Month: November 2022

Ulrich, Sebastian; Sadeghpour, Amin; Rossi, Rene M.; Bruns, Nico; Boesel, Luciano F. published the artcile< Wide Range of Functionalized Poly(N-alkyl acrylamide)-Based Amphiphilic Polymer Conetworks via Active Ester Precursors>, SDS of cas: 71195-85-2, the main research area is polyalkylacrylamide amphiphilic polymer network ester precursor.

A versatile strategy for the fabrication of functional poly(N-alkyl acrylamide)-based amphiphilic polymer conetworks (APCNs) from hydrophobic precursor networks is presented. Herein, the active ester monomer pentafluorophenyl acrylate (PFPA) acts as a general hydrophobic masking group for N-alkyl acrylamides. Amidation reactions with different amines allow the transformation of one PFPA-based hydrophobic precursor network into a multitude of different APCNs that possess optical transparency and nanophase-separated morphologies. Accordingly, the properties of these ACPNs can be tailored to the desired application by simple variation of the amide functionality. Furthermore, combination of PFPA with another hydrophobically masked monomer allows for the functionalization of the hydrophilic phase of APCNs in precisely defined amounts Controlled integration of pendant groups such as pH-responsive imidazole, fluorescent dyes, and biotin for specific protein binding is achieved, greatly expanding the functionality of the APCNs. Such functionalized APCNs could find application as stimuli-responsive drug delivery membranes, smart hydrogels, biosensors, or as matrixes for biocatalysis.

Macromolecules (Washington, DC, United States) published new progress about Amidation. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, SDS of cas: 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ruff, Yves; Martinez, Roberto; Pelle, Xavier; Nimsgern, Pierre; Fille, Pascale; Ratnikov, Maxim; Berst, Frederic published the artcile< An Amphiphilic Polymer-Supported Strategy Enables Chemical Transformations under Anhydrous Conditions for DNA-Encoded Library Synthesis>, Application of C19H34O2, the main research area is amphiphilic polymer chem transformation anhydrous DNA library; DNA-encoded libraries; decarboxylative coupling; drug discovery; encoded library technologies; solid-supported synthesis.

The use of DNA-encoded libraries has emerged as a powerful hit generation technol. Combining the power of combinatorial chem. to enumerate large compound collections with the efficiency of affinity selection in pools, the methodol. makes it possible to interrogate vast chem. space against biol. targets of pharmaceutical relevance. Thus, the chem. transformations employed for the synthesis of encoded libraries play a crucial role in the identification of diverse and drug-like starting points. Currently established transformations have mostly been limited to water-compatible reactions to accommodate the growing oligonucleotide tag. Herein, we describe the development of a practical catch-and-release methodol. utilizing a cationic, amphiphilic PEG-based polymer to perform chem. transformations on immobilized DNA conjugates under anhydrous conditions. We demonstrate the usefulness of our APTAC (amphiphilic polymer-facilitated transformations under anhydrous conditions) approach by performing several challenging transformations on DNA-conjugated small mols. in pure organic solvents: the addition of a carbanion equivalent to a DNA-conjugated ketone in THF, the synthesis of saturated heterocycles using the tin (Sn) amine protocol (SnAP) in dichloromethane, and the dual-catalytic (Ir/Ni) metallaphotoredox decarboxylative cross-coupling of carboxylic acids to DNA-conjugated aryl halides in DMSO. In addition, we demonstrate the feasibility of the latter in multititer-plate format.

ACS Combinatorial Science published new progress about Immobilization, molecular. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mai, Yang; Ouyang, Yaqi; Yu, Mian; Qin, Yujia; Girardi, Michael; Saltzman, W. Mark; Cocco, Emiliano; Zhao, Chao; Yu, Liu; Jia, Yizhen; Xiao, Lingyun; Dou, Liu; Deng, Wenbin; Liu, Yang; Xie, Julin; Deng, Yang published the artcile< Topical formulation based on disease-specific nanoparticles for single-dose cure of psoriasis>, Application of C19H34O2, the main research area is psoriasis topical formulation disease specific nanoparticle; Disease-specific treatment; Formulation optimization; Local drug delivery; Psoriasis; Single-dose cure; Surface-modified nanoparticles.

First-line treatments for mild to moderate psoriasis are typically topical formulations containing corticosteroids, however, the therapeutic efficacy of these formulations is compromised by limited penetration and skin retention. Even more challenging, off-target corticosteroids are known to adversely affect healthy skin, including induction of epidermal and dermal atrophy. Here, we report a nanoparticle-based topical formulation that cures psoriasis in a single dose, but leaves healthy skin intact. Specifically, we developed tris(hydroxymethyl)aminomethane-modified bioadhesive nanoparticles (Tris-BNPs) that exploit the high permeability characteristic of psoriasis to penetrate only psoriatic skin but not the healthy skin. Furthermore, as Tris-BNPs diffuse and penetrate into the epidermis, the Tris mols. slowly diffuse away, exposing the aldehyde groups of BNPs, which can bind to amine groups present within lesional skin, leading to long local retention of BNPs in lesions of psoriatic skin. The accumulated BNPs within lesions release corticosteroids over a 鈭?3 day period to maintain local drug concentration above the therapeutic level. In addition to deeper penetration and longer retention compared with com. psoriasis treatments, the topical applied Tris-BNPs were not affected by sweating, humidity, or active wiping due to their preferential accumulation between the stratum corneum and the basal cells of the epidermis. Overall, Tris-BNP as a topical formulation hold promise to overcome the limitations of current psoriasis treatment.

Journal of Controlled Release published new progress about Adhesion, physical. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Smagowicz, J.; Wierzchowski, K. L. published the artcile< The phosphorescence of hindered aminopyrimidines>, Reference of 112-63-0, the main research area is phosphorescence aminopyridimidine; pyrimidine alkyl amino phosphorescence; alkylpyrimidine phosphorescence.

The quantum yields, lifetimes, and polarizations of phosphorescence of 4- and 5-aminopyrimidines and their hindered alkyl derivatives were measured in solvents of different polarity at 90掳K. The model presented for interpretation of these data allows determining the matrix elements of spin-orbit coupling between the emitting singlet and triplet states. These elements are 0.2-0.8 cm-1 in aminopyrimidines and increase as the amino group becomes more twisted relative to the ring. Spin-orbit coupling of higher 1(n,蟺*) states with emitting triplets is 鈭?0 times stronger than that of the lowest 1(l,a蟺*).

Journal of Luminescence published new progress about Amino group. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sandbhor, Puja; Goda, Jayant. S.; Mohanty, Bhabani; Chaudhari, Pradip; Dutt, Shilpee; Banerjee, Rinti published the artcile< Bio-polymeric transferrin-targeted temozolomide nanoparticles in gel for synergistic post-surgical GBM therapy>, Application In Synthesis of 112-63-0, the main research area is biopolymeric transferrin temozolomide nanoparticle gel synergistic glioblastoma.

Spatiotemporal targeting of anti-glioma drugs remains a pressing issue in glioblastoma (GBM) treatment. We challenge this issue by developing a minimally invasive in situ implantable hydrogel implant comprising transferrin-targeted temozolomide-miltefosine nanovesicles in the surgically resected GBM cavity (tumor bed). Injection of the “”nanovesicle in hydrogel system”” in orthotopic GBM-bearing mice improved drug penetration into the peri-cavitary region (鈭?.5 mm in depth) with the potential to act as a bridge therapy in the immediate postoperative period, before the initiation of adjuvant radiotherapy. The controlled and sustained release of temozolomide over a month in the surgical cavity eradicated the microscopic GBM cells present within the tumor bed, thereby augmenting the efficacy of adjuvant therapy. The drug (temozolomide and miltefosine) combination was tolerable and efficiently inhibited tumor growth, causing significant prolongation of the survival of tumor-bearing mice compared to that with the free drug. Direct implantation at the target site in the brain resulted in spatiotemporal anti-glioma activity with minimal extracranial and systemic distribution. Nanovesicle in flexible hydrogel systems can be used as potential platforms for the post-surgical management of GBM before initiating adjuvant radiation therapy.

Nanoscale published new progress about Apoptosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Takemura, Naho; Sumida, Yuto; Ohmiya, Hirohisa published the artcile< Organic Photoredox-Catalyzed Silyl Radical Generation from Silylboronate>, Related Products of 112-63-0, the main research area is silyl radical generation method silylboronate light driven; three component reaction silyl radical acylimidazole alkene photocatalysis; acylsilane derivative radical preparation heterocyclic carbene photocatalysis.

A visible-light-driven silyl radical generation method from silylboronates was developed. The activation of silylboronates with a catalytic amount of mild base promoted the single-electron oxidation process to form silyl radicals. Facile single electron transfer for the borate form readily occurred without H atom transfer for hydrosilane in the presence of various photoredox catalysts. Combining this protocol with radical-mediated N-heterocyclic carbene catalysis enabled the acylsilylation of alkenes via a radical relay process with silyl radical generation. Also, the recent advanced methods for the synthesis of silylboronates significantly improved the utility of this silyl radical generation alkenes acylimidazole.

ACS Catalysis published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Xiaowei; Jin, Feng; Jiang, Shiyu; Cao, Jun; Meng, Yanchun; Xu, Yu; ChunmengWang; Chen, Yong; Yang, Huijuan; Kong, Yunyi; Liu, Xin; Luo, Zhiguo published the artcile< Rh-endostatin combined with chemotherapy in patients with advanced or recurrent mucosal melanoma: retrospective analysis of real-world data>, Category: esters-buliding-blocks, the main research area is recombinant human endostatin recurrent mucosal melanoma chemotherapy; Lymphocyte-to-monocyte ratio; Mucosal melanoma; Recombinant human endostatin (Rh-endostatin); Survival.

Mucosal melanoma is rare and has distinct clin. and genetic features. Even with advances in targeted and immune therapies, the survival of patients with advanced or recurrent mucosal melanomas remains poor. The standard treatment remains controversial and we conducted this real-world study aimed to explore continuous i.v. recombinant human endostatin (Rh-endostatin) infusion plus chemotherapy in this population in the first-line setting. Overall, 43 patients with advanced or recurrent mucosal melanoma treated at Fudan University Shanghai Cancer Center between Apr. 2017 and August 2020 were retrospectively included. Patients received dacarbazine plus cisplatin or temozolomide plus cisplatin per the investigators’ preference. Rh-endostatin (105 mg/m2) was administered with continuous infusion for 168 h (Civ 168 h). Of the 43 patients, 72.1% had metastatic disease, and the most common primary site was the gastrointestinal tract (51.2%). The most commonly observed mutations were NRAS (23.1%), BRAF (7.7%) and CKIT mutations (5.1%). An objective response was observed in 12 (30.0%) of the 40 evaluable patients, and disease control was achieved in 31 (77.5%) patients. With a median follow-up of 17.6 mo, the median progression-free survival (PFS) and overall survival (OS) were 4.9 and 15.3 mo, resp. Addnl., high lymphocyte-to-monocyte ratio (LMR) (p = 0.023, HR 0.29, 95% CI: 0.10-0.84) and BRAF/KIT/RAS mutation (p = 0.028, HR 0.24, 95% CI: 0.07-0.86) were independently correlated with prolonged OS. Toxicity was manageable overall. Continuous Rh-endostatin infusion plus chemotherapy was effective and safe for the treatment of advanced or recurrent mucosal melanoma. High LMR was correlated with favorable PFS and OS in this patient population.

Investigational New Drugs published new progress about Anemia. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tripathi, Prashasti; Puranik, Vineeta; Purwar, Shalini published the artcile< Comparison of branded and non-branded food samples widely consumed in north India with reference to Trans fatty acid content>, Application of C19H34O2, the main research area is trans fatty acid content branded nonbranded food sample.

Trans fatty acids (TFA) are the geometrical isomers of monounsaturated and polyunsaturated fatty acids that affect the function-al and physicochem. properties of these fatty acids, which in turn affect their metabolism in humans. Since the database available for trans fatty acids in food from India is scarce, the research report generates data about trans fatty acid content in selected foods popular in north India. In this report, various food samples like cookies, chocolates, biscuits, pizza, fries, indigenous snacks like samosa, pakora and indigenous sweets like jalebi, gulab jamun, and laddoo were analyzed for the Trans Fatty Acid (TFA) content by gas chromatog. A large variation was found in trans fatty acid content among these food samples. The results also showed that only 4.5% of the samples were found to contain TFA less than 0.5% while approx. 8% of samples having more than 5% TFA (1 branded and 6 non-branded samples). Also, a large variation was found in the trans fatty acid content of branded and non-branded food samples with the mean value of TFA in branded and non-branded food groups as 1.781 and 6.125 resp. and the t-value of 0.852 between the two groups. When regulations are emphasizing on labeling the TFA content on the product, there are arrays of unlabeled products which are not governed under any regulations. Hence there is a need for strong food regulations to bring levels of trans fats in processed foods to negligible levels.

Journal of Applied and Natural Science published new progress about Bakery cakes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hong, Dan-Yan; Liu, Yungen; Wu, Liangliang; Lo, Vanessa Kar-Yan; Toy, Patrick H.; Law, Siu-Man; Huang, Jie-Sheng; Che, Chi-Ming published the artcile< RuV-Acylimido Intermediate in [Ru(IV)(Por)Cl2]-Catalyzed C-N Bond Formation: Spectroscopic Characterization, Reactivity, and Catalytic Reactions>, Name: (2R,3R,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate, the main research area is ruthenium catalyzed acylnitrene transfer organic substrate alkene; aryl indolylamide preparation crystal structure; mol structure aryl indolylamide; C鈭扤 bond formation; RuV-imido complex; acylnitrene transfer; porphyrinoids; ruthenium.

Metal-catalyzed C-N bond formation reactions via acylnitrene transfer have recently attracted much attention, but direct detection of the proposed acylnitrenoid/acylimido M(NCOR) (R = aryl or alkyl) species in these reactions poses a formidable challenge. Herein, the authors report on Ru(NCOR) intermediates in C-N bond formation catalyzed by [Ru(IV)(Por)Cl2]/N3COR, a catalytic method applicable to aziridine/oxazoline formation from alkenes, amination of substituted indoles, 伪-amino ketone formation from silyl enol ethers, amination of C(sp3)-H bonds, and functionalization of natural products and carbohydrate derivatives (up to 99% yield). Exptl. studies, including HR-ESI-MS and EPR measurements, coupled with DFT calculations, lend evidence for the formulation of the Ru(NCOR) acylnitrenoids as a Ru(V)-imido species.

Angewandte Chemie, International Edition published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Name: (2R,3R,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fuerstner, Alois; Bonnekessel, Melanie; Blank, Jarred T.; Radkowski, Karin; Seidel, Guenter; Lacombe, Fabrice; Gabor, Barbara; Mynott, Richard published the artcile< Total synthesis of myxovirescin A1>, Synthetic Route of 112-63-0, the main research area is myxovirescin A1 total synthesis regioselective Negishi Suzuki coupling; stereoselective hydrogenation oxyallylation total synthesis myxovirescin A1; ring closing metathesis total synthesis myxovirescin A1; hydrosilylation trans total synthesis myxovirescin A1.

A convergent total synthesis of the antibiotic macrolide myxovirescin A1 (I) is described that is largely based on reagent- and catalyst-controlled transformations. This includes a highly regioselective Negishi reaction of dibromo-alkene (E)-BrCH:CBrCH2OMe with an alkynyl-zinc reagent, and a palladium catalyzed alkyl-Suzuki coupling of the resulting enyne derivative (E)-MeC顚咰CH:CBrCH2OMe (II) with the 9-BBN-adduct derived from alkene III. The latter was obtained via an asym. hydrogenation of the chlorinated 尾-ketoester EtO2CCH2COCH2Cl and an anti-selective oxyallylation of the functionalized aldehyde (S)-OHCCH2CH(CH2N3)OCH2OMe as the key steps. The preparation of a bis-borylated allyl-donor used in the oxyallylation step, however, required careful optimization and led to important insights into the nature of the classical hydroborating agent “”di(isopinocampheyl)borane (Ipc2BH)””. It was unambiguously shown by X-ray crystallog. that in the solid state this compound is dimeric, but it is prone to undergo an essentially quant. mono-deborylation when dissolved in CH2Cl2 or benzene; its composition in ethereal solvents is even more complex as evident from 11B NMR data. The product derived from II and III was elaborated into the enyne-yne derivative IV, which served as the substrate for an exquisitely selective ring closing alkyne metathesis reaction (RCAM) catalyzed by a molybdenum tris-amido complex activated in situ with CH2Cl2. The resulting cyclic enyne was subjected to a ruthenium catalyzed trans-hydrosilylation/proto-desilylation tandem. Although [Cp*Ru(MeCN)3]PF6 had previously been recommended as catalyst of choice for trans-hydrosilylation reactions of internal alkynes, this complex failed to afford the desired product, whereas its sterically less hindered congener [CpRu(MeCN)3]PF6 permitted the reaction to be performed in appreciable yield, but at the expense of a lower stereoselectivity. AgF-mediated proto-desilylation of the isomeric silanes followed by cleavage of the remaining acetal protecting groups afforded myxovirescin A1 and its hitherto unknown 14Z-isomer.

Chemistry – A European Journal published new progress about Allylation (oxyallylation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics