Month: November 2022

Melnick, Kaitlyn F.; Miller, Patricia; Carmichael, Ethan; McGrath, Kyle; Ghiaseddin, Ashley; Tran, David D.; Rahman, Maryam published the artcile< The trial effect in patients with glioblastoma: effect of clinical trial enrollment on overall survival>, Application of C19H34O2, the main research area is Clinical Trial; Glioblastoma; Glioma; Neuro-oncology.

Abstract: Purpose: To determine whether participation in a clin. trial was associated with improved survival in patients with glioblastoma (GBM). Methods: Following IRB approval, patients were identified using CPT and ICD codes. Data was collected using retrospective review of electronic medical records. When necessary, death data was obtained from online obituaries. Inverse propensity score matching was utilized to transform the two cohorts to comparable sets. Survival was compared using Kaplan-Meyer curves and Wilcoxon Rank Sum Test. Results: In this cohort of 365 patients, 89 were enrolled in a clin. trial and 276 were not. Patients enrolled in clin. trials had a significantly higher mean baseline KPS score, higher proportion of surgical resections, and were more likely to receive temozolomide treatment than patients not enrolled in a clin. trial. After inverse propensity score matching, patients enrolled in a clin. trial lived significantly longer than those not enrolled (28.8 vs 22.2 mo, p = 0.005). A potential confounder of this study is that patients not in a clin. trial had significantly fewer visits with neuro-oncologists than patients enrolled in a clin. trial (7 ± 8 vs 12 ± 9, p < 0. 0001). Conclusions: Clin. trials enroll patients with the most favorable prognostic features. Even when correcting for this bias, clin. trial enrollment is an independent predictor of increased survival regardless of treatment arm. Journal of Neuro-Oncology published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Guangzhe; Dong, Huijuan; Ma, Yao; Shao, Kun; Li, Yueqing; Wu, Xiaodan; Wang, Shisheng; Shao, Yujie; Zhao, Weijie published the artcile< Structure-activity relationships study of neolamellarin A and its analogues as hypoxia inducible factor-1 (HIF-1) inhibitors>, Computed Properties of 39987-25-2, the main research area is neolamellarin A derivative preparation HIF1 inhibitory activity SAR; Anti-tumor; Hypoxia inducible factor (HIF)-1; Marine alkaloids; Neolamellarin A; Structure-activity relationship.

The novel marine pyrrole alkaloid neolamellarin A derived from sponge has been shown to inhibit hypoxia-induced HIF-1 activity. In this work, we designed and synthesized neolamellarin A (I) and its series of derivatives by a convergent synthetic strategy. The HIF-1 inhibitory activity and cytotoxicity of these compounds were evaluated in Hela cells by dual-luciferase reporter gene assay and MTT assay, resp. The results showed that neolamellarin A (IC50 = 10.8 ± 1.0 μM) and compound II (IC50 = 11.9 ± 3.6 μM) had the best HIF-1 inhibitory activity and low cytotoxicity. Our SAR research focused on the effects of key regions aliphatic carbon chain length, aromatic ring substituents and C-7 substituent on biol. activity, providing a basis for the subsequent research on the development of novel pyrrole alkaloids as HIF-1 inhibitors and design of small mol. probes for target protein identification.

Bioorganic & Medicinal Chemistry Letters published new progress about Alkaloids Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses) (pyrrole). 39987-25-2 belongs to class esters-buliding-blocks, and the molecular formula is C6H12ClNO4, Computed Properties of 39987-25-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Balijapalli, Umamahesh; Tang, Xun; Okada, Daichi; Lee, Yi-Ting; Karunathilaka, Buddhika S. B.; Auffray, Morgan; Tumen-Ulzii, Ganbaatar; Tsuchiya, Youichi; Sandanayaka, Atula S. D.; Matsushima, Toshinori; Nakanotani, Hajime; Adachi, Chihaya published the artcile< A 2,6-Dicarbonitrile Diphenyl-1λ5-Phosphinine (DCNP)-A Robust Conjugated Building Block for Multi-Functional Dyes Exhibiting Tunable Amplified Spontaneous Emission>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is dicarbonitrile diphenyl phosphinine dye building block amplified spontaneous emission.

Highly efficient organic light-emitting diodes (OLEDs) with the concurrent achievement of high external electroluminescence quantum efficiency (EQE) and low light amplification thresholds under optical excitation have been considered as a crucial evolution towards the development of high-performance elec. pumped organic semiconductor laser diodes. Herein, a series of 2,6-dicarbonitrile-diphenyl-1λ5-phosphinine (DCNP) based donor (D)-acceptor (A) type dyes with different electron-withdrawing and donating moieties have been designed and characterized. The well-manipulated D-A strength with tunable optical properties guaranteed the low amplified spontaneous emission (ASE) thresholds of below 10μJ cm-2 and furnished a wide-range color-tuning capability in the visible region (485-595 nm). Furthermore, employing a thermally-activated delayed fluorescence (TADF) mol. as a triplet harvester boosted the performance of OLEDs based on mDMCz that exhibits an exceptional EQE value of 18.4% which is an eightfold enhancement as compared with that of standard fluorescence OLEDs. Also, the TADF-assistant fluorescence (TAF) system enables a reduction of the ASE threshold to 3μJ cm-2 and excellent ASE stability. These results provide a rational design strategy to construct color-tunable lasing dyes with reduced ASE thresholds and clarify their potentiality as the fluorescent dopant in the TAF system to utilize up-converted triplet excitons via efficient energy transfer.

Advanced Optical Materials published new progress about Absorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Feenstra, R. W.; Stokkingreef, E. H. M.; Nivard, R. J. F.; Ottenheijm, H. C. J. published the artcile< An efficient synthesis of N-hydroxy α-amino acid derivatives of high optical purity>, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate, the main research area is hydroxy amino acid; substitution hydroxy ester triflate benzylhydroxylamine.

(S)-HOCHRCO2R1 (R = Me, R1 = Et; R = CH2Ph, CH2CHMe2, CH2CO2Me, R1 = Me) were treated with (CF3SO2)2O (Tf2O) to give (S)-TfOCHRCO2R1, which were treated in situ with PhCH2ONH2 to give 78-89% (R)-PhCH2ONHCHRCO2R1 via a SN2 reaction. (S)-PhCH2ONHCHPhCO2Me was prepared similarly from (R)-HOCHPhCO2Me. The optical purity of the products ranged from 76 to 100%.

Tetrahedron Letters published new progress about Nucleophilic substitution reaction. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dai, Q.; Wang, H.; Wang, Y.; Xiao, M.; Jin, H.; Li, M.; Xia, T. published the artcile< Enhancing the sensory attributes and antioxidant properties of snus by mixing it with tea>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is tea beverage snus antioxidant sensory property.

In the present work, we investigated the chem. and volatile compositions of three tea-containing snus samples, after which their acceptability on the aromatic and taste coordination was evaluated by a professional panel. Results showed that the tea-containing snus samples exhibited better acceptability on the aroma and taste coordination profiles. Dahongpao tea (DT)-containing snus (DT-snus) exhibited the best acceptability of aromatic coordination, whereas the most favorable taste coordination was exhibited by Keemun black tea (KBT)-containing snus (KBT-snus). The antioxidant activity determined by the DPPH and ABTS assays revealed that Lu’an Guapian tea (LGT)-containing snus (LGT-snus) exhibited the highest free-radical scavenging ability. LGT-snus was also found to have the highest content of total polyphenols, amino acids, and caffeine. The highest levels of total flavonoids and soluble sugars were found in DT-snus and KBT-snus, resp. There were 88, 68, and 74 volatiles found in DT-snus, LGT-snus, and KBT-snus, resp., among which, nitrogenous compounds constituted the major category. High levels of nicotine, megastigmatrienone, neophytadiene, nicotyrine, and cotinine, which are the major volatiles in snus, were detected in the tea-containing snus samples. The mixing of tea introduced the flavor profiles of the volatiles present in the original tea into the tea-containing snus samples. Benzaldehyde, β-ionone, hexanoic acid, 3-(Z)-hexenyl ester, pyrazines, and nerolidol from LGT; furfural, benzeneethanol, nerolidol, linalool, and cedrol from DT; and nonanal, geraniol, cis-jasmone, benzenemethanol, and Me salicylate from KBT were found in high concentrations in the corresponding tea-containing snus samples.

International Food Research Journal published new progress about Acids Role: ANT (Analyte), FFD (Food or Feed Use), PRP (Properties), ANST (Analytical Study), BIOL (Biological Study), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Williams, Ashley S.; Koves, Timothy R.; Pettway, Yasminye D.; Draper, James A.; Slentz, Dorothy H.; Grimsrud, Paul A.; Ilkayeva, Olga R.; Muoio, Deborah M. published the artcile< Nicotinamide riboside supplementation confers marginal metabolic benefits in obese mice without remodeling the muscle acetyl-proteome>, Computed Properties of 112-63-0, the main research area is nicotinamide riboside supplementation obesity muscle acetyl proteome remodeling; Nutrition; Physiology; Proteomics.

Nicotinamide riboside supplements (NRS) have been touted as a nutraceutical that promotes cardiometabolic and musculoskeletal health by enhancing NAD (NAD+) biosynthesis, mitochondrial function, and/or the activities of NAD-dependent sirtuin deacetylase enzymes. This investigation examined the impact of NRS on whole body energy homeostasis, skeletal muscle mitochondrial function, and corresponding shifts in the acetyl-lysine proteome, in the context of diet-induced obesity using C57BL/6NJ mice. The study also included a genetically modified mouse model that imposes greater demand on sirtuin flux and associated NAD+ consumption, specifically within muscle tissues. In general, whole body glucose control was marginally improved by NRS when administered at the midpoint of a chronic high-fat diet, but not when given as a preventative therapy upon initiation of the diet. Contrary to anticipated outcomes, the study produced little evidence that NRS increases tissue NAD+ levels, augments mitochondrial function, and/or mitigates diet-induced hyperacetylation of the skeletal muscle proteome.

iScience published new progress about Acetylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Eberhardt, Marc; Mruk, Ralf; Zentel, Rudolf; Theato, Patrick published the artcile< Synthesis of pentafluorophenyl (meth)acrylate polymers: New precursor polymers for the synthesis of multifunctional materials>, COA of Formula: C9H3F5O2, the main research area is pentafluorophenyl acrylate methacrylate polymerization amine alc reactivity multifunctional polymer.

Pentafluorophenyl acrylate and -methacrylate were polymerized using AIBN as a thermal initiator. The obtained polymers were soluble polymeric active esters that could be used for the preparation of multifunctional polymers. The reactivity of poly(pentafluorophenyl acrylate) and poly(pentafluorophenyl methacrylate) towards primary and secondary amines, as well as alcs. was investigated in a quant. way. Both poly(active esters) reacted satisfactorily with aliphatic primary and secondary amines but only low conversion was found in the case of aromatic amines. Conversions of only 30% were reached when poly(pentafluorophenyl acrylate) was treated with one equivalent of alc. under base catalysis. In time resolved FT-IR studies the rate constants of the polymer analogous reactions were determined

European Polymer Journal published new progress about Fluoropolymers Role: SPN (Synthetic Preparation), PREP (Preparation). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, COA of Formula: C9H3F5O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Parrot, Isabelle; Bisi, Helene; Folliard, Arnaud; Bonnard, Michel published the artcile< Volatile Compounds from Flowers of Elaeagnus x submacrophylla Servett.: Extraction, Identification of Flavonoids, and Antioxidant Capacity>, Computed Properties of 112-63-0, the main research area is Elaeagnus submacrophylla flavonoid volatile compound extraction antioxidant capacity; Elaeagnus submacrophylla; antioxidants; flavonoids; phenolic content; volatile compounds.

Beneficial to the ecosystem and with significant potential in permaculture, Elaeagnus x submacrophylla Servett. was studied here mainly for the identification of its floral odorants. After olfactory evaluation and determination of the volatile profile of freshly picked flowers by headspace/solid phase microextraction coupled with gas chromatog./mass spectrometry, an ethanolic extract was prepared and investigated for its antioxidant capacity. Unusual mols. were identified in the floral headspace, such as isochavicol or chrysanthemum acetate. The evaluation of the in vitro free radical scavenging capacity (from 0.4 to 1.3 mmol TE/g) and total phenolic content (65.1 mg GAE/g) of the extract pointed out a promising antioxidant activity, potentially related to the identification of several flavonoid glycosides. These results have to be considered in the context of the ever-increasing need to produce innovative natural extracts with notably interesting claims for the cosmetic field.

ChemPlusChem published new progress about Alcohols Role: ANT (Analyte), FFD (Food or Feed Use), PAC (Pharmacological Activity), ANST (Analytical Study), BIOL (Biological Study), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kammel, Richard; Tarabova, Denisa; Broz, Bretislav; Hladikova, Veronika; Hanusek, Jiri published the artcile< Formation of 3-[amino(aryl)-methylidene]-1,3-dihydro-2H-indol-2-ones involving ring transformation of 2-aryl-5-(2-aminophenyl)-4-hydroxy-1,3-thiazoles>, Product Details of C9H9NO4, the main research area is Hammett correlation kinetics ring transformation aryl aminophenyl hydroxythiazole; amino arylmethylidene indolone preparation Eschenmoser coupling; ring transformation aryl aminophenyl hydroxythiazole kinetics.

The reaction of 3-bromooxindole with substituted (hetero)aromatic thioamides in acetonitrile was studied. At room temperature the reaction preferably gives products of ring transformation i.e. 2-aryl-5-(2-aminophenyl)-4-hydroxy-1,3-thiazoles whereas at elevated temperature products of an Eschenmoser coupling reaction, i.e. 3-[amino(aryl)-methylidene]-1,3-dihydro-2H-indol-2-ones, are formed exclusively. There exist only two exceptions (4-methoxy and 2-pyridinthioamide) in which the Eschenmoser coupling reaction always takes place. Also N-methylation of the starting 3-bromooxindole completely prevents formation of thiazoles. The prepared thiazoles are unstable in solution and they undergo slow ring transformation to the expected Eschenmoser coupling products. The rate limiting step of this rearrangement involves cleavage of an intermediary thiirane ring, which is slowed down by electron-withdrawing substituents on the thioamide (ρ = -1.15).

Tetrahedron published new progress about C-S bond (cleavage). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Product Details of C9H9NO4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bandarage, Upul K.; Court, John; Gao, Huai; Nanthakumar, Suganthini; Come, Jon H.; Giroux, Simon; Green, Jeremy published the artcile< ROCK inhibitors 4: Structure-activity relationship studies of 7-azaindole-based rho kinase (ROCK) inhibitors>, Electric Literature of 112-63-0, the main research area is ROCK inhibitors protein kinase A microsome hepatocyte; 7-Azaindole; Rho kinase (ROCK); Thiazole; protein kinase A (PKA).

Rho kinase (ROCK) inhibitors are of therapeutic value for the treatment of disorders such as hypertension and glaucoma, and potentially of wider use against diseases such as cancer and multiple sclerosis. We previously reported a series of potent and selective ROCK inhibitors based on a substituted 7-azaindole scaffold. Here we extend the SAR exploration of the 7-azaindole series to identify leads for further evaluation. New compounds such as 16, 17, 19, 21 and 22 showed excellent ROCK potency and protein kinase A (PKA) selectivity, combined with microsome and hepatocyte stability.

Bioorganic & Medicinal Chemistry Letters published new progress about Bioavailability. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics