Month: November 2022

Liu, Ruiying; Zheng, Ying; Han, Tao; Lan, Jie; He, Laixi; Shi, Jianyou published the artcile< Angiogenic Actions of Paeoniflorin on Endothelial Progenitor Cells and in Ischemic Stroke Rat Model>, Related Products of 112-63-0, the main research area is paeoniflorin neuroprotectant VEGF endothelial cell angiogenesis ischemic stroke; Angiogenesis; Biological Features; Endothelial Progenitor Cells; Ischemic Stroke; Paeoniflorin; Vascular Regeneration.

Ischemic stroke is one of the major diseases with high morbidity, mortality, and disability rate all over the world. Chinese herb-derived active components would provide valuable candidate compounds for ischemic stroke therapy. Paeoniflorin (PF) is an active ingredient from Paeoniae Radix which possesses neurovascular effect after ischemia. However, so far, few studies are reported on the efficacy and mechanism of PF from angiogenesis aspects. Results from our in vitro studies showed that the ability for proliferation, migration, and tube formation in bone marrow-derived endothelial progenitor cells (BM-EPCs) was promoted by coculturing with PF (100μM). Furthermore, to investigate the angiogenic effects of PF in vivo, we constructed an ischemic stroke model in rats and found that PF could reduce cerebral infarction, alleviate pathol. injury, and increase the secretion of pro-angiogenic factors and cerebral vascular d. after intraperitonially administration of 40 mg · kg-1 · day-1 for 14 days. Up-regulating the expression of VEGF/VEGF-R2 might be the mechanism of PF’s angiogenic action. In conclusion, the present study provides evidence that PF is an active monomer of Traditional Chinese Medicine which shows angiogenic actions on endothelial progenitor cells and in ischemic stroke rat model.

American Journal of Chinese Medicine published new progress about Angiogenesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Elajaili, Hanan; Hernandez-Lagunas, Laura; Harris, Peter; Sparagna, Genevieve C.; Jonscher, Raleigh; Ohlstrom, Denis; Sucharov, Carmen C.; Bowler, Russell P.; Suliman, Hagir; Fritz, Kristofer S.; Roede, James R.; Nozik, Eva S. published the artcile< Extracellular superoxide dismutase (EC-SOD) R213G variant reduces mitochondrial ROS and preserves mitochondrial function in bleomycin-induced lung injury>, Application of C19H34O2, the main research area is SOD2 polymorphism ROS glutathione mitochondrial respiration lung injury.

Extracellular superoxide dismutase (EC-SOD) is highly expressed in the lung and vasculature. A common human single nucleotide polymorphism (SNP) in the matrix binding region of EC-SOD leads to a single amino acid substitution, R213G, and alters EC-SOD tissue binding affinity. The change in tissue binding affinity redistributes EC-SOD from tissue to extracellular fluids. Mice (R213G mice) expressing a knock-in of this EC-SOD SNP exhibit elevated plasma and reduced lung EC-SOD content and activity and are protected against bleomycin-induced lung injury and inflammation. It is unknown how the redistribution of EC-SOD alters site-specific redox-regulated mols. relevant for protection. In this study, we tested the hypothesis that the change in the local EC-SOD content would influence not only the extracellular redox microenvironment where EC-SOD is localized but also protect the intracellular redox status of the lung. Mice were treated with bleomycin and harvested 7 days post-treatment. Superoxide levels, measured by ESR (EPR), were lower in plasma and Bronchoalveolar lavage fluid (BALF) cells in R213G mice compared to wild-type (WT) mice, while lung cellular superoxide levels in R213G mice were not elevated post-bleomycin compared to WT mice despite low lung EC-SOD levels. Lung glutathione redox potential (EhGSSG), determined by HPLC and fluorescence, was more oxidized in WT compared to R213G mice. In R213G mice, lung mitochondrial oxidative stress was reduced shown by mitochondrial superoxide level measured by EPR in lung and the resistance to bleomycin-induced cardiolipin oxidation Bleomycin treatment suppressed mitochondrial respiration in WT mice. Mitochondrial function was impaired at baseline in R213G mice but did not exhibit further suppression in respiration post-bleomycin. Collectively, the results indicate that R213G variant preserves intracellular redox state and protects mitochondrial function in the setting of bleomycin-induced inflammation.

Advances in Redox Research published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (SOD1). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ogoshi, Yosuke; Matsui, Takuya; Mitani, Ikuo; Yokota, Masahiro; Terashita, Masakazu; Motoda, Dai; Ueyama, Kazuhito; Hotta, Takahiro; Ito, Takashi; Hase, Yasunori; Fukui, Kenji; Deai, Katsuya; Yoshiuchi, Hiromi; Ito, Soichiro; Abe, Hiroyuki published the artcile< Discovery of JTZ-951: A HIF Prolyl Hydroxylase Inhibitor for the Treatment of Renal Anemia>, Application In Synthesis of 112-63-0, the main research area is JTZ951 HIF prolyl hydroxylase inhibitor kidney anemia.

Inhibition of hypoxia inducible factor prolyl hydroxylase (PHD) represents a promising strategy for the discovery of a next generation treatment for renal anemia. We identified several 5,6-fused ring systems as novel scaffolds of the PHD inhibitor on the basis of pharmacophore anal. In particular, triazolopyridine derivatives showed potent PHD2 inhibitory activities. Examination of the predominance of the triazolopyridines in potency by electrostatic calculations suggested favorable π-π stacking interactions with Tyr310. Lead optimization to improve the efficacy of erythropoietin release in cells and in vivo by improving cell permeability led to the discovery of JTZ-951 (compound 14), with a 5-phenethyl substituent on the triazolopyridine group, which increased Hb levels with daily oral dosing in rats. Compound 14 was rapidly absorbed after oral administration and disappeared shortly thereafter, which could be advantageous in terms of safety. Compound 14 was selected as a clin. candidate.

ACS Medicinal Chemistry Letters published new progress about Hemoglobins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dezanet, Lorenza N. C.; Miailhes, Patrick; Lascoux-Combe, Caroline; Chas, Julie; Maylin, Sarah; Gabassi, Audrey; Rougier, Hayette; Delaugerre, Constance; Lacombe, Karine; Boyd, Anders published the artcile< Profiles of liver fibrosis evolution during long-term tenofovir treatment in HIV-positive patients coinfected with hepatitis B>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is human liver fibrosis tenofovir HIV hepatitis B; group-based trajectory models; hepatic fibrosis; hepatitis B virus; human immunodeficiency virus.

Data on liver fibrosis evolution and its involvement in liver-related morbidity are scarce in individuals with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) co-infection during treatment. We identified profiles of liver fibrosis evolution in coinfected patients undergoing tenofovir (TDF). We included 169 HIV-HBV-coinfected patients on TDF-based antiretroviral therapy. Virol. and clin. data were obtained at TDF-initiation and every 6-12 mo. From data on non-invasive liver fibrosis assessments collected yearly (FibroTest), we established clusters of individuals with similar liver fibrosis evolution using group-based trajectory models. Four profiles of liver fibrosis evolution were established from a median follow-up of 7.6 years (IQR = 3.1-13.1): low fibrosis with no progression (29.6%, profile A), low fibrosis with progression (22.5%, profile B), moderate fibrosis with high fluctuation (39.6%, profile C), and cirrhosis with no regression (8.3%, profile D). When compared to profile A, baseline HBeAg-pos. status was associated with profiles B (P = .007) and C (P = .004), older age with profiles C (P < .001) and D (P = .001), exposure to second-generation protease inhibitors with profile C (P = .004), and CD4+ <500/mm3 at the last visit with profiles C (P = .02) and D (P = .002). Incident liver-related events occurred in profiles other than A (B, n = 1/38; C, n = 6/67; D, n = 3/14) and all five cases of hepatocellular carcinoma occurred in profiles C (n = 2) and D (n = 3). TDF-treated HIV-HBV coinfected individuals do not seem to benefit from comparable levels of liver fibrosis regression as in HBV mono-infection. Liver-related morbidity occurs mainly in those with fluctuating or consistently high fibrosis levels. Liver International published new progress about Alcohols Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nitsche, Tobias; Steinkoenig, Jan; De Bruycker, Kevin; Bloesser, Fabian R.; Blanksby, Stephen J.; Blinco, James P.; Barner-Kowollik, Christopher published the artcile< Mapping the Compaction of Discrete Polymer Chains by Size Exclusion Chromatography Coupled to High-Resolution Mass Spectrometry>, SDS of cas: 112-63-0, the main research area is polystyrene tetrazole fumarate exclusion chromatog mass spectrometry.

We introduce a powerful approach based on the combination of size exclusion chromatog. with high-resolution mass spectrometry to selectively follow the compaction of discrete polymer chains that have uniform elemental composition Single-chain nanoparticles (SCNP) have attracted considerable interest for a wide range of applications associated with their adjustable morphol. However, the precise characterization of morphol. changes during the compaction is still challenging using existing anal. techniques. We employ a polystyrene backbone functionalized with tetrazole and fumarate moieties to utilize the nitrile imine-mediated tetrazole-ene cycloaddition for compaction. As every compaction step is associated with an elimination of one nitrogen mol., it can be monitored via high-resolution electrospray ionization mass spectrometry. The combination with size exclusion chromatog. enables the direct correlation of changes in mass with changes in morphol. associated with the compaction. By establishing a calibration between the retention time and the hydrodynamic radius, ion chromatograms of discrete chains can be directly applied to determine the reduction in hydrodynamic radius associated with each crosslinking event. Therefore, accessing the compaction of discrete polymer chains becomes possible for the first time.

Macromolecules (Washington, DC, United States) published new progress about Hydrodynamic radius. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dorko, Eva; Kotai, Bianka; Foldes, Tamas; Gyomore, Adam; Papai, Imre; Soos, Tibor published the artcile< Correlating electronic and catalytic properties of frustrated Lewis pairs for imine hydrogenation>, Application In Synthesis of 112-63-0, the main research area is borane acidity frustrated Lewis pair catalysis imine hydrogenation.

Gradually substituting meta- and para-hydrogen atoms to fluorines or chlorines, a series of seventeen triarylboranes with a general BX2Y structure was generated for frustrated Lewis pair hydrogenation of imines and comprehensively characterized using combined exptl. and theor. methods.

Journal of Organometallic Chemistry published new progress about Boranes Role: CAT (Catalyst Use), PEP (Physical, Engineering or Chemical Process), PRP (Properties), SPN (Synthetic Preparation), USES (Uses), PROC (Process), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cotrina, Ellen Y.; Pinto, Marta; Bosch, Lluis; Vila, Marta; Blasi, Daniel; Quintana, Jordi; Centeno, Nuria B.; Arsequell, Gemma; Planas, Antoni; Valencia, Gregorio published the artcile< Modulation of the Fibrillogenesis Inhibition Properties of Two Transthyretin Ligands by Halogenation>, Product Details of C19H34O2, the main research area is fibrillogenesis transthyretin ligand halogenation.

The amyloidogenic protein transthyretin (TTR) is thought to aggregate into amyloid fibrils by tetramer dissociation which can be inhibited by a number of small mol. compounds Our anal. of a series of crystallog. protein-inhibitor complexes has shown no clear correlation between the observed mol. interactions and the in vitro activity of the inhibitors. From this anal., it emerged that halogen bonding (XB) could be mediating some key interactions. Anal. of the halogenated derivatives of two well-known TTR inhibitors has shown that while flufenamic acid affinity for TTR was unchanged by halogenation, diflunisal gradually improves binding up to 1 order of magnitude after iodination through interactions that can be interpreted as a suboptimal XB (carbonyl Thr106: I…O distance 3.96-4.05 Å; C-I…O angle 152-156°) or as rather optimized van der Waals contacts or as a mixture of both. These results illustrate the potential of halogenation strategies in designing and optimizing TTR fibrillogenesis inhibitors.

Journal of Medicinal Chemistry published new progress about Drug design. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bhaumik, Atanu; Peterson, Gregory I.; Kang, Cheol; Choi, Tae-Lim published the artcile< Controlled Living Cascade Polymerization To Make Fully Degradable Sugar-Based Polymers from D-Glucose and D-Galactose>, Reference of 4098-06-0, the main research area is degradable monosaccharide polymer cascade polymerization synthesis.

Monomers derived from glucose and galactose, which contain an endocyclic alkene (in the sugar ring) and a terminal alkyne, underwent a cascade polymerization to prepare new polymers with the ring-opened sugar incorporated into the polymer backbone. Polymerizations were well-controlled, as demonstrated by a linear increase in mol. weight with monomer-to-initiator ratio and generally narrow mol. weight dispersity values. The living nature of the polymerization was supported by the preparation of a block copolymer from two different sugar-based monomers. The resulting polymers were also fully degradable. They underwent fast and complete depolymerization to small mols. under acidic conditions.

Journal of the American Chemical Society published new progress about Carbohydrates Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (polymers). 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Reference of 4098-06-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Watanabe, Yutaka; Hirofuji, Hajimu; Ozaki, Shoichiro published the artcile< Synthesis of a phosphatidylinositol 3,4,5-trisphosphate>, Related Products of 112-63-0, the main research area is phosphatidylinositol trisphosphate; distearylglycerol phosphite regioselective phosphorylation inositol.

A phosphatidylinositol 3,4,5-trisphosphate I (R = R1) was synthesized from myo-inositol via regioselective phosphorylation of inositol I (R = H) with dibenzyl 1,2-distearyl-sn-glycerol phosphite.

Tetrahedron Letters published new progress about Phosphorylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Patra, Atanu; Gelat, Fabien; Pannecoucke, Xavier; Poisson, Thomas; Besset, Tatiana; Biju, Akkattu T. published the artcile< Synthesis of 4-Difluoromethylquinolines by NHC-Catalyzed Umpolung of Imines>, Computed Properties of 112-63-0, the main research area is aldimine preparation heterocyclic carbene catalyzed umpolung intramol cyclization; fluoromethylquinoline preparation; benzaldehyde condensation fluoropropenylaniline.

The N-heterocyclic carbene (NHC)-catalyzed umpolung of aldimines for the synthesis of 4-difluoromethylquinoline derivatives is reported. In the presence of NHCs, the intramol. cyclization of aldimines bearing a moderately electron-poor double bond due to the presence of the -CF3 group likely proceeds via the intermediacy of the aza-Breslow intermediate. The key to the success of this aza-Stetter type transformation is the NHC generated from the bicyclic triazolium salt using DBU as the base.

Organic Letters published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics