Month: November 2022

Dai, Peng-Fei; Ning, Xiao-Shan; Wang, Hua; Cui, Xian-Chao; Liu, Jie; Qu, Jian-Ping; Kang, Yan-Biao published the artcile< Cleavage of C(aryl)-CH3 Bonds in the Absence of Directing Groups under Transition Metal Free Conditions>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is carbon carbon bond cleavage borylation metal free condition diboron; tolyl bond cleavage borylation metal free condition; boranes aryl preparation reactivity; borylation; cross-coupling; oxidation; radicals; reaction mechanisms.

Organic chemists now can construct C-C σ-bonds selectively and sequentially, whereas methods for the selective cleavage of C-C σ-bonds, especially for unreactive hydrocarbons, remain limited. Activation by ring strain, directing groups, or in the presence of a carbonyl or a cyano group is usually required. By using a sequential strategy site-selective cleavage and borylation of C(aryl)-CH3 bonds was developed under directing group free and transition metal free conditions. Me groups of various arenes are selectively cleaved and replaced by boryl groups. Mechanistic anal. suggests that it proceeds by a sequential intermol. oxidation and coupling of a transient aryl radical, generated by radical decarboxylation, involving a pyridine-stabilized persistent boryl radical.

Angewandte Chemie, International Edition published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ahmed, Ghadia; Awan, Zahoor ul Hussain; Butt, Faaz Ahmed; Raza, Faizan; Hashmi, Saud; Gnana Kumar, G.; Christy, Maria published the artcile< The study of different redox mediators for competent Li-air batteries>, Product Details of C19H34O2, the main research area is review lithium air battery energy storage stability.

A review. Li-air batteries attract abundant attention in recent years with superior performance, and have largely replaced traditional methods of energy storage. The main objective of Li-air battery is to provide long-range elec.-vehicles, while functioning as an environmentally friendly and compact energy storage solution They offer the highest theor. energy d. (3500 Wh/kg), almost 20% higher than the ordinary Li-ion batteries. Nonetheless, Li-air batteries still face numerous issues, the most serious of which are high overpotential and parasitic reactions. Several redox mediators (RM) have been studied in order to reduce the high overpotential and the influence of side reactions. RM function in the electrolyte as soluble catalysts, limiting the formation of singlet oxygen while promoting the formation of discharge product Li2O2. This research primarily focuses on the optimization of Li-air cells with different redox mediators in conjunction with appropriate electrolyte, as a result reducing overpotential, parasitic byproducts and increasing efficiency. Under standard electrolytic conditions, ruthenocene exhibits high stability by completing 83 cycles, thus outperforming the other mediators being investigated. Further, di-tert-butyl-1,4-benzoquinone is more commonly used for discharge reaction and has been shown to increase the capacity of Li-O2 batteries by 80 times. This study reconfirms lithium bis(trifluoromethylsulfonyl) imide in tetraethyleneglycol dimethylether as the most stable electrolyte.

Journal of Power Sources published new progress about Batteries (lithium air). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Al-Ansari, Sali; Jalali, Rozita; Bronckers, Antonius L. J. J.; van Tellingen, Olaf; Raber-Durlacher, Judith; Nadjmi, Nasser; Brook, Alan Henry; de Lange, Jan; Rozema, Frederik R. published the artcile< Tooth Formation as Experimental Model to Study Chemotherapy on Tissue Development: Effect of a Specific Dose of Temozolomide/Veliparib>, Reference of 112-63-0, the main research area is ameloblast; antineoplastic agents; dental epithelium; gap junction; ion and fluid transport; tooth formation.

Background: Chemotherapy treatment of cancer in children can influence formation of normal tissues, leading to irreversible changes in their structure and function. Tooth formation is susceptible to several types of chemotherapy that induce irreversible changes in the structure of enamel, dentin and dental root morphol. These changes can make the teeth more prone to fracture or to caries when they have erupted. Recent studies report successful treatment of brain tumors with the alkylating drug temozolomide (TMZ) in combination with veliparib (VLP) in a glioblastoma in vivo mouse model. Whether these drugs also affect tooth formation is unknown. Aim: In this study the effect of TMZ/VLP on incisor formation was investigated in tissue sections of jaws from mice and compared with mice not treated with these drugs. Materials and method: The following aspects were studied using immunohistochem. of specific protein markers including: (1) proliferation (by protein expression of proliferation marker Ki67) (2) a protein involved in paracellular ion transport (expression of tight junction (TJ) protein claudin-1) and (3) in transcellular passage of ions across the dental epithelium (expression of Na+, K+ 2Cl- cotransporter/NKCC1). Results: Chemotherapy with TMZ/VLP strongly reduced immunostaining for claudin-1 in distal parts of maturation ameloblasts. No gross changes were found in the treated mice, either in cell proliferation in the dental epithelium at the cervical loop or in the immunostaining pattern for NKCC1 in (non-ameloblastic) dental epithelium. The salivary glands in the treated mice contained strongly reduced immunostaining for NKCC1 in the basolateral membranes of acinar cells. Discussion/Conclusions: Based on the reduction of claudin-1 immunostaining in ameloblasts, TMZ/VLP may potentially influence forming enamel by changes in the structure of TJs structures in maturation ameloblasts, structures that are crucial for the selective passage of ions through the intercellular space between neighboring ameloblasts. The strongly reduced basolateral NKCC1 staining seen in fully-grown salivary glands of TMZ/VLP-treated mice suggests that TMZ/VLF could also influence ion transport in adult saliva by the salivary gland epithelium. This may cause treated children to be more susceptible to caries.

Genes published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Altinoz, Meric A.; Ozpinar, Aysel published the artcile< Oxamate targeting aggressive cancers with special emphasis to brain tumors>, Electric Literature of 112-63-0, the main research area is oxamate brain tumor progression; Glioblastoma; Invasive pituitary adenoma; Medulloblastoma; Oxamate; Phenformin; Warburg effect.

Cancer is one of the main causes of human mortality and brain tumors, including invasive pituitary adenomas, medulloblastomas and glioblastomas are common brain malignancies with poor prognosis. Therefore, the development of innovative management strategies for refractory cancers and brain tumors is important. In states of mitochondrial dysfunction – commonly encountered in malignant cells – cells mostly shift to anaerobic glycolysis by increasing the expression of LDHA (Lactate Dehydrogenase-A) gene. Oxamate, an isosteric form of pyruvate, blocks LDHA activity by competing with pyruvate. By blocking LDHA, it inhibits protumorigenic cascades and also induces ROS (reactive oxygen species)-induced mitochondrial apoptosis of cancer cells. In preclin. studies, oxamate blocked the growth of invasive pituitary adenomas, medulloblastomas and glioblastomas. Oxamate also increases temozolomide and radiotherapy sensitivity of glioblastomas. Oxamate is highly polar, which may preclude its clin. utilization due to low penetrance through cell membranes. However, this obstacle could be overcome with nanoliposomes. Moreover, different oxamate analogs were developed which inhibit LDHC4, an enzyme also involved in cancer progression and germ cell physiol. Lastly, phenformin, an antidiabetic agent, exerts anticancer effects via complex I inhibition in the mitochondria and leading the overproduction of ROS. Oxamate combination with phenformin reduces the lactic acidosis-causing side effect of phenformin while inducing synergistic anticancer efficacy. In sum, oxamate as a single agent and more efficiently with phenformin has high potential to slow the progression of aggressive cancers with special emphasis to brain tumors.

Biomedicine & Pharmacotherapy published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ono, Masahiro; Haratake, Mamoru; Nakayama, Morio; Kaneko, Yoshikazu; Kawabata, Koichi; Mori, Hiroshi; Kung, Mei-Ping; Kung, Hank F. published the artcile< Synthesis and biological evaluation of (E)-3-styrylpyridine derivatives as amyloid imaging agents for Alzheimer's disease>, Computed Properties of 112-63-0, the main research area is iodine 125 dimethylaminostyrylpyridine preparation amyloid imaging agent Alzheimer.

A new series of (E)-3-styrylpyridine derivatives as potential diagnostic imaging agents targeting amyloid plaques in Alzheimer’s disease (AD) were synthesized and examined When in vitro binding studies using AD brain homogenates were carried out with a series of styrylpyridine derivatives, (E)-2-Bromo-5-(4-dimethylaminostyryl)pyridine (7) with a dimethylamino group showed the highest binding affinity. Compound 7 intensely stained neuritic and diffused plaques and cerebrovascular amyloids on postmortem AD brain sections. (E)-2-Iodo-5-(4-dimethylaminostyryl)pyridine (9), the iodo derivative of compound 7, also stained senile plaques in human AD sections. The radioiodinated ligand [125I]9 was successfully prepared through an iododestannylation reaction from the corresponding tributyltin derivatives using hydrogen peroxide as the oxidant in high yields and with high radiochem. purity. A biodistribution study in normal mice after an i.v. injection of [125I]9 displayed high brain uptake and fast washout. Taken together, the data suggest that the new radio tracer, [125I]9, may be useful as a radioiodinated imaging agent for mapping Aβ plaques in the brains of patients with AD.

Nuclear Medicine and Biology published new progress about Alzheimer disease. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kumar, Manoj; Reddy, Thurpu Raghavender; Gurawa, Aakanksha; Kashyap, Sudhir published the artcile< Copper(II)-catalyzed stereoselective 1,2-addition vs. Ferrier glycosylation of ""armed"" and ""disarmed"" glycal donors>, Category: esters-buliding-blocks, the main research area is trisaccharide stereoselective addition copper catalyzed glycoconjugate glycal nucleoside; amino acid glycoside preparation stereoselective glycosylation Ferrier glycal alc.

Selective activation of “”armed’ and ”disarmed”” glycal donors enabling the stereo-controlled glycosylations by employing Cu(II)-catalyst as the promoter has been realized. The distinctive stereochem. outcome in the process is mainly influenced by the presence of diverse protecting groups on the donor and the solvent system employed. The protocol is compatible with a variety of aglycons including carbohydrates, amino acids, and natural products to access deoxy-glycosides and glycoconjugates with high α-anomeric selectivity. Notably, the synthetic practicality of the method is amply verified for the stereoselective assembling of trisaccharides comprising 2-deoxy components. Mechanistic studies involving deuterated experiments validate the syn-diastereoselective 1,2-addition of acceptors on the double bond of armed donors.

Organic & Biomolecular Chemistry published new progress about Addition reaction catalysts, stereoselective. 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hajipour, Abdol Reza; Ruoho, Arnold E. published the artcile< Nitric acid in the presence of P2O5 supported on silica gel - a useful reagent for nitration of aromatic compounds under solvent-free conditions>, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate, the main research area is arene nitric acid silica supported phosphorus oxide nitration solventfree; nitro aromatic preparation.

A variety of aromatic compounds are nitrated to parent nitro aromatic compounds under solvent-free conditions using 65% HNO3 in the presence of P2O5 supported on silica gel. This methodol. is useful for nitration of activated and deactivated aromatic rings.

Tetrahedron Letters published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hong, Sihui; She, Yongxin; Cao, Xiaolin; Wang, Miao; He, Yahui; Zheng, Lufei; Wang, Shanshan; Abd El-Aty, A. M.; Hacimuftuoglu, Ahmet; Yan, Mengmeng; Wang, Jing published the artcile< A novel CdSe/ZnS quantum dots fluorescence assay based on molecularly imprinted sensitive membranes for determination of triazophos residues in cabbage and apple>, Reference of 3290-92-4, the main research area is cadmium selenium zinc sulfide quantumdot fluorescence triazofos sensitive membrane; CdSe/ZnS QDs probe; cabbage and apple; fluorescence assay; imprinted array film; triazophos.

In the present study we have developed a direct competitive CdSe/ZnS quantum dot (QD) fluorescence assay based on micro-array-imprinted membranes for the determination of triazophos in cabbage and apple. The imprinted membranes were directly synthesized on the surface of a 96-well plate by thermal polymerization using triadimefon as the dummy template. Under optimal conditions, the assay showed an excellent linear response over the concentration ranges of 0.1-10,000μg L-1 with a good coefficient of determination (R2= 0.982). The sensitivity (IC50) and limit of detection (LOD, expressed as IC15) of the developed assay were 3.63 mg L-1 and 0.31μg L-1, resp. The applicability of the developed approach was tested for detecting triazophos in incurred samples. The method showed excellent recoveries (109.6-118.9%) and relative standard deviations (RSDs) between 9.9 and 19.5%. The obtained results correlated well with those obtained by LC-MS/MS (R2= 0.9995). The competitive assay using CdSe/ZnS QDs as fluorescence-labeled probe showed good sensitivity, steady and fast response, and excellent anti-interference ability compared to conventional fluorescence-quenching methods. Finally, the feasibility of the proposed methodol. was successfully applied for detection of triazophos in real samples.

Frontiers in Chemistry (Lausanne, Switzerland) published new progress about Apple. 3290-92-4 belongs to class esters-buliding-blocks, and the molecular formula is C18H26O6, Reference of 3290-92-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

De Joarder, Dripta; Gayen, Subrata; Sarkar, Rajarshi; Bhattacharya, Rajarshi; Roy, Sima; Maiti, Dilip K. published the artcile< (Ar-tpy)RuII(ACN)3: A Water-Soluble Catalyst for Aldehyde Amidation, Olefin Oxo-Scissoring, and Alkyne Oxygenation>, Application In Synthesis of 4098-06-0, the main research area is aldehyde amidation olefin scissoring alkyne oxygenation ruthenium catalyst water.

The synthetic chemists always look for developing new catalysts, sustainable catalysis, and their applications in various organic transformations. Herein, the authors report a new class of water-soluble complexes, (Ar-tpy)RuII(ACN)3, using designed terpyridines possessing electron-donating and -withdrawing aromatic residues for tuning the catalytic activity of the Ru(II) complex. These complexes displayed excellent catalytic activity for several oxidative organic transformations including late-stage C-H functionalization of aldehydes with NH2OR to valuable primary amides in nonconventional aqueous media with excellent yield. Its diverse catalytic power was established for direct oxo-scissoring of a wide range of alkenes to furnish aldehydes and/or ketones in high yield using a low catalyst loading in the water. Its smart catalytic activity under mild conditions was validated for dioxygenation of alkynes to highly demanding labile synthons, 1,2-diketones, and/or acids. This general and sustainable catalysis was successfully employed on sugar-based substrates to obtain the chiral amides, aldehydes, and labile 1,2-diketones. The catalyst is recovered and reused with a moderate turnover. The proposed mechanistic pathway is supported by isolation of the intermediates and their characterization. This multifaceted sustainable catalysis is a unique tool, especially for late-stage functionalization, to furnish the targeted compounds through frequently used amidation and oxygenation processes in the academia and industry.

Journal of Organic Chemistry published new progress about Addition reaction catalysts (oxygenation catalysts). 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Application In Synthesis of 4098-06-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Piroli, Gerardo G.; Manuel, Allison M.; Patel, Tulsi; Walla, Michael D.; Shi, Liang; Lanci, Scott A.; Wang, Jingtian; Galloway, Ashley; Ortinski, Pavel I.; Smith, Deanna S.; Frizzell, Norma published the artcile< Identification of novel protein targets of dimethyl fumarate modification in neurons and astrocytes reveals actions independent of Nrf2 stabilization>, HPLC of Formula: 112-63-0, the main research area is neuroblastoma cell neuron astrocyte Nrf2 dimethyl fumarate; Chemical biology; Dimethyl fumarate; Drug targets*; Mechanism of action; Post-translational modifications*; Protein adducts; Succination.

The fumarate ester di-Me fumarate (DMF) has been introduced recently as a treatment for relapsing remitting multiple sclerosis (RRMS), a chronic inflammatory condition that results in neuronal demyelination and axonal loss. DMF is known to act by depleting intracellular glutathione and modifying thiols on Keap1 protein, resulting in the stabilization of the transcription factor Nrf2, which in turn induces the expression of antioxidant response element genes. We have previously shown that DMF reacts with a wide range of protein thiols, suggesting that the complete mechanisms of action of DMF are unknown. Here, we investigated other intracellular thiol residues that may also be irreversibly modified by DMF in neurons and astrocytes. Using mass spectrometry, we identified 24 novel proteins that were modified by DMF in neurons and astrocytes, including cofilin-1, tubulin and collapsin response mediator protein 2 (CRMP2). Using an in vitro functional assay, we demonstrated that DMF-modified cofilin-1 loses its activity and generates less monomeric actin, potentially inhibiting its cytoskeletal remodeling activity, which could be beneficial in the modulation of myelination during RRMS. DMF modification of tubulin did not significantly impact axonal lysosomal trafficking. We found that the oxygen consumption rate of N1E-115 neurons and the levels of proteins related to mitochondrial energy production were only slightly affected by the highest doses of DMF, confirming that DMF treatment does not impair cellular respiratory function. In summary, our work provides new insights into the mechanisms supporting the neuroprotective and remyelination benefits associated with DMF treatment in addition to the antioxidant response by Nrf2.

Molecular & Cellular Proteomics published new progress about Actin filament. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics