Month: November 2022

Lin, Qiaowei; Huang, Ling; Liu, Wenhua; Li, Zejian; Fang, Ruopian; Wang, Da-Wei; Yang, Quan-Hong; Lv, Wei published the artcile< High-performance lithium-sulfur batteries enabled by regulating Li2S deposition>, HPLC of Formula: 112-63-0, the main research area is indium tin oxide lithium sulfur battery.

Lithium-sulfur batteries (LSBs) have received intensive attention in recent years due to their high theor. energy d. derived from the lithiation of sulfur. In the discharge process, sulfur transforms into lithium polysulfides (LiPSs) that dissolve in liquid electrolytes and then into insoluble Li2S precipitated on the electrode surface. The electronically and ionically insulating Li2S leads to two critical issues, including the sluggish reaction kinetics from LiPSs to Li2S and the passivation of the electrode. In this regard, controlling the Li2S deposition is significant for improving the performance of LSBs. In this perspective, we have summarized the recent achievements in regulating the Li2S deposition to enhance the performance of LSBs, including the solution-mediated growth of Li2S, sulfur host enhanced nucleation and catalysis induced kinetic improvement. Moreover, the challenges and possibilities for future research studies are discussed, highlighting the significance of regulating the Li2S deposition to realize the high electrochem. performance and promote the practical uses of LSBs.

Physical Chemistry Chemical Physics published new progress about Battery electrolytes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dao, Nam V.; Ercole, Francesca; Li, Yuhuan; Davis, Thomas P.; Kaminskas, Lisa M.; Sloan, Erica K.; Quinn, John F.; Whittaker, Michael R. published the artcile< Nitroxide-functional PEGylated nanostars arrest cellular oxidative stress and exhibit preferential accumulation in co-cultured breast cancer cells>, Reference of 71195-85-2, the main research area is human breast cancer oxidative stress nitroxide; polyethylene glycol nanostar ROS anticancer.

The limited application of traditional antioxidants to reducing elevated levels of reactive oxygen species (ROS) is potentially due to their lack of stability and biocompatibility when tested in a biol. milieu. For instance, the poor biol. antioxidant performance of small mol. nitroxides arises from their limited diffusion across cell membranes and their significant side effects when applied at high doses. Herein, we describe the use of nanostructured carriers to improve the antioxidant activity of a typical nitroxide derivative, (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO). Polymers with star-shaped structures were synthesized and were further conjugated to TEMPO moieties via amide linkages. The TEMPO-loaded stars have small hydrodynamic sizes (<20 nm), and are better tolerated by cells than free TEMPO in a breast cancer-fibroblast co-culture, a system exhibiting elevated ROS levels. At a well-tolerated concentration, the polymer with the highest TEMPO-loading capacity successfully downregulated ROS production in co-cultured cells (a significant decrease of up to 50% vs. basal ROS levels), which was accompanied by a specific reduction in superoxide anion generation in the mitochondria. In contrast, the equivalent concentration of free TEMPO did not achieve the same outcome. Further investigation showed that the TEMPO-conjugated star polymers can be recycled inside the cells, thus providing longer term scavenging activity. Cell association studies demonstrated that the polymers can be taken up by both cell types in the co-culture, and are found to co-locate with the mitochondria. Interestingly the stars exhibited preferential mitochodria targeting in the co-cultured cancer cells compared to accompanying fibroblasts. The data suggest the potential of TEMPO-conjugated star polymers to arrest oxidative stress for various applications in cancer therapy. Journal of Materials Chemistry B: Materials for Biology and Medicine published new progress about Animal tissue coculture. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Reference of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hasegawa, Masatoshi; Yamasaki, Yuko; Sonta, Nanae; Shindo, Yoichi; Sugimura, Tokuko; Kitahara, Ayao published the artcile< Clustering of Aerosol OT Reversed Micelles As Studied by Nonradiative Energy Transfer of Solubilized Probes>, Formula: C19H34O2, the main research area is cluster AOT reverse micelle energy transfer; fluorescence probe AOT reverse micelle cluster.

Water-soluble anionic fluorescent mols. tetrasodium 1,3,6,8-pyrenetetrasulfonate (PyTS) and trisodium 8-hydroxy-1,3,6-pyrenetrisulfonate (pyranine) were solubilized in sep. reversed micellar cores in AOT/n-heptane system. The reversed micelle system showed an extent of nonradiative energy transfer from PyTS to pyranine higher than for the aqueous solution system in comparison at a critical probe concentration, [P]C. The values of [P]C, where each micelle is occupied by statistically one probe mol., were determined as a probe concentration where the solubilized disodium 2,6-naphthalenedisulfonate (NpDS) begins to show the intramicellar excimer fluorescence. The results reveal that at surfactant concentrations higher than 0.1 M the AOT reversed micelles are not randomly dispersed in isolated state in n-heptane but form clusters through intermicellar flocculation.

Journal of Physical Chemistry published new progress about Clusters. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Naismith, Robert T.; Wundes, Annette; Ziemssen, Tjalf; Jasinska, Elzbieta; Freedman, Mark S.; Lembo, Anthony J.; Selmaj, Krzysztof; Bidollari, Ilda; Chen, Hailu; Hanna, Jerome; Leigh-Pemberton, Richard; Lopez-Bresnahan, Maria; Lyons, Jennifer; Miller, Catherine; Rezendes, David; Wolinsky, Jerry S.; The EVOLVE-MS-2 Study Group published the artcile< Diroximel Fumarate Demonstrates an Improved Gastrointestinal Tolerability Profile Compared with Dimethyl Fumarate in Patients with Relapsing-Remitting Multiple Sclerosis: Results from the Randomized, Double-Blind, Phase III EVOLVE-MS-2 Study>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is diroximel fumarate gastrointestinal tolerability prole human.

Abstract: Background: Diroximel fumarate (DRF) is a novel oral fumarate approved in the USA for relapsing forms of multiple sclerosis. DRF is converted to monomethyl fumarate, the pharmacol. active metabolite of di-Me fumarate (DMF). DRF 462 mg and DMF 240 mg produce bioequivalent exposure of monomethyl fumarate and are therefore expected to have similar efficacy/safety profiles; the distinct chem. structure of DRF may contribute to its tolerability profile. Objectives: The objective of this study was to compare the gastrointestinal tolerability of DRF and DMF over 5 wk in patients with relapsing-remitting multiple sclerosis. Methods: EVOLVE-MS-2 was a phase III, randomized, double-blind, head-to-head, 5-wk study evaluating the gastrointestinal tolerability of DRF 462 mg vs DMF 240 mg, administered twice daily in patients with relapsing-remitting multiple sclerosis, using two self-administered gastrointestinal symptom scales: Individual Gastrointestinal Symptom and Impact Scale (IGISIS) and Global Gastrointestinal Symptom and Impact Scale (GGISIS). The primary endpoint was the number of days with an IGISIS intensity score ≥ 2 relative to exposure. Other endpoints included the degree of gastrointestinal symptom severity measured by IGISIS/GGISIS and assessment of safety/tolerability. Results: DRF-treated patients experienced a statistically significant reduction (46%) in the number of days with an IGISIS symptom intensity score ≥ 2 compared with DMF-treated patients (rate ratio [95% confidence interval]: 0.54 [0.39-0.75]; p = 0.0003). Lower rates of gastrointestinal adverse events (including diarrhea, nausea, vomiting, and abdominal pain) were observed with DRF than DMF (34.8% vs 49.0%). Fewer patients discontinued DRF than DMF because of adverse events (1.6% vs 5.6%) and gastrointestinal adverse events (0.8% vs 4.8%). Conclusions: DRF demonstrated an improved gastrointestinal tolerability profile compared with DMF, with less severe gastrointestinal events and fewer days of self-assessed gastrointestinal symptoms, fewer gastrointestinal adverse events, and lower discontinuation rates because of gastrointestinal adverse events. Clin. Trials Registration: ClinicalTrials.gov (NCT03093324).

CNS Drugs published new progress about Abdominal pain. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Netto, J B; Melo, E S A; Oliveira, A G S; Sousa, L R; Santiago, L R; Santos, D M; Chagas, R C R; Gonçalves, A S; Thomé, R G; Santos, H B; Reis, R M; Ribeiro, R I M A published the artcile< Matteucinol combined with temozolomide inhibits glioblastoma proliferation, invasion, and progression: an in vitro, in silico, and in vivo study.>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is .

Glioblastoma is the most prevalent and malignant brain tumor identified in adults. Surgical resection followed by radiotherapy and chemotherapy, mainly with temozolomide (TMZ), is the chosen treatment for this type of tumor. However, the average survival of patients is around 15 months. Novel approaches to glioblastoma treatment are greatly needed. Here, we aimed to investigate the anti-glioblastoma effect of the combination of matteucinol (Mat) (dihydroxyflavanone derived from Miconia chamissois Naudin) with the chemotherapeutic TMZ in vitro using tumor (U-251MG) and normal astrocyte (NHA) cell lines and in vivo using the chick embryo chorioallantoic membrane (CAM) assay. The combination was cytotoxic and selective for tumor cells (28 μg/mL Mat and 9.71 μg/mL TMZ). Additionally, the combination did not alter cell adhesion but caused morphological changes characteristic of apoptosis in vitro. Notably, the combination was also able to reduce tumor growth in the chick embryo model (CAM assay). The docking results showed that Mat was the best ligand to the cell death membrane receptor TNFR1 and to TNFR1/TMZ complex, suggesting that these two molecules may be working together increasing their potential. In conclusion, Mat-TMZ can be a good candidate for pharmacokinetic studies in view of clinical use for the treatment of glioblastoma.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ziu, Mateo; Goyal, Sharad; Olson, Jeffrey J. published the artcile< Congress of Neurological Surgeons systematic review and evidence-based guidelines update on the role of radiation therapy in the management of progressive and recurrent glioblastoma in adults>, Product Details of C19H34O2, the main research area is meta analysis temozolomide anticancer radiation therapy adult recurrent glioblastoma; Adult; Brain tumor; Glioblastoma; Glioma; Progressive; Radiation therapy; Radiosurgery; Recurrent.

These recommendations apply to adult patients (18 years of age and above) with progressive/recurrent glioblastoma multiforme (pGBM) after first line combined multimodality treatment. Can re-irradiation (by using conventional radiotherapy, fractionated radiosurgery, or single fraction radiosurgery) be used in patients with pGBM after the first adjuvant combined multimodality treatment with radiation and chemotherapy. Level III: When the target tumor is amenable for addnl. radiation, re-irradiation is recommended as it provides improved local tumor control, as measured by best imaging response. Such re-irradiation can take the form of conventional fractionation radiotherapy, fractionated radiosurgery, or single fraction radiosurgery. Level III: Re-Irradiation is recommended in order to maintain or improve a patients neurol. status and quality of life prior to any further tumor progression.

Journal of Neuro-Oncology published new progress about Adult, mammalian. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kang, Qing-Qing; Meng, Ya-Nan; Zhang, Jun-Hao; Li, Long; Ge, Guo-Ping; Zheng, Hongxing; Liu, Hongxin; Wei, Wen-Ting published the artcile< Iron-catalyzed oxidative cyclization of olefinic 1,3-dicarbonyls with ketone C(sp3)-H bonds: Facile access to 2,3-dihydrofurans>, Recommanded Product: Ethyl 3-oxo-3-phenylpropanoate, the main research area is dihydrofuran preparation regioselective; olefinic dicarbonyl compound ketone oxidative cyclization iron catalyst; dicarbonyl compound allyl bromide allylation.

Iron-catalyzed oxidative cyclization of olefinic 1,3-dicarbonyls with ketone C(sp3)-H bonds through C-C and C-O bond formations has been described for the first time. A broad substrate scope and ease of scale-up are the attractive features of this synthetic method, which provides a series of potentially bioactive 2,3-dihydrofurans. The reaction pathway is proposed to involve a radical addition of the in situ-formed α-carbonyl radical to the C=C bond of olefinic 1,3-dicarbonyls followed by intramol. 5-endo-trig cyclization.

New Journal of Chemistry published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (unsaturated). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Recommanded Product: Ethyl 3-oxo-3-phenylpropanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Qiankun; Xia, Jin; Wang, Jianping; He, Zhuoyao; Zhao, Wenbin; Qian, Yong; Zheng, Liang; Liu, Rui; Lu, Xingcai published the artcile< Experimental study on ignition and combustion characteristics of biodiesel-butanol blends at different injection pressures>, Synthetic Route of 112-63-0, the main research area is butanol biodiesel ignition combustion injection pressure.

In this work, the biodiesel derived from animal and vegetable oils was investigated, and it was mixed with 10%, 30% and 50% of n-butanol by volume The objective of the investigation is to explore the ignition and combustion characteristics of biodiesel-butanol blends at different injection pressures. The experiment was performed in a constant volume combustion chamber. An injector with a single-hole nozzle was adapted to inject different fuels into the combustion chamber with a static environment. The ignition and combustion processes were captured by a high-speed camera with schlieren imaging technique and natural luminosity imaging technique, resp. A few macroscopic ignition and combustion parameters were obtained and analyzed, such as ignition delay time, ignition distance, flame area and flame luminosity. Results show that the ignition delay times of all tested fuels increase with decreased injection pressure or increased n-butanol proportion. Increasing the injection pressure or n-butanol proportion could increase the ignition distance. The variation law of the flame area is analogus to that of spatially integrated natural luminosity. Increasing the n-butanol proportion or injection pressure decrease the combustion duration and the variation rate of flame area and spatially integrated natural luminosity. The time integrated natural luminosity decreases with increasing the injection pressure or n-butanol proportion. In addition, the flame has a larger fluctuation with adding a large proportion of n-butanol, which is not beneficial for ignition and combustion processes.

Renewable & Sustainable Energy Reviews published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kamjam, Manita; Wongsawaeng, Doonyapong; Ngaosuwan, Kanokwan; Kiatkittipong, Worapon; Hosemann, Peter; Assabumrungrat, Suttichai published the artcile< Upgrading palm biodiesel properties via catalyst-free partial hydrogenation using needle-plate dielectric barrier discharge plasma torch>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is fatty acid methyl ester dielec barrier discharge partial hydrogenation.

Summary : SummaryA catalyst-free and ambient condition dielec. barrier discharge (DBD) plasma torch has been used to efficaciously synthesize partially hydrogenated fatty acid Me ester (H-FAME) obtained from refined palm oil. The electrode configuration was a needle-to-plate type. The effects of power, H2 flow rate, discharge gap, process temperature and reaction duration on H-FAME compositions and properties were examined For 1 h of reaction time, the optimal condition was 100 W input power, 1.0 L/min H2 flow rate, 1.0 cm discharge gap and 90°C reaction temperature Under this condition, the H-FAME contained saturated FAMEs of 56.8% and unsaturated FAMEs of 43.1%, compared to saturated FAMEs of 48.8% and unsaturated FAMEs of 51.0% in the feed FAME. After 1 h of treatment, the oxidation stability increased by 10.7 h (from 12.8 to 23.5 h), while the cloud point increased from 13.5 to 16.0°C. A reduction rate of iodine value was 13.4%/h (reduction from 50.6 to 43.8). The trans-fatty acid formation was not detected in the palm H-FAME. Partial hydrogenation through the DBD plasma torch without using artificial antioxidants or metal catalysts is an environment-friendly and potentially alternative approach, which can substitute conventional catalytic hydrogenation of FAME for enhancing the oxidation stability of biodiesel.

International Journal of Energy Research published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

More, Swati S.; Vince, Robert published the artcile< Inhibition of Glyoxalase I: The First Low-Nanomolar Tight-Binding Inhibitors>, Reference of 77215-54-4, the main research area is glutathione based peptide hydroxamate preparation low nanomolar inhibitor glyoxalase.

A series of rational modifications to the structure of known S-(N-aryl-N-hydroxycarbamoyl)glutathione-based glyoxalase I inhibitors culminated in the discovery of the first single-digit nanomolar inhibitor. This study makes available key information about possible means to address the issues of metabolic instability, low potency, and synthetic complexity that have plagued the area of glyoxalase I inhibition. Knowledge garnered from this study has implications in the design of inhibitors with higher conformational definition and lower peptidic character.

Journal of Medicinal Chemistry published new progress about Enzyme functional sites, active. 77215-54-4 belongs to class esters-buliding-blocks, and the molecular formula is C12H24N2O4, Reference of 77215-54-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics