Month: November 2022

Dagar, Neha; Singh, Swati; Raha Roy, Sudipta published the artcile< Synergistic Effect of Cerium in Dual Photoinduced Ligand-to-Metal Charge Transfer and Lewis Acid Catalysis: Diastereoselective Alkylation of Coumarins>, Application In Synthesis of 94-02-0, the main research area is carboxylic acid coumarin photoinduced decarboxylative alkylation cerium; alkylcoumarin diastereoselective preparation; cerium diastereoselective decarboxylative alkylation catalyst.

We report the dual role of cerium to promote the photoinduced ligand-to-metal charge transfer (LMCT) process for the generation of the alkyl radical and subsequent Lewis acid catalysis to construct stereodefined C-C bonds. This paradigm utilized ubiquitous carboxylic acids as alkyl radical surrogates and offers excellent diastereoselectivity for the formation of C-4 alkylated coumarins in good to excellent yield. UV-vis spectroscopy studies in combination with in situ Fourier transform IR spectroscopy are consistent with the proposed mechanism, supporting the participation of the CeIV-carboxylate complex in photoinduced LMCT and its subsequent homolysis to generate the alkyl radial through the exclusion of CO2. Finally, the oxophilicity of cerium enables a two-point complexation with the in situ generated enolate intermediate and facilitates the diastereoselective protonation to form the desired product. Furthermore, this mild and atom-economical catalytic manifolds allow the late-stage modification of pharmaceuticals.

Journal of Organic Chemistry published new progress about Carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Application In Synthesis of 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chennaiah, Ande; Vankar, Yashwant D. published the artcile< One-Step TEMPO-Catalyzed and Water-Mediated Stereoselective Conversion of Glycals into 2-Azido-2-deoxysugars with a PIFA-Trimethylsilyl Azide Reagent System>, Synthetic Route of 4098-06-0, the main research area is protecting group disaccharide crystal structure trisaccharide monosaccharide azidolysis antibody; phase transfer catalyst azidodeoxy monosaccharide glycal tempo catalyzed preparation.

An unprecedented water-mediated and TEMPO-catalyzed, one-step, highly regiospecific and stereoselective functionalization of glycals to 2-azido-2-deoxysugars has been developed using a PIFA-Me3SiN3 reagent system in the presence of Bu4NHSO4 as a phase-transfer catalyst. The method is metal-free, proceeds under mild reaction conditions, and tolerates a variety of protecting groups. Using this method, the synthesis of an important trisaccharide unit bound by the monoclonal anti-I Ma antibody has also been demonstrated.

Organic Letters published new progress about Azidation. 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Synthetic Route of 4098-06-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ai, Zhengdong; Ma, Chong; Wan, Ruiming; Yin, Jingyi; Li, Guiming; Li, Yan; Chen, Li published the artcile< Anticancer Activity and Molecular Mechanism of Momordica cochinchinensis Seed Extract in Chronic Myeloid Leukemia Cells>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Momordica chronic myeloid leukemia seed signal transduction anticancer.

Targeting Bcr-Abl is the key to the treatment of chronic myeloid leukemia. Despite great progress in the treatment of patients with chronic CML, advanced CML patients are still unable to obtain effective and safe drugs. Momordica cochinchinensis seed is the dried ripe seed of Momordica cochinchinensis, which is a kind of fruit and consumed for dietary as well as medicinal uses. This study aimed to investigate the anticancer activity of Momordica cochinchinensis seed extract (MCSE) in CML cells. CML cells (KBM5 and KBM5-T315I) were treated with MCSE and analyzed for growth, apoptosis, and signal transduction. Nude mouse xenograft model was used to evaluate the antitumor activity of MCSE In Vivo. MCSE significantly reduced the cell viability of CML cells, triggered G0/G1 phase arrest in KBM5 cells and S phase arrest in KBM5-T315I cells. Concurrently, MCSE caused the activation of caspase-3, -8, -9, PARP and the degradation of Mcl-1, ultimately triggering endogenous and exogenous cell apoptosis. Meanwhile, MCSE downregulated Bcr-Abl levels and its downstream signaling pathways. Addnl., MCSE inhibited the growth of CML cells in nude mouse xenografts. Taken together, this study demonstrated the anticancer mechanism of MCSE, namely blocking Bcr-Abl and downregulating Mcl-1, and finally induced apoptosis of CML cells.

Nutrition and Cancer published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

More, Swati S.; Vince, Robert published the artcile< A metabolically stable tight-binding transition-state inhibitor of glyoxalase-I>, Quality Control of 77215-54-4, the main research area is glutathione analog urea isostere preparation inhibition glyoxalase I antitumor.

The design, synthesis, and enzyme kinetics evaluation of a transition-state inhibitor of glyoxalase-I is described. The union of the hydroxamic acid zinc-chelator with a urea isostere for the Glu-Cys amide bond led to a glutathione analog which retained inhibitory potency toward glyoxalase-I while possessing resistance toward γ-glutamyltranspeptidase mediated breakdown. This compound is viewed as a potential lead for the development of second-generation glyoxalase-I inhibitors wherein, the problems pertaining to metabolism and selectivity are overcome.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 77215-54-4 belongs to class esters-buliding-blocks, and the molecular formula is C12H24N2O4, Quality Control of 77215-54-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Stefancich, Giorgio; Artico, Marino; Massa, Silvio; Vomero, Salvatore published the artcile< Research on nitrogen heterocyclic compounds. XII. Synthesis of 5H-pyrrolo[1,2-b][2]benzazepine derivatives>, Electric Literature of 112-63-0, the main research area is pyrrolobenzazepine; carboxymethylbenzylpyrrole preparation cyclization; chloromethylbenzylpyrrolecarboxaldehyde cyclization.

Several routes to the unknown 5H-pyrrolo[1,2-b][2]benzazepine ring system have been explored. 1-(2-Cyanobenzyl)pyrrole was useful as starting material for 1-(2-carboxymethylbenzyl)pyrrole and 1-(2-chloromethylbenzyl)-2-pyrrolecarboxaldehyde. Polyphosphoric acid-catalyzed intramol. cyclization of the former substance and treatment of the latter compound with KCN led to 11-oxo-10,11-dihydo-5H-pyrrolo[1,2-b][2]benzazepine and to 10-cyano-5H-pyrrolo[1,2-b][2]benzazepine, resp., which were converted to the parent nucleus 5H-pyrrolo[1,2-b][2]benzazepine and its 10,11-dihydro- and 1,2,3,10,11,11a-hexahydro derivatives

Journal of Heterocyclic Chemistry published new progress about Cyclization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Tianzeng; Chen, Tieqiao; Han, Li-Biao published the artcile< Oxidative Dephosphorylation of Benzylic Phosphonates with Dioxygen Generating Symmetrical trans-Stilbenes>, Application In Synthesis of 112-63-0, the main research area is benzylic phosphonate oxidative dephosphorylation; stilbene stereoselective preparation.

Under a dioxygen atm., benzylphosphonates and related phosphoryl compounds can readily produce the corresponding trans-stilbenes in high yields with high selectivity upon treatment with bases. Various functional groups were tolerable under the reaction conditions.

Journal of Organic Chemistry published new progress about Dephosphorylation (oxidative). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Amin, Iyman; Prashant Saxena published the artcile< Glioblastoma a Malignant Form of Tumor: a Review on Its Cellular Target, Route, and Its Treatment>, Computed Properties of 112-63-0, the main research area is review bevacizumab temozolomide anticancer agent glioblastoma.

A review. The pathophysiol. of glioblastoma is so complex; it affects a number of different cellular processes. The FDA has approved a number of treatments, including temozolomide and bevacizumab, yet the survival rate remains the same at 1 yr or less. As a result of the failure of different chemotherapies and target pharmacol. therapies, we must concentrate on the use of less toxic agents, such as natural compounds, which may have a greater prognostic value. This quick overview covers the following topics: Glioblastoma has a variety of various routes associated with it, including mol. and patrimonial indications. Treatments for glioblastoma are available. Certain natural compounds may have the ability to minimize toxicity while also improving prognostic value. Glioblastoma multiforme is a grade 4 glioma brain tumor that develops from glial cells in the brain. The grade of a brain tumor indicates how probable it is to grow and spread. Grade 4 tumors are the most dangerous and aggressive. Despite the FDAs approval of temozolomide with bevacizumab and several other drugs, the 1-yr survival rate remains constant We must focus on the use of less toxic agents, such as natural compounds, that may have a greater prognostic value and less toxicity, due to the failure of various chemotherapies, surgeries, radiation, and target pharmaceutical therapies.

Current Tissue Microenvironment Reports published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

I-Ju Leu, Julia; Murphy, Maureen E.; George, Donna L. published the artcile< Targeting ErbB3 and cellular NADPH/NADP+ abundance sensitizes cutaneous melanomas to ferroptosis inducers>, Computed Properties of 347174-05-4, the main research area is drug targeting ErbB3 NADPH NADP tachyphylaxis melanoma ferroptosis.

Melanoma is a serious health challenge. Ferroptosis is a regulated form of oxidative cell death that shows varied efficacy in melanoma. We aimed to better understand the mol. basis for this differential ferroptosis sensitivity. We find that elevated expression of ErbB3 (V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3) associates with ferroptosis resistance and that ErbB3 knockdown sensitizes to ferroptosis inducers. ErbB3 depletion also promotes a marked reduction in the cellular ratio of GSH/GSSG (reduced/oxidized glutathione) and that of NADPH/NADP+ (reduced/oxidized NADP), together with an increase in the abundance of the lipid peroxidation product malondialdehyde (MDA). We identify several small mol. inhibitors targeting ErbB3 signaling pathways that also reduce the NADPH/NADP+ and GSH/GSSG ratios, concomitantly sensitizing the melanomas to ferroptosis activators. These findings point to a previously unrecognized role of ErbB3 in ferroptosis sensitivity and provide new insight into pathways that regulate this cell death process.

ACS Chemical Biology published new progress about Antioxidants. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Computed Properties of 347174-05-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lo, Kong Mun; Ng, Seik Weng published the artcile< Dipyridinium tribromidochloridobis(4-chlorophenyl)stannate(IV)>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is crystal structure stannate chlorophenyl bromo chloro complex dipyridinium salt; mol structure stannate chlorophenyl bromo chloro complex dipyridinium salt; hydrogen bond stannate chlorophenyl bromo chloro complex dipyridinium salt.

The tin atom in the substituted ammonium stannate(IV), (C5H6N)2[SnBr3(C6H4Cl)2Cl], lies on a center of symmetry in a distorted octahedral coordination geometry. Each independent halogen site is occupied by bromine and chlorine anions in an approx. 3:1 ratio. The pyridinium cation forms a hydrogen bond to only one of the halogen atoms. Crystallog. data are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shang, Rui; Huang, Zheng; Chu, Ling; Fu, Yao; Liu, Lei published the artcile< Palladium-Catalyzed Decarboxylative Coupling of Potassium Nitrophenyl Acetates with Aryl Halides>, HPLC of Formula: 30095-98-8, the main research area is palladium catalyzed decarboxylative cross coupling diaryl methane preparation; potassium nitrophenylacetate aryl halide reactant palladium catalyzed decarboxylative coupling.

A palladium-catalyzed decarboxylative cross-coupling of potassium 2- and 4-nitrophenyl acetates with aryl chlorides and bromides has been developed. Because the nitro group can be readily converted to many other functional groups, the new reaction provides a useful method for the preparation of diverse 1,1-diaryl methanes, e.g. 1-nitro-2-(4-vinylbenzyl)benzene, and their derivatives

Organic Letters published new progress about Aromatic nitro compounds Role: SPN (Synthetic Preparation), PREP (Preparation). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, HPLC of Formula: 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics