Month: November 2022

Zhao, Chenglong; Weber, Stefan; Schols, Dominique; Balzarini, Jan; Meier, Chris published the artcile< Prodrugs of γ-Alkyl-Modified Nucleoside Triphosphates: Improved Inhibition of HIV Reverse Transcriptase>, Related Products of 112-63-0, the main research area is nucleoside triphosphate prodrug HIV reverse transcriptase human; DNA polymerases; antiviral agents; biological activity; nucleoside triphosphates; prodrugs.

The development of nucleoside triphosphate prodrugs is one option to apply nucleoside reverse transcriptase inhibitors. Herein, we report the synthesis and evaluation of d4TTP analogs, in which the γ-phosphate was modified covalently by lipophilic alkyl residues, and acyloxybenzyl prodrugs of these γ-alkyl-modified d4TTPs, with the aim of delivering of γ-alkyl-d4TTP into cells. Selective formation of γ-alkyl-d4TTP was proven with esterase and in CD4+-cell extracts In contrast to d4TTP, γ-alkyl-d4TTPs proved highly stable against de-phosphorylation. Primer extension assays with HIV reverse transcriptase (RT) and DNA-polymerases α, β or γ showed that γ-alkyl-d4TTPs were substrates for HIV-RT only. In antiviral assays, compounds were highly potent inhibitors of HIV-1 and HIV-2 also in thymidine-kinase-deficient T-cell cultures (CEM/TK-). Thus, the intracellular delivery of such γ-alkyl-nucleoside triphosphates may potentially lead to nucleoside triphosphates with a higher selectivity towards the viral polymerase that can act in virus-infected cells.

Angewandte Chemie, International Edition published new progress about AIDS (disease). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Secrist, John A. III; Hickey, Charles J.; Norris, Robert E. published the artcile< A convenient total synthesis of (±)-(7E,9E)-trisporic acid B methyl ester>, SDS of cas: 60705-25-1, the main research area is total synthesis methyl trisporate; trisporic acid B total synthesis.

The title compound I was totally synthesized using as a key step a Michael-aldol sequence on MeO2CCHMeCOCH(OMe)2 to give cyclohexenone II.

Journal of Organic Chemistry published new progress about 60705-25-1. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, SDS of cas: 60705-25-1.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yu, Wuyang; Cheng, Qian; Ye, Jingjie; Zhang, Mingkang; Zhang, Cheng; Gao, Fan; Ding, Xinglan; Feng, Jun; Zhang, Xian-Zheng published the artcile< Establishment of Facile Nanomedicine Construction Methodology to Comprehensively Overcome Hurdles across Tumor-Specific Nano-Delivery>, Application In Synthesis of 112-63-0, the main research area is hyaluronic acid nitroindol carboxylic acid tumor antitumor CD44 targeting.

To advance clin. translation of antitumor nanomedicines, the development of a universally applicable, facile, and safe methodol. for nanomedicine construction to overcome major hurdles across tumor-specific nano-delivery in an all-in-one manner would be highly desirable. This study puts forward a HAylation strategy based on pos. charged nanocore (NC+) and hyaluronic acid (HA) that is naturally present in the human body. HAylation leads to prolonged blood duration and active tumor targeting. It is demonstrated that HAylation facilitates not only selective uptake of nanomedicines by tumor cells but also deep tumor infiltration via the special transcytosis pathway. This characteristic is ascribed to the site-specific exposure of NC+ in tumor cells due to fast HA degradation exclusively in response to HAase and an acidic pH in the lysosome after tumor accumulation. HAylation enables the free construction of a NC+ nano-core with versatile functions. Here, a NC+ core is fabricated by directly assembling a photodynamic therapy (PDT) agent and an inhibitor of the DNA base excision repair (BER) pathway. The inhibition of BER-mediated DNA repair has proven powerful to amplify antitumor efficacy since DNA damage is one major cell-killing mechanism for many anticancer therapeutics. HAylation holds promise for the simplification of the industrial production of nanomedicines and arms nanomedicines to thoroughly overcome fundamental nano-delivery hurdles.

Advanced Functional Materials published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bedford, G. R.; Partridge, M. W. published the artcile< Convenient preparation of ο-aminoaryl cyanides>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is .

ο-Aminophenyl cyanide (I) and the related compounds can be prepared by thermal decomposition of isatin 3-oxime (II) and related isatins in good yield. The method is applicable to the production of substituted ο-aminoaryl cyanides having orientations not readily accessible by methods hitherto used. Decomposition of the oximes is vigorous, and for a 50 g. amount is complete in about 3 min. When no solvent is used, provision must be made to trap the aminoaryl cyanide entrained in the evolved CO2. II (50 g., recrystallized from 50% aqueous alc.) was melted and heated so that I was collected in receivers containing Et2O. Evaporation of the Et2O gave pure I in 65% yield, m. 49-50°; Ac derivative, m. 134°. Similarly 48 g. 5-methylisatin 3-oxime gave 17.6 g. 2-amino-4-methylphenyl cyanide, b15 150-2°, m. 59-60°; 5-chloroisatin 3-oxime (5 g.) decomposed during 15 min. at 250° gave 2 g. 2-amino-5-chlorophenyl cyanide, m. 96-8°; 7-carboxyisatin 3-oxime (5.1 g.) gave 0.62 g. 2-amino-5-cyanobenzoic acid, needles, m. 280-2° (this compound was amphoteric and gave a pos. diazo test); 5-nitroisatin 3-oxime (5 g.) heated 45 min. in refluxing PhNO2 gave 2.6 g. 2-amino-5-nitrophenyl cyanide, m. 205-6°.

Journal of the Chemical Society published new progress about Nitriles Role: BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Glen, Pauline E.; O’Neill, James A. T.; Lee, Ai-Lan published the artcile< Synthesis of a C1-symmetric Box macrocycle and studies towards active-template synthesis of mechanically planar chiral rotaxanes>, Synthetic Route of 112-63-0, the main research area is box macrocycle active template synthesis mech planar chiral rotaxane.

A C1-sym. Box macrocycle has been synthesized for the first time. The Box macrocycle along with other C1 and C2-sym. Box ligands were evaluated and compared as ligands in the Cadiot-Chodkiewicz, oxidative Heck and CuAAC “”click”” reactions as part of our studies towards achieving active-metal template synthesis of mech. planar chiral rotaxanes. This study constitutes the first report of Cadiot-Chodkiewicz and CuAAC “”click”” reactions using Box ligands, as well as the first dedicated study of oxidative Heck reactions using Box ligands.

Tetrahedron published new progress about Alkadiynes Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhou, Jian; Xu, Ningbo; Liu, Boyang; Wang, Chenyang; He, Zhenyan; Lenahan, Cameron; Tang, Wenhui; Zeng, Huijun; Guo, Hongbo published the artcile< lncRNA XLOC013218 promotes cell proliferation and TMZ resistance by targeting the PIK3R2-mediated PI3K/AKT pathway in glioma>, Related Products of 112-63-0, the main research area is Sp1; chemoresistance; glioma; lncRNA XLOC; temozolomide.

The discovery of long noncoding RNAs (lncRNAs) has improved the understanding of development and progression in various cancer subtypes. However, the role of lncRNAs in temozolomide (TMZ) resistance in glioblastoma multiforme (GBM) remains largely undefined. In this present study, the differential expression of lncRNAs was identified between U87 and U87 TMZ-resistant (TR) cells. lncRNA XLOC013218 (XLOC) was drastically upregulated in TR cells and was associated with poor prognosis in glioma. Overexpression of XLOC markedly increased TMZ resistance, promoted proliferation, and inhibited apoptosis in vitro and in vivo. In addition, RNA-seq anal. and gain-of-function or loss-of-function studies revealed that PIK3R2 was the potential target of XLOC. Mechanistically, XLOC recruited specificity protein 1 (Sp1) transcription factor and promoted the binding of Sp1 to the promoters of PIK3R2, which elevated the expression of PIK3R2 in both mRNA and protein levels. Finally, PIK3R2-mediated activation of the PI3K/AKT signaling pathway promoted TMZ resistance and cell proliferation, but inhibited cell apoptosis. In conclusion, these data highlight the vital role of the XLOC/Sp1/PIK3R2/PI3K/AKT axis in GBM TMZ resistance.

Cancer Science published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Xiaoai; Chen, Haiqiang; Xiao, Jie; Liu, Jingyi; Tang, Niang; Zhou, Aimei published the artcile< Variations of volatile flavour compounds in finger citron (Citrus medica L. var. sarcodactylis) pickling process revealed by E-nose, HS-SPME-GC-MS and HS-GC-IMS>, Application of C19H34O2, the main research area is Citrus volatile flavor pickling E nose; E-nose; Finger citron; HS-GC-IMS; HS-SPME-GC-MS; Pickling process; Volatile flavour.

In this study, the variations of volatile flavor components in the pickling process of finger citron were investigated by electronic nose (E-nose), headspace solid phase microextraction-gas chromatog.-mass spectrometry (HS-SPME-GC-MS) and headspace-gas chromatog.-ion mobility spectrometry (HS-GC-IMS). Linalool, limonene, (E)-3,7-dimethyl-1,3,6-octatriene, myrcene, 3-carene, β-pinene, α-pinene, terpinolene, 1-methyl-4-(1-methylethyl)-1,4-cyclohexadiene, α-terpinene, (S)-β-bisabolene, 1-isopropyl-2-methylbenzene and 1-methyl-4-(1-methylethenyl)-benzene were the stable substances at relatively high contents in finger citron at different pickling process. Salting and drying steps in the pickling process exerted greatest influence on the volatile components of finger citron. Salting promoted the generation of aldehydes, esters and acids, but led to the disappearance of alcs., while drying promoted the generation of alcs., phenols, aldehydes and acids at the expense of reduction in terpenoids. Our study revealed that the characteristic volatile compounds of finger citron pickled products was mainly formed by the biol. reactions in the salting stage and thermal chem. transformations in the drying stage. This study also validated the suitability of E-nose combined with HS-SPME-GC-MS and HS-GC-IMS in tracking the changes of volatile components in finger citron during the pickling process.

Food Research International published new progress about Citron. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Haynes, Cally J. E.; Berry, Stuart N.; Garric, Joachim; Herniman, Julie; Hiscock, Jennifer R.; Kirby, Isabelle L.; Light, Mark E.; Perkes, Gregory; Gale, Philip A. published the artcile< Small neutral molecular carriers for selective carboxylate transport>, Application In Synthesis of 112-63-0, the main research area is crystal structure neutral carrier carboxylate transport.

A series of neutral thiourea receptors were found to mediate the antiport of chloride with a range of biol. relevant carboxylate anions across phospholipid bilayers. Simple structural modification of the carriers resulted in a change in the lactate/pyruvate transport selectivity.

Chemical Communications (Cambridge, United Kingdom) published new progress about Bilayer biological membrane (unilamellar vesicles). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guemues, Selcuk; Tuerker, Lemi published the artcile< Substituent effect on the aromaticity of 1,3-azole systems>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is oxazole imidazole thiazole substituent effect aromaticity.

The effects of substituent type and position on the aromaticity of certain derivatives of oxazole, imidazole and thiazole have been theor. investigated by using d. functional theory at the levels of B3LYP/6-31G(d,p) and B3LYP/6-31++G(d,p) methods. The second heteroatom substitution decreased aromaticity of furan, pyrrole and thiophene. The decreased aromaticity was gained back to some extent by the substitution of strong electron withdrawing groups or atoms (NO2 and F). Nucleus-independent chem. shift (NICS) data have been considered to determine the aromaticity of the systems. The most effective substitution to enhance the aromaticity has been calculated to be at position 4. The variation of the bond lengths of the main skeleton supported the findings through NICS calculations The frontier MO energies have also been reported to draw a general correlation between these energies and the aromaticity of the system.

Heterocyclic Communications published new progress about Aromaticity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lin, Carol Sze Ki; Kirpluks, Mikelis; Priya, Anshu; Kaur, Guneet published the artcile< Conversion of food waste-derived lipid to bio-based polyurethane foam>, Formula: C19H34O2, the main research area is polyurethane foam lipid food waste.

Food waste contains complex nutrients such as carbohydrates, fats, proteins which could be broken down into simpler substrates such as sugars (e.g., glucose), lipids and proteins (e.g., free amino nitrogen). These components can be used for conversion into useful bio-based products such as chems., materials and fuels. This research aimed at the development of bio-based polyurethane (PU) materials using food waste-derived lipids. Since the quality of lipid plays an important role in polyol synthesis, optimal extraction procedures were developed to select the most appropriate method for polyol synthesis. From obtained lipids, two polyol synthesis methods were used, lipid transamidation with diethanolamine (DEOA or DEA) and lipid epoxidation and subsequent epoxy ring opening with trimethylolpropane. Bio-polyol obtained in transamidation reaction was used to obtain rigid PU foams with three different isocyanate indexes of 130; 150 and 200 while bio-polyol form epoxy ring opening was used to obtain rigid PU foams with an isocyanate index of 150. The initial formulations were suitable to produce good quality rigid PU foam samples at a laboratory scale. The resultant rigid PU foams are promising for further studies and development of thermal insulation materials.

Case Studies in Chemical and Environmental Engineering published new progress about Enzymic hydrolysis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics