Month: November 2022

Naidu, K. Reddi Mohan; Dadapeer, E.; Reddy, C. Bhupendra; Rao, A. Janardhan; Reddy, C. Suresh; Raju, C. Naga published the artcile< Polyethylene glycol-promoted dialkyl, aryl/heteroaryl phosphonates>, Synthetic Route of 112-63-0, the main research area is phosphite halide Michaelis Arbuzov rearrangement polyethylene glycol; phosphonate preparation.

A new, straightforward polyethylene glycol-promoted method for Michaelis-Arbuzov rearrangement was described.

Synthetic Communications published new progress about Haloalkanes Role: RCT (Reactant), RACT (Reactant or Reagent) (aryl, heteroaryl). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kaur-Bhambra, Jasmeet; Wardak, Daniel L. R.; Prosser, James I.; Gubry-Rangin, Cecile published the artcile< Revisiting plant biological nitrification inhibition efficiency using multiple archaeal and bacterial ammonia-oxidizing cultures>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is ammonia plant biol nitrification inhibition multiple archaea oxidizing culture.

Nitrification is a major process within the nitrogen (N) cycle leading to global losses of N, including fertilizer N, from natural and agricultural systems and producing significant nitrous oxide emissions. One strategy for the mitigation of these losses involves nitrification inhibition by plant-derived biol. nitrification inhibitors (BNIs). Cultivation-based studies of BNIs, including screening for new compounds, have predominantly investigated inhibition of a single ammonia-oxidising bacterium (AOB), Nitrosomonas europaea, even though ammonia oxidation in soil is usually dominated by ammonia-oxidising archaea (AOA), especially in acidic soils, and AOB Nitrosospira sp., rather than Nitrosomonas, in fertilised soils. This study aimed to assess the sensitivity of ammonia oxidation by a range of AOA and AOB pure cultures to BNIs produced by plant roots (Me 3-(4-hydroxyphenyl) propionate, sakuranetin and 1,9-decanediol) and shoots (linoleic acid, linolenic acid and Me linoleate). AOA were generally more sensitive to BNIs than AOB, and sensitivity was greater to BNIs produced by shoots than those produced by roots. Sensitivity also varied within AOA and AOB cultures and between different BNIs. In general, N. europaea was not a good indicator of BNI inhibition, and findings therefore highlight the limitations of use of a single bioassay strain and suggest the use of a broader range of strains that are more representative of natural soil communities.

Biology and Fertility of Soils published new progress about Acid soils. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jin, Bo; Wang, Tong; Chen, Jia-yi; Liu, Xiao-qing; Zhang, Yi-xin; Zhang, Xiu-ying; Sheng, Zun-lai; Yang, Hong-Liang published the artcile< Synthesis and biological evaluation of 3-(pyridine-3-yl)-2-oxazolidinone derivatives as antibacterial agents>, SDS of cas: 112-63-0, the main research area is pyridinyl oxazolidinone preparation mol docking antibiofilm antibacterial activity; 3-(pyridine-3-yl)-2-oxazolidinone; antibacterial activity; biofilm formation inhibitory activity; drug resistance development; molecular docking.

In this research, a series of 3-(pyridine-3-yl)-2-oxazolidinone derivatives I [R = (pyridin-3-yl)carbonyl, Me, N-cyclohexylcarbamoyl, etc.], II (X = F, H) was designed, synthesized, and evaluated for in vitro antibacterial activity, which included bacteriostatic, morphol., kinetic studies, and mol. docking. The results demonstrated that compounds II [R = cyclohexanecarbonyl, (2E)-3-(furan-2-yl)prop-2-enoyl (III), (2E)-3-(pyridin-3-yl)prop-2-enoyl, N-(4-chlorophenyl)carbamoyl; X = F] exhibited strong antibacterial activity similar to that of linezolid toward five Gram-pos. bacteria. After observing the effect of the drug on the morphol. and growth dynamics of the bacteria, the possible modes of action were predicted by mol. docking. Furthermore, the antibiofilm activity and the potential drug resistance assay were proceeded. These compounds exhibited universal antibiofilm activity and compound III showed significant concentration-dependent inhibition of biofilm formation. Compound III also showed a stable effect on S. pneumoniae (ATCC 49619) with less drug resistance growth for 15 days, which is much longer than that of linezolid. Overall, these results can be used to guide further exploration of novel antimicrobial agents.

Frontiers in Chemistry (Lausanne, Switzerland) published new progress about Antibacterial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Xiao-San; Chen, Tang-Ji; Xu, Zhi-Peng; Long, Juan; He, Miao-Ying; Zhan, He-Hui; Zhuang, Hai-Cai; Wang, Qi-Lin; Liu, Li; Yang, Xue-Mei; Tang, Jin-Shan published the artcile< Synthesis and biological evaluation of 3β-O-neoglycosides of caudatin and its analogues as potential anticancer agents>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is neoglycoside caudatin analogs preparation anticancer structure activity relationship; 3β-O-neoglycosides; Anticancer activity; Caudatin; Glycosylated modification.

In order to study the structure-activity relationship (SAR) of C21-steroidal glycosides toward human cancer cell lines and explore more potential anticancer agents, a series of 3β-O-neoglycosides of caudatin and its analogs were synthesized. The results revealed that most of peracetylated 3β-O-monoglycosides demonstrated moderate to significant antiproliferative activities against four human cancer cell lines (MCF-7, HCT-116, HeLa, and HepG2). Among them, 3β-O-(2,3,4-tri-O-acetyl-β-L-glucopyranosyl)-caudatin exhibited the highest antiproliferative activity aganist HepG2 cells with an IC50 value of 3.11 μM. Mech. studies showed that compound3β-O-(2,3,4-tri-O-acetyl-β-L-glucopyranosyl)-caudatin induced both apoptosis and cell cycle arrest at S phase in a dose dependent manner. Overall, these present findings suggested that glycosylation is a promising scaffold to improve anticancer activity for naturally occurring C21-steroidal aglycons, and compound3β-O-(2,3,4-tri-O-acetyl-β-L-glucopyranosyl)-caudatin represents a potential anticancer agent deserved further investigation.

Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Di; Yang, Bing; Chang, Shi-Quan; Ma, Sheng-Suo; Sun, Jian-Xin; Yi, Lin; Li, Xing; Shi, Hui-Mei; Jing, Bei; Zheng, Ya-Chun; Zhang, Chun-Lan; Chen, Feng-Guo; Zhao, Guo-Ping published the artcile< Protective effect of paeoniflorin on H2O2 induced Schwann cells injury based on network pharmacology and experimental validation>, SDS of cas: 112-63-0, the main research area is paeoniflorin neuroprotectant Schwann cell cytotoxicity apoptosis neurol disorder; H(2)O(2); Hydrogen peroxide; Network pharmacology; Paeoniflorin; Schwann cells; p38MAPK.

This study was to investigate the protective effect of paeoniflorin (PF) on hydrogen peroxide-induced injury. Firstly, “”SMILES”” of PF was searched in Pubchem and further was used for reverse mol. docking in Swiss Target Prediction database to obtain potential targets. Injury-related mols. were obtained from GeenCards database, and the predicted targets of PF for injury treatment were selected by Wayne diagram. For mechanism anal., the protein-protein interactions were constructed by String, and the KEGG anal. was conducted in Webgestalt. Then, cell viability and cytotoxicity assay were established by CCK8 assay. Also, the exptl. cells were allocated to control, model (200μmol·L-1 H2O2), SB203580 10μmol·L-1 (200μmol·L-1 H2O2+ SB203580 10μmol·L-1), PF 50μmol·L-1 (200μmol·L-1 H2O2+ PF 50μmol·L-1), and PF 100μmol·L-1 (200μmol·L-1 H2O2+ PF 100μmol·L-1) groups. We measured the intracellular ROS, Hoechst 33258 staining, cell apoptosis, the levels of Bcl-xl, Bcl-2, Caspase-3, Cleaved-caspase3, Cleaved-caspase7, TRPA1, TRPV1, and the phosphorylation expression of p38MAPK. There are 96 potential targets that may be associated with PF for injury treatment. Then, we chose the “”Inflammatory mediator regulation of TRP channels”” pathway for the exptl. verification from the first 10 KEGG pathway. In exptl. verification, H2O2 decreased the cell viability moderately (P < 0.05), and 100μmol·L -1 PF increased the cell viability significantly (P < 0.05). Depending on the difference of intracellular ROS fluorescence intensity, PF inhibited H 2O2-induced reactive oxygen species production in Schwann cells. In Hoechst 33258 staining, PF reversed the condensed chromatin and apoptotic nuclei following H2O2 treatment. Moreover, Flow cytometry results showed that PF could substantially inhibit H2O2 induced apoptosis (P < 0.05). Pretreatment with PF obviously reduced the levels of Caspase3, Cleaved-caspase3, Cleaved-caspase7, TRPA1, TRPV1, and the phosphorylation expression of p38MAPK after H 2O2 treatment (P < 0.05), increased the levels of Bcl-2, and Bcl-xl ( P < 0.05). PF inhibited Schwann cell injury and apoptosis induced by hydrogen peroxide, which mechanism was linked to the inhibition of phosphorylation of p38MAPK. Chinese Journal of Natural Medicines (Amsterdam, Netherlands) published new progress about Apoptosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ogretir, Cemil; Yarligan, Selma published the artcile< AM1 and PM3 study of the protonation tautomerization and valence tautomerization of some 4-substituted imidazoles>, Application of C19H34O2, the main research area is MO protonation tautomerization substituted imidazole; valence tautomerization substituted imidazole.

The gas-phase geometries, relative stabilities, ionization potentials and proton affinities of the different tautomers of some 4-substituted imidazoles and their N-Me derivatives were calculated with full geometry optimization. The predominance of the a (i.e. 1H-form) form with an electron-acceptor group at the 4-position over the b (i.e. 3H-form) form and the predominance of the b (i.e. 3H-form) form with an electron-donor group at the 4-position over the a (i.e. 1H-form) form were confirmed. A correlation between exptl. obtained acidity constants, pKa, and calculated proton affinities was detected.

Journal of Molecular Structure: THEOCHEM published new progress about AM1 (molecular orbital method). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lee, Yeong-Beom; Young Woo, Han; Yoon, Chong-Bok; Shim, Hong-Ku published the artcile< Simple synthetic route to soluble polyimides via nitro-displacement reaction and their second-order nonlinear optical properties>, Application of C19H34O2, the main research area is polyimide preparation second order NLO property.

Nonlinear optical (NLO) functionalized polyimides were directly synthesized using the nitro-displacement reaction between an alkanediol monomer and a diimide monomer without a thermal curing step. The polyimides were soluble in aprotic polar solvents such as DMSO, dimethylacetamide, DMF, and N-methylpyrrolidone, and showed glass transitions at temperatures between 172 and 198°C. We observed good thermal stability up to around 300°C (at 5% weight loss) for the polymers. The weight-average mol. weights of the resulting polymers were 10,400-15,100 (Mw/Mn = 1.84-2.00). The poled polymer films showed good nonlinearity (d33 = 76 pm V-1) in the Maker fringe method for second harmonic generation.

Journal of Materials Chemistry published new progress about Polyamines, polyether-polyimide- Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Burgenske, Danielle M; Talele, Surabhi; Pokorny, Jenny L; Mladek, Ann C; Bakken, Katrina K; Carlson, Brett L; Schroeder, Mark A; He, Lihong; Hu, Zeng; Gampa, Gautham; Kosel, Matthew L; Decker, Paul A; Kitange, Gaspar J; Schmitt-Hoffmann, Anne; Bachmann, Felix; Vaubel, Rachael A; Eckel-Passow, Jeanette E; Giannini, Caterina; McSheehy, Paul; Lane, Heidi A; Elmquist, William F; Sarkaria, Jann N published the artcile< Preclinical modeling in glioblastoma patient-derived xenograft (GBM PDX) xenografts to guide clinical development of lisavanbulin-a novel tumor checkpoint controller targeting microtubules.>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is drug efficacy; glioblastoma; microtubule-targeting agents; patient-derived xenografts.

BACKGROUND: Glioblastoma (GBM) is an incurable disease with few approved therapeutic interventions. Radiation therapy (RT) and temozolomide (TMZ) remain the standards of care. The efficacy and optimal deployment schedule of the orally bioavailable small-molecule tumor checkpoint controller lisavanbulin alone, and in combination with, standards of care were assessed using a panel of IDH-wildtype GBM patient-derived xenografts. METHODS: Mice bearing intracranial tumors received lisavanbulin +/-RT +/-TMZ and followed for survival. Lisavanbulin concentrations in plasma and brain were determined by liquid chromatography with tandem mass spectrometry, while flow cytometry was used for cell cycle analysis. RESULTS: Lisavanbulin monotherapy showed significant benefit (P < .01) in 9 of 14 PDXs tested (median survival extension 9%-84%) and brain-to-plasma ratios of 1.3 and 1.6 at 2- and 6-hours postdose, respectively, validating previous data suggesting significant exposure in the brain. Prolonged lisavanbulin dosing from RT start until moribund was required for maximal benefit (GBM6: median survival lisavanbulin/RT 90 vs. RT alone 69 days, P = .0001; GBM150: lisavanbulin/RT 143 days vs. RT alone 73 days, P = .06). Similar observations were seen with RT/TMZ combinations (GBM39: RT/TMZ/lisavanbulin 502 days vs. RT/TMZ 249 days, P = .0001; GBM26: RT/TMZ/lisavanbulin 172 days vs. RT/TMZ 121 days, P = .04). Immunohistochemical analyses showed a significant increase in phospho-histone H3 with lisavanbulin treatment (P = .01). CONCLUSIONS: Lisavanbulin demonstrated excellent brain penetration, significant extension of survival alone or in RT or RT/TMZ combinations, and was associated with mitotic arrest. These data provide a strong clinical rationale for testing lisavanbulin in combination with RT or RT/TMZ in GBM patients. Neuro-oncology published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guo, Xin; Basu, Kallol; Cabral, Jose A.; Paquette, Leo A. published the artcile< Relative Rate Profile for Ring-Closing Metathesis of a Series of 1-Substituted 1,7-Octadienes as Promoted by a 4,5-Dihydroimidazol-2-ylidene-Coordinated Ruthenium Catalyst>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is ruthenium imidazolylidene catalyzed ring closing metathesis octadiene Hammett analysis.

This report details the kinetic responses of nine compounds of type 6 [RCH:CH(CH2)2CH(OCH2Ph)CH2CH:CH2] to ring-closing metathesis as promoted by Grubbs’ Ru-dihydroimidazolylidene catalyst to give the identical product 7 [4-(benzyloxy)cyclohexene]. The exptl. observations have been subjected to Hammett anal. The ρ value for the composite aromatic derivatives (R = p-XC6H4-) differs from that of the aliphatic series, although both are neg. because electron-donating groups accelerate the reaction.

Organic Letters published new progress about Alkadienes Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), PROC (Process), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Jiangyan; Wang, Weitao; Kong, Jiaqi; Yue, Yadong; Dong, Yiyang; Zhang, Jichuan; Liu, Li published the artcile< Application of UHPLC-Q-TOF MS based untargeted metabolomics reveals variation and correlation amongst different tissues of Eucommia ulmoides Oliver>, Product Details of C19H34O2, the main research area is metabolomic variation Eucommia liquid chromatog mass spectrometry.

The biol. function of Eucommia ulmoides Oliver (EU) is related to its metabolites. However, due to the complexity of distribution of metabolites in different tissues, currently, the comprehensive information anal. on metabolome of EU has been limited. In this study, we analyzed the components of leaves, seeds and barks of EU by using ultra high-performance liquid chromatog.-tandem time-of-flight mass spectrometer (UHPLC-Q-TOF MS) untargeted metabolomics before 2373 metabolites were identified in total. By using Principal Component Anal. (PCA), Partial Least Square Discriminant Anal. (PLS-DA) and other multivariate statistical anal. methods, there were 116 metabolites expressing differently in all samples. The result showed that the metabolic composition of leaves was similar to that of barks and there still existed significant differences amongst different tissues in HCA anal. Besides, the heatmap of differential metabolites also showed the higher concentrations of organic acids and derivatives, lipids and lipid-like mols. in seeds compared to leaves and barks. Furthermore, we detected 13,456 metabolites-metabolites correlations and determined 1098 metabolic pairs which resulted in significant correlation by Pearsons correlation anal. At last, all detected metabolites were annotated in KEGG and 966 of them had KEGG ID. After enrichment anal., 311 metabolites were mapped in 168 pathways and 26 of these pathways had apparent influence in the metabolic differences amongst different parts of EU. This work provides the first comprehensive metabolomic of EU, which will provide theor. basis for the separation and identification of medicinal activities of EU and potentially help advance studies in EU metabolic engineering.

Microchemical Journal published new progress about Eucommia ulmoides. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics