Month: November 2022

Enders, Dieter; Henseler, Alexander; Lowins, Sebastian published the artcile< N-Heterocyclic carbene catalyzed nucleophilic acylation of trifluoromethyl ketimines>, Formula: C19H34O2, the main research area is fluoromethyl ketimine furaldehyde nucleophilic acylation heterocyclic carbene catalyst; amino fluoromethyl ketone preparation.

An efficient N-heterocyclic carbene (NHC)-catalyzed nucleophilic acylation of trifluoromethyl ketimines was developed. The combination of N-aryl trifluoromethyl ketimines with furan-2-aldehydes led chemoselectively to the corresponding 伪-amino 伪-trifluoromethyl ketones in moderate to very good yields (32-87%) providing ready access to this pharmaceutically important class of compounds

Synthesis published new progress about Acylation (nucleophilic). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Li Qun published the artcile< Ruthenium(II)-terpyridine complexes-containing glyconanoparticles for one- and two-photon excited fluorescence imaging>, Safety of Perfluorophenyl acrylate, the main research area is ruthenium terpyridine complex glyconanoparticle fluorescence cell imaging.

The synthesis of ruthenium(II)-terpyridine complexes-containing glyconanoparticles (Ru-GNPs) for one- and two-photon excited fluorescence imaging was described. Ru-GNPs were built from diblock copolymers of pentafluorophenyl acrylate (PFA) and 2-(2′,3′,4′,6′-tetra-O-acetyl-尾-D-glucosyloxy)ethyl methacryalte (AcGlcEMA), prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization The pendant reactive pentafluorophenyl ester groups were substituted and the copolymer cross-linked by the two-photon absorption (TPA) chromophore, bis[4′-(4-aminophenyl)-2,2′:6′,2”-terpyridyl]ruthenium(II) hexafluorophosphate. After deacetylation of the acetyl-protecting groups in the AcGlcEMA block, TPA nanoparticles with cross-linked ruthenium(II)-terpyridine complexes as the core and glycopolymers as the corona were obtained. The resulting Ru-GNPs exhibit good water dispersity, one-photon absorption and emission and low cytotoxicity towards KB cell line. Ru-GNPs also undergo two-photon excitation when excited in the near-IR (NIR, 720-880 nm) in water, with TPA cross-sections in the range of 0.2-22 G枚ppert-Mayer (GM, 1 GM = 10-50 cm4 s1 photon-1). Ru-GNPs are thus potentially useful as effective cellular labeling agents for one- and two-photon excited fluorescence imaging.

European Polymer Journal published new progress about Fluorescence imaging. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Safety of Perfluorophenyl acrylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

DeSimone, R. W.; Blum, C. A. published the artcile< Substituted 3-(2-benzoxazyl)-benzimidazol-2-(1H)-ones: A new class of GABAA brain receptor ligands>, Reference of 112-63-0, the main research area is benzoxazolylbenzimidazolone preparation GABA receptor ligand; structure activity benzoxazolylbenzimidazolone GABA receptor binding; benzodiazepine receptor ligand preparation structure activity.

A novel class of potent benzodiazepine receptor (BZR) ligands I (R = H, Me; X = CH, N; Y = O, S; Z = CH, N; R1, R2 = H, F, MeO; R3, R4, R5 = H, F) and II (n = 1, 2), has been designed and synthesized aided by mol. modeling of known benzodiazepine ligands such as CGS-8216 and the use of known pharmacophore models. The structure-activity relationship was studied.

Bioorganic & Medicinal Chemistry Letters published new progress about GABAA receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Critcher, Douglas J.; Connolly, Stephen; Wills, Martin published the artcile< Total Synthesis of Halicholactone and Neohalicholactone>, Formula: C6H10O5, the main research area is halicholactone neohalicholactone total synthesis absolute configuration.

The total syntheses of the marine natural products neohalicholactone and halicholactone, in enantiomerically pure form, were reported. Key steps in the syntheses of each compound included a cis-selective Wittig reaction, stereoselective cyclopropanation, nine-membered lactone formation using the Yamaguchi method and late-stage stereoselective Cr(II)/Ni(II) mediated coupling of vinyl iodides (R,E)-Me(CH2)4CH(OSiPh2CMe3)CH:CHI and (1E,3R,5Z)-MeCH2CH:CHCH2CH(OSiMe2CMe3)CH:CHI with aldehyde I. In the case of the neohalicholactone synthesis the two major components, which were coupled in this convergent synthesis, were each derived from the enantiomers of com. available malic acid. The synthesis served to confirm the original assignment of absolute configuration which was made by Yamada and Clardy. It was also demonstrated, through the preparation of diastereoisomers, that another reported compound closely related to neohalicholactone was likely to be the 15-epineohalicholactone.

Journal of Organic Chemistry published new progress about Cyclopropanation (stereoselective). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Formula: C6H10O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Alazet, Sebastien; Le Vaillant, Franck; Nicolai, Stefano; Courant, Thibaut; Waser, Jerome published the artcile< Divergent Access to (1,1) and (1,2)-Azidolactones from Alkenes using Hypervalent Iodine Reagents>, SDS of cas: 112-63-0, the main research area is azidolactone preparation; alkene carboxylic acid cyclic hypervalent iodine azidation cyclization; 1,2 shift; azides; hypervalent iodine; lactones; photoredox.

A versatile synthesis of azidolactones, e.g., I through azidation and cyclization of carboxylic acids onto alkenes, e.g., 2-(1-phenylvinyl)benzoic acid has been developed. Based on either photoredox or palladium catalysis, (1,1) and (1,2) azido lactones can be selectively synthesized. The choice of catalyst and benziodoxol(on)e reagent serving as azide source was essential to initiate either a radical or Lewis acid mediated process with divergent outcome. These transformations were carried out under mild conditions using low catalyst loading and gave access to a large scope of azido lactones.

Chemistry – A European Journal published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ravu, Ranga Rao; Jacob, Melissa R.; Khan, Shabana I.; Wang, Mei; Cao, Liang; Agarwal, Ameeta K.; Clark, Alice M.; Li, Xing-Cong published the artcile< Synthesis and Antifungal Activity Evaluation of Phloeodictine Analogues>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is phloeodictine analog preparation antifungal cytotoxicity structure activity relationship alkylation.

The phloeodictine-based 6-hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium structural moiety with an n-tetradecyl side chain at C-6 has been demonstrated to be a new antifungal template. Thirty-four new synthetic analogs with modifications of the bicyclic tetrahydropyrrolopyrimidinium skeleton and the N-1 side chain have been prepared and evaluated for in vitro antifungal activities against the clin. important fungal pathogens including Cryptococcus neoformans ATCC 90113, Candida albicans ATCC 90028, Candida glabrata ATCC 90030, Candida krusei ATCC 6258, and Aspergillus fumigatus ATCC 90906. Nineteen compounds showed antifungal activities against the aforementioned five fungal pathogens with min. inhibitory concentrations (MICs) in the range 0.88-10渭M, and all were fungicidal with min. fungicidal concentrations (MFCs) similar to the resp. MIC values. Three compounds were especially active against C. neoformans ATCC 90113 with MIC/MFC values of 1.0/1.0, 1.6/1.6, and 1.3/2.0渭M but exhibited low cytotoxicity with an IC50 > 40渭M against the mammalian Vero cells. The structure and antifungal activity relationship indicates that synthetic modifications of the phloeodictines can afford analogs with potent antifungal activity and reduced cytotoxicity, necessitating further preclin. studies of this new class of antifungal compounds

Journal of Natural Products published new progress about Alkylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Chun-yun; Pan, Guo-qing; Liu, Lai-jun; Bai, Guo-tao; Zhang, Wei; Liu, Zhong-xue published the artcile< RP-HPLC determination of aflatoxin M1 in milk and its products>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is milk product aflatoxin reversed phase high performance liquid chromatog.

Reversed phase high performance liquid chromatog. was applied to the determinations of aflatoxin M1 in milk and its products. The sample was extracted with chloroform and purified by passing through silica gel solid phase extraction column and aflatoxin M1 was eluted from the solid phase extraction column with a mixed solution of chloroform and acetone (1+1). The eluate was separated by gradient elution with acetonitrile solution of different concentration from ZORBAX SB C18, column and their contents determined by fluorescence detector. Linear relationship between values of peak area and mass concentration of aflatoxin M1 was obtained in the range of 1.0-25 渭g/L-1, with detection limit (3S/N) 0.05 渭g/kg-1. The proposed method was used in the anal. of milk and milk powder for their contents of aflatoxin M1and values of recovery found by standard addition method were in the range of 76.0-80.0% and 76.7-90.8% resp. and values of relative standard deviation’s (n=6) found were less than 7.0%.

Lihua Jianyan, Huaxue Fence published new progress about Milk. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shi, Wenqiang; Wang, Yu; Wu, Chunhui; Yang, Feipu; Zheng, Wei; Wu, Song; Liu, Yongjian; Wang, Zhen; He, Yang; Shen, Jingshan published the artcile< Synthesis and biological investigation of triazolopyridinone derivatives as potential multireceptor atypical antipsychotics>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is triazolopyridinone derivative preparation multireceptor atypical antipsychotic agent; 5-HT1A receptor; Antipsychotic; Multireceptor; Triazolopyridinone.

A series of triazolopyridinone derivatives originating from the antidepressant trazodone was designed and pharmacol. evaluated. Most of the compounds with a multireceptor functional profile exhibited high potency at the D2, 5-HT1A, and 5-HT2A receptors. Compounds 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2 H)-one, 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-8-fluoro-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one, 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-5-methoxy-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one and 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyridine-6-carbonitrile were selected for further evaluation of druggable potential. Among these compounds, 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one, as a D2 receptor partial agonist, demonstrated very potent inhibition of quipazine-induced head-twitch response, which validated its 5-HT2A receptor antagonistic efficacy in vivo. 2-(4-(4-(Benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2-H)-one also demonstrated a dose-dependent effect on PCP-induced hyperactivity when administered orally. Thus, 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one endowed with a triazolopyridinone scaffold represents a valuable lead for the development of novel atypical antipsychotics.

Bioorganic & Medicinal Chemistry Letters published new progress about 5-HT1A receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cherng, Yie-Jia published the artcile< Efficient nucleophilic substitution reactions of quinolyl and isoquinolyl halides with nucleophiles under focused microwave irradiation>, Quality Control of 112-63-0, the main research area is microwave nucleophilic substitution quinolyl isoquinolyl halide.

Nucleophilic substitution reactions of 2-chloroquinoline, 3-bromoquinoline and 4-bromoisoquinoline with thiolate, alkoxy ions and aniline were completed within several minutes under microwave irradiation This method gives the desired products with yields up to 99% in a short reaction time, and is superior to the classical heating process.

Tetrahedron published new progress about Microwave irradiation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Strazzolini, P.; Giumanini, A. G.; Runcio, A. published the artcile< Nitric acid in dichloromethane solution. Facile preparation from potassium nitrate and sulfuric acid>, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate, the main research area is arene potassium nitrate sulfuric acid nitration; ester potassium nitrate sulfuric acid nitrolysis; nitro arene preparation.

Pure dry HNO3 can be liberated from KNO3 with 96% H2SO4 directly into CH2Cl2 to yield solutions of variable concentration for use in a number of organic reactions. The present method efficiently replaces the employment of 100% HNO3 in some synthetic applications, avoiding the problems associated in storage and handling the acid. The procedure is exemplified by nitration of arenes and nitrolysis of tert-Bu esters.

Tetrahedron Letters published new progress about Aromatic nitro compounds Role: SPN (Synthetic Preparation), PREP (Preparation). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics