Month: November 2022

Jeong, Gwi-Taek; Kim, Sung-Koo published the artcile< Efficient conversion of glucosamine to ethyl levulinate catalyzed by methanesulfonic acid>, Category: esters-buliding-blocks, the main research area is glucosamine ethyl levulinate methanesulfonic acid.

Abstract: This study is focused on the possibility of using crustacean waste shells for sustainable biofuels and chem. production We investigated the synthesis of Et levulinate (EL) from glucosamine by the methanesulfonic acidcatalyzed hydrothermal reaction using Box-Behnken design. In the Et levulinate synthesis, higher water content highly inhibited the formation of EL. Among the reaction factors, reaction temperature, catalyst concentration, and reaction time pos. affected the outcome more than substrate concentration The optimized reaction conditions were 200°C reaction temperature, 60 g/L substrate concentration, 0.75 M catalyst concentration, and 44.9 min. Under these conditions, a 22.76 mol% EL yield was achieved. These results suggest that crustacean waste shells can be used for renewable feedstocks to produce valuable chems. and biofuels.

Korean Journal of Chemical Engineering published new progress about Temperature effects, biological. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Svoboda, Jiri; Palecek, Jaroslav; Dedek, Vaclav; Mostecky, Jiri published the artcile< One-step synthesis of substituted 2-aryl-2-(bromoalkyl)-1,3-dioxolanes>, Electric Literature of 112-63-0, the main research area is bromoketalization cyclic acetophenone; ketalization bromo cyclic acetophenone; dioxolane bromoalkyl aryl.

Bromoketalization of p-RC6H4COCHR1R2 (R = H, Me2CHCH2, Ph, Me, R1 = R2 = H; R = Me2CHCH2, R1 = H, R2 = Me; R = H, R1 = R2 = Me) with ethylene glycol and pyridinium perbromide, dioxane dibromide or PhN+Me3 Br3- gave 35-84% I.

Collection of Czechoslovak Chemical Communications published new progress about Bromination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xue, Yuan; Park, Han Seul; Jiang, Chao; Yu, Jin-Quan published the artcile< Palladium-Catalyzed β-C(sp3)-H Nitrooxylation of Ketones and Amides Using Practical Oxidants>, Quality Control of 112-63-0, the main research area is ketone amide nitrooxylation palladium catalyst carbon hydrogen bond activation.

Herein, a Pd(II)-catalyzed β-C(sp3)-H nitrooxylation of ketones and native amides was reported. The fine-tuned removable aminooxyamide auxiliary enabled β-C(sp3)-H functionalization of various aliphatic ketones. Practical iron(III) nitrate nonahydrate was used as the nitrate source and a single-electron oxidant for Pd(II)/Pd(III)/Pd(IV) catalysis. For amide substrates, N-iodosuccinimide (NIS) was applied as a bystanding two-electron oxidant in combination with silver nitrate for β-C(sp3)-H nitrooxylation. Palladacycle intermediates were isolated and characterized to elucidate the reaction mechanism for the C(sp3)-H activation of ketones with the L,X-type imino-amide directing group.

ACS Catalysis published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nowak, Andrew P.; Gross, Adam F.; Drummey, Kevin; Nelson, Ashley M.; Hocken, Alexis; Pritchard, Cailean Q.; Mott, Russell; Ventuleth, Michael; Graetz, Jason published the artcile< Visually and Infrared Transparent Poly(oxalamide) Films with Mechanical Toughness>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is visually IR transparent polyoxalamide film toughness.

The growing maturity and sophistication of autonomous vehicles incorporate increasing numbers of sensors to produce multiple data streams detailing vehicle surroundings. As part of the continuous and reliable transmission of data, protection of lenses and windows for sensors from environmental damage is necessary across bands including visible (400-750 nm), near IR (0.75 to 1.5μm), and thermal wavelengths (8-15μm). Here, we report a crosslinked poly(oxalamide) based on aliphatic amine monomers and dioxalate species, resulting in transparency in both visible (400-750 nm) and multiple IR bands (0.75-1.5μm, 3.5-5.5μm, and 8-12μm). Mech. toughness (ε = ~200%, σ = 35 MPa) and network resiliency toward fluids and thermal exposure are reflective of the crosslinked network and contribute to durability and the potential to protect brittle substrates. This was demonstrated by casting free-standing films bonded onto a germanium window using the identical poly(oxalamide) resin as an adhesive. Imaging through a thermal IR camera with the coated window before and after exposure to an abrasive sand stream showed the ability to protect the underlying substrate and maintain image quality while the unprotected window was severely degraded.

ACS Applied Polymer Materials published new progress about Abrasion resistance. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guo, Aishun; Fang, Guixia; Lin, Zhenrong; Zheng, Shuishun; Zhuang, Zhijun; Lin, Ruisheng; Lin, Yanling published the artcile< Overexpression of lncRNA IRAIN restrains the progression and Temozolomide resistance of glioma via repressing IGF-1R-PI3K-NF-κB signaling pathway>, Reference of 112-63-0, the main research area is .

Background. Increasing studies have found that long noncoding RNAs (lncRNAs) contribute to regulating tumor progression. This study explores the expression characteristics, effects, and related mechanisms of lncRNA IGF1R antisense imprinted non-protein coding RNA (IRAIN) in glioma. Methods. Quant. real-time PCR (qRT-PCR) was implemented to testify the IRAIN profile in glioma tissues and paracancerous tissues, and the link between the IRAIN level and the clinicopathol. indicators of glioma was analyzed. IRAIN overexpression and knockdown cell models were constructed in glioma cells. Cell proliferation was verified by the colony formation experiment, while flow cytometry was implemented to monitor apoptosis. Transwell assay was performed to examine cell invasion and migration. Western blot (WB) was adopted to compare the profiles of the apoptosis-related proteins (Bax, Bcl2, and Caspase3) and IGF-1R-PI3K-NF-κB pathway. Results. IRAIN was down-regulated in glioma tissues (compared with adjacent normal tissues), and the low IRAIN expression was significantly linked with the larger tumor volume and higher pathol. stages. Functionally, overexpressing IRAIN abated glioma cell proliferation, invasion, and migration, promoted apoptosis, and attenuated IGF-1R-PI3K-NF-κB expression and temozolomide (TMZ) resistance, which was also confirmed in the xenograft tumor experiment The WB result showed that overexpressing IRAIN inactivated the IGF-1R-PI3K-NF-κB pathway. Addnl., the IGF-1R knockdown model was established in U251 cells. Si-IGF-1R induced cell proliferation inhibition, promoted cell death, and reduced cell migration and TMZ resistance, whereas Si-IGF-1R + IRAIN group showed no addnl. effects on glioma cells compared with the Si-IGF-1R group. Conclusion. IRAIN repressed glioma development and TMZ resistance by inactivating the IGF-1R-PI3K-NF-κB axis.

Histology and Histopathology published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hudlicky, Milos published the artcile< Fluorination with diethylaminosulfur trifluoride and related aminofluorosulfuranes>, SDS of cas: 617-55-0, the main research area is review SN; review Defluorination; review Epoxide cleavage; review Heterocycle formation; review Dehydrohalogenation; review Deamination; review Cyclization; review Labeling; review Allylic; review Dearomatization; review Oxidation; review Ether cleavage; review Chemoselective; review Oxygenation; review N Silylation; review Substitution; review Alkoxylation; review Ring formation; review Geoselective; review N Desilylation; review Amination; review Dehalogenation; review Acetal cleavage; review Aromatization; review Acylation; review Dehydrogenation; review Selective; review Ring expansion; review O Debenzylation; review Migration; review Addition; review Heterocyclization; review Dechlorination; review Cleavage; review Alkylation; review Elimination; review Fluorination; review Regioselective; review Deoxygenation; review O Desilylation; review Coupling; review O Sulfonation; review Transhalogenation; review Intramol; review S Oxidation; review C Amination; review S Desilylation; review O Alkylation; review Acetalization; review Ring cleavage; review Rearrangement; review Isomerization; review Etherification; review Sulfonation; review O Acylation; review S Amination; review Stereoselective; review Deiodination; review Retention; review Esterification; review Halogenation; review Dehydration; review Inversion; review Lactonization; review Diastereoselective; review Condensation; review Dehydroxylation; review Desulfurization; review Silylation; review Dealkoxylation; review Dehydrofluorination; review Chlorination; review Debromination; review S Deoxygenation; review Desilylation; review Ring contraction; review Thioacetal cleavage; review Debenzylation; review Desulfonation; review Shift; review P Oxidation; review Sulfurization.

A review of the article Fluorination with diethylaminosulfur trifluoride and related aminofluorosulfuranes.

Organic Reactions (Hoboken, NJ, United States) published new progress about Organic synthesis. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, SDS of cas: 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Takino, Toshikazu; Yasui, Hiroyuki; Yoshitake, Akira; Hamajima, Yoshio; Matsushita, Rokuji; Takada, Jitsuya; Sakurai, Hiromu published the artcile< A new halogenated antidiabetic vanadyl complex, bis(5-iodopicolinato)oxovanadium(IV): in vitro and in vivo insulinomimetic evaluations and metallokinetic analysis>, Application In Synthesis of 112-63-0, the main research area is vanadyl iodopicolinate diabetes treatment.

A new vanadyl complex, bis(5-iodopicolinato)oxovanadium(IV), VO(IPA)2, with a VO(N2O2) coordination mode, was prepared by mixing 5-iodopicolinic acid and VOSO4 at pH 5, with the structure characterized by electronic absorption, IR, and EPR spectra. Introduction of the halogen atom on to the ligand enhanced the in vitro insulinomimetic activity (IC50=0.45 mM) compared with that of bis(picolinato)oxovanadium(IV) (IC50=0.59 mM). The hyperglycemia of streptozotocin-induced insulin-dependent diabetic rats was normalized when VO(IPA)2 was given by daily i.p. injection. The normoglycemic effect continued for more than 14 days after the end of treatment. To understand the insulinomimetic action of VO(IPA)2, the organ distribution of vanadium and the blood disposition of vanadyl species were investigated. In diabetic rats treated with VO(IPA)2, vanadium was distributed in almost all tissues examined, especially in bone, indicating that the action of vanadium is not peripheral. Vanadyl concentrations in the blood of normal rats given VO(IPA)2 remain significantly higher and longer than those given other complexes because of its slower clearance rate. VO(IPA)2 binds with the membrane of erythrocytes, probably owing to its high hydrophobicity in addition to its binding with serum albumin. The longer residence of vanadyl species shows the higher normoglyceric effects of VO(IPA)2 among three complexes with the VO(N2O2) coordination mode. On the basis of these results, VO(IPA)2 is indicated to be a preferred agent to treat insulin-dependent diabetes mellitus in exptl. animals.

JBIC, Journal of Biological Inorganic Chemistry published new progress about Antidiabetic agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kee, Choon Wee; Chan, Ke Min; Wong, Ming Wah; Tan, Choon-Hong published the artcile< Selective Bromination of sp3 C-H Bonds by Organophotoredox Catalysis>, COA of Formula: C19H34O2, the main research area is CH bond activation regioselective bromination photoredox catalyst radical cation.

Bromination of aliphatic and benzylic sp3 C-H bonds was achieved with visible light photoredox catalysis in the presence of morpholine by using a low loading of Eosin Y disodium salt, an inexpensive organic dye, as a photoredox catalyst, easy-to-handle CBr4 is the source of bromine. The light source was a low-power household lamp and the reaction was performed without the need of an inert atm. and anhydrous solvent. Preliminary exptl. and computational studies on the mechanism strongly suggested that an N-morpholino radical was responsible for the C-H activation step. It was proposed that this was a radical relay reaction, in which a longer-lived morpholine radical was generated from a CBr3 radical, which was relatively more transient, by a thermodynamically favorable reaction and addnl. evidence for the existence of such an N-radical was obtained from radical trapping experiments The strong preference of this reaction for electron-rich hydrogen atoms, and the high sensitivity to the steric environment around the C-H bond enabled bromination to occur on the relatively stronger C-H bond (as quantified by bond dissociation enthalpy) on the same mol. The potential for utilizing this reaction to achieve mild and regioselective bromination of sp3 C-H bonds in complex mols. was exemplified by the bromination of (+)-sclareolide and acetate-protected estrone.

Asian Journal of Organic Chemistry published new progress about Abstraction reaction catalysts. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Odham, Goran; Pettersson, Bente; Stenhagen, Einar published the artcile< Use of optically active half-esters of methoxy-substituted succinic acids in the stereospecific synthesis of long chain oxygenated compounds>, Synthetic Route of 617-55-0, the main research area is tetradecanoate ester methoxy; chain lengthening malate ester; electrolytic chain lengthening lauric acid.

The isomeric half-esters of (S)-methoxysuccinic acid have been prepared in the search of suitable intermediates for the synthesis of the β-glycol group of phthiocerol. The half-esters have very similar properties and differ mainly in the mass spectra and ir spectra. Chain-lengthening of (S)-methyl 2-methoxy-3-carboxypropanoate by mixed electrolysis with dodecanoic acid in DMF gave a 21% yield of (S)-methyl 2-methoxytetradecanoate.

Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry published new progress about Coupling reaction. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Synthetic Route of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pohida, Katherine; Maloney, David J.; Mott, Bryan T.; Rai, Ganesha published the artcile< Room-Temperature, Copper-Free Sonogashira Reactions Facilitated by Air-Stable, Monoligated Precatalyst [DTBNpP] Pd(crotyl)Cl>, Application of C19H34O2, the main research area is Sonogashira coupling palladium DTBNpP crotyl catalyzed.

A novel application of [DTBNpP] Pd(crotyl)Cl (DTBNpP = di-tert-butylneopentylphosphine) (P2), an air-stable, com.-available palladium precatalyst that allows rapid access to a mono-ligated state, has been identified for room temperature, copper-free Sonogashira couplings of challenging aryl bromides and alkynes. The mild reaction conditions with TMP in DMSO afford up to 97% yields, excellent functional group tolerability, and broad reaction compatibility with access to one-pot indole formation.

ACS Omega published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics