Month: November 2022

Jiao, Wenhui; Zhu, Shan; Shao, Jingrong; Zhang, Xiaoliang; Xu, Yanglu; Zhang, Yixuan; Wang, Ran; Zhong, Yuxu; Kong, Dexin published the artcile< ZSTK474 sensitizes glioblastoma to temozolomide by blocking homologous recombination repair>, Synthetic Route of 112-63-0, the main research area is .

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. Temozolomide (TMZ) is used as the standard chemotherapeutic agent for GBM but with limited success, and treatment failure is mainly due to tumor resistance. One of the leading causes of TMZ resistance is the upregulation of the DNA repair mechanism. Therefore, targeting the DNA damage response (DDR) is proposed to be an effective strategy to sensitize tumor cells to TMZ. In the present study, we demonstrated that the combined use of the PI3K inhibitor ZSTK474 and TMZ showed synergetic anticancer effects on human GBM cells in vitro and in vivo. The combination treatment led to significantly increased cell apoptosis and DNA double strand breaks (DSBs). In addition, a mechanistic study indicated that TMZ enhanced the homologous recombination (HR) repair efficiency in GBM cells, while ZSTK474 impaired HR repair by blocking the phosphorylation of ATM and the expression of BRCA1/2 and Rad51, thereby sensitizing GBM cells to TMZ. Moreover, TMZ activated the PI3K signaling pathway through upregulation of the PI3K catalytic subunits p110α and p110β and the phosphorylation of Akt. Meanwhile, ZSTK474 blocked the activity of the PI3K/Akt pathway. Taken together, our findings suggested that the combination of ZSTK474 and TMZ might be a potential therapeutic option for GBM.

BioMed Research International published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Boyington, Allyson J.; Riu, Martin-Louis Y.; Jui, Nathan T. published the artcile< Anti-Markovnikov Hydroarylation of Unactivated Olefins via Pyridyl Radical Intermediates>, Product Details of C19H34O2, the main research area is alkylpyridine preparation; halopyridine olefin regioselective hydroarylation iridium catalyst.

The intermol. alkylation of pyridine units with simple alkenes has been achieved via a photoredox radical mechanism. This process occurs with complete regiocontrol, where single-electron reduction of halogenated pyridines regiospecifically yields the corresponding radicals in a programmed fashion, and radical addition to alkene substrates occurs with exclusive anti-Markovnikov selectivity. This system is mild, tolerant of many functional groups, and effective for the preparation of a wide range of complex alkylpyridines.

Journal of the American Chemical Society published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nagy, Audric; Collard, Laurent; Indukuri, Kiran; Leyssens, Tom; Riant, Olivier published the artcile< Enantio-, Regio- and Chemoselective Copper-Catalyzed 1,2-Hydroborylation of Acylsilanes>, Computed Properties of 112-63-0, the main research area is hydroboration reduction ketone acylsilane preparation hydroxyalkylsilane enantiomer copper catalyst; copper diphosphine complex catalyst asym hydroboration acylsilane preparation hydroxyalkylsilane; chiral alc preparation hydroxyalkylsilane asym reduction ketone acylsilane pinacolboronate; acylsilane; asymmetric synthesis; copper; hydroborylation; hydroxysilanes.

Enantioselective synthesis of synthetically significant (α-hydroxyallyl)silanes, (α-hydroxybenzyl)silanes, and (α-hydroxyalkyl)silanes is reported. The present copper-catalyzed 1,2-selective hydroborylation of acylsilanes affords the aforementioned products in high yields and with high enantiomeric excesses. This robust and scalable additive-free catalytic system relies on the use of low copper(II) acetate and diphosphine ligand loadings at room temperature in the presence of a com. available and bench-stable hydride source.

Chemistry – A European Journal published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation) (silylated). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Taylor, D. Martin; Morgan, Hywel; D’Silva, Claudius published the artcile< Behavior of avidin and avidin/bisbiotin polymers at the air-water interface>, COA of Formula: C19H34O2, the main research area is avidin biotin derivative polymer interface; bisbiotin avidin polymer interface.

The surface behavior of avidin and two polymers, formed by affinity polymerization from two-different stoichiometric mixtures of avidin and the bifunctional ligand bisbiotin, has been investigated at the air/water interface. Strong hysteresis in the pressure-area isotherms is attributed to mech. distortion of the mols. When subjected to step change in pressure, the monolayer area relaxes to a new equilibrium value following first-order dynamics, the time constant being of the order of minutes for a pressure change of 5 mN m-1. Equilibrium isotherms for the fully relaxed monolayers are linear over most of the pressure range, with both compression and expansion isotherms exactly coincident. Monolayers of the avidin/bisbiotin polymer were deposited onto electron microscope grids by the Langmuir-Blodgett technique and imaged in a transmission electron microscope. The area per repeat unit was estimated to be ∼30 nm2 in good agreement with previous estimates, but much smaller than the area per mol. obtained by extrapolating the pressure-area isotherm to zero pressure. Finally it is shown that spreading solvents containing a high percentage of chloroform cause avidin to denature at the air/water interface, this manifesting itself as a large mol. area at low surface pressure. However, it appears that denaturation may be reversed almost completely when the monolayer is compressed. The investigation suggests that it may be feasible to fabricate mol. electronic networks based on affinity polymerization

Journal of Colloid and Interface Science published new progress about Avidins Role: BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Akiel, Maaged A.; Alshehri, Ohoud Y.; Aljihani, Shokran A.; Almuaysib, Amani; Bader, Ammar; Al-Asmari, Ahmed I.; Alamri, Hassan S.; Alrfaei, Bahauddeen M.; Halwani, Majed A. published the artcile< Viridiflorol induces anti-neoplastic effects on breast, lung, and brain cancer cells through apoptosis>, Application of C19H34O2, the main research area is brain cancer cells anti neoplastic effect breast lung apoptosis; Anticancer; Apoptosis; Natural product; Viridiflorol, Cytotoxicity, Drug discovery.

All active natural mols. are not fully exploited as therapeutic agents, causing delays in the advancement of anticancer drug discovery. Viridiflorol is a natural volatile element that may work as anti-cancer compound We tested the anticancer properties of viridiflorol at different concentrations ranging from 0.03 to 300μM in vitro on three cancer cells including breast (MCF-7), lung (A549) and brain (Daoy). The cancer cells responses were documented after treatment using MTT and Annexin V assays. Viridiflorol showed cytotoxic effects against all tested cell lines, reducing cell viability in a concentration-dependent manner with variable IC50 values. Daoy and A549 cell lines were more sensitive to viridiflorol when compared with temozolomide and doxorubicin, resp. Viridiflorol demonstrated the highest anticancer activity against the Daoy cells with an estimated IC50 of 0.1μM followed by MCF-7 at 10μM, and A549 at 30μM. In addition, upon exposure to concentrations ranging from 30μM to 300μM of viridiflorol, early and late apoptotic cell death was induced in a concentration dependent manner in Daoy (55.8-72.1), MCF-7 (36.2-72.7) and A459 (35-98.9) cell lines, resp. In conclusion, viridiflorol demonstrates cytotoxic and apoptotic ability in three different cancer cell lines (brain, breast and lung).

Saudi Journal of Biological Sciences published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pandey, A. K.; Chowdhury, A. R. published the artcile< Essential oil of Ocimum basilicum L. from Satpura plateau of central India>, Electric Literature of 112-63-0, the main research area is Ocimum oil camphor gas chromatog.

The composition of the volatile oil of O. basilicum L. growing in India determined by GC-MS indicated the presence of 55 compounds, of which 43 were identified constituting 96.78% of the oil. The main compounds were camphor (19.97%), eugenol (14.1%), camphene (8.92%), γ-gurjunene (4.94%), trans-caryophyllene (3.64%), calarene (3.59%), linalool (2.95%), (Z,E)-α-farnesene (2.82%), patchoulene (2.79%), spathulenol (2.7%), myrtenol (2.48%), and viridiflorol (2.06%). O. basilicum containing camphor as a major constituent was reported 1st time from central India.

Indian Perfumer published new progress about Gas chromatography-mass spectrometry. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hernandez-Ruiz, Raquel; Rubio-Presa, Ruben; Suarez-Pantiga, Samuel; Pedrosa, Maria R.; Fernandez-Rodriguez, Manuel A.; Tapia, M. Jose; Sanz, Roberto published the artcile< Mo-Catalyzed One-Pot Synthesis of N-Polyheterocycles from Nitroarenes and Glycols with Recycling of the Waste Reduction Byproduct. Substituent-Tuned Photophysical Properties>, Recommanded Product: Ethyl 2-hydroxyacetate, the main research area is polyheterocycle preparation green chem; nitroarene glycol tandem reduction imine formation intramol cyclization oxidation; dioxomolybdenum complex catalyst waste reuse; N-heterocycles; dioxomolybdenum; nitroaromatics; photophysical properties; reuse of waste.

A catalytic domino reduction-imine formation-intramol. cyclization-oxidation for the general synthesis of a wide variety of biol. relevant N-polyheterocycles, such as quinoxaline- and quinoline-fused derivatives, and phenanthridines, is reported. A simple, easily available, and environmentally friendly dioxomolybdenum(VI) complex has proven to be a highly efficient and versatile catalyst for transforming a broad range of starting nitroarenes involving several redox processes. Not only is this a sustainable, step-economical as well as air- and moisture-tolerant method, but also it is worth highlighting that the waste byproduct generated in the first step of the sequence is recycled and incorporated in the final target mol., improving the overall synthetic efficiency. Moreover, selected indoloquinoxalines have been photophys. characterized in cyclohexane and toluene with exceptional fluorescence quantum yields above 0.7 for the alkyl derivatives

Chemistry – A European Journal published new progress about Absorption spectra. 623-50-7 belongs to class esters-buliding-blocks, and the molecular formula is C4H8O3, Recommanded Product: Ethyl 2-hydroxyacetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lee, Yu-Lin; Lin, Kuan-Yin; Cheng, Shu-Hsing; Lu, Po-Liang; Wang, Ning-Chi; Ho, Mao-Wang; Yang, Chia-Jui; Liou, Bo-Huang; Tang, Hung-Jen; Huang, Shie-Shian; Huang, Sung-Hsi; Chen, Tun-Chieh; Lin, Chi-Ying; Lin, Shih-Ping; Lee, Yuan-Ti; Hung, Chien-Ching published the artcile< Dual therapy with dolutegravir plus boosted protease inhibitor as maintenance or salvage therapy in highly experienced people living with HIV>, Category: esters-buliding-blocks, the main research area is dolutegravir protease inhibitor antiHIV agent HIV; Antiretroviral resistance; Dyslipidaemia; Integrase strand transfer inhibitor; Two-drug regimen; Weight gain.

Real-world experience with dolutegravir (DTG) plus boosted protease inhibitor (bPI) as a two-drug regimen is limited for highly experienced HIV-pos. patients with virol. failure or intolerance to antiretroviral therapy. Patients receiving DTG plus bPI between Sept. 2016 and June 2019 at 15 designated hospitals for HIV care in Taiwan were retrospectively included in this study. A standardised case record form was used to collect clin. data. The primary endpoint was virol. response, defined as achieving or maintaining plasma HIV-RNA <50 copies/mL at Week 48. A total of 77 patients were included; 58 (75.3%) had documented genotypic resistance to 1-4 antiretroviral classes. The most commonly used PI was darunavir (87.0%; 67/77). Seven patients (9.1%) had no virol. data at Week 48, including three with loss to follow-up, one severe hyperlipidemia, one renal failure and cardiovascular disease, one superimposed HBV infection and one death from anal cancer. The virol. response rate increased from 59.7% at baseline to 90.9% at Week 24 and 85.7% at Week 48. The only patient (1.3%) with virol. failure at Week 48 had poor adherence and baseline low-level resistance to darunavir with resistance-associated mutations at M46L, I50V and V82A. Compared with baseline, mean total cholesterol increased by 20.1 mg/dL and weight by 2.8 kg at Week 48, while the estimated glomerular filtration rate decreased by 14.4 mL/min/1.73m2 (both P < 0.05). We conclude that a two-drug regimen containing DTG plus bPI was effective in highly-experienced HIV-pos. patients, but metabolic impact and weight gain should be closely monitored. International Journal of Antimicrobial Agents published new progress about Anti-HIV agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Vysotskii, Yu. B. published the artcile< Quantum-chemical interpretation of the substituent effect on the pKa of molecules with conjugated bonds using the PPP method>, Formula: C19H34O2, the main research area is substituent effect basicity conjugated heterocycle; quantum chem conjugated heterocycle PPP.

Change in pKa of unsaturated heterocycles induced by functionalization is proportional to the difference in residual π-electron changes in the unsubstituted heterocycle and its conjugate acid at the site of functionalization.

Teoreticheskaya i Eksperimental’naya Khimiya published new progress about Basicity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liang, Xianyu; Liu, Fan; Wan, Yiqun; Yin, Xiaoying; Liu, Weiting published the artcile< Facile synthesis of molecularly imprinted polymers for selective extraction of tyrosine metabolites in human urine>, Electric Literature of 3290-92-4, the main research area is molecularly imprinted polymer tyrosine metabolite extraction urine; Human urine; Molecular imprinted polymer; Selective extraction; Tyrosine metabolites; Ultra-high performance liquid chromatography.

In this study a method is developed for quant. anal. of three potential biomarkers, including 4-hydroxyphenyl acetic acid (PHPAA), 4-hydroxyphenyl lactic acid (PHPLA) and 3,4-hydroxyphenylpropionic acid (PHPA), in human urine. Mol. imprinted polymers (MIPs) as the sample clean up materials were applied to selectively extract these tyrosine metabolites, followed by precise detection using ultra-high performance liquid chromatog. coupled with a fluorescence detector (UHPLC-FLD). The MIP was prepared by precipitation polymerization adopting PHPAA as the template mol., 1-vinylimidazole (1-vinyl) as functional monomer, trimethylolpropane triacrylate (TRIM) as crosslinker, 2-methylpropionitrile (AIBN) as initiator and acetonitrile as a porogen. The mol. recognition properties and selectivity of MIPs were systematically evaluated, of which results demonstrated high selectivity for three analytes in human urine. Parameters affecting the extraction efficiency were further optimized. Under the optimum conditions, the limits of detection of PHPAA, PHPLA, and PHPA were 1.8 × 10-4, 4.7 × 10-5 and 5.8 × 10-5 mmol L-1, resp., and the recoveries were in the range of 75.7%-110.3%. The method described here provided insights into the future development of materials for highly efficient and selective enrichment of targeted substances.

Journal of Chromatography A published new progress about Homo sapiens. 3290-92-4 belongs to class esters-buliding-blocks, and the molecular formula is C18H26O6, Electric Literature of 3290-92-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics