Month: November 2022

Mapelli, Roberto; Julita, Chiara; Bianchi, Sofia Paola; Gallina, Nicolò; Lucchini, Raffaella; Midulla, Martina; Puci, Flavia; Saddi, Jessica; Trivellato, Sara; Panizza, Denis; De Ponti, Elena; Arcangeli, Stefano published the artcile< Association between treatment-related lymphopenia and survival in glioblastoma patients following postoperative chemoradiotherapy.>, Category: esters-buliding-blocks, the main research area is Glioblastoma; Immunosuppression; Lymphopenia; Radiotherapy; Temozolomide.

PURPOSE: Our study investigated the association between treatment-related lymphopenia and overall survival (OS) in a series of glioblastoma (GBM) patients. We also explored clinical and dosimetric predictors of lymphocytes depletion. METHODS: Between 2015 and 2019, 64 patients were treated at the same institution with postoperative chemoradiotherapy. Peripheral lymphocyte count (PLC) data and dose-volume histogram parameters were collected. Radiotherapy (RT) schedule consisted in standard total dose of 60 Gy in 30 daily fractions, with concomitant and adjuvant temozolomide (TMZ). Posttreatment acute absolute lymphopenia (nadir AAL) was calculated as a PLC lower than 1.0 × 103/mm3. Acute relative lymphopenia (ARL) was expressed by the nadir-PLC/baseline-PLC ratio < 0.5. Nadir-PLC was the lowest PLC registered between the end of RT and the first month of follow-up. Survival rates were estimated with Kaplan-Meier curves. Clinical and dosimetric variables related to AAL/ARL and OS were identified by univariate and multivariate analyses. RESULTS: A total of 57 patients were eligible and included in the analyses. The median PLC was significantly decreased following chemoradiotherapy (2180/mm3 vs 900/mm3). Median OS was 16 months (range 5-55 months), with no significant difference between patients who developed nadir AAL and those who did not (16 months vs 16.5 months; p = 0.304). When considering ARL vs non-ARL, median OS was 14 months vs 26 months (p = 0.013), respectively. In multivariate Cox regression only age, sex, extent of surgery, access to adjuvant chemotherapy and brain D98% were independently associated with OS. CONCLUSION: Although iatrogenic immunosuppression could be associated with inferior clinical outcomes, our data show that treatment-related lymphopenia does not adversely affect GBM survival. Prospective studies are required to confirm these findings. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Deyan; Liu, Yang; Zhang, Zetian; Li, Shan; Yang, Kaifeng; Li, Zhengjun published the artcile< Ingeniously incorporating hollow mesoporous silica into waterborne polyurethane film to improve water vapor permeability>, Quality Control of 112-63-0, the main research area is hollow mesoporous silica waterborne polyurethane film.

Incorporating hollow mesoporous silica (HMS) into waterborne polyurethane (WPU) to improve water vapor permeability (WVP) remains a major challenge. Herein, HMS-I and HMS-II with large hollow size and mesoporous structure were prepared with n-hexane as pore-expanding agent, and template was removed by calcination and extraction, resp. Then, HMS/WPU composite emulsion was prepared by dispersing the pre-prepared polyurethane prepolymer terminated by 3-(aminopropyl)triethoxysilane (APTES) into aqueous medium containing HMS particles, with the help of co-condensation between silanol on HMS surface and silanol produced by Si-OEt hydrolysis of APTES. The results showed that the WVP of the composite film was greatly improved, especially HMS-II/WPU was better than HMS-I/WPU. This design strategy provides a prospect for the preparation and extensive application of HMS/WPU functional composites.

Materials Letters published new progress about Calcination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cui, Hai-Lei; Huang, Ji-Rong; Lei, Jie; Wang, Zhao-Feng; Chen, Shi; Wu, Li; Chen, Ying-Chun published the artcile< Direct Asymmetric Allylic Alkylation of Butenolides with Morita-Baylis-Hillman Carbonates>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Morita Baylis Hillman carbonate butenolide regioselective asym allylic alkylation; cinchona alkaloid catalyst asym allylic alkylation; substituted butenolide stereoselective preparation; bicyclic lactone preparation.

The direct asym. allylic alkylation of β,γ-butenolides with MBH carbonates to access γ,γ-disubstituted butenolides containing adjacent quaternary and tertiary chiral centers, e.g. I, has been presented in excellent stereoselectivities (86-96% ee, dr >95:5) and moderate to good yield (50-83%). Their synthetic utility has been well demonstrated by the facile construction of bicyclic lactones bearing 4-5 stereogenic centers, e.g. II.

Organic Letters published new progress about Allylic alkylation catalysts, stereoselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Karve, Aniruddha S.; Desai, Janki M.; Dave, Nimita; Wise-Draper, Trisha M.; Gudelsky, Gary A.; Phoenix, Timothy N.; DasGupta, Biplab; Sengupta, Soma; Plas, David R.; Desai, Pankaj B. published the artcile< Potentiation of temozolomide activity against glioblastoma cells by aromatase inhibitor letrozole>, COA of Formula: C19H34O2, the main research area is Aromatase inhibitors; Drug-resistance; Glioblastoma; Letrozole; Synergism; Temozolomide.

Abstract: Purpose: The DNA alkylating agent temozolomide (TMZ), is the first-line therapeutic for the treatment of glioblastoma (GBM). However, its use is confounded by the occurrence of drug resistance and debilitating adverse effects. Previously, we observed that letrozole (LTZ), an aromatase inhibitor, has potent activity against GBM in pre-clin. models. Here, we evaluated the effect of LTZ on TMZ activity against patient-derived GBM cells. Methods: Employing patient-derived G76 (TMZ-sensitive), BT142 (TMZ-intermediately sensitive) and G43 and G75 (TMZ-resistant) GBM lines we assessed the influence of LTZ and TMZ on cell viability and neurosphere growth. Combination Index (CI) anal. was performed to gain quant. insights of this interaction. We then assessed DNA damaging effects by conducting flow-cytometric anal. of H2A. X formation and induction of apoptotic signaling pathways (caspase3/7 activity). The effects of adding estradiol on LTZ-induced cytotoxicity and DNA damage were also evaluated. Results: Co-treatment with LTZ at a non-cytotoxic concentration (40 nM) reduced TMZ IC50 by 8, 37, 240 and 640 folds in G76, BT-142, G43 and G75 cells, resp. The interaction was deemed to be synergistic based on CI anal. LTZ co-treatment also significantly increased DNA damaging effects of TMZ. Addition of estradiol abrogated these LTZ effects. Conclusions: LTZ increases DNA damage and synergistically enhances TMZ activity in TMZ sensitive and TMZ-resistant GBM lines. These effects are abrogated by the addition of exogenous estradiol underscoring that the observed effects of LTZ may be mediated by estrogen deprivation. Our study provides a strong rationale for investigating the clin. potential of combining LTZ and TMZ for GBM therapy.

Cancer Chemotherapy and Pharmacology published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rogers, Jane E.; Lam, Michael; Halperin, Daniel M.; Dagohoy, Cecile G.; Yao, James C.; Dasari, Arvind published the artcile< Fluorouracil, Doxorubicin with Streptozocin and Subsequent Therapies in Pancreatic Neuroendocrine Tumors>, Electric Literature of 112-63-0, the main research area is fluorouracil doxorubicin streptozocin anticancer pancreatic neuroendocrine cancer; Everolimus; Gastroenteropancreatic neuroendocrine tumors; Neuroendocrine tumors; Pancreatic neoplasms; Streptozocin; Temozolomide.

We evaluated outcomes of treatment with 5-fluorouracil (5-FU), doxorubicin, and streptozocin (FAS) in well-differentiated pancreatic neuroendocrine tumors (PanNETs) and its impact on subsequent therapy (everolimus or temozolomide). Advanced PanNET patients treated at our center from 1992 to 2013 were retrospectively reviewed. Patients received bolus 5-FU (400 mg/m2), streptozocin (400 mg/m2) (both IV, days 1-5), and doxorubicin (40 mg/m2 IV, day 1) every 28 days. Overall response rate (ORR) was assessed using RECIST version 1.1. Of 243 eligible patients, 220 were evaluable for ORR, progression-free survival (PFS), and toxicity. Most (≥90%) had metastatic, nonfunctional PanNETs; 14% had prior therapy. ORR to FAS was 41% (95% confidence interval [CI]: 36-48%). Median follow-up was 61 mo. Median PFS was 20 (95% CI: 15-23) months; median overall survival (OS) was 63 (95% CI: 60-71) months. Cox regression analyses suggested improvement with first-line vs. subsequent lines of FAS therapy. Main adverse events ≥ grade 3 were neutropenia (10%) and nausea/vomiting (5.5%). Dose reductions were required in 32% of patients. Post-FAS everolimus (n = 108; 68% second line) had a median PFS of 10 (95% CI: 8-14) months. Post-FAS temozolomide (n = 60; 53% ≥ fourth line) had an ORR of 13% and median PFS of 5.2 (95% CI: 4-12) months. In this largest reported cohort of PanNETs treated with chemotherapy, FAS demonstrated activity without significant safety concerns. FAS did not appear to affect subsequent PFS with everolimus; this sequence is being evaluated prospectively. Responses were noted with subsequent temozolomide-based regimens although PFS was possibly limited by line of therapy.

Neuroendocrinology published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Weici; Li, Yuanzhen; Liu, Rui; Yang, Shuang; Liu, Jian; Fang, Xinqiang published the artcile< Kinetic resolution of 2,2-disubstituted-1,3-diketones via carbene catalysis>, Application In Synthesis of 112-63-0, the main research area is formylbenzyl diketone carbene catalyst enantioselective regioselective kinetic resolution; formylalkyl diketone carbene catalyst enantioselective regioselective kinetic resolution.

The successful organocatalytic kinetic resolution of 1,3-diketones with central quaternary stereocenters through the introduction of internal nucleophiles was reported. Two basic resolution modes were established, allowing access to a broad scope of enantioenriched 1,3-diketones with quaternary stereocenters, together with a large variety of tetralone derivatives with vicinal fully substituted carbon centers, and both of them were not easily available via currently known methods. The inherent principles between the different combinations of ketone groups and the resolution patterns were also disclosed. This work constituted a good complementary choice for the construction of 1,3-diketones with quaternary stereogenic centers and provided insightful information for further studies on diketone substrate-mediated intramol. annulations and kinetic resolutions

Organic Chemistry Frontiers published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Shulun; Guo, Wei; Liu, Xiaohua; Sun, Pu; Wang, Yi; Ding, Chunyong; Meng, Linghua; Zhang, Ao published the artcile< Design, synthesis and antitumor study of a series of N-Cyclic sulfamoylaminoethyl substituted 1,2,5-oxadiazol-3-amines as new indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is cyclic sulfamoylaminoethyloxadiazolamine preparation antitumor indoleamine dioxygenase inhibitor human; Immunotherapy; Indoleamine 2,3-dioxygenase; Life span; Oxadiazole; PD-1.

Indoleamine 2,3-dioxygenase 1 (IDO1) plays a key role in tryptophan catabolism which is an important mechanism in immune tolerance. The small mol. epacadostat is the most advanced IDO1 inhibitor, but its phase III trials as a single agent or in combinations with PD-1 antibody failed to show appreciable objective responses. To gain more insight on the antitumor efficacy of IDO1 inhibitors, a series of analogs of epacadostat by incorporating a cyclic aminosulfonamide moiety as the sidechain capping functionality has been designed. N-(3-bromo-4-fluorophenyl)-4-((2-(1,1-dioxido-1,2,5-thiadiazolidin-2-yl)ethyl)amino)-N’-hydroxy-1,2,5-oxadiazole-3-carboximidamide was found to display significant potency against recombinant hIDO1 and hIDO1 expressed HEK293 cancer cells and this compound has improved physico-chem. properties, acceptable PK parameters as well as optimal cardiac safety. Similar to epacadostat, the above compound is ineffective as single agent in the CT-26 syngeneic xenograft model, however, the combination of this compound with PD-1 antibody showed both elevated tumor growth inhibition and prolonged median life span.

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Yue; Yi, Xin; Huo, Bo; He, Yi; Guo, Xian; Zhang, Zihao; Zhong, Xiaoxuan; Feng, Xin; Fang, Ze-Min; Zhu, Xue-Hai; Wei, Xiang; Jiang, Ding-Sheng published the artcile< BRD4770 functions as a novel ferroptosis inhibitor to protect against aortic dissection>, SDS of cas: 347174-05-4, the main research area is gene expression BRD4770 ferroptosis inhibitor aortic dissection smooth musclecell; Aortic dissection; BRD4770; Ferroptosis; Histone methylation; Inflammation; Smooth muscle cell.

Smooth muscle cell (SMC) loss is the characteristic feature in the pathogenesis of aortic dissection (AD), and ferroptosis is a novel iron-dependent regulated cell death driven by the excessive lipid peroxidation accumulation. However, whether targeting ferroptosis is an effective approach for SMC loss and AD treatment remains unclear. Here, we found that the iron level, ferroptosis-related mols. TFR, HOMX1, ferritin and the lipid peroxidation product 4-hydroxynonenal were increased in the aorta of AD. Then, we screened several inhibitors of histone methyltransferases and found that BRD4770 had a protective effect on cystine deprivation-, imidazole ketone erastin- or RSL3-induced ferroptosis of SMCs. The classic ferroptosis pathways, System Xc–GPX4, FSP1-CoQ10 and GCH1-BH4 pathways which were inhibited by ferroptosis inducers, were re-activated by BRD4770 via inhibiting mono-, di- and tri- methylated histone H3 at lysine 9 (H3K9me1/2/3). RNA-sequencing anal. revealed that there was a pos. feedback regulation between ferroptosis and inflammatory response, and BRD4770 can reverse the effects of inflammation activation on ferroptosis. More importantly, treatment with BRD4770 attenuated aortic dilation and decreased morbidity and mortality in a β-Aminopropionitrile monofumarate-induced mouse AD model via inhibiting the inflammatory response, lipid peroxidation and ferroptosis. Taken together, our findings demonstrate that ferroptosis is a novel and critical pathol. mechanism that is involved in SMC loss and AD development. BRD4770 is a novel ferroptosis inhibitor and has equivalent protective effect to Ferrostatin-1 at the optimal concentration Translating insights into the anti-ferroptosis effects of BRD4770 may reveal a potential therapeutic approach for targeting SMC ferroptosis in AD.

Pharmacological Research published new progress about Animal gene, CXCL1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, SDS of cas: 347174-05-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sousa, Andressa Rodrigues de Oliveira; Silva, Edson Mario de Andrade; Filho, Mauricio Antonio Coelho; Costa, Marcio Gilberto Cardoso; Filho, Walter dos Santos Soares; Micheli, Fabienne; Maserti, Biancaelena; Gesteira, Abelmon da Silva published the artcile< Metabolic responses to drought stress and rehydration in leaves and roots of three Citrus scion/rootstock combinations>, Electric Literature of 112-63-0, the main research area is Citrus scion rootstock drought stress leaf metabolite rehydration.

Drought is one of the most destructive environmental challenges for agriculture, and citrus trees are cultivated in semiarid areas. The current study used physiol. and untarget mass spectrometry anal. to assess the differential response to drought and rehydration in leaves and roots of three scion/rootstock combinations in which the same scion Valencia Orange was grafted onto three different rootstocks, namely, ‘Rangpur Lime’, ‘Sunki Maravilha’ and ‘Sunki Tropical’, known to have a different response to drought. The main question to be answer was whether the soil disease tolerant ‘Sunki Tropicalp could be used as alternative to the drought tolerant/disease susceptible rootstock ‘Rangpur lime’ to cultivate citrus in semiarid areas. Thirty-seven metabolites in leaves and forty-six in roots, mainly amino acids, as well as a few carbohydrates and organic acids were found differentially expressed after drought and/or rehydration in the three combinations. Overall, the results demonstrated that the three scion/rootstock combinations responded differently at metabolite levels to water changes. The few leaf metabolites found in the scion grafted on ‘Rangpur Lime’ and ‘Sunki Maravilha’ support the resp. drought avoidance and tolerance strategy, already observed in those rootstocks’. Rangur Lime’ and ‘Sunki Tropical’ shared at roots levels several common drought response mechanisms. Moreover, the high number of differential metabolites triggered in the scion by ‘Sunki Tropical’ seems to be useful for overcoming the drought effects without depleting the fruit quality. From our data, we argue that ‘Sunki Tropical’ is a drought tolerant genotypes that could be used as alternative to ‘Ranpur Lime’ to sustain citrus production in semiarid areas.

Scientia Horticulturae (Amsterdam, Netherlands) published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xue, Xiuru; Wang, Yanhua; Han, Fu-She published the artcile< A thermoregulated phase-separable chiral Pt nanocatalyst for recyclable asymmetric hydrogenation of α-ketoesters>, Computed Properties of 73349-07-2, the main research area is asym hydrogenation ketoester platinum nanocatalyst chiral ionic liquid; cinchonidine polyethylene glycol chiral ionic liquid catalyst asym hydrogenation.

The design and preparation of a chiral Pt nanocatalyst system possessing thermoregulated phase-separation property and its application in recyclable asym. hydrogenation of α-ketoesters are presented. The catalyst was prepared from polyethylene glycol monomethyl ether and cinchonidine.

Chemical Communications (Cambridge, United Kingdom) published new progress about Carboxylic esters Role: RCT (Reactant), RACT (Reactant or Reagent) (α-ketoesters). 73349-07-2 belongs to class esters-buliding-blocks, and the molecular formula is C5H10O3, Computed Properties of 73349-07-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics