Month: November 2022

Mori, Kenji; Ikunaka, Masaya published the artcile< Pheromone synthesis. 65. Synthesis of all of the four energetically possible stereoisomers of 7-ethyl-2-methyl-1,6-dioxaspiro[4.5]decane. A pheromone produced by bees Paravespura vulgaris L. and Andrena haemorrhoa F>, Related Products of 617-55-0, the main research area is dioxaspirodecane ethylmethyl isomer preparation; pheromone ethymethyldioxaspirodecane isomer preparation.

All 4 energetically possible stereoisomers [(2R,5R,7R)-, (2R,5S,7S)-, (2S,5R,7R)- and (2S,5S,7S)] of 7-ethyl-2-methyl-1,6-dioxaspiro[4.5]decane were synthesized from Et (S)-lactate and di-Me (S)-malate or Me (R)-β-hydroxyvalerate employing dianion alkylation as the key-step.

Tetrahedron published new progress about Plant pheromones Role: SPN (Synthetic Preparation), PREP (Preparation). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Related Products of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Lili; Ma, Tianyi; Fang, Weiwei; Liu, Yuqing; Konstantinov, Kostantin; Wang, Jiazhao; Liu, Hua-Kun published the artcile< Facile Fabrication of Ag Nanocrystals Encapsulated in Nitrogen-doped Fibrous Carbon as an Efficient Catalyst for Lithium Oxygen Batteries>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is silver nanocrystal nitrogen carbon encapsulation catalyst lithium oxygen battery.

A facile synthesis of Ag nanocrystals encapsulated in nitrogen-doped carbon fiber (NCF) is proposed, based on the simultaneous reaction between pyrrole and Ag+ ions in an aqueous solvent followed by a heat treatment. The as-prepared Ag/NCF demonstrated superior catalytic behavior toward ORR and OER. Besides improved cycling stability, a much lower discharge/charge gap of 0.89 V (vs Li/Li+) compared with 1.38 V for NCF cathode with a fixed capacity of 500 mAh g-1 was obtained in lithium oxygen batteries. The introduction of Ag crystals into NCF facilitates the oxygen reduction reaction/oxygen evolution reaction kinetics. X-ray diffraction anal. coupled with Raman spectroscopy confirmed that Ag/NCF cathode could reversibly catalyze Li2O2 formation and decomposition The NCF matrix offers a conductive network to realize rapid mass transfer and the encapsulated Ag nanocrystals supplied effective catalytic active sites. The combined action between both contributes to the superior electrocatalytic performance.

Energy & Environmental Materials published new progress about Aqueous solutions. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Price, Daniel J.; Drewry, David H.; Schaller, Lee T.; Thompson, Brian D.; Reid, Paul R.; Maloney, Patrick R.; Liang, Xi; Banker, Periette; Buckholz, Richard G.; Selley, Paula K.; McDonald, Octerloney B.; Smith, Jeffery L.; Shearer, Todd W.; Cox, Richard F.; Williams, Shawn P.; Reid, Robert A.; Tacconi, Stefano; Faggioni, Federico; Piubelli, Chiara; Sartori, Ilaria; Tessari, Michela; Wang, Tony Y. published the artcile< An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model>, Product Details of C19H34O2, the main research area is diarylazaindole pharmacokinetics blood brain barrier CAMKK2 AMPK satiety obesity; CAMKK2; Inhibitor; Satiety.

Hypothalamic CAMKK2 represents a potential mechanism for chem. affecting satiety and promoting weight loss in clin. obese patients. Single-digit nanomolar inhibitors of CAMKK2 were identified in three related ATP-competitive series. Limited optimization of kinase selectivity, solubility, and pharmacokinetic properties were undertaken on all three series, as SAR was often transferrable. Ultimately, a 2,4-diaryl 7-azaindole was optimized to afford a tool mol. that potently inhibits AMPK phosphorylation in a hypothalamus-derived cell line, is orally bioavailable, and crosses the blood-brain barrier. When dosed orally in rodents, compound 4t limited ghrelin-induced food intake.

Bioorganic & Medicinal Chemistry Letters published new progress about Antiobesity agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kyselka, Jan; Cihelkova, Klara; Lopes-Lutz, Daise; Chudoba, Josef; Vachalova, Tereza; Alishevich, Katsiaryna; Hradkova, Iveta; Bercikova, Marketa; Mikolaskova, Monika; Filip, Vladimir published the artcile< Mechanism Controlling High-Temperature Degradation of Sunflower Oil Triacylglycerols in the Absence of Oxygen>, Electric Literature of 112-63-0, the main research area is sunflower oil triacylglycerol temperature degradation oxygen absence.

The aim of the present study is to describe the mechanism controlling heat-induced formation of sunflower oil triacylglycerol and fatty acid Me ester oligomers. The unique combination of high-performance size-exclusion chromatog. with hyphenated electrospray ionization mass spectrometry (MS), atm. pressure chem. ionization-MS, and high-temperature gas chromatog.-MS techniques allows differentiating between radical coupling species and Diels-Alder cycloadducts. Targeted anal. of thermally degraded sunflower oils confirms the exact structures of various acyclic oligomers accompanied by less-abundant products of pericyclic transformations. A series of model experiments simulate the impact of dienophile nature on the course of Diels-Alder reactions. Thus, α-tocopherylquinone, δ-tocopherylquinone, and methyl-(E)-11-oxoundec-9-enoate are synthesized as naturally occurring dienophiles bearing electron-withdrawing groups. The geometry of poor dienophiles does not affect concerted cyclization, while the structure of electron deficient dienophiles can overcome low reactivity. In the absence of oxygen, heat-induced degradation of polyunsaturated triacylglycerols proceed predominantly via a radical pathway, whereas concerted reactions represent minor mechanisms. Sunflower oil triacylglycerol mols. in the system without propagation stage can be effectively protected by natural and/or synthetic antioxidants. Application of chelates is also recommended. However, antioxidant-derived quinones, such as α-tocopherylquinone, can enter the Diels-Alder reaction even more easily than dienophiles without electron-withdrawing groups. Unsaturated core aldehydes possess the same reactivity. Examination of the mechanism controlling high-temperature degradation of triacylglycerols is especially important for processing engineers in edible oil refineries and food technologists. New perspective may help them to minimize undesirable changes in polyunsaturated species.

European Journal of Lipid Science and Technology published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Chengliang; Zhang, Xu; Zhao, Wei; Liu, Xin; Wang, Qingfu; Sun, Jingjiang published the artcile< Synthesis of Aliphatic Hyperbranched Polycarbonates via Organo-Catalyzed ""A1+B2""-Ring-Opening Polymerization>, Reference of 112-63-0, the main research area is aliphatic hyperbranched polycarbonate organo catalyzed ring opening polymerization.

Hyperbranched aliphatic polycarbonates (HBPCs) have attracted significant attention in the field of biomedical application owing to their abundant end groups, biocompatibility, and nontoxic degradation products. However, their practical application is hampered by tedious synthesis procedures. The present work described a novel organo-catalyzed “”A1+B2″”-ring-opening polymerization (ROP) using a monofunctional primary alc. (A1) as an initiator and a bicyclic carbonate monomer (B2) for the straightforward synthesis of HBPCs under mild conditions. No gelation was observed up to 90% conversion of the cyclic carbonate ring. HBPCs with molar masses in the range from 7 to 20 kg/mol were obtained. Based on the “”A1+B2″”-ROP, HBPCs bearing a variety of functionalities including alkene, alkyne, aldehyde, furan, azide, and mPEG groups, which are of great significance in the field of click chem., have been successfully prepared by using functional alc. initiators. This polymerization strategy allowed for precise control over the HBPC structure: (1) the hyperbranched polymer (HBP) backbone can be adjusted by design of a bicyclic carbonate monomer with various linkages; (2) the use of an appropriate initiator leads to the introduction of functional end groups. Overall, the “”A1+B2″”-ROP provides an efficient method for preparing a variety of HBPs like hyperbranched polyester, polyether, polyphosphate, and poly(amino acid) with complex architectures in a single step.

Macromolecules (Washington, DC, United States) published new progress about Biocompatible materials. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Arribas, Andres; Calvelo, Martin; Fernandez, David F.; Rodrigues, Catarina A. B.; Mascarenas, Jose L.; Lopez, Fernando published the artcile< Highly Enantioselective Iridium(I)-Catalyzed Hydrocarbonation of Alkenes: A Versatile Approach to Heterocyclic Systems Bearing Quaternary Stereocenters>, Quality Control of 623-50-7 , the main research area is alkenyl azaheterocycle iridium phosphine catalyst enantioselective regioselective hydrocarbonation; fused polycyclic azaheterocycle preparation; C-H activation; enantioselective; heterocycles; hydrocarbonation; iridium.

A versatile, highly enantioselective intramol. hydrocarbonation reaction that provides a direct access to heteropolycyclic systems bearing chiral quaternary carbon stereocenters was reported. The method, which relies on an iridium(I)/bisphosphine chiral catalyst, was particularly efficient for the synthesis of five-, six- and seven-membered fused indole and pyrrole products, bearing one and two stereocenters, with enantiomeric excesses of up to >99%. DFT computational studies allowed to obtain a detailed mechanistic profile and identify a cluster of weak non-covalent interactions as key factors to control the enantioselectivity.

Angewandte Chemie, International Edition published new progress about Amides Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 623-50-7 belongs to class esters-buliding-blocks, and the molecular formula is C4H8O3, Quality Control of 623-50-7 .

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Selman, Mohammed; Ou, Paula; Rousso, Christopher; Bergeron, Anabel; Krishnan, Ramya; Pikor, Larissa; Chen, Andrew; Keller, Brian A.; Ilkow, Carolina; Bell, John C.; Diallo, Jean-Simon published the artcile< Dimethyl fumarate potentiates oncolytic virotherapy through NF-κB inhibition>, HPLC of Formula: 112-63-0, the main research area is dimethyl fumarate anticancer antiviral agent NFkappaB breast colon cancer.

Resistance to oncolytic virotherapy is frequently associated with failure of tumor cells to get infected by the virus. Di-Me fumarate (DMF), a common treatment for psoriasis and multiple sclerosis, also has anticancer properties. We show that DMF and various fumaric and maleic acid esters (FMAEs) enhance viral infection of cancer cell lines as well as human tumor biopsies with several oncolytic viruses (OVs), improving therapeutic outcomes in resistant syngeneic and xenograft tumor models. This results in durable responses, even in models otherwise refractory to OV and drug monotherapies. The ability of DMF to enhance viral spread results from its ability to inhibit type I interferon (IFN) production and response, which is associated with its blockade of nuclear translocation of the transcription factor nuclear factor κB (NF-κB). This study demonstrates that unconventional application of U.S. Food and Drug Administration-approved drugs and biol. agents can result in improved anticancer therapeutic outcomes.

Science Translational Medicine published new progress about Adenoviridae. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Urbanczyk, Sophia; Baris, Olivier R.; Hofmann, Joerg; Taudte, R. Verena; Guegen, Naig; Golombek, Florian; Castiglione, Kathrin; Meng, Xianyi; Bozec, Aline; Thomas, Jana; Weckwerth, Leonie; Mougiakakos, Dimitrios; Schulz, Sebastian R.; Schuh, Wolfgang; Schloetzer-Schrehardt, Ursula; Steinmetz, Tobit D.; Brodesser, Susanne; Wiesner, Rudolf J.; Mielenz, Dirk published the artcile< Mitochondrial respiration in B lymphocytes is essential for humoral immunity by controlling the flux of the TCA cycle>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is mitochondrial respiration B lymphocyte humoral immunity TCA cycle DNT; B lymphocyte; CP: Immunology; HIF1; TCA cycle; class switch recombination; germinal center; hypoxia inducible factor 1; mTOR; mammalian target of Rapamycin; mitochondrial DNA; mitochondrial respiration; oxidative phosphorylation; phosphatidic acid; plasma cell.

To elucidate the function of oxidative phosphorylation (OxPhos) during B cell differentiation, we employ CD23Cre-driven expression of the dominant-neg. K320E mutant of the mitochondrial helicase Twinkle (DNT). DNT-expression depletes mitochondrial DNA during B cell maturation, reduces the abundance of respiratory chain protein subunits encoded by mitochondrial DNA, and, consequently, respiratory chain super-complexes in activated B cells. Whereas B cell development in DNT mice is normal, B cell proliferation, germinal centers, class switch to IgG, plasma cell maturation, and T cell-dependent as well as T cell-independent humoral immunity are diminished. DNT expression dampens OxPhos but increases glycolysis in lipopolysaccharide and B cell receptor-activated cells. Lipopolysaccharide-activated DNT-B cells exhibit altered metabolites of glycolysis, the pentose phosphate pathway, and the tricarboxylic acid cycle and a lower amount of phosphatidic acid. Consequently, mTORC1 activity and BLIMP1 induction are curtailed, whereas HIF1α is stabilized. Hence, mitochondrial DNA controls the metabolism of activated B cells via OxPhos to foster humoral immunity.

Cell Reports published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dunn, Robert O. published the artcile< Fuel properties of low-erucic acid pennycress (LEAP) oil biodiesel>, Reference of 112-63-0, the main research area is low erucic acid pennycress oil biodiesel fuel property.

Biodiesel is a renewable biobased fuel obtained from transesterification of plant seed oil with methanol. This fuel has phys. properties that make it attractive as an alternative fuel for compression-ignition (diesel) engines. In the United States (US), there is a need to increase the production of sustainable and environmentally friendly biofuels, including biodiesel, to supplement fossil fuels. To meet these challenges, emphasis is being placed on expanding the use of low-cost non-food oils as feedstocks for biodiesel. Low-erucic acid pennycress (LEAP) was developed from field pennycress as a cover crop for use in the Upper Midwestern US. The objective of the present study was to convert LEAP oil to biodiesel (fatty acid Me esters [FAME]) and evaluate its fuel properties. The same process was applied to FAME made from natural field pennycress (FPC) oil as a baseline for comparison of results. The LEAP oil-FAME (LEAP-ME) had a kinematic viscosity at 40°C (KV40) that was lower than that of FPC oil-FAME (FPC-ME), and nearly equivalent to the KV40 of soybean oil-FAME (SME). The total saturated-FAME (SFAME) concentration of LEAP-ME (5.40 mass%) was greater than that of FPC-ME. Since SFAME have high m.ps., this caused LEAP-ME to have a higher cloud point (CP) than FPC-ME. However, the CP of LEAP-ME (-6.8°C) was lower than those of canola oil-FAME (CaME; -2.5°C) and SME (-2.8°C). The oxidative induction period at 110°C (IP110) of LEAP-ME was poor (0.83 h), indicating that it would need to be treated with antioxidants before distribution as an alternative diesel fuel.

Industrial Crops and Products published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dias, L. G.; Hacke, A.; Bergara, S. F.; Villela, O. V.; Mariutti, L. R. B.; Bragagnolo, N. published the artcile< Identification of volatiles and odor-active compounds of aromatic rice by OSME analysis and SPME/GC-MS>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is aromatic rice volatile odor compound OSME analysis SPME GCMS; 2-acetyl-1-pyrroline; Aroma; Flavor; Olfactometry; Oryza sativa; Volatile profile.

During cooking, aromatic rice has a pleasant and characteristic aroma, a relevant factor to add sale value and attract consumer interest. This work studied the volatile compounds of aromatic rice (IAC 500) aiming at identifying those responsible for the aroma and flavor of the cooked rice. The description of the aromatic notes of the IAC 500 rice was carried out by a trained and selected sensory panel, followed by olfactometry (OSME) and identification by GC-MS of the rice volatile compounds extracted by SPME. A total of 80 volatiles was sensorially perceived and/or detected in the chromatog. effluent, of which 65 were identified, 44 presented some odor, and 36 were odorless. Among the odorous compounds, 15 were not detected by GC-FID or GC-MS. This study confirmed the compound 2-acetyl-1-pyrroline as the impacting volatile compound to the aroma of aromatic rice since it presented a very low percentage of area in the chromatogram and a high odor intensity. Other 43 compounds presented odor in lower intensities, but also contributed to the overall aroma of IAC 500 rice. From the 11 aromatic notes mentioned by the trained panel (cooked vegetable/seed, corn, hominy, green, porridge, popcorn, fresh baked cake/bread, milk, caramel, tapioca flour and flower), eight were related to the volatile compounds responsible for their aroma.

Food Research International published new progress about Analysis (olfactometry). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics