Month: November 2022

Cai, Yifeng; Liu, Caixia; Yu, Zhiao; Wu, Haomin; Wang, Yaoda; Ma, Wencan; Zhang, Qiuhong; Jia, Xudong published the artcile< A flexible and highly conductive quasi-solid single-ion polymer electrolyte for high performance Li-metal batteries>, SDS of cas: 112-63-0, the main research area is single ion polymer electrolyte lithium battery.

A series of flexible and highly conductive quasi-solid single-ion polymer electrolytes (abbreviated as PU-TFMSI) based on lithium sulfonimide are presented. Owing to the crosslinked structure with three types of segments (hard segment, soft segment and Li rich segment), PU-TFMSI displays a stretchability of 1350% and toughness of 13.6 MJ m-3. These PU-TFMSI single-ion electrolytes deliver high ionic conductivity over 1.3 x 10-4 S cm-1 at ambient temperature, a wide electrochem. stability window (up to 5.0 V vs Li+/Li), a high lithium transfer number (LTN 鈭?0.9), and good compatibility with electrodes. The LiFePO4/PU-TFMSI-2/Li coin cell exhibits stable cycling with an average Coulombic efficiency of 99.58% and superior rate performance. Furthermore, the LiFePO4//Li soft pouch cell with PU-TFMSI-2 single-ion electrolyte maintains functionality under bending. The flexible single-ion polymer electrolytes designed in this study have the potential to be applied in flexible devices and stretchable batteries.

Journal of Power Sources published new progress about Current efficiency. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hong, Seung-Mo; Kim, Oh Young; Hwang, Seok-Ho published the artcile< Optimization of synthetic parameters of high-purity trifunctional mercapto esters and their curing behavior for the thiol-epoxy click reaction>, Quality Control of 112-63-0, the main research area is mercaptopropionic acid trimethylolpropane esterification thiol epoxy click reaction.

The direct esterification reaction between 3-mercaptopropionic acid (3-MPA) and trimethylolpropane (TMP) was conducted in the presence of various catalyst concentrations of p-toluenesulfonic acid (p-TSA) to examine the optimized synthetic conditions needed to produce high-purity trimethylolpropane-tris(3-mercaptopropionate) (TMPMP). The purity of the desired TMPMP and uncompleted side-product reduced as the acid catalyst concentration in this esterification reaction increased while the generation of thioester-based side-product increased. The equivalent ratio between epoxy and the manufactured TMPMP was maintained at 1 : 1 to monitor the curing behavior of the thiol-epoxy click reaction using the DSC technique. The thermal features of the base-catalyzed TMPMP-cured epoxy resin were assessed according to the purity of the TMPMP curing agent.

RSC Advances published new progress about Click chemistry. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gautam, Megha; Gabrani, Reema published the artcile< Combinatorial Effect of Temozolomide and Naringenin in Human Glioblastoma Multiforme Cell Lines>, SDS of cas: 112-63-0, the main research area is temozolomide naringenin human glioblastoma multiforme.

Glioblastoma multiforme (GBM) is a grade IV, lethal, and the most common type of brain tumor. GBM can acquire resistance to temozolomide (TMZ) recommended for its treatment. Naringenin (NAG), a flavonoid generally found in grapefruit, has antioxidant, anti-proliferative, and anti-inflammatory properties. It has been reported that phytochems. can reduce resistance and improve the efficacy of a chemo-resistant drug. The combinatorial effect of TMZ and NAG on cell proliferation was evaluated using 3-4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide (MTT) assay, and the apoptosis in the U87MG and LN229 GBM cells were evaluated by change in fluorescence intensity. The effect of NAG and TMZ on anchorage-independent single-cell colony formation and cell migration was investigated. NAG and TMZ demonstrated enhanced cytotoxic effects on U87MG and LN229 cell lines. The combination index value being less than one indicated the synergistic action of the two drugs in restricting the growth of the cells. The NAG and TMZ together resulted in higher fluorescence intensity as compared to the alone drug. Further, the study showed a marked reduction in the migration of the cells and the formation of a single cell colony.

Nutrition and Cancer published new progress about Antiproliferative agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wu, Qifan; Zhao, Bin; Fan, Zhijin; Guo, Xiaofeng; Yang, Dongyan; Zhang, Nailou; Yu, Bin; Zhou, Shuang; Zhao, Jiabao; Chen, Fan published the artcile< Discovery of Novel Piperidinylthiazole Derivatives As Broad-Spectrum Fungicidal Candidates>, Application of C19H34O2, the main research area is piperidinylthiazole derivative preparation fungicide phytopathogenic fungi; 3,4-dichloroisothiazole; RNA sequencing; antifungal activity; broad spectrum; piperidinylthiazole.

Oxathiapiprolin is one of the best active fungicides discovered for oomycetes control. To develop a fungicide candidate with a broad spectrum of activity, 22 new piperidinylthiazole derivatives were designed and synthesized. Compound (I) showed the best activity against Pseudoperonospora cubensis (Berk. et Curt.) Rostov and Phytophthora infestans in vivo with 100% and 80% of inhibition, resp., at 1 mg/L, and 72.87% of field efficacy against P. cubensis at 1 g ai/667 m2 validated these results. Compound (II) exhibited a broad spectrum of excellent activity against Sclerotinia sclerotiorum with EC50 = 0.30 mg/L (>10 times more active than oxathiapiprolin and azoxystrobin in vitro), good activity against Botrytis cinerea, Cercospora arachidicola, and Gibberella zeae with EC50 of 14.54, 5.57, and 14.03 mg/L in vitro and against P. cubensis and P. infestans with 60% and 30% inhibition rates, resp., at 1 mg/L in vivo. Mode of action studies by RNA sequencing anal. discovered oxysterol-binding protein (OSBP), chitin synthase (CHS1), and (1,3)-尾-glucan synthase (FKS2) as the potent target of II against S. sclerotiorum. Quenching studies validated that OSBP was the same target of both II and oxathiapiprolin; it was quenched by both of them. Our studies discovered isothiazole-containing piperidinylthiazole as an OSBP target-based novel lead for fungicide development.

Journal of Agricultural and Food Chemistry published new progress about Agrochemical fungicides. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Choi, Jiyeon; Schattling, Philipp; Jochum, Florian D.; Pyun, Jeffrey; Char, Kookheon; Theato, Patrick published the artcile< Functionalization and patterning of reactive polymer brushes based on surface reversible addition and fragmentation chain transfer polymerization>, Reference of 71195-85-2, the main research area is polypentafluorophenyl acrylate polymer brush RAFT polymerization.

We present the synthesis of reactive polymer brushes prepared by surface reversible addition-fragmentation chain transfer polymerization of pentafluorophenyl acrylate. The reactive ester moieties can be used to functionalize the polymer brush film with virtually any functionality by simple post-polymerization modification with amines. Dithiobenzoic acid benzyl-(4-ethyltrimethoxylsilyl) ester was used as the surface chain transfer agent (S-CTA) and the anchoring group onto the silicon substrates. Reactive polymer brushes with adjustable mol. weight, high grafting d., and conformal coverage through the grafting-from approach were obtained. Subsequently, the reactive polymer brushes were converted with amino-spiropyrans resulting in reversible light-responsive polymer brush films. The wetting behavior could be altered by irradiation with UV or visible light. Furthermore, a patterned surface of polymer brushes was obtained using a lithog. technique. UV irradiation of the S-CTA-modified substrates leads to a selective degradation of S-CTA in the exposed areas and gives patterned activated polymer brushes after a subsequent RAFT polymerization step. Conversion of the patterned polymer brushes with 5-((2-aminoethyl)amino)naphthalene-1-sulfonic acid resulted in patterned fluorescent polymer brush films. The utilization of reactive polymer brushes offers an easy approach in the fabrication of highly functional brushes, even for functionalities whose introduction is limited by other strategies. 漏 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about Binding energy. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Reference of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Feng, Pengfei; Yang, Xiaoxi; Feng, Xiaoxia; Zhao, Guodong; Li, Xiaochen; Cao, Jing; Tang, Yu; Yan, Chun-Hua published the artcile< Highly Stable Perovskite Quantum Dots Modified by Europium Complex for Dual-Responsive Optical Encoding>, Formula: C11H12O3, the main research area is stable perovskite quantum dot modified europium complex dual responsive; dual-responsive; optical encoding; perovskite quantum dots; rare-earth complex; surface modification.

Inorganic perovskite quantum dots (QDs) have attracted great scientific attention in the field of luminescent materials, but the application has been limited by the inferior stability that results from highly dynamic capping ligands. In this work, we use a rare-earth complex to modify perovskite QDs with ligand exchange to realize perovskite functionalization; meanwhile, the stability of perovskite QDs is greatly improved. D. functional theory calculation results show that the adsorption energy of the europium complex to QDs is higher than that with traditional ligands, which provides a thermodn. basis for stability improvement. Furthermore, the modified QDs exhibit attractive dual-response property, including temperature and pH response ascribed to QDs and europium complexes, resp. The superior property can be applied to multi-stimuli-responsive optical encoding, which is further capable of enhancing the security of encrypted information. This study not only affords a strategy for the synthesis of highly stable perovskites but also provides a method for the functionalization of perovskites.

ACS Nano published new progress about Adsorption. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Formula: C11H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lee, Jae Chul; Hong, Kwon Ho; Becker, Andreas; Tash, Joseph S.; Schonbrunn, Ernst; Georg, Gunda I. published the artcile< Tetrahydroindazole inhibitors of CDK2/cyclin complexes>, Electric Literature of 112-63-0, the main research area is tetrahydroindazole preparation antiproliferative CDK2 cyclin inhibitor SAR mol docking; CDK2; Cyclins; Kinase inhibitors; Tetrahydroindazoles.

Over 50 tetrahydroindazoles I [R = 2-pyridyl, thiazol-2-yl, pyrimidin-4-yl, etc.] were synthesized after I [R = 2-pyridyl] was identified as a hit compound in a high throughput screen for inhibition of CDK2 in complex with cyclin A. The activity of the most promising analogs was evaluated by inhibition of CDK2 enzyme complexes with various cyclins. Analogs I [R = thiazol-2-yl, pyrimidin-4-yl] showed 3-fold better binding affinity for CDK2 and 2- to 10-fold improved inhibitory activity against CDK2/cyclin A1, E, and O compared to screening hit 3. The data from the enzyme and binding assays indicate that the binding of the analogs to a CDK2/cyclin complex is favored over binding to free CDK2. Computational anal. was used to predict a potential binding site at the CDK2/cyclin E1 interface.

European Journal of Medicinal Chemistry published new progress about Antiproliferative agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kong, Lingchun; Li, Jingjing; Yang, Yuqin; Tang, Huixin; Zou, Hong published the artcile< Paeoniflorin alleviates the progression of retinal vein occlusion via inhibiting hypoxia inducible factor-1伪/vascular endothelial growth factor/STAT3 pathway>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Retinal vein occlusion; hypoxia-inducible factor-1伪; paeoniflorin; vascular endothelial growth factor.

Retinal vein occlusion (RVO) is a severe retinal vascular disease involving several complications, leading to weakening of vision and even blindness. Globally, over 16 million patients with RVO were found in the middle-aged population. Paeoniflorin (PF), a monomer of Taohong Siwu decoction, was reported to exhibit many pharmacol. activities including anti-inflammatory, antioxidant, cardioprotective, and neuroprotective effects. However, the effect of PF on the progression of RVO remains unclear. In the current study, CCK8 assay was performed to investigate the cell viability. In addition, transwell assay and western blot were used to measure cell invasion and protein expression, resp. Moreover, a mouse model of oxygen-induced dischemic retinopathy (OIR) was established. We found PF was able to inhibit the migration and angiogenesis of human retinal capillary endothelial cells under normoxia. Addnl., PF notably prevented hypoxia-induced angiogenesis of human retinal capillary endothelial cells via inhibiting hypoxia-inducible factor-1伪 (HIF-1伪)/vascular endothelial growth factor (VEGF)/STAT3 pathway. Eventually, PF significantly alleviated the retinal lesions in the mouse with OIR. All in all, PF was able to alleviate the progression of retinal vein occlusion via inhibiting HIF-1伪/VEGF/STAT3 pathway. These findings might provide some theor. knowledge for exploring novel effective treatment for patients with RVO.

Bioengineered published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kharaneko, A. O.; Pekhtereva, T. M.; Kharaneko, O. I. published the artcile< Synthesis of 3-Phenyl-1H-[1,4]oxazino[4,3-a]benzimidazol-1-one and Its Transformation into 4-Phenyl-2,5-dihydro-1H-[1,2,5]triazepino[5,4-a]benzimidazol-1-one>, Electric Literature of 112-63-0, the main research area is phenyl oxazinobenzimidazolone preparation; dihydrotriazepinobenzimidazolone preparation; phenylpyrazino benzimidazolone preparation; benzimidazole preparation.

A synthetic route was proposed to 3-phenyl-1H-[1,4]oxazino[4,3-a]benzimidazol-1-one I, which was the first representative of a new heterocyclic system. The transformation of the title compound I to 4-phenyl-2,5-dihydro-1H-[1,2,5]triazepino[5,4-a]benzimidazol-1-one II via reaction with hydrazine hydrate was studied.

Russian Journal of Organic Chemistry published new progress about Benzimidazoles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Xiaoshan; Luo, Liuhong; Song, Chang; Li, Jianjun; Chen, Huanhuan; Zhu, Qiuying; Lan, Guanghua; Liang, Shujia; Shen, Zhiyong; Cao, Zhiqiang; Feng, Yi; Liao, Lingjie; Xing, Hui; Shao, Yiming; Ruan, Yuhua published the artcile< Survey of pretreatment HIV drug resistance and the genetic transmission networks among HIV-positive individuals in southwestern China, 2014-2020>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is human immunodeficiency virus drug resistance genetic transmission China; Antiretroviral therapy (ART); Drug resistance mutations (DRMs); Genetic transmission networks; HIV; Pretreatment drug resistance (PDR).

Pretreatment drug resistance (PDR) can limit the effectiveness of HIV antiretroviral therapy (ART). The aim of this study was to assess the prevalence of PDR among HIV-pos. individuals that initiated antiretroviral therapy in 2014-2020 in southwestern China. Consecutive cross-sectional surveys were conducted in Qinzhou, Guangxi. We obtained blood samples from individuals who were newly diagnosed with HIV in 2014-2020. PDR and genetic networks analyses were performed by HIV-1 pol sequences using the Stanford HIV-database algorithm and HIV-TRACE, resp. Univariate and multivariate logistic regression models were used to explore the potential factors associated with PDR. In total, 3236 eligible HIV-pos. individuals were included. The overall prevalence of PDR was 6.0% (194/3236). The PDR frequency to NNRTI (3.3%) was much higher than that of NRTI (1.7%, p < 0.001) and PI (1.2%, p < 0.001). A multivariate logistic regression anal. revealed that PDR was significantly higher among individuals aged 18-29 (adjusted odds ratio (aOR): 1.79, 95% CI 1.28-2.50) or 30-49 (aOR: 2.82, 95% CI 1.73-4.82), and harboring CRF08_BC (aOR: 3.23, 95% CI 1.58-6.59). A total of 1429 (43.8%) sequences were linked forming transmission clusters ranging in size from 2 to 119 individuals. Twenty-two individuals in 10 clusters had the same drug resistant mutations (DRMs), mostly to NNRTIs (50%, 5/10). The overall prevalence of PDR was medium, numerous cases of the same DRMs among genetically linked individuals in networks further illustrated the importance of surveillance studies for mitigating PDR. BMC Infectious Diseases published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics