Month: November 2022

Yi, Chae S.; Zeczycki, Tonya N.; Guzei, Ilia A. published the artcile< Highly Cooperative Tetrametallic Ruthenium-μ-Oxo-μ-Hydroxo Catalyst for the Alcohol Oxidation Reaction>, Formula: C19H34O2, the main research area is ruthenium oxo hydroxo phosphine cluster preparation alc oxidation catalyst; crystal structure ruthenium hydroxo phosphine tetranuclear dinuclear cluster; alc oxidation transfer dehydrogenation catalyzed ruthenium tetranuclear cluster.

The tetrametallic Ru-oxo-hydroxo-hydride complex {[(PCy3)(CO)RuH]4(μ4-O)(μ3-OH)(μ2-OH)} (1) was synthesized in two steps from monomeric (PCy3)(CO)RuHCl (2). The tetrameric 1 is a highly effective catalyst for the transfer dehydrogenation of alcs. Complex 1 showed a different catalytic activity pattern toward primary and secondary benzyl alcs., as indicated by the Hammett correlation for the oxidation reaction of p-X-C6H4CH2OH (ρ = -0.45) and p-X-C6H4CH(OH)CH3 (ρ = +0.22) (X = OMe, CH3, H, Cl, CF3). Both a sigmoidal curve from the plot of initial rate vs. [PhCH(OH)CH3] (K0.5 = 0.34M; Hill coefficient, n = 4.2 ± 0.1) and the phosphine inhibition kinetics revealed the highly cooperative nature of the complex for the oxidation of secondary alcs. The crystal structure of the intermediate (PCy3)2(CO)RuH(μ-OH)(μ-H)(PCy3)(CO)RuH (3) is also reported.

Organometallics published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hayashi, H.; Nakanishi, K.; Brandon, C.; Marmur, J. published the artcile< Structure and synthesis of dihydroxypentyluracil from bacteriophage SP-15 deoxyribonucleic acid>, Name: (S)-Dimethyl 2-hydroxysuccinate, the main research area is bacteriophage dihydroxypentyluracil; ribonucleic acid bacteriophage SP15.

(S)-(+)-5-(4′,5′-Dihydroxypentyl)uracil, a base which replaces thymine in bacteriophage SP-15 DNA was prepared starting from (S)-(-)-malic acid establishing the 4′ configuration as being (S). The optical purity (100%) of a synthetic intermediate PhCH:CH(CH2)2CH(OMTPA)CH2OMTPA [MTPA = (+)-MeOCH(CF3)CO] was checked by NMR.

Journal of the American Chemical Society published new progress about DNA Role: RCT (Reactant), RACT (Reactant or Reagent). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Name: (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Roslan, Nurul Asmawati; Zainal Abidin, Sumaiya; Abdullah, Norhayati; Osazuwa, Osarieme Uyi; Abdul Rasid, Ruwaida; Yunus, Nursofia Mohd published the artcile< Esterification reaction of free fatty acid in used cooking oil using sulfonated hypercrosslinked exchange resin as catalyst>, Formula: C19H34O2, the main research area is fatty acid cooking oil esterification sulfonated hypercrosslinked exchange resin; esterification kinetics physicochem property.

The production of valuable fatty acid alkyl ester (FAAE) com. known as biodiesel from used cooking oil (UCO) as feedstock has recently gained global interest. To carry out this production process, an esterification reaction is necessary to minimize the amount of free fatty acid (FFA) in the UCO. The purpose of this research work is to evaluate the performance of the newly snythesized sulfonated hypercrosslinked exchange resin (SHER) for the esterification reaction. The catalyst was first synthesized and characterized using various physicochem. analyses (i.e. FTIR, surface morphol., N2 physisorption anal. and TGA and further subjected to the esterification reaction to determine the reaction kinetics. The esterification reaction was conducted at various catalyst loading (1-8 wt%), reaction temperatures (40-60°C), and methanol to oil molar ratios (6:1-24:1). From the characterization study, SHER was found to have high decomposition temperature (up to 398°C) and sp. surface area (836 m2 g-1). Addnl., SHER had the capability to accommodate high number of active sites which could benefit the esterification reaction. The highest FFA conversion of 97% was achieved at 5 wt% catalyst loading, 60°C of reaction temperature and 12:1 methanol to oil mole ratio in 2 h reaction time. Analyses of the spent catalyst revealed the presence of impurities residue on the SHER’s surface following the esterification reaction, and the catalyst pore remained evident even after several reusability cycles.

Chemical Engineering Research and Design published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Proto, Maria Chiara; Fiore, Donatella; Piscopo, Chiara; Laezza, Chiara; Bifulco, Maurizio; Gazzerro, Patrizia published the artcile< Modified adenosines sensitize glioblastoma cells to temozolomide by affecting DNA methyltransferases>, Category: esters-buliding-blocks, the main research area is glioblastoma adenosine temozolomide resistance DNA methyltransferase protein expression; DNA methyltransferases; Fbxw7; MGMT; N6-benzyladenosine; N6-isopentenyladenosine; chemoresistance; glioblastoma; temozolomide.

Glioblastoma (GBM) is the most common and lethal primary malignant brain tumor, and due to its unique features, its management is certainly one of the most challenging ones among all cancers. N6-isopentenyladenosine (IPA) and its analog N6-benzyladenosine (N6-BA) are modified nucleosides endowed with potent antitumor activity on different types of human cancers, including GBM. Corroborating our previous finding, we demonstrated that IPA and N6-BA affect GBM cell line proliferation by modulating the expression of the F-box WD repeat domain-containing-7 (FBXW7), a tumor suppressor with a crucial role in the turnover of many proteins, such as SREBPs and Mcl1, involved in malignant progression and chemoresistance. Luciferase assay revealed that IPA-mediated upregulation of FBXW7 translates in transcriptional inactivation of its oncogenic substrates (Myc, NFkB, or HIF-1α). Moreover, downregulating MGMT expression, IPA strongly enhances the killing effect of temozolomide (TMZ), producing a favorable sensitizing effect starting from a concentration range much lower than TMZ EC50. Through DNA methyltransferase (DNMT) activity assay, anal. of the global DNA methylation, and the histone modification profiles, we demonstrated that the modified adenosines behave similar to 5-AZA-dC, known DNMT inhibitor. Overall, our results provide new perspectives for the first time, suggesting the modified adenosines as epigenetic tools able to improve chemo- and radiotherapy efficacy in glioblastoma and potentially other cancers.

Frontiers in Pharmacology published new progress about Acetylated histone H3 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sadd, Matthew; Agostini, Marco; Xiong, Shizhao; Matic, Aleksandar published the artcile< Polysulfide Speciation and Migration in Catholyte Lithium-Sulfur Cells>, Application of C19H34O2, the main research area is polysulfide speciation migration lithium sulfur battery catholyte; catholyte; lithium−sulfur (Li−S) battery; operando Raman spectroscopy; polysulfides; radical species.

Semi-liquid catholyte Lithium-Sulfur (Li-S) cells have shown to be a promising path to realize high energy d. energy storage devices. In general, Li-S cells rely on the conversion of elemental sulfur to soluble polysulfide species. In the case of catholyte cells, the active material is added through polysulfide species dissolved in the electrolyte. Herein, we use operando Raman spectroscopy to track the speciation and migration of polysulfides in the catholyte to shed light on the processes taking place. Combined with ex-situ surface and electrochem. anal. we show that the migration of polysulfides is central in order to maximize the performance in terms of capacity (active material utilization) as well as interphase stability on the Li-metal anode during cycling. More specifically we show that using a catholyte where the polysulfides have the dual roles of active material and conducting species, e. g. no traditional Li-salt (such as LiTFSI) is present, results in a higher mobility and faster migration of polysulfides. We also reveal how the formation of long chain polysulfides in the catholyte is delayed during charge as a result of rapid formation and migration of shorter chain species, beneficial for reaching higher capacities. However, the depletion of ionic species during the last stage of charge, due to the conversion to and precipitation of elemental sulfur on the cathode support, results in polarization of the cell before full conversion can be achieved.

ChemPhysChem published new progress about Battery anodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Anjali, Kaiprathu; Vijayan, Arya; Venkatesha, Naragalu J.; Sakthivel, Ayyamperumal published the artcile< Niobium based macromolecule preparation and its potential application in biomass derived levulinic acid esterification>, Electric Literature of 112-63-0, the main research area is preparation niobium carboxyphenylporphyrin complex levulinate esterification; levulinate esterification niobium carboxyphenylporphyrin complex catalyst; niobium macromol biomass levulinate esterification.

Niobium incorporated meso-tetra-(4-carboxyphenyl)-porphyrin (Nb-TCPP) was prepared for the first time and grafted through the axial position by the surface amine groups present on functionalized SBA-15 (SBA-AM). The synthesized TCPP ligand, Nb-TCPP complex, and the grafted Nb-TCPP-SBA-AM complex were thoroughly characterized by various anal. and spectroscopic techniques such as FTIR, UV-visible, DR UV-visible, CHN, 1H NMR, powder XRD, and N2 sorption studies. The catalytic activity of the homogeneous (Nb-TCPP) and the heterogenized (Nb-TCPP-SBA-AM) complex were explored for the esterification of levulinic acid. The studies revealed that Nb-TCPP and Nb-TCPP-SBA-AM showed comparatively good catalytic activity (74-80% conversion) for the esterification of levulinic acid using methanol under mild reaction conditions with the formation of Me levulinate and α-angelica lactone as the major products.

Inorganic Chemistry Communications published new progress about Esterification. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Song, Sirong; Ma, Dongbin; Xu, Lixia; Wang, Qiong; Liu, Lanxiang; Tong, Xiaoguang; Yan, Hua published the artcile< Low-intensity pulsed ultrasound-generated singlet oxygen induces telomere damage leading to glioma stem cell awakening from quiescence>, Electric Literature of 112-63-0, the main research area is glioma stem cell quiescence telomere damage LIPUS singlet oxygen; Cancer; Cell biology; Medical device; Stem cells research.

Cancer stem cells, quiescent and drug resistant, have become a therapeutic target. Unlike high-intensity focused ultrasound directly killing tumor, low-intensity pulsed ultrasound (LIPUS), a new noninvasive phys. device, promotes pluripotent stem cell differentiation and is primarily applied in tissue engineering but rarely in oncotherapy. We explored the effect and mechanism of LIPUS on glioma stem cell (GSC) expulsion from quiescence. Here, we observed that LIPUS led to attenuated expression of GSC biomarkers, promoted GSC escape from G0 quiescence, and significantly weakened the Wnt and Hh pathways. Of note, LIPUS transferred sonomech. energy into cytochrome c and B5 proteins, which converted oxygen mols. into singlet oxygen, triggering telomere crisis. The in vivo and in vitro results confirmed that LIPUS enhanced the GSC sensitivity to temozolomide. These results demonstrated that LIPUS “”waked up”” GSCs to improve their sensitivity to chemotherapy, and importantly, we confirmed the direct targeted proteins of LIPUS in GSCs.

iScience published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Downes, Thomas D.; Jones, S. Paul; Klein, Hanna F.; Wheldon, Mary C.; Atobe, Masakazu; Bond, Paul S.; Firth, James D.; Chan, Ngai S.; Waddelove, Laura; Hubbard, Roderick E.; Blakemore, David C.; De Fusco, Claudia; Roughley, Stephen D.; Vidler, Lewis R.; Whatton, Maria Ann; Woolford, Alison J.-A.; Wrigley, Gail L.; O’Brien, Peter published the artcile< Design and Synthesis of 56 Shape-Diverse 3D Fragments>, SDS of cas: 33402-75-4, the main research area is alkyl piperidine pyrrolidine fragment diastereoselective preparation; 3D fragments; conformational diversity; fragment-based drug discovery; medicinal chemistry; synthesis design.

Fragment screening collections were often predominantly populated with flat, 2D mols. A workflow for the design and synthesis of 56 3D disubstituted pyrrolidine and piperidine fragments that occupy under-represented areas of fragment space (as demonstrated by a principal moments of inertia (PMI) anal.) was described. A key, and unique, underpinning design feature of this fragment collection was that assessment of fragment shape and conformational diversity (by considering conformations up to 1.5 kcal mol-1 above the energy of the global min. energy conformer) was carried out prior to synthesis and was also used to select targets for synthesis. The 3D fragments were designed to contain suitable synthetic handles for future fragment elaboration. Finally, by comparing our 3D fragments with six com. libraries, it was clear that our collection was high three-dimensionality and shape diversity.

Chemistry – A European Journal published new progress about Conformers. 33402-75-4 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO2, SDS of cas: 33402-75-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Qanash, Husam; Yahya, Reham; Bakri, Marwah M.; Bazaid, Abdulrahman S.; Qanash, Sultan; Shater, Abdullah F.; T. M., Abdelghany published the artcile< Anticancer, antioxidant, antiviral and antimicrobial activities of Kei Apple (Dovyalis caffra) fruit>, Formula: C19H34O2, the main research area is anticancer antioxidant antiviral antimicrobial Dovyalis fruit.

Secondary plant metabolites remain one of the key sources of therapeutic agents despite the development of new approaches for the discovery of medicinal drugs. In the current study, chem. anal., and biol. activities of Kei apple (Dovyalis caffra) methanolic extract were evaluated. Chem. anal. was performed using HPLC and GC-MS. Antiviral and anticancer effect were assessed using the crystal violet technique and activity against human liver cells (HepG2), resp. Antibacterial activity was tested with the disk diffusion method. The obtained results showed that chlorogenic acid (2107.96 ± 0.07 μg/g), catechin (168 ± 0.58 μg/g), and gallic acid (15.66 ± 0.02 μg/g) were the main bioactive compounds identified by HPLC techniques. While, compounds containing furan moieties, as well as levoglucosenone, isochiapin B, dotriacontane, 7-nonynoic acid and tert-hexadecanethiol, with different biol. activities were identified by GC-MS. Addnl., inhibition of 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) scavenging was 79.25% at 2000 μg/mL, indicating its antioxidant activity with IC50 of 728.20 ± 1.04 μg/mL. The tested extract exhibited potential anticancer activity (58.90% toxicity) against HepG2 cells at 1000 μg/mL. Potential bacterial inhibition was observed mainly against Escherichia coli and Proteus vulgaris, followed by Staphylococcus aureus and Bacillus subtilis with a diameter of growth inhibition ranging from 13 to 24 mm. While weak activities were recorded for fungi Candida albicans (10 mm). The extract showed mild antiviral activity against human coronavirus 229E with a selective index (SI) of 10.4, but not against human H3N2 (SI of 0.67). The mol. docking study′s energy ratings were in good promise with the experiment documents of antibacterial and antiviral activities. The findings suggest that D. caffra juice extract is a potential candidate for further experiments to assess its use as potential alternative therapeutic agent.

Scientific Reports published new progress about Aberia caffra. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Watanabe, Yutaka; Munetsugu, Hirofumi; Hayashi, Minoru published the artcile< Comparison of cyclic and acyclic phosphites by selective phosphorylation. Synthesis of phosphatidylinositol 4-phosphate>, Application of C19H34O2, the main research area is palmitoylglycerol phosphite phosphorylation inositol; cyclic acyclic phosphite preparation phosphitylation; phosphatidylinositol phosphate preparation.

To compare the synthetic utility of cyclic xylylene N,N-diethylphosphoramidite and its acyclic analog, dibenzyl ester, both phosphites derived from them with dipalmitoylglycerol were subjected to the selective phosphorylation at the OH-3 position in 1,2:4,5-di-O-cyclohexylidene-myo-inositol in the presence of pyridinium tribromide, and the cyclic version showed to be much superior to the acyclic. The 3-O-phosphorylated product was conveniently converted into phosphatidylinositol 4-phosphate.

Chemistry Letters published new progress about Cyclitols Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics