Month: November 2022

Tanabe, Tadashi; Okuda, Kazuo; Izumi, Yoshiharu published the artcile< Asymmetric hydrogenation of carbon-oxygen double bond with modified Raney nickel catalyst. XXV. Contributions of pH-adjusting reagents in asymmetric hydrogenation>, SDS of cas: 112-63-0, the main research area is asymmetric hydrogenation nickel; Raney asymmetric hydrogenation; pH Raney asymmetric hydrogenation.

In the asymmetric hydrogenation of Me acetoacetate with modified Raney Ni catalysts, the effect of pH-adjusting reagents were studied using DS-tartaric acid, Ls-2-hydroxyiosovaleric acid, L-glutamic acid, and L-aspartic acid as the modifying reagents. The effects of metal ions and ammonium ion were examined at pH 5.0. The asymmetric activity of the catalyst modified with the 2-hydroxy monocarboxylic acid or 2-amino dicarboxylic acid was not affected by the pH-adjusting reagents. However, 2-hydroxy dicarboxylic acid was markedly influenced by the reagents. The univalent metal ion was more effective than divalent or ammonium ions. Sodium hydroxide was the best pH-adjusting reagent. The adsorption state of the modifying reagent was discussed on the basis of the effects of the pH-adjusting reagent.

Bulletin of the Chemical Society of Japan published new progress about Hydrogenation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mu, Anthony U.; Kim, Yeon-Ju; Miranda, Octavio; Vazquez, Mariela; Strzalka, Joseph; Xu, Jie; Fang, Lei published the artcile< Hydrogen-Bond-Promoted Planar Conformation, Crystallinity, and Charge Transport in Semiconducting Diazaisoindigo Derivatives>, Application of C19H34O2, the main research area is semiconducting diazaisoindigo derivative field effect transistor hydrogen bond conjugation.

Conformational control of π-conjugated mols. using intramol. noncovalent bonds represents a promising strategy to tailor the solid-state mol. packing and electronic properties of these materials. Here, we report the design and synthesis of two model compounds featuring intramol. hydrogen bonds formed between a center diazaisoindigo unit (the acceptor) and flanking indole units (the donor). Computational and exptl. investigations show that these hydrogen bonds enthalpically stabilize the coplanar mol. conformation by >10 kcal/mol. The formation of these hydrogen bonds is also slightly favorable in terms of entropy, ensuring the high-temperature stability of the planar conformation. Thermal annealing of thin films of these compounds imparts high crystallinity and orientation in the solid state, while the non-hydrogen bond control only gave an amorphous solid. Field-effect transistor devices fabricated from these thin films exhibit hole mobilities up to 0.270 cm2 V-1 s-1, in contrast to the lack of measurable charge carrier mobility for the non-hydrogen bond control. This work demonstrates an efficient synthetic strategy to incorporate robust intramol. hydrogen bonds into conjugated π-systems and elucidates the mechanism on how such hydrogen bonds promote the desired mol. conformation, solid-state packing, and electronic performances of conjugated organic materials.

ACS Materials Letters published new progress about Annealing. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wiernicki, Bartosz; Maschalidi, Sophia; Pinney, Jonathan; Adjemian, Sandy; Vanden Berghe, Tom; Ravichandran, Kodi S.; Vandenabeele, Peter published the artcile< Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity>, Product Details of C15H22N2O2, the main research area is cancer ferroptosis impede dendritic cell antitumor immunity.

Immunogenic cell death significantly contributes to the success of anti-cancer therapies, but immunogenicity of different cell death modalities widely varies. Ferroptosis, a form of cell death that is characterized by iron accumulation and lipid peroxidation, has not yet been fully evaluated from this perspective. Here we present an inducible model of ferroptosis, distinguishing three phases in the process-‘initial’ associated with lipid peroxidation, ‘intermediate’ correlated with ATP release and ‘terminal’ recognized by HMGB1 release and loss of plasma membrane integrity-that serves as tool to study immune cell responses to ferroptotic cancer cells. Co-culturing ferroptotic cancer cells with dendritic cells (DC), reveals that ‘initial’ ferroptotic cells decrease maturation of DC, are poorly engulfed, and dampen antigen cross-presentation. DC loaded with ferroptotic, in contrast to necroptotic, cancer cells fail to protect against tumor growth. Adding ferroptotic cancer cells to immunogenic apoptotic cells dramatically reduces their prophylactic vaccination potential. Our study thus shows that ferroptosis neg. impacts antigen presenting cells and hence the adaptive immune response, which might hinder therapeutic applications of ferroptosis induction.

Nature Communications published new progress about Adaptive immunity. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Product Details of C15H22N2O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hua, Wuxing; Li, Huan; Pei, Chun; Xia, Jingyi; Sun, Yafei; Zhang, Chen; Lv, Wei; Tao, Ying; Jiao, Yan; Zhang, Bingsen; Qiao, Shi-Zhang; Wan, Ying; Yang, Quan-Hong published the artcile< Selective Catalysis Remedies Polysulfide Shuttling in Lithium-Sulfur Batteries>, Reference of 112-63-0, the main research area is indium catalyst polysulfide electrolyte selective catalysis lithium sulfur battery; lithium polysulfides; lithium-sulfur batteries; selective catalysis; shuttle effect.

The shuttling of soluble lithium polysulfides between the electrodes leads to serious capacity fading and excess use of electrolyte, which severely bottlenecks practical use of Li-S batteries. Here, selective catalysis is proposed as a fundamental remedy for the consecutive solid-liquid-solid sulfur redox reactions. The proof-of-concept Indium (In)-based catalyst targetedly decelerates the solid-liquid conversion, dissolution of elemental sulfur to polysulfides, while accelerates the liquid-solid conversion, deposition of polysulfides into insoluble Li2S, which basically reduces accumulation of polysulfides in electrolyte, finally inhibiting the shuttle effect. The selective catalysis is revealed, exptl. and theor., by changes of activation energies and kinetic currents, modified reaction pathway together with the probed dynamically changing catalyst (LiInS2 catalyst), and gradual deactivation of the In-based catalyst. The In-based battery works steadily over 1000 cycles at 4.0 C and yields an initial areal capacity up to 9.4 mAh cm-2 with a sulfur loading of ∼9.0 mg cm-2.

Advanced Materials (Weinheim, Germany) published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Bao Qiong; Li, Xin Kang; Lin, Yuan; Li, Ze Ying; Zhang, Xiang-Zhi; Feng, Na; Ma, Ai-Jun; Chen, Chao Yang; Tan, Lin Fan published the artcile< Development and validation of ultra-high performance supercritical fluid chromatography method for quantitative determination of six compounds in Guizhi Fuling capsule and tablet samples>, SDS of cas: 112-63-0, the main research area is Guizhi fuling formula; multiple compounds; ultra-high performance supercritical fluid chromatography.

A fast and simple ultra-high performance supercritical fluid chromatog. method has been developed for the determination of six analytes, namely (paeonol, coumarin, cinnamic alc., cinnamic acid, paeoniflorin, and amygdalin) in Guizhi Fuling capsule and tablet samples. The influence of the key chromatog. parameters for the separation purposes was evaluated. The optimal column was Trefoil CEL1 column. The optimal mobile phase was a gradient mixture of carbon dioxide and methanol at flow rate of 1.0 mL/min. The back pressure of the system was set to 1.38 x 107 Pa and the temperature to 45°C. The six compounds were separated within 11 min by the proposed ultra-high performance supercritical fluid chromatog. method with satisfactory resolution Method validation confirmed that the procedure is accurate with the recovery rates from 87.04 to 104.30%, intraday precision values less than 4.81% and interday precision less than 5.22%, and linear with R2 higher than 0.9967. Therefore, this work provides a simple and novel method for the simultaneous anal. of six compounds in Guizhi Fuling capsule and tablet samples.

Journal of Separation Science published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Orzolek, Brandon J.; Rahman, Anisur Md; Iovine, Peter M. published the artcile< Synthesis of Biorenewable Starch-Farnesene Amphiphilic Conjugates via Transesterification of Terpene-Derived Diels-Alder Adducts>, Recommanded Product: Perfluorophenyl acrylate, the main research area is synthesis biorenewable starch farnesene amphiphilic conjugate; transesterification terpene derived Diels Alder adduct.

Herein we describe a new class of terpene-starch esters synthesized from biorenewable building blocks. Although our work is specific to starch, we believe the synthetic methodol. can be extended to a wide range of polysaccharide substrates. In our approach, an ester functionality is first introduced to the farnesene backbone via high yielding, solvent-free Diels-Alder chem. The farnesene esters are subsequently transesterified with starch to produce a range of starch-farnesene amphiphilic biopolymers. The key transesterification reaction between farnesene and starch employs 1,5,6-triazabicyclo[4.4.0]dec-5-ene (TBD) as a guanidine base organocatalyst and is capable of producing materials with a high degree of substitution (DS). The DS can be modulated by altering the starch/farnesene feed ratio. Low DS starch-farnesene esters show surfactant-like properties while the higher DS materials were successfully solvent-cast into standalone films. Thermal and mech. tests reveal starch-farnesene esters to be robust under both solution and thermal processing conditions. Given the versatility of the synthetic method, the biorenewability of the components, and the biodegradability of the ester linkage joining the subunits, the newly produced polymer amphiphiles appear to be a promising class of new green materials.

ACS Sustainable Chemistry & Engineering published new progress about Amphiphiles. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Recommanded Product: Perfluorophenyl acrylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gillanders, Ross N.; Glackin, James M. E.; Babic, Zdenka; Mustra, Mario; Simic, Mitar; Kezic, Nikola; Turnbull, Graham A.; Filipi, Janja published the artcile< Biomonitoring for wide area surveying in landmine detection using honeybees and optical sensing>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is amitraz honeybee pheromone REST sampling luminescence quenching environmental modeling; Apis mellifera carnica; Environmental modelling; Honeybee; Luminescence quenching; Nitroaromatic; REST sampling.

Humanitarian demining is a worldwide effort and the range of climates and environments prevent any one detection method being suitable for all sites, so more tools are required for safe and efficient explosives sensing. Landmines emit a chem. flux over time, and honeybees can collect the trace residues of explosives (as particles or as vapor) on their body hairs. This capability was exploited using a passive method allowing the honeybees to freely forage in a mined area, where trace explosives present in the environment stuck to the honeybee body, which were subsequently transferred onto an adsorbent material for anal. by a fluorescent polymer sensor. Potential false pos. sources were investigated, namely common bee pheromones, the anti-varroa pesticide Amitraz, and the environment around a clean apiary, and no significant response was found to any from the sensor. The mined site gave a substantial response in the optical sensor films, with quenching efficiencies of up to 38%. A model was adapted to estimate the mass of explosives returned to the colony, which may be useful for estimating the number of mines in a given area.

Chemosphere published new progress about Apis mellifera carnica. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Delahaye, Maarten; Tanini, Flaminia; Holloway, Joshua O.; Winne, Johan M.; Du Prez, Filip E. published the artcile< Double neighbouring group participation for ultrafast exchange in phthalate monoester networks>, Electric Literature of 112-63-0, the main research area is phthalate monoester network ultrafast exchange thermal mech rheol property.

Phthalate monoesters (PMEs) were recently introduced as a simple dynamic covalent bond for implementation in covalent adaptable networks (CANs), which undergo rapid transesterifications in the absence of catalysts, due to the neighboring group participation (NGP) of a carboxylic acid moiety. In this work, it is shown that the PME transesterification can be very significantly accelerated by the presence of another neighboring group on the reactive alc. moieties. The kinetic effects are demonstrated using a short model study of PMEs with different substituents at the β-carbon position, showing a remarkable acceleration for alcs. containing tertiary amines on the β-carbon. Following the model study, materials were synthesized by a (partial) replacement of the conventionally used diol with a β-amino-diol, leading to the formation of networks with an increased Tg and Young’s-modulus, which is rationalized as a result of the formation of an ionic network (COO- and NHR3+). Stress relaxation experiments show a decrease in relaxation times by a factor of 500, compared to similar networks derived from non-amine-substituted hydroxyl monomers. This ultrafast relaxation, enabled by a double NGP, resulted in CANs that show potential to be processed through extrusion while maintaining their overall network connectivity.

Polymer Chemistry published new progress about Creep. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ohkuma, Takeshi; Kurono, Nobuhito; Sakaguchi, Yusuke; Yamauchi, Kohei; Yurino, Taiga published the artcile< Enantioselective Cyanosilylation of Alkynyl Ketones Catalyzed by Combined Systems Consisting of Chiral Ruthenium(II) Complex and Lithium Phenoxide>, SDS of cas: 112-63-0, the main research area is ketone alkynyl cyanotrimethylsilane ruthenium complex lithium cyanosilylation catalyst; alkynyl tertiary cyanohydrin silyl ether stereoselective preparation.

Asym. cyanosilylation of alkynyl ketones with the catalyst systems consisting of amino acid/2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (BINAP)/ruthenium(II) complex and lithium phenoxide (Ru·Li cat.) was studied. The reaction was conducted in tert-Bu Me ether (TBME) at -78 °C with a substrate-to-catalyst molar ratio (S/C) as high as 2000. A series of simple and functionalized ketones was converted into the alkynyl tertiary cyanohydrin derivatives in up to 99% ee. Appropriate selection of an amino-acid ligand of the catalyst according to the substrate structure was crucially important to achieve high enantioselectivity and a wide scope of substrates. Transformation of the chiral cyanohydrin product into a functionalized lactone was also examined

Advanced Synthesis & Catalysis published new progress about Alkoxysilanes Role: SPN (Synthetic Preparation), PREP (Preparation) (alkynyl tertiary cyanohydrin). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

published the artcile< Dual Temozolomide and ICI Treatment Is Efficacious and Safe in MSS mCRC.>, Related Products of 112-63-0, the main research area is .

Patients with MSS and MGMT-depleted mCRC exhibited clinical benefit post-temozolomide and ICI treatment.

Cancer discovery published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics