Month: November 2022

Murai, Masahito; Nishinaka, Naoki; Takai, Kazuhiko published the artcile< Iridium-Catalyzed Sequential Silylation and Borylation of Heteroarenes Based on Regioselective C-H Bond Activation>, Product Details of C19H34O2, the main research area is iridium catalyzed sequential silylation borylation heteroarene quinoline derivative; boryl silyl quinoline heteroarene derivative preparation; quinoline iridium chloride complex preparation crystal structure; mol structure iridium quinoline chloride complex; C−H bond activation; borylation; heteroarenes; iridium; silylation.

An Ir-catalyzed regioselective sequential silylation and borylation of heteroarenes was developed, which represents a rare example of unsym. intermol. C-H bond difunctionalization through the introduction of two different functionalities during a 1-pot transformation. Although the substrate scope for the dehydrogenative silylation of heteroarenes was limited mainly to electron-rich five-membered rings, the current reaction proceeds with both electron-rich and electron-deficient heteroarenes with the aid of heteroatom-directing C-H bond activation. The regioselectivity of the 2nd borylation was controlled by both steric factors and the electronic effect of the silyl group installed in the 1st step. In combination with the classic cross-coupling reaction, this method provides rapid access to multisubstituted heteroarenes.

Angewandte Chemie, International Edition published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent) (heteroarenes). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lv, Min; Cai, Yuanzhen; Hou, Weikun; Peng, Kan; Xu, Ke; Lu, Chao; Yu, Wenxing; Zhang, Weisong; Liu, Lin published the artcile< The RNA-binding protein SND1 promotes the degradation of GPX4 by destabilizing the HSPA5 mRNA and suppressing HSPA5 expression, promoting ferroptosis in osteoarthritis chondrocytes>, HPLC of Formula: 347174-05-4, the main research area is ferroptosis osteoarthritis chondrocyte gene expression analysis; Chondrocyte; Ferroptosis; GPX4; HSPA5; Osteoarthritis; SND1.

Heat shock protein family A member 5 (HSPA5), a recently identified suppressor of ferroptosis, was reported to potentially regulating osteoarthritis. However, the exact role of HSPA5 and how its expression was regulated in osteoarthritis are largely unclear. Rat primary chondrocytes were treated with 10 ng/mL IL-1β for 24 h and incubated with ferrostatin-1 (a ferroptosis inhibitor). Cell viability, production of TNF-α, ROS and MDA, expression levels of collagen II, MMP13, GPX4, and SND1, and Fe2+ concentration were detected. Gain- and loss-of-function manipulations were performed to investigate the effect of HSPA5 on chondrocyte functions, and SND1 shRNA (sh-SND1) was transfected into IL-1β-treated primary chondrocytes alone or together with sh-HSPA5. Furthermore, the interaction between HSPA5 and GPX4 and the regulation of HSPA5 on GPX4 were explored. Finally, SND1 was knocked down in the rats with osteoarthritis, and the histopathol., expression of HSPA5-GPX4 axis, and levels of oxidative stress markers were evaluated. IL-1β treatment could enhance extracellular matrix (ECM) degradation (collagen II reduced and MMP13 increased), promote ferroptosis, manifested by decreased cell viability, increased levels of TNF-α, ROS, MDA, and Fe2+ concentrations, and decreased level of GPX4 protein, and increase SND1 expression in chondrocytes, which could be reversed by ferrostatin-1. Knockdown of SND1 enhanced ECM degradation and suppressed ferroptosis IL-1β-treated chondrocytes, which could be eliminated by knockdown of HSPA5. SND1 bound with HSPA5 at the 3’UTR and destabilized the HSPA5 mRNA. HSPA5 protein directly bound with GPX4 protein and pos. regulate its expression. HSPA5 overexpression suppressed IL-1β-induced chondrocyte ferroptosis, while this effect was counteracted by GPX4 silencing. Knockdown of SND1 upregulated HSPA5 and GPX4 in rat cartilage, inhibited inflammatory damage and ferroptosis, and alleviated OA progression. The RNA-binding protein SND1 promotes the degradation of GPX4 by destabilizing the HSPA5 mRNA and suppressing HSPA5 expression, promoting ferroptosis in osteoarthritis chondrocytes.

Inflammation Research published new progress about 3′-Untranslated region Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, HPLC of Formula: 347174-05-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zurlinden, Todd J.; Saili, Katerine S.; Rush, Nathaniel; Kothiya, Parth; Judson, Richard S.; Houck, Keith A.; Hunter, E. Sidney; Baker, Nancy C.; Palmer, Jessica A.; Thomas, Russell S.; Knudsen, Thomas B. published the artcile< Profiling the ToxCast library with a pluripotent human (H9) stem cell line-based biomarker assay for developmental toxicity>, Reference of 112-63-0, the main research area is toxcast library pluripotent human stem cell line development toxicity; developmental toxicity; embryonic stem cells; predictive toxicology.

The Stemina devTOX quickPredict platform is a human pluripotent stem cell-based assay that predicts the developmental toxicity potential based on changes in cellular metabolism following chem. exposure. Using this assay, we screened 1065 ToxCast phase I and II chems. in single-concentration or concentration-response for the targeted biomarker (ratio of ornithine to cystine secreted or consumed from the media). The dataset from the Stemina (STM) assay is annotated in the ToxCast portfolio as STM. Major findings from the anal. of ToxCast_STM dataset include (1) 19% of 1065 chems. yielded a prediction of developmental toxicity, (2) assay performance reached 79%-82% accuracy with high specificity (> 84%) but modest sensitivity (< 67%) when compared with in vivo animal models of human prenatal developmental toxicity, (3) sensitivity improved as more stringent weights of evidence requirements were applied to the animal studies, and (4) statistical anal. of the most potent chem. hits on specific biochem. targets in ToxCast revealed pos. and neg. associations with the STM response, providing insights into the mechanistic underpinnings of the targeted endpoint and its biol. domain. The results of this study will be useful to improving our ability to predict in vivo developmental toxicants based on in vitro data and in silico models. Toxicological Sciences published new progress about Analysis (toxicol.). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Amouzadeh Tabrizi, Mahmoud; Shamsipur, Mojtaba; Saber, Reza; Sarkar, Saeed; Zolfaghari, Najmeh published the artcile< An ultrasensitive sandwich-type electrochemical immunosensor for the determination of SKBR-3 breast cancer cell using rGO-TPA/FeHCFnano labeled Anti-HCT as a signal tag>, COA of Formula: C19H34O2, the main research area is breast cancer cell graphene oxide.

Here in, a high sensitive sandwich-type electrochem. immunosensor for the determination of SKBR-3 breast cancer cell has been fabricated using of green synthesized reduced graphene oxide as a platform to the immobilization of primary Herceptin antibody (Anti-HCT). The various reduced graphene oxide-tetrasodium 1, 3, 6, 8-pyrenetetrasulfonic acid/metal hexacyanoferrates (rGO-TPA/MHCFnano) nanocomposites included rGO-TPA/FeHCF, rGO-TPA/CoHCF, rGO-TPA/NiHCF and rGO-TPA/CuHCF were used as electrochem. labels of secondary Herceptine antibody. The obtained result showed that the sensitivity of proposed sandwich-type electrochem. immunosensor for the determination of SKBR-3 breast cancer cells (30,000 cells mL-1) using rGO-TPA/FeHCFnano labeled secondary Herceptine antibody was higher than the other rGO-TPA/MHCFnano-labeled secondary Herceptine antibodies. The differential pulse voltammetry (DPV) technique was used for the determination of SKBR-3 breast cancer cell in the concentration range of 500-30,000 cells mL-1 with the limit of detection of 21 cells mL-1. The proposed sandwich-type electrochem. immunosensor exhibited high selectivity, liner range responsibility and good stability.

Sensors and Actuators, B: Chemical published new progress about Biocompatibility. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Devi, Jai; Kothari, Seema; Banerji, Kalyan K. published the artcile< Kinetics and mechanism of oxidation of some α-amino acids by pyridinium hydrobromide perbromide>, COA of Formula: C19H34O2, the main research area is kinetics mechanism oxidation amino acid; pyridinium hydrobromide perbromide oxidation.

Oxidation of nine α-amino acids by pyridinium hydrobromide perbromide (PHPB) in aqueous acetic acid leads to the formation of the corresponding aldehydes. The reaction is first order with respect to PHPB. Michaelis-Menten type kinetics are observed with respect to some of the amino acids while other amino acids exhibit a second order dependence. The oxidation of perdeuterioglycine showed the absence of a kinetic isotope effect. The effect of solvent composition indicates that the reaction rate increases with an increase in the polarity of the medium. Addition of pyridinium hydrobromide and bromide ion have no effect on the rate of oxidation The reaction is susceptible to both polar and steric effects of the substituents. It failed to induce polymerization of acrylonitrile. Suitable mechanisms have been proposed.

Indian Journal of Chemistry, Section A: Inorganic, Bio-inorganic, Physical, Theoretical & Analytical Chemistry published new progress about Amino acids Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), PROC (Process), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fan, Yuqi; Cao, Xiunan; Zhang, Mengmeng; Wei, Shujie; Zhu, Yameng; Ouyang, Huizi; He, Jun published the artcile< Quantitative Comparison and Chemical Profile Analysis of Different Medicinal Parts of Perilla frutescens (L.) Britt. from Different Varieties and Harvest Periods>, Application In Synthesis of 112-63-0, the main research area is Perilla harvest period medicinal profile; GC-MS; Perilla frutescens (L.) Britt.; UPLC-MS/MS; UPLC-Q-TOF-MS/MS; chemical profile; multivariate analysis; plant metabolomics.

Perilla frutescens (L.) Britt. is a plant that has been classified as one of the “”One Root of Medicine and Food””, and it can be used both as medicine and as food. To explore the influence of different varieties and harvest periods on the quality of different medicinal parts of P. frutescens, a comprehensive study on the chem. constituents of P. frutescens based on plant metabolomics was conducted. A total of 57 nonvolatile chem. components and 105 volatile chem. components of P. frutescens were characterized by ultrahigh-performance liquid chromatog. coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS) and gas chromatog.-mass spectrometry (GC-MS). Furthermore, 35, 27, and 2 nonvolatile constituents as well as 16, 16, and 18 volatile constituents were identified as potential markers for discriminating P. frutescens between different medicinal parts, different varieties, and different harvest periods, resp. Besides, 22 bioactive compounds of P. frutescens were quant. determined by a new sensitive UPLC-MS/MS method. This study comprehensively compares the differences and similarities of P. frutescens among the different medicinal parts, different varieties, and different harvest periods, and the results of this study may provide a theor. basis and guidance for studying the quality evaluation and the optimization of the harvest period of this plant.

Journal of Agricultural and Food Chemistry published new progress about Food analysis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fang, Junwei; Wang, Liping; Wang, Yang; Qiu, Mingfeng; Zhang, Yongyu published the artcile< Metabolomics combined with pattern recognition and bioinformatics analysis methods for the development of pharmacodynamic biomarkers on liver fibrosis>, Related Products of 112-63-0, the main research area is liver fibrosis pharmacodynamic biomarker metabolomics bioinformatics analysis method.

The major obstacle for the development of targeted therapies is the lack of pharmacodynamic (PD) biomarkers to provide an early readout of biol. activities. As the modulation of metabolites may reflect the biol. changes occurring in the targets, metabolomics is promising to be an efficient way to explore PD biomarkers. In the present study, a liver fibrosis rat model was established by i.p. injection of CCl4 twice weekly for 6 wk, the treatment of total aglycon extracts of Scutellaria baicalensis (TAES) was begun 4 wk after the modeling, and gas chromatog.-mass spectrometry (GC-MS) based metabolomics combined with pattern recognition and network anal. were carried out for the research on PD biomarkers of TAES on liver fibrosis. After 2 wk of treatment, TAES shows pos. effects on CCl4-induced liver fibrosis. In the metabolomics study, 63 urinary metabolites contributing to liver fibrosis were identified. Six metabolic pathways significantly enriched in metabolomics data were mapped onto a network to determine global patterns of metabolic alterations in liver fibrosis. By topol. anal., 6 metabolites with high centrality in the metabolic sub-network were selected as potential PD biomarkers. Within 24 h of the final administration, the 6 identified urine metabolic biomarkers with response to time variation of TAES were validated as PD biomarkers. This integrative study presents an attractive strategy to explore PD biomarkers, which may give insight into the actual pharmacol. effect of target drugs, and the information from PD biomarkers can be combined with pharmacokinetics to select the optimal dose and a schedule of administration for the drugs.

Molecular BioSystems published new progress about Aglycons Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Marso, Tuan Mohommed Mudassar; Kalpage, Chandrakantha Senajith; Udugala-Ganehenege, Manawadevi Yasatissa published the artcile< ZnO/CuO composite catalyst to pre-esterify waste coconut oil for producing biodiesel in high yield>, COA of Formula: C19H34O2, the main research area is zinc copper oxide composite catalyst waste coconut oil biodiesel.

The study reported herein describes a two-stepped catalytic approach to produce biodiesel from waste-coconut oil in high (> 90%) yield. In this regard, pre-esterification of the Free Fatty Acid (FFA) content (9.58 mg KOH g-1) of waste coconut oil in the presence of a simple ZnO/CuO composite, as a heterogeneous acid-catalyst to prevent competitive saponification and hydrolysis side reactions caused by FFA, followed by the base-catalyzed transesterification of the triglyceride of oil was performed. The ZnO/CuO catalyst was synthesized using a simultaneous precipitation method, and characterized by spectroscopic (FTIR, UV-Vis), SEM, XRD and XRF techniques. The surface acidity of the catalyst and the FFA value (AV) of the oil before and after the pre-esterification was determined using the Hammett indicator method. The pre-esterification was performed at different temperatures (5-125°C), time intervals (15-235 min), and using different weight percentages (wt%) of catalyst loading (0.005-2.665) and methanol-to-oil ratios. The optimum reaction conditions were identified using a central composite rotatable design (CCRD). The results of the study revealed that a small amount of the catalyst (1.66 wt%) is enough, and the catalyst could be easily recovered and reused 3-4 catalytic runs for reducing the AV of waste coconut oil by 94.53% under milder conditions (within 113 min, at 55°C in the presence of 10.5:1 methanol-to-oil ratio) than those conditions reported so far. The biodiesel obtained this way was free from soap, and consistent with ASTM-D6751 and EN-14214 standards

Reaction Kinetics, Mechanisms and Catalysis published new progress about Acid number. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mailliet, Patrick; Segal-Bendirdjian, Evelyne; Kozelka, Jiri; Barreau, Michel; Baudoin, Bernard; Bissery, Marie-Christine; Gontier, Sylvie; Laoui, Abdelazize; Lavelle, Francois published the artcile< Asymmetrically substituted ethylenediamine platinum(II) complexes as antitumor agents: synthesis and structure-activity relationships>, Category: esters-buliding-blocks, the main research area is antitumor ethylenediamine platinum complex preparation.

A series of platinum dichloroethylenediamine complexes [PtCl2(R-en)] bearing a side chain on one carbon atom of the ethylenediamine ligand, with or without a functional group on the side chain, have been prepared and investigated for antitumor activity against L1210 leukemia. They were tested both in vitro, with cisplatin-sensitive and resistant cell lines, and in vivo, with cisplatin-sensitive and resistant tumors grafted i.p. in B6D2F1 mice. The rationale for this study was to test how charge, polarity and shape fo the R side chain influence antitumor activity. Complexes carrying one or more ammonium groups on the side chain were all inactive. Derivatives with a carbamate function attached by the nitrogen atom, via a methylene group, to the ethylenediamine moiety (‘N-bound’ carbamate) were highly active in vitro and in vivo. The best results were obtained with those carbamates bearing hydrophobic substituents of intermediate size. Replacement of N-bound by O-bound carbamate or by urea groups led to decreased in vivo activity. Sulfonamide derivatives were all inactive. Good to excellent activities were also recorded for complexes bearing bulky bicycloalkyl substituents, without any functional group, attached to one ethylenediamine carbon atom. Thus, it is the steric features of the side chain rather than its polarity that appear to favor the antitumor activity of the complex. Compared to cisplatin and oxaliplatin, the present complexes do not exhibit advantages in terms of exptl. antitumor activities in solid tumor models.

Anti-Cancer Drug Design published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Choochottiros, Chantiga published the artcile< Thermal crosslinking of polylactide/star-shaped polycaprolactone for toughening and resistance to thermal deformation>, HPLC of Formula: 112-63-0, the main research area is polylactide star polycaprolactone blend thermal crosslinking deformation toughening.

The applications of polylactic acid (PLA) are limited by its brittleness and poor thermal resistance. Here, the toughness of PLA and its resistance to thermal deformation were enhanced by crosslinking it with star-shaped polycaprolactone using dicumyl peroxide as a thermal initiator. The mech. properties of the blended and crosslinked films were investigated via tensile testing. The crosslinked films of PLA/st4PCL-G exhibited toughness 1.2 times greater than that of neat PLA. The resistance to thermal deformation was investigated in a hot oven and in hot water. Although the glass-transition temperature (Tg) of the crosslinked films was lower than that of neat PLA, the crosslinked films exhibited resistance to thermal deformation and maintained shape stability without any shrinkage or distortion at temperatures greater than Tg.

Polymer Journal (Tokyo, Japan) published new progress about Crystallinity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics