Month: November 2022

Knyazev, V. N.; Drozdov, V. A. published the artcile< Use of new titrants for conducting redox reactions in nonaqueous media>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is titrant redox nonaqueous potentiometry; borohydride titrant nonaqueous potentiometry; aminoethylhydroquinone titrant nonaqueous potentiometry; hydroquinone aminoethyl titrant nonaqueous potentiometry; chlorooxochromium titrant nonaqueous potentiometry; chromyl chloride titrant nonaqueous potentiometry; chlorooxochromate potassium titrant nonaqueous potentiometry; pyridine bromide perbromide redox titrant; selenium titration nonaqueous potentiometric.

NaBH4, 2,5-bis(diethylaminomethyl)hydroquinone, CrO2Cl2, CrO2(OK)Cl, and C5H5N.HBr3 were examined as titrants in nonaqueous media for Ag and UO22+ nitrates, Ti(IV), Hg(II), and Sn(II,IV) chlorides, H2SeO3, I, o- and p-benzoquinones, hydroquinone, resorcinol, pyrocatechol, alcs., aldehydes, etc. The titrations at 20±0.2.degree. were performed by using a potentiometer with different electrode pairs. With NaBH4 and a calomel – Pt electrode pair, individual compounds can be determined and Ag+ and Hg2+ salts can be differentially titrated in pyridine medium. The titrations with Mannich base were carried out in EtOH or MeOH; calomel – Pt and Pt- Sb electrode pairs were suitable for the titrations The reactions with Ag, Cu(II), and Hg(II) salts were quant. The Ag(I), Cu(II), and Hg(II) salts were reduced to Ag0, Cu(I), Hg(I). The mixtures of Ag+ + Hg2+ and Ag+ + Cu2+ can be titrated quant. PhOH, cresols, xylenols, guaiacol, hydroxybenzoic acids, styrene, aryl-α-tetralol, cyclohexene, diphenylpropane, 4-hydroxydiphenyl, and a number of other di- and trihydric phenols as well as their derivatives reacted quant. with C5H5N.HBr3 in an alk. medium (NaOAc), whereas α,β-nonsatd. acids did not.

Izvestiya Timiryazevskoi Sel’skokhozyaistvennoi Akademii published new progress about Reducing agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Qu, Jinglin; Yan, Zijuan; Wang, Xuchao; Deng, Jun; Liu, Feipeng; Rong, Zi-Qiang published the artcile< Nickel-catalyzed cross-coupling of epoxides with aryltriflates: rapid and regioselective construction of aryl ketones>, Related Products of 112-63-0, the main research area is aryl ketone regioselective preparation; aryltriflate epoxide nickel catalyst cross coupling.

Herein, a facile synthetic method for the construction of ketones RCH2C(O)Ar [R = Ph, 2-MeC6H4, Bn, etc.; Ar = Ph, 4-FC6H4, 4-C(O)Me, etc.] via Ni-catalyzed cross coupling of epoxides with aryltriflates was presented. A range of easily accessible epoxides could be highly regioselectively converted to the corresponding aryl ketones with good yields in a redox neutral fashion.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aryl triflates Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Abram, Michal; Rapacz, Anna; Mogilski, Szczepan; Latacz, Gniewomir; Lubelska, Annamaria; Kaminski, Rafal M.; Kaminski, Krzysztof published the artcile< Multitargeted Compounds Derived from (2,5-Dioxopyrrolidin-1-yl)(phenyl)-Acetamides as Candidates for Effective Anticonvulsant and Antinociceptive Agents>, Product Details of C19H34O2, the main research area is epilepsy neuropathic pain anticonvulsant antinociceptive multitargeted drugs hybrid compound; Hybrid compounds; anticonvulsant activity; antinociceptive activity; epilepsy; multitargeted drugs; neuropathic pain.

We developed a focused set of original hybrid pyrrolidine-2,5-dione derivatives with potent anticonvulsant and antinociceptive properties. These hybrid compounds demonstrated broad-spectrum protective activity in a range of mouse models, such as the maximal electroshock (MES) test, the pentylenetetrazole-induced seizures (scPTZ), and the 6 Hz (32 mA) seizures. Compound 22(I) showed the most potent anticonvulsant activity (ED50 MES = 23.7 mg/kg, ED50 6 Hz (32 mA) = 22.4 mg/kg, ED50scPTZ = 59.4 mg/kg). In addition, 22 revealed potent efficacy in the formalin-induced tonic pain. These in vivo activities of 22 are likely mediated by several targets and may result from the inhibition of central sodium/calcium currents and transient receptor potential vanilloid 1 (TRPV1) receptor antagonism. Finally, the lead compound 22 revealed drug-like absorption, distribution, metabolism, excretion, toxicity (ADME-Tox) properties in the in vitro assays, making it a potential candidate for further development in epilepsy and neuropathic pain indications.

ACS Chemical Neuroscience published new progress about Analgesics. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tian, Heng-Zhi; Tang, Qing-Gang; Lin, Guo-Qiang; Sun, Xing-Wen published the artcile< Asymmetric synthesis of chiral 1,2-oxazinane and hexahydropyridazine spirocyclic scaffolds by organocatalytic [4 + 2] cycloaddition>, SDS of cas: 112-63-0, the main research area is indolinone alkoxycarbonylmethylene diastereoselective enantioselective cycloaddition unsaturated ester hydrazide; oxazinane spiro oxindole asym synthesis; pyridazinone spiro oxindole asym synthesis.

A novel approach to synthesize chiral 1,2-oxazinane spirocyclic scaffolds I (X = O; Y = H2; R1 = H, 5-MeO, 6-Br, 7-F, etc.; R2 = Me, Et, t-Bu, PhCH2; R3 = Boc, Cbz; R4 = Et; R5 = Ac, Boc, PhCO) by organocatalytic [4 + 2] cycloaddition reaction between methyleneindolinones II and γ-aminooxy-α,β-unsaturated esters EtO2CCH:CHCH2ONHR5 has been developed. Furthermore, a hydrazide 1,4-synthon PhCH2NHNHC(O)CH:CHCO2R4 (R4 = Me, Et, n-Bu) was designed and synthesized to construct the corresponding chiral hexahydropyridazine spirocyclic scaffolds I (X = NH; Y = O; R3 = Boc; R5 = PhCH2) via [4 + 2] cycloaddition reaction with methyleneindolinones II. Both reactions gave the corresponding products in good to excellent yields, excellent diastereoselectivity and good enantioselectivity.

RSC Advances published new progress about [4+2] Cycloaddition reaction (stereoselective). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhu, Jinhui; Yousuf, Mohammed Adnan; Yang, Wenmin; Zhu, Qiuying; Shen, Zhiyong; Lan, Guanghua; Chen, Yi; Chen, Huanhuan; Fan, Wensheng; Xing, Hui; Shao, Yiming; Ruan, Yuhua; Li, Liming published the artcile< Mortality and attrition rates within the first year of antiretroviral therapy initiation among people living with HIV in Guangxi, China: an observational cohort study>, Formula: C19H34O2, the main research area is stavudine azidothymidine tenofovir antiretroviral agent human immunodeficiency virus infection.

To assess the mortality and attrition rates within the first year of antiretroviral therapy (ART) initiation among people living with human immunodeficiency virus (PLHIV) in rural Guangxi, China. The core treatment indicators and data were collected with standard and essential procedures as per the Free ART Manual guidelines across all the rural health care centers of Guangxi. Participants. 58,115 PLHIV who were under ART were included in the study. The data collected included sociodemog. characteristics that consist of age, sex, marital status, route of HIV transmission, CD4 cell count before ART, initial ART regimen, level of ART site, and year of ART initiation. Primary and Secondary Outcome Measures. Mortality and attrition rate following ART initiation. The average mortality rate was 5.94 deaths, and 17.52 attritions per 100 person-years within the first year of ART initiation among PLHIV. The mortality rate was higher among i.v. drug users (Adjusted Hazard Ratio (AHR) 1.27, 95% Confidence Interval (CI) 1.14-1.43), prefecture as a level of ART site (AHR 1.14, 95% CI 1.02-1.28), and county as the level of ART site (AHR 2.12, 95% CI 1.90-2.37). Attrition was higher among i.v. drug users (AHR 1.87, 95% CI 1.75-2.00), the first-line ART containing AZT (AHR 1.09, 95% CI 1.03-1.16), and first-line ART containing LVP/r (AHR 1.34, 95% CI 1.23-1.46). The mortality and attrition rates were both at the highest level in the first year of post-ART; continued improvement in the quality of HIV treatment and care is needed.

BioMed Research International published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Naves, Yves Rene; Conia, Jean Marie published the artcile< On a putative synthesis of piperitenone>, Reference of 112-63-0, the main research area is .

The compound C10H14O, prepared by Bergmann and Bracha (CA 54, 22703c) by condensation of mesityl oxide (2-methyl-2-penten-4-one) (I) and Me vinyl ketone (II) in the presence of Na tert-pentoxide, which was claimed to be 2-isopropylidene-5-methyl-5-cyclohexen-2-one (III), was shown to be isoxylitone (3-methyl-4-isopropylidene-5-isopropyl-2-cyclohexen-1-one) (IV), formed by the condensation of 2 mols. of I. The infrared spectra of III and IV and of their resp. dinitrophenylhydrazones were given. IV was unchanged by heating with HCO2H and not susceptible to catalytic dehydrogenation with Pd.

Bulletin de la Societe Chimique de France published new progress about IR spectra. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Minhas, Harsimran K.; Riley, William; Stuart, Alison M.; Urbonaite, Martyna published the artcile< Activation of the hypervalent fluoroiodane reagent by hydrogen bonding to hexafluoroisopropanol>, COA of Formula: C19H34O2, the main research area is dicarbonyl compound hypervalent fluoroiodane fluorination; fluoro dicarbonyl compound preparation; alkenyl carboxylic acid hypervalent fluoroiodane regioselective fluorocyclization; fluorolactone preparation.

Hexafluoroisopropan-2-ol (HFIP) is an excellent solvent for promoting fluorinations with the hypervalent fluoroiodane and crucially, it removes the need for transition metals or TREAT-HF activators. The fluoroiodane reagent was used in HFIP to monofluorinate 1,3-carbonyl compounds and to fluorocyclize unsaturated carboxylic acids in excellent yields under mild reaction conditions.

Organic & Biomolecular Chemistry published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Polishchuk, Pavel G.; Muratov, Eugene N.; Artemenko, Anatoly G.; Kolumbin, Oleg G.; Muratov, Nail N.; Kuz’min, Victor E. published the artcile< Application of Random Forest Approach to QSAR Prediction of Aquatic Toxicity>, Reference of 112-63-0, the main research area is QSAR random forest aquatic toxicity Tetrahymena modeling lipophilicity polarizability.

This work is devoted to the application of the random forest approach to QSAR anal. of aquatic toxicity of chem. compounds tested on Tetrahymena pyriformis. The simplex representation of the mol. structure approach implemented in HiT QSAR Software was used for descriptors generation on a two-dimensional level. Adequate models based on simplex descriptors and the RF statistical approach were obtained on a modeling set of 644 compounds Model predictivity was validated on two external test sets of 339 and 110 compounds The high impact of lipophilicity and polarizability of investigated compounds on toxicity was determined It was shown that RF models were tolerant for insertion of irrelevant descriptors as well as for randomization of some part of toxicity values that were representing a “”noise””. The fast procedure of optimization of the number of trees in the random forest has been proposed. The discussed RF model had comparable or better statistical characteristics than the corresponding PLS or KNN models.

Journal of Chemical Information and Modeling published new progress about Amines Role: ADV (Adverse Effect, Including Toxicity), PRP (Properties), BIOL (Biological Study) (amyl-). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wan, Yiting; Gu, Cancan; Kong, Jueying; Sui, Jin; Zuo, Ling; Song, Yanhua; Chen, Jing published the artcile< Long noncoding RNA ADAMTS9-AS1 represses ferroptosis of endometrial stromal cells by regulating the miR-6516-5p/GPX4 axis in endometriosis>, Name: Ethyl 3-amino-4-(cyclohexylamino)benzoate, the main research area is ADAMTS9 AS1 miR65165p GPX4 ferroptosis endometriosis.

Endometriosis (EMs) is one of the most frequent diseases of reproductive-age women and is characterized by the growth of endometrial tissues beyond the uterus. The enhanced proliferative and migratory potential of endometrial stromal cells (ESCs) plays an important role in the progression of EMs. Mounting studies have demonstrated that long noncoding RNAs (lncRNAs) exert an important role in regulating the development and progression of EMs. Given the aberrant expression of lncRNA ADAMTS9-AS1 in ectopic endometrium (ecEM), we investigated the biol. effect of ADAMTS9-AS1 on ESC proliferation and migration and explored the underlying mechanism. The current data showed that ADAMTS9-AS1 expression was significantly upregulated in ecEM compared with eutopic endometrium (euEM) in patients with EMs and in a murine model of EMs. Functionally, ADAMTS9-AS1 knockdown in ectopic ESCs (EESCs) decreased cell viability and migration, whereas ADAMTS9-AS1 overexpression in normal ESCs (NESCs) enhanced cell viability and migration. More importantly, the effect of ADAMTS9-AS1 inhibition on decreasing ESC viability was significantly blocked by ferrostatin-1 (Fer-1, a ferroptosis inhibitor), and ADAMTS9-AS1 overexpression repressed erastin (a ferroptosis activator)-induced cell death. Furthermore, the regulatory role of ADAMTS9-AS1 in ferroptosis was defined and evidenced by increased reactive oxygen species (ROS) levels and malonyl dialdehyde (MDA) content and decreased expression of glutathione peroxidase 4 (GPX4) after ADAMTS9-AS1 inhibition. Mechanistically, ADAMTS9-AS1 functioned as a competing endogenous RNA (ceRNA) by sponging miR-6516-5p to derepress the expression of GPX4, the critical repressor of ferroptosis. Taken together, these results demonstrate that upregulated ADAMTS9-AS1 accelerates ESC proliferation and migration by regulating miR-6516-5p/GPX4-dependent ferroptosis and may be a potential target for the treatment of EMs.

Scientific Reports published new progress about Apoptosis. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Name: Ethyl 3-amino-4-(cyclohexylamino)benzoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

McKenzie, Lallie C.; Huffman, Lauren M.; Hutchison, James E. published the artcile< The evolution of a green chemistry laboratory experiment greener brominations of stilbene>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is green chem education laboratory experiment bromination reagent stilbene.

The use of green metrics to compare three bromination laboratory procedures demonstrates the effectiveness of an incremental greening process for chem. curricula. Ongoing assessment and introduction of improved methods into the organic teaching laboratory leads to innovative experiments that improve safety and effectively teach green principles and applications as well as traditional chem. concepts and laboratory skills. As a result of this process, bromination of alkenes can now be introduced to students through the use of a safe, effective, modern procedure.

Journal of Chemical Education published new progress about Bromination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics