and PS lamellar domains with PPFPA in the interface. At high PEG side-chain d., the segregation is between the PPFPA-g-PEG brush block and the PS linear block, and the domain morphol. is determined by the composition of the brush block. A partial exptl. phase diagram is presented, and it illustrates the importance of both side-chain length and d. on the microdomain morphol. of brush-linear diblock copolymers.

ACS Macro Letters published new progress about Acrylic polymers, fluorine-containing, block, diblock Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Electric Literature of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hsu, Day-Shin; Liang, Suz-Ping published the artcile< NHC-Mediated Synthesis of Tricyclic Spirocarbocycles via an Intramolecular Stetter Reaction of Cyclic Enal-Enones>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is tricyclic spirocarbocycle preparation; cyclic enal enone intramol Stetter reaction nitrogen heterocyclic carbene.

A general and efficient method for the synthesis of tricyclic spirocarbocycles is described. Various cyclic enal-enones were reacted with an N-heterocyclic carbene and an intramol. Stetter reaction proceeded smoothly to give various tricyclic spiro-1,4-diketones in 31-72% yields. The ring size of the spiro compounds can be easily controlled using different cyclic enals and enones, or by altering the length of the carbon tether.

Journal of Organic Chemistry published new progress about Diketones Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Saini, Nipun; Virdee, Manjot S.; Helfrich, Kaylee K.; Kwan, Sze Ting Cecilia; Mooney, Sandra M.; Smith, Susan M. published the artcile< Untargeted Metabolome Analysis Reveals Reductions in Maternal Hepatic Glucose and Amino Acid Content That Correlate with Fetal Organ Weights in a Mouse Model of Fetal Alcohol Spectrum Disorders>, Reference of 112-63-0, the main research area is FASD maternal hepatic glucose amino acid metabolome analysis; amino acids; fetal weight; gluconeogenesis; glucose; hepatic metabolism; maternal–fetal metabolism; pregnancy; prenatal alcohol exposure; untargeted metabolomics.

Prenatal alc. exposure (PAE) causes fetal growth restrictions. A major driver of fetal growth deficits is maternal metabolic disruption; this is under-investigated following PAE. Untargeted metabolomics on the dam and fetus exposed to alc. (ALC) revealed that the hepatic metabolome of ALC and control (CON) dams were distinct, whereas that of ALC and CON fetuses were similar. Alc. reduced maternal hepatic glucose content and enriched essential amino acid (AA) catabolites, N-acetylated AA products, urea content, and free fatty acids. These alterations suggest an attempt to minimize the glucose gap by increasing gluconeogenesis using AA and glycerol. In contrast, ALC fetuses had unchanged glucose and AA levels, suggesting an adequate draw of maternal nutrients, despite intensified stress on ALC dams. Maternal metabolites including glycolytic intermediates, AA catabolites, urea, and one-carbon-related metabolites correlated with fetal liver and brain weights, whereas lipid metabolites correlated with fetal body weight, indicating they may be drivers of fetal weight outcomes. Together, these data suggest that ALC alters maternal hepatic metabolic activity to limit glucose availability, thereby switching to alternate energy sources to meet the high-energy demands of pregnancy. Their correlation with fetal phenotypic outcomes indicates the influence of maternal metabolism on fetal growth and development.

Nutrients published new progress about Alcohols Role: ADV (Adverse Effect, Including Toxicity), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Orita, Akihiro; Tanahashi, Chiaki; Kakuda, Atsushi; Otera, Junzo published the artcile< Highly Powerful and Practical Acylation of Alcohols with Acid Anhydride Catalyzed by Bi(OTf)3>, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate, the main research area is alc acylation anhydride bismuth triflate catalyst.

Bi(OTf)3-catalyzed acylation of alcs. with acid anhydride was evaluated in comparison with other acylation methods. The Bi(OTf)3-acid anhydride protocol was so powerful that sterically demanding or tertiary alcs. could be acylated smoothly. Less reactive acylation reagents such as benzoic and pivalic anhydride are also activated by this catalysis. In these cases, a new technol. was developed in order to overcome difficulty in separation of the acylated product from the remaining acylating reagent: methanolysis of the unreacted anhydride into easily separable Me ester realized quite easy separation of the desired acylation product. The Bi(OTf)3-acid anhydride protocol was applicable to a wide spectrum of alcs. bearing various functionalities. Acid-labile THP- or TBS-protected alc., furfuryl alc., and geraniol could be acylated as well as base-labile alcs. Even acylation of functionalized tertiary alcs. was effected at room temperature

Journal of Organic Chemistry published new progress about Acylation. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chernov, Alexandr N.; Tsapieva, Anna; Alaverdian, Diana A.; Filatenkova, Tatiana A.; Galimova, Elvira S.; Suvorova, Mariia; Shamova, Olga V.; Suvorov, Alexander N. published the artcile< In Vitro Evaluation of the Cytotoxic Effect of Streptococcus pyogenes Strains, Protegrin PG-1, Cathelicidin LL-37, Nerve Growth Factor and Chemotherapy on the C6 Glioma Cell Line>, Application In Synthesis of 112-63-0, the main research area is anticancer PG1 LL37 NGF chemotherapy cytotoxicity Streptococcus glioma; LL-37; MTT assay; NGF; PG-1; Streptococcus pyogenes; cathelicidin family peptides; chemotherapy; cytotoxicity; glioma C6; human normal fibroblasts; real-time xCELLigence system; trypan blue assay.

Brain cancer treatment, where glioblastoma represents up to 50% of all CNS malignancies, is one of the most challenging calls for neurooncologists. The major driver of this study was a search for new approaches for the treatment of glioblastoma. We tested live S. pyogenes, cathelicidin family peptides and NGF, assessing the oncolytic activity of these compounds as monotherapy or in combination with chemotherapeutics. For cytotoxicity evaluation, we used the MTT assay, trypan blue assay and the xCELLigence system. To evaluate the safety of the studied therapeutic approaches, we performed experiments on normal human fibroblasts. Streptococci and peptides demonstrated high antitumor efficiency against glioma C6 cells in all assays applied, surpassing the effect of chemotherapeutics (doxorubicin, carboplatin, cisplatin, etoposide). A real-time cytotoxicity anal. showed that the cell viability index dropped to 21% 2-5 h after S. pyogenes strain exposure. It was shown that LL-37, PG-1 and NGF also exhibited strong antitumor effects on C6 glioma cells when applied at less than 10-4 M. Synergistic effects for combinations of PG-1 with carboplatin and LL-37 with etoposide were shown. Combinations of S. pyogenes strain #7 with NGF or LL-37 demonstrated a cytotoxic effect (56.7% and 57.3%, accordingly) on C6 glioma cells after 3 h of exposure.

Molecules published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Yansong; Jin, Yujuan; Wang, Bo; Tian, Huafeng; Weng, Yunxuan; Sun, Kangdi; Men, Shuang published the artcile< Preparation and characterization of compatibilized and toughened polylactic acid/cellulose acetate films by long-chain hyperbranched polymers>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is compatibilized toughened polylactide cellulose acetate hyperbranched polymer.

A type of long-chain hyperbranched polymers (LCHBPs) was prepared by grafting hydroxyl-terminated flexible long chain onto hyperbranched polymers (HBPs). The structure of LCHBPs was confirmed by Fourier transform IR (FT-IR) and NMR (1H-NMR) anal. It was then used as the modifier for toughening and compatibilizing the polylactic acid (PLA)/cellulose acetate (CA) blends. Upon the addition of LCHBPs, the compatibility between PLA and CA was improved, the dispersion of CA particles in PLA matrix was more uniform, and the brittle-ductile tear transition of the PLA/CA blends was occurred. The crystallization of PLA was promoted by the addition of LCHBPs. By adding LCHBPs, glass transition temperature and cold crystallization temperature were reduced, the crystallizability was enhanced, and the crystallization temperature range was expanded. The thermal decomposition temperature of the PLA/CA was found increased with the addition of LCHBPs. When the content of LCHBPs was 1 phr, the elongation at break and the tear strength of the PLA/CA blends were increased by 484% and 38.24%, resp. Meanwhile, the thermal stability and hydrophilic properties of the blend films were improved by adding LCHBPs.

Journal of Applied Polymer Science published new progress about Crystallization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics