Month: November 2022

Lu, Chuanjun; Guo, Yueyan; Yan, Jun; Luo, Zonghua; Luo, Hai-Bin; Yan, Ming; Huang, Ling; Li, Xingshu published the artcile< Design, Synthesis, and Evaluation of Multitarget-Directed Resveratrol Derivatives for the Treatment of Alzheimer's Disease>, Related Products of 112-63-0, the main research area is resveratrol derivative preparation Alzheimer treatment beta amyloid aggregation inhibitor; biometal chelator resveratrol derivative Alzheimer treatment; antioxidant resveratrol derivative Alzheimer treatment.

A series of multitarget-directed resveratrol derivatives was designed and synthesized for the treatment of Alzheimer’s disease (AD). In vitro studies indicated that most of the target compounds exhibit significant inhibition of self-induced β-amyloid (Aβ) aggregation and Cu(II)-induced Aβ1-42 aggregation and acted as potential antioxidants and biometal chelators. In particular, compounds I (R = Me) (II) and I (R = H) (III) are potential lead compounds for AD therapy (II, IC50 = 7.56 μM and III, IC50 = 6.51 μM for self-induced Aβ aggregation; the oxygen radical absorbance capacity assay using fluorescein (ORAC-FL) values are 4.72 and 4.70, resp.). Moreover, these compounds are capable of disassembling the highly structured Aβ fibrils generated by self- and Cu(II)-induced Aβ aggregation. Furthermore, II crossed the blood-brain barrier (BBB) in vitro and did not exhibit any acute toxicity in mice at doses of up to 2000 mg/kg. Taken together, the data indicate that II is a very promising lead compound for AD.

Journal of Medicinal Chemistry published new progress about Alzheimer disease. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Proctor, Rupert S. J.; Chuentragool, Padon; Colgan, Avene C.; Phipps, Robert J. published the artcile< Hydrogen Atom Transfer-Driven Enantioselective Minisci Reaction of Amides>, Recommanded Product: Methyl 4-methylnicotinate, the main research area is amide heteroarene chiral phosphoric acid diacetyl light Minisci reaction; heteroarenyl alkyl amide stereoselective preparation.

Minisci-type reactions constitute one of the most powerful methods for building up complexity around basic heteroarenes. The most desirable variants involve formal oxidative coupling of a C-H bond on each partner, leading back to the simplest possible starting materials. We herein disclose a method that enables such a coupling of linear amides and heteroarenes with full control of enantioselectivity at the newly formed stereocenter as well as site selectivity on both the heteroarene and the amide. This is achieved by the use of a chiral phosphoric acid catalyst in conjunction with diacetyl as a combined hydrogen atom transfer reagent and oxidant. Diacetyl is directly photoexcitable, and thus, no extraneous photocatalyst is required: an added feature that contributes to the simplicity and practicality of the protocol.

Journal of the American Chemical Society published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 33402-75-4 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO2, Recommanded Product: Methyl 4-methylnicotinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Iba, Hikari; Watanabe, Takuya; Motomura, Saori; Harada, Kyoka; Uesugi, Haruka; Shibahara, Takenori; Kubota, Kaori; Katsurabayashi, Shutaro; Iwasaki, Katsunori published the artcile< A Japanese herbal medicine attenuates anxiety-like behavior through GABAA receptor and brain-derived neurotrophic factor expression in a rat model of premenstrual syndrome>, Product Details of C19H34O2, the main research area is premenstrual syndrome anxiety GABAA receptor neurotrophic factor expression; Anxiety; GABA(A) receptor β2-subunit; Herbal medicine; Premenstrual syndrome; Progesterone.

Inochinohaha White (IHW) is a Japanese herbal medicine for treating women with anxiety associated with premenstrual syndrome (PMS). In this study, we examined the effects of IHW on anxiety-like behavior in rats undergoing progesterone withdrawal (PWD), a model for PMS. Female rats were injected daily with progesterone for 21 days. Water and ethanol extracts of IHW (WE-IHW and EE-IHW, resp.) were administered orally 15 days after the initiation of progesterone injections. Anxiety-like behavior in an elevated plus maze was evaluated 48 h after the final injection of progesterone. PWD induced anxiety-like behavior, and EE-IHW (300 mg/kg), but not WE-IHW, significantly attenuated this behavior. Administration of the GABA agonists, diazepam or muscimol, significantly attenuated PWD-induced anxiety-like behavior. To investigate the underlying mechanisms of IHW action, we analyzed GABAA receptor expression in the amygdala of these rats. EE-IHW ameliorated the PWD-induced decrease in GABAA receptor β2-subunit mRNA, although β2-subunit protein was unchanged. Brain-derived neurotrophic factor (BDNF) has been reported to have anxiolytic effects and enhance GABAergic synaptic transmission. We found that EE-IHW increased BDNF levels in a dose-dependent manner. Our results suggest that EE-IHW attenuates PWD-induced anxiety-like behavior by increasing GABAA receptor-mediated signaling via increases in β2-subunit and BDNF in the amygdala.

Journal of Pharmacological Sciences (Amsterdam, Netherlands) published new progress about Amygdala. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Yan; Wu, Weibo; Li, Hu; Zhao, Wenfeng; Yang, Song published the artcile< Sustainable and rapid production of biofuel γ-valerolactone from biomass-derived levulinate enabled by a fluoride-ionic liquid>, Related Products of 112-63-0, the main research area is biofuel valerolactone biomass derived levulinate fluoride ionic liquid.

γ-Valerolactone (GVL) is a versatile biomass-derived mol. for both value-added chems. and biofuels, which is typically prepared from levulinates over metal particles or oxides in the presence of hydrogen, formic acid or alc. Herein, we reported a rapid and mild approach for cascade hydrogenation-cyclization of Et levulinate (EL) to GVL in the presence of readily available ionic liquid tetrabutylammonium fluoride ([TBA]F) and polymethylhydrosiloxane (PMHS) as catalyst and hydrogen source, resp. After reacting at room temperature for 30 min, a high GVL yield of 85% with TOF value of 52 h-1 could be obtained over 3 mol% [TBA]F. In addition to optimizing reaction parameters, the catalytic mechanism was also elucidated for the one-pot sequential transformation of EL to GVL.

Energy Sources, Part A: Recovery, Utilization, and Environmental Effects published new progress about Biofuels. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Iwasaki, Masayuki; Iino, Shohei; Nishihara, Yasushi published the artcile< Palladium-Catalyzed Annulation of o-Iodobiphenyls with o-Bromobenzyl Alcohols: Synthesis of Functionalized Triphenylenes via C-C and C-H Bond Cleavages>, Application of C19H34O2, the main research area is palladium phosphine catalyzed annulation iodobiphenyl bromobenzyl alc triphenylene; decarbonylative cross coupling intramol cyclization triphenylene synthesis.

Treatment of o-iodobiphenyls with o-bromobenzyl alcs. in the presence of cesium carbonate under palladium catalysis affords a series of highly substituted triphenylenes [e.g., o-iodobiphenyl + 2-(2-bromophenyl)-2-propanol in presence of PdCl2(NCPh)2/P[3,5-(CF3)2C6H3]3 and Cs2CO3 afforded triphenylene in 81% yield].. The reaction involves two C-C bond formations and C-C and C-H bond cleavages. A combination of palladium and an electron-deficient phosphine ligand proves to be effective for both decarbonylative cross-coupling and intramol. cyclization.

Organic Letters published new progress about Aralkyl alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lizarzaburu, Mike; Turcotte, Simon; Du, Xiaohui; Duquette, Jason; Fu, Angela; Houze, Jonathan; Li, Leping; Liu, Jinqian; Murakoshi, Michiko; Oda, Kozo; Okuyama, Ryo; Nara, Futoshi; Reagan, Jeff; Yu, Ming; Medina, Julio C. published the artcile< Discovery and optimization of a novel series of GPR142 agonists for the treatment of type 2 diabetes mellitus>, Electric Literature of 112-63-0, the main research area is alkylphenylalaninamide pyridinylphenylamine oxobipyridinylamine preparation GPR142 agonist; structure alkylphenylalaninamide pyridinylphenylamine oxobipyridinylamine GPR142 agonism exposure; cytochrome P 450 inhibition alkylphenylalaninamide pyridinylphenylamine oxobipyridinylamine.

N-alkylphenylalaninamides of pyridinylphenyl- and oxobipyridinylamines such as I were prepared as GPR142 agonists for potential use as antidiabetic agents for type 2 diabetes and tested for their agonism of GPR142 in vitro and in human plasma and their inhibition of cytochrome P 450 enzymes such as isoforms 3A4 and 2D6. Optimization of the original lead compound gave agonists 90 times more potent against human GPR142. Inhibition of cytochrome P 450 isoforms 3A4 and 2D6 was reduced by increasing the polarity of the biarylamine moiety. The pharmacokinetics of I and a thiazolylmethyl phenylalaninamide of an aminopyridinylbenzoate were determined in rats.

Bioorganic & Medicinal Chemistry Letters published new progress about G protein-coupled receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (GPR 142). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Moser, Russell J.; Brown, Ellis Vincent published the artcile< Mass spectra of some 5- and 6-substituted 2-pyridinecarboxylic acids. Nature of fragmentation step for loss of carbon dioxide>, Application of C19H34O2, the main research area is pyridine carboxylic acid mass spectra.

The fragmentation patterns were obtained by electron-impact on 6-acetamido-, 6-amino-, 6-bromo-, 6-chloro-, 6-methoxy-, 6-methyl-, 6-nitro-, 5-carboxy-, 5-iodo-, 5-methoxy- and 5-nitro-2-pyridinecarboxylic acids, as well as 2- and 3-pyridinecarboxylic acids. Most of these acids lost CO2 [M – 44] as their first major fragmentation. This is in direct contrast to the substituted benzoic acids which show loss of OH [M – 17] or CO2H [M – 45] in their first major fragmentation. The ring N may determine which pathway predominates.

Organic Mass Spectrometry published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Taylor, D. M.; Morgan, H.; D’Silva, C. published the artcile< Characterization of chemisorbed monolayers by surface potential measurements>, Synthetic Route of 112-63-0, the main research area is chemisorption aminopropylsilane biotin avidin gold.

Chemisorption was used to immobilize uniform, low-defect d. monolayers of (3-aminopropyl)silane and of d-biotin on evaporated gold substrates. The quality of the monolayers was confirmed by surface potential measurements and by copper decoration. Avidin was immobilized to these monolayers by (i) crosslinking to the (3-aminopropyl)silane with glutaraldehyde and (ii) binding directly to the biotin ligand. The changes in surface potential observed during each immobilization step are shown to be related directly to the mol. structure of each chemisorbed layer. Significantly, when the avidin is immobilized on the biotin monolayer the tetrameric protein is oriented with one pair of biotin binding sites on the upper surface of the protein monolayer. This allows the bifunctional ligand, 1,12-bis(biotinamide)dodecane to be bound to the protein giving the possibility of attaching further protein layers to form mol. organizates suitable for mol. electronic and mol. sensing applications.

Journal of Physics D: Applied Physics published new progress about Avidins Role: PRP (Properties). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pomel, V.; Rovera, J. C.; Godard, A.; Marsais, F.; Queguiner, G. published the artcile< Synthesis of new pyridine intermediates as precursors for the elaboration of streptonigrin analogs by the metalation-cross-coupling strategy>, Quality Control of 112-63-0, the main research area is aminopyridinecarboxylic acid precursor streptonigrin analog preparation; pyridinecarboxylic acid amino preparation.

3-Amino-6-pyridinecarboxylic acid derivatives, precursor for the pyridine C ring of streptonigrin analogs, were prepared from readily available 2-amino-6-chloro-3-nitropyridine.

Journal of Heterocyclic Chemistry published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Utaka, Masanori; Watabu, Hisashi; Higashi, Hiroshi; Sakai, Takashi; Tsuboi, Sadao; Torii, Sigeru published the artcile< Asymmetric reduction of aliphatic short- to long-chain β-keto acids by use of fermenting bakers' yeast>, COA of Formula: C5H10O3, the main research area is oxoalkanoic acid stereoselective reduction; fatty acid oxo stereoselective reduction; hydroxyalkanoic acid stereoselective preparation.

Me(CH2)nCOCH2CO2H (I, n = 0-4, 7-10, 12, 14) were reduced with fermenting bakers’ yeast to optically active Me(CH2)nCH(OH)CH2CO2H (II) isolated as their Me esters. In all cases, (R)-II acids were obtained in ≥98% enantiomeric excess (ee), except for I (n = 0), which afforded (S)-II (n = 0) in 86% ee. Inhibition of fermentation was observed for I (n = 7), but lowering of the substrate concentration was effective in decreasing the inhibition.

Journal of Organic Chemistry published new progress about Enzymic reduction, stereoselective. 73349-07-2 belongs to class esters-buliding-blocks, and the molecular formula is C5H10O3, COA of Formula: C5H10O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics