Month: November 2022

Castro-Granell, Vanessa; Garin, Noe; Jaen, Angeles; Cenoz, Santiago; Galindo, Maria Jose; Fuster-RuizdeApodaca, Maria Jose published the artcile< Prevalence, beliefs and impact of drug-drug interactions between antiretroviral therapy and illicit drugs among people living with HIV in Spain>, HPLC of Formula: 112-63-0, the main research area is drug interaction antiretroviral illicit agent HIV infection population.

Drug use implies important challenges related to HIV management, particularly due to an increased risk of potential interactions between antiretroviral therapy (ART) and illicit drugs (pDDIs). This study analyses the prevalence and severity of pDDIs among people living with HIV (PLHIV). It also explores their awareness of pDDIs and their beliefs about the toxicity that they may cause, as well as the impact of pDDIs on selected health variables. We conducted an online cross-sectional survey across 33 Spanish hospitals and NGOs to collect demographics and clin. data. pDDIs were checked against the Interaction Checker developed by Liverpool University. The sample of the present study was composed of 694 PLHIV who used illicit drugs. They represented 49.5% of the 1,401 PLHIV that participated in the survey. After excluding 38 participants due to lack of information on their ART or illicit drug use, 335 (51.1%) participants consuming drugs presented with some potentially significant pDDIs between their ART and illicit drugs, with a mean of 2.1±1.7 (1-10) pDDIs per patient. The drugs most frequently involved in pDDIs were cocaine, cannabis, MDMA and nitrates (“”poppers””). The prevalence of pDDIs across ART regimens was: protease inhibitors (41.7%); integrase inhibitor-boosted regimens (32.1%), and non-nucleoside reverse transcriptase inhibitors (26.3%). An awareness of pDDIs and beliefs about their potential toxicity correlated pos. with intentional non-adherence (p<0.0001). Participants with pDDIs exhibited a higher prevalence of intentional non-adherence (2.19±1.04 vs. 1.93±0.94; p = 0.001). The presence of pDDIs was not associated with poorer results in the clin. variables analyzed. A significant proportion of PLHIV who use drugs experience pDDIs, thereby requiring close monitoring. pDDIs should be considered in the clin. management of HIV patients. Adequate information about pDDIs and indicators about how to manage ART when PLHIV use drugs could improve ART non-adherence. PLoS One published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kobbelgaard, Sara; Brandes, Sebastian; Jorgensen, Karl Anker published the artcile< Asymmetric organocatalyzed [1,3]-sigmatropic rearrangements>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is beta amino acid asym preparation organocatalysis; sigmatropic rearrangement beta hydroxy ester cinchona alkaloid catalyst.

The first organocatalyzed enantioselective [1,3]-sigmatropic O- to N-rearrangement reactions are presented. The reactions take place under regio- and enantioselective control, and are catalyzed by cinchona alkaloids. Two reactions have been developed; the first one is the rearrangement of imidates to amides, while the other rearrangement occurs from carbamates to amines via a decarboxylation. Both transformations give nitrogen protected β-amino acid derivatives as the product. These novel asym. organocatalyzed [1,3]-sigmatropic O- to N-rearrangement reactions provide a reliable and efficient synthetic method for obtaining enantio-enriched β-amino acid derivatives in good yields from racemic starting materials.

Chemistry – A European Journal published new progress about [1,3]-Sigmatropic rearrangement (asym., O- to N-rearrangement reaction). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kongprawes, Grittima; Wongsawaeng, Doonyapong; Hosemann, Peter; Ngaosuwan, Kanokwan; Kiatkittipong, Worapon; Assabumrungrat, Suttichai published the artcile< Improvement of oxidation stability of fatty acid methyl esters derived from soybean oil via partial hydrogenation using dielectric barrier discharge plasma>, Computed Properties of 112-63-0, the main research area is fatty acid methyl ester soybean oil hydrogenation dielec barrier.

Oxidation stability is an important biodiesel property. One of the methods to improve oxidation stability is partially hydrogenated fatty acid Me esters (H-FAME). The present research studied the novel production technique of H-FAME derived from soybean FAME using non-thermal parallel-plate dielec. barrier discharge (DBD) plasma. This green hydrogenation method does not require a catalyst and can be performed under atm. pressure and at room temperature The reaction using DBD plasma could effectively initiate the hydrogenation reaction, and the results showed similar performance to catalysis technique. The optimized process parameters for 35 mL of FAME were 25% H2, 5.5 h of reaction time, and ambient temperature This condition exhibited the highest conversion of polyunsaturated FAMEs (C18:2 and C18:3) and the highest yield of C18:1. DBD plasma hydrogenation resulted in the reduction of iodine value from 128 to 67.4. The oxidation stability was enhanced from 2.13 to 10 h while the cloud point increased from -1°C to 11°C (still within the ASTM D6751 standard). This plasma process is a new alternative and eco-friendly method for H-FAME production

International Journal of Energy Research published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Douarre, Maxime; Marti-Centelles, Vicente; Rossy, Cybille; Pianet, Isabelle; McClenaghan, Nathan D. published the artcile< Regulation of Macrocycle Shuttling Rates in [2]Rotaxanes by Amino-Acid Speed Bumps in Organic-Aqueous Solvent Mixtures>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is amino acid rotaxane preparation mol shuttle steric effect.

A homologous series of two-station [2]rotaxanes incorporating amino-acid units in the mol. thread has been developed. The degenerate [2]rotaxanes exhibit amino-acid specific shuttling rates between two fumaric stations related to the steric factor associated to the amino-acid side chain, as demonstrated by variable-temperature 1H NMR spectroscopy and exchange spectroscopy (EXSY). This allows tuning of the macrocycle shuttling rate over 4 orders of magnitude, which has a relatively small solvent dependency.

European Journal of Organic Chemistry published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nury, T.; Yammine, A.; Ghzaiel, I.; Sassi, K.; Zarrouk, A.; Brahmi, F.; Samadi, M.; Rup-Jacques, S.; Vervandier-Fasseur, D.; Pais de Barros, J. P.; Bergas, V.; Ghosh, S.; Majeed, M.; Pande, A.; Atanasov, A.; Hammami, S.; Hammami, M.; Mackrill, J.; Nasser, B.; Andreoletti, P.; Cherkaoui-Malki, M.; Vejux, A.; Lizard, G. published the artcile< Attenuation of 7-ketocholesterol- and 7β-hydroxycholesterol-induced oxiapoptophagy by nutrients, synthetic molecules and oils: Potential for the prevention of age-related diseases>, Reference of 112-63-0, the main research area is review oxiapoptophagy nutrient synthetic mol 7beta hydroxycholesterol ketocholesterol; 7-Ketocholesterol; 7β-Hydroxycholesterol; Age-related diseases; Endoplasmic reticulum; Lysosome; Mitochondria; Nutrients; Oxiapoptophagy; Oxysterol; Peroxisome.

A review. Age-related diseases for which there are no effective treatments include cardiovascular diseases; neurodegenerative diseases such as Alzheimer′s disease; eye disorders such as cataract and age-related macular degeneration; and, more recently, Severe Acute Respiratory Syndrome (SARS-CoV-2). These diseases are associated with plasma and/or tissue increases in cholesterol derivatives mainly formed by auto-oxidation: 7-ketocholesterol, also known as 7-oxo-cholesterol, and 7β-hydroxycholesterol. The formation of these oxysterols can be considered as a consequence of mitochondrial and peroxisomal dysfunction, leading to increased in oxidative stress, which is accentuated with age. 7-ketocholesterol and 7β-hydroxycholesterol cause a specific form of cytotoxic activity defined as oxiapoptophagy, including oxidative stress and induction of death by apoptosis associated with autophagic criteria. Oxiaptophagy is associated with organelle dysfunction and in particular with mitochondrial and peroxisomal alterations involved in the induction of cell death and in the rupture of redox balance. As the criteria characterizing 7-ketocholesterol- and 7β-hydroxycholesterol-induced cytotoxicity are often simultaneously observed in major age-related diseases (cardiovascular diseases, age-related macular degeneration, Alzheimer′s disease) the involvement of these oxysterols in the pathophysiol. of the latter seems increasingly likely. It is therefore important to better understand the signalling pathways associated with the toxicity of 7-ketocholesterol and 7β-hydroxycholesterol in order to identify pharmacol. targets, nutrients and synthetic mols. attenuating or inhibiting the cytotoxic activities of these oxysterols. Numerous natural cytoprotective compounds have been identified: vitamins, fatty acids, polyphenols, terpenes, vegetal pigments, antioxidants, mixtures of compounds (oils, plant extracts) and bacterial enzymes. However, few synthetic mols. are able to prevent 7-ketocholesterol- and/or 7β-hydroxycholesterol-induced cytotoxicity: di-Me fumarate, monomethyl fumarate, the tyrosine kinase inhibitor AG126, memantine, simvastatine, Trolox, dimethylsufoxide, mangafodipir and mitochondrial permeability transition pore (MPTP) inhibitors. The effectiveness of these compounds, several of which are already in use in humans, makes it possible to consider using them for the treatment of certain age-related diseases associated with increased plasma and/or tissue levels of 7-ketocholesterol and/or 7β-hydroxycholesterol.

Ageing Research Reviews published new progress about Alzheimer disease. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Wanchun; Yuan, Qiuyun; Zhang, Shuxin; Zuo, Mingrong; Li, Tengfei; Li, Junhong; Zhou, Xingwang; Li, Mao; Feng, Wentao; Xia, Xiaoqiang; Chen, Mina; Liu, Yanhui published the artcile< Elevated GIGYF2 expression suppresses tumor migration and enhances sensitivity to temozolomide in malignant glioma>, Formula: C19H34O2, the main research area is GIGYF2 tumor migration temozolomide malignant glioma.

Glioma is a common type of malignant and aggressive tumor in the brain. Despite progress on mechanistic studies, current understanding of the initiation and progression of glioma remains incomplete. GIGYF2 is a critical regulator in neural development and degeneration, however, its contribution in glioma is not yet elucidated. In this study, using an integrative approach spanning bioinformatic anal. and functional approaches, we explored the potential contribution of GIGYF2 in glioma. Bioinformatic data from public database and our cohort showed that GIGYF2 expression was closely associated with low glioma malignancy and better patient survival. Elevation of GIGYF2 expression impaired cell migration and enhanced temozolomide sensitivity of human glioma cells. We further establish its mol. mechanism by demonstrating that GIGYF2 inhibits MMP-9 mediated cell migration pathway and pro-survival AKT/Bax/Caspase-3 signaling. Our work identifies the suppressive role of GIGYF2 in gliomas, and clarifies the relationship between GIGYF2 expression and glioma malignancy, which may provide a potential target for future interventions.

Cancer Gene Therapy published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (GIGYF2). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Potcoava, Mariana C.; Futia, Gregory L.; Gibson, Emily A.; Schlaepfer, Isabel R. published the artcile< Lipid profiling using Raman and a modified support vector machine algorithm>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is lipid profiling raman modified support vector machine algorithm; LNCaP cells; Raman spectroscopy; cholesterol; fatty acids; lipid droplets; support vector machine.

Lipid droplets are dynamic organelles that play important cellular roles. They are composed of a phospholipid membrane and a core of triglycerides and sterol esters. Fatty acids have important roles in phospholipid membrane formation, signaling, and synthesis of triglycerides as energy storage. Better non-invasive tools for profiling and measuring cellular lipids are needed. Here we demonstrate the potential of Raman spectroscopy to determine with high accuracy the composition changes of the fatty acids and cholesterol found in the lipid droplets of prostate cancer cells treated with various fatty acids. The methodol. uses a modified least squares fitting (LSF) routine that uses highly discriminatory wavenumbers between the fatty acids present in the sample using a support vector machine algorithm. Using this new LSF routine, Raman micro-spectroscopy can become a better non-invasive tool for profiling and measuring fatty acids and cholesterol for cancer biol.

Journal of Raman Spectroscopy published new progress about Drops. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Heng-Yen; Anderson, Laura L. published the artcile< Interrupted Fischer-Indole Intermediates via Oxyarylation of Alkenyl Boronic Acids>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is oxyarylation alkenyl boronic acid arylhydroxamic acid copper catalyst; interrupted Fischer indole intermediate preparation copper mediated catalyzed oxyarylation; carbon oxygen bond formation rearrangement reaction mechanism study.

The oxyarylation of alkenyl boronic acids with N-arylhydroxamic acids has been achieved under both copper-mediated and copper-catalyzed conditions to provide access to interrupted Fischer-indole intermediates. This transformation is believed to proceed through a copper-promoted C-O bond forming event followed by a [3,3] rearrangement. The scope of the method is described and mechanistic experiments are discussed.

Organic Letters published new progress about [3,3]-Sigmatropic rearrangement. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Verma, Vipin Kumar; Kumar, Kh Bronson; Sagar, Komal; Majumdar, Soham; Pal, Shivani; Mehta, Arpita; Vats, Ajn; Rani, Kumari Vandana; Sehgal, Neeta; Prakash, Om published the artcile< Amelioration of immune and digestive system through weed supplemented feed against Aeromonas hydrophila in Clarias gariepinus>, Application of C19H34O2, the main research area is Aeromonas Azolla Ceratophyllum Clarias liver kidney digestive system; Aeromonas hydrophila; Azolla pinnata; Ceratophyllum demersum; Clarias gariepinus; Immunostimulatory role; Improved digestibility; Supplemented feed.

Aquaculture is one of the important globally growing industries. It serves as an important food source of protein for human beings. With the expanding demand for the fish and their products it has become extremely important to improve the aquaculture practices. Aquaculture in India has witnessed huge mortalities caused by bacteria, viruses, fungi, nematodes etc. Aquatic weeds plants are harmful for aquaculture in many ways. Present study is aimed to overcome the disease caused by Aeromonas hydrophila (fish pathogenic bacteria) through feed supplementation of two aquatic weed plants (Azolla pinnata and Ceratophyllum demersum). The fish were divided into 6 groups: exptl. groups (fish fed on supplementary feed at 5% and 2.5% concentration for individual plant and challenged with bacteria), pos. control (fish fed on non-supplemented feed and challenged with bacteria) and neg. control (fish fed on non-supplementary feed and not challenged with bacteria). It was observed that supplemented feed enhanced both cell mediated and humoral immunity in fish. Therefore, we advocate that feed formulated with incorporation of Azolla pinnata and Ceratophyllum demersum leaf powder at 5% and 2.5% could be used to prevent disease caused by A. hydrophila or can be used to enhance fish health by boosting its immune system. The results of this study also showed an improved digestibility in fish fed on supplemented feed.

Fish & Shellfish Immunology published new progress about Aeromonas hydrophila. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lou, Xiaohui; Cai, Yeyan; Zheng, Haijun; Zhang, Yazhuo published the artcile< MicroRNA-146b-5p/EPHA7 axis regulates cell invasion, metastasis, proliferation, and temozolomide-induced chemoresistance via regulation of IRAK4/TRAF6/NF-κB signaling pathway in aggressive pituitary adenoma>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is EPHA7 cell invasion metastasis proliferation TMZ signaling pathway APA.

Aggressive pituitary adenoma (APA) is a huge challenge for neurosurgeons. Temozolomide (TMZ) is conventionally used in chemotherapy against APA, but acquired resistance developed during long-term therapy limits its benefits. MiRNA-146b-5p has been confirmed to inhibit tumor metastasis. This study aimed to explore the underlying biol. functions of miRNA-146b-5p in APA. Sixty confirmed APA tissues and corresponding adjacent normal tissues were collected. We established a TMZ-resistant cell line (GH3/TMZ) by exposing GH3 cells to gradually increasing doses of TMZ for 5 mo. Cell Counting Kit-8 assay, flow cytometric anal., RNA pull-down assay, 5-ethynyl-20-deoxyuridine assay, dual-luciferase reporter gene assay, wound healing assay, and invasion assay were used to explore the malignant biol. characteristics of cells. Immunohistochem. (IHC), western blotting anal., and real-time quant. PCR (qRT-PCR) were used to analyze the expression level of related proteins and nucleic acids. The expression of miRNA-146b-5p was down-regulated not only in APA tissues but also in PA cell lines compared with the matched adjacent non-tumor tissues or normal human astrocyte (NHA) cells. Low expression of miRNA-146b-5p was notably associated with poorer disease-free survival rate (P = 0.032), overall survival rate (P = 0.039), larger tumor size (P = 0.028), poorer Knosp grade (P = 0.020), and poorer Hardy grade (P = 0.006) in APA patients. MiRNA-146b-5p neg. regulated cell proliferation, invasion, migration, and induced apoptosis in GH3 cells. Overexpression of miRNA-146b-5p suppressed IRAK4 and TRAF6 protein expression and neg. regulated NF-κB phosphorylation. The restoration of EPHA7 expression in GH3 cells notably reversed the inhibitory effects of miRNA-146b-5p. MiRNA-146b-5p expression was significantly down-regulated and EPHA7 gene expression was significantly up-regulated in GH3/TMZ cells, compared to the parental cell line. Similarly, EPHA7 was up-regulated, while the miRNA-146b-5p level was down-regulated in chemoresistance tissues more than in chemosensitive tissues. The autophagic activity was decreased markedly with increasing miRNA-146b-5p expression, while it was enhanced after Lv-EPHA7 treatment in GH3/TMZ cells. MiRNA-146b-5p can inhibit EPHA7 expression, suppress the IRAK4/TRAF6/NF-κB signaling pathway, and weaken PA cell invasion, metastasis, proliferation, and TMZ-induced chemo-resistance in vitro.

Histology and Histopathology published new progress about Apoptosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics