Month: November 2022

Poisson, Jean-Francois; Normant, Jean F. published the artcile< A configurationally stable alkoxy allenyl zinc reagent, en route to anti-anti vicinal amino diols>, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate, the main research area is vicinal amino diol stereoselective preparation; alkoxy allenyl zinc configurationally stable preparation addition imine.

The reaction of an alkoxyallenyl zinc reagent with benzyl imines derived from lactic and mandelic acids proceeds highly diastereoselectively and leads to 2-amino-1,3-diol derivatives with an anti-anti pattern. Thus, successive treatment of MeOCH2OCH2CCSiMe3 with EtCMeLi and ZnBr2 in THF gave the intermediate allenyl zinc reagent I which reacted with the benzyl imines II (R = Ph, Me) in THF at -70° to give the protected anti-anti-amino alcs. III.

Organic Letters published new progress about Addition reaction, stereoselective. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pang, Xianwu; Tang, Kailing; He, Qin; Huang, Jinghua; Fang, Ningye; Zhou, Xinjuan; Zhu, Qiuying; Wu, Xiuling; Shen, Zhiyong; Liang, Shujia published the artcile< HIV drug resistance and HIV transmission risk factors among newly diagnosed individuals in Southwest China>, Synthetic Route of 112-63-0, the main research area is HIV drug resistance and HIV1 transmission diagnosis Southwest China; Antiretroviral resistance; Antiretroviral therapy; HIV drug resistance; Human immunodeficiency virus 1; Primary antiretroviral resistance; Transmitted drug resistance.

The widespread use of antiretroviral therapy (ART) has resulted in the development of transmitted drug resistance (TDR), which reduces ART efficacy. We explored TDR prevalence and its associated risk factors in newly diagnosed individuals in Guangxi. We enrolled 1324 participants who were newly diagnosed with HIV-1 and had not received ART at voluntary counselling and testing centers (VCT) in Guangxi, China, who had not received ART. Phylogenetic relationship, transmission cluster, and genotypic drug resistance analyses were performed using HIV-1 pol sequences. We analyzed the association of demog. and virol. factors with TDR. In total, 1151 sequences were sequenced successfully, of which 83 (7.21%) showed evidence of TDR. Multivariate logistic regression anal. revealed that there was significant difference between the prevalence of TDR and unmarried status (adjusted odds ratio (aOR) = 2.41, 95% CI: 1.23-4.71), and CRF08_BC subtype (aOR = 2.03, 95% CI: 1.13-3.64). Most cases of TDR were related to resistance to non-nucleoside reverse transcriptase inhibitors (4.87%) and V179E was the most common mutation detected. We identified a total of 119 HIV transmission clusters (n = 585, 50.8%), of which 18 (15.1%) clusters showed evidence of TDR (36, 41.86%). Three clusters were identified that included drug-resistant individuals having a transmission relationship with each other. The following parameters were associated with TDR transmission risk: Unmarried status, educational level of junior high school or below, and CRF08_BC subtype may be a risk of the transmission of TDR. Our findings indicated that moderate TDR prevalence and highlighted the importance of continuous TDR monitoring and designing of strategies for TDR mitigation.

BMC Infectious Diseases published new progress about Antiviral agent resistance. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zou, Changfei; Yang, Li; Luo, Kaili; Liu, Lei; Tao, Xiyuan; Yi, Lingguang; Liu, Xianhu; Zhang, Xiaoyan; Wang, Xianyou published the artcile< In Situ Formed Protective Layer: Toward a More Stable Interface between the Lithium Metal Anode and Li6PS5Cl Solid Electrolyte>, Application of C19H34O2, the main research area is lithium metal battery anode solid electrolyte interface ionic liquid.

Due to the advantages of high safety and high energy d., solid-state lithium batteries (SSLBs) are promising competitors for next-generation batteries. Unfortunately, the growth of Li dendrites and irreversible capacity loss caused by the Li metal anode/solid electrolyte interfacial incompatibility remain challenges. Herein, an in situ formed artificial protective layer between the lithium metal anode and solid electrolyte Li6PS5Cl (LPSC) is introduced. A stable solid electrolyte interface (SEI) is in situ formed in the Li/Li6PS5Cl interface via the electrochem. reduction of the liquid electrolyte LiTFSI/tetraethylene glycol di-Me ether (Li(G4)TFSI), which is beneficial for the improvement of the stability of interfacial chem. and homogeneous lithium deposition behavior. The assembled Li/Li(G4)TFSI-assisted Li6PS5Cl/Li sym. cells enable stable cycles for 850 and 400 h at a c.d. of 0.1 and 0.2 mA/cm2, resp. Moreover, the LiNi0.6Co0.1Mn0.3O2(NCM613)/Li(G4)TFSI-assisted Li6PS5Cl/Li SSLBs can achieve prominent cycling stability at room temperature This work provides a new insight into the interfacial modification to design SSLBs with high energy d.

ACS Applied Energy Materials published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wu, Qing-Juan; Lv, Wen-Liang; Li, Juan-Mei; Zhang, Ting-Ting; Zhou, Wen-Hui; Zhang, Qiang; Wang, Jiu-Chong; Wang, Qing-Nan; Yao, Zi-Ang; Qiang, Rui; Chen, Si-Tong; Zhao, Xin; Liu, Shuang; Cao, Zheng-Min; Xu, Lei; Li, Gao-Hui; Chen, Jing; Wang, Li published the artcile< YinQiSanHuang Jiedu decoction for the treatment of hepatitis B-related compensated liver cirrhosis: study protocol for a multi-center randomized controlled trial>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is YinQiSanHuang Jiedu decoction hepatitis B liver cirrhosis treatment.

Hepatitis B-related compensated liver cirrhosis is related to a higher risk of hepatocellular carcinoma, and antiviral therapy is the preferred method. As the pathol. mechanisms of liver fibrosis are complex, drugs developed for a single target are difficult to be effective in clin. practice, so there are no chem. drugs or biol. drugs with clear efficacy available for clin. application at present. Traditional Chinese medicine is a kind of medical science that has been gradually formed during thousands of years and continuously enriched by the people of all ethnic groups in China. Traditional Chinese medicine shows curative effects in the treatment of liver diseases, especially in the field of liver fibrosis prevention and treatment. This study aims to test the integrative medicine (Chinese medicine plus antiviral therapy) effective on lowing hepatocellular carcinoma risk among patients with hepatitis-related compensated liver cirrhosis. This is a multi-center randomized controlled trial, and a total of 5 hospitals and 802 patients will be involved in. All the subjects are randomly allocated to the YinQiSanHuang Jiedu decoction (YQSHD) group (n = 401) or the placebo group (n = 401). The YQSHD group receives YQSHD granule with entecavir (ETV), and the placebo group receives YQSHD placebo with ETV. The treatment period will last for 52 wk, and the follow-up period for 52 ± 2 wk. The primary outcome measure is the annual incidence of HCC. Outcomes will be assessed at baseline and after treatment. The objective of this trial is ′′the integrative of YQSHD with ETV reduce the annual incidence of HCC to 1%′′. The protocol has been approved by the Medical Ethics Committee of Guang′anmen Hospital, China (Number2019-006-KY), and the other centers in the trial will not begin recruiting until the local ethical approval has been obtained. Trial final results will be disseminated via publication.

Trials published new progress about Amino acids Role: NPO (Natural Product Occurrence), PAC (Pharmacological Activity), THU (Therapeutic Use), BIOL (Biological Study), OCCU (Occurrence), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Wenjuan; Li, Jing; Jin, Qianwen; Liu, Yanyu; Zhang, Yongguang; Zhao, Yan; Wang, Xin; Nurpeissova, Arailym; Bakenov, Zhumabay published the artcile< Rational Construction of Sulfur-Deficient NiCo2S4-x Hollow Microspheres as an Effective Polysulfide Immobilizer toward High-Performance Lithium/Sulfur Batteries>, SDS of cas: 112-63-0, the main research area is hollow microsphere nickel cobalt sulfide polysulfide immobilizer; lithium sulfur battery.

The synergistic strategy combining architectural design with defect engineering in transition-metal sulfides offers a promising opportunity to realize high-efficiency polysulfide adsorption/conversion surface catalysis in lithium/sulfur (Li/S) batteries. Here, defect-rich yolk-shell hollow spheres composed of ultrafine NiCo2S4-x nanoparticles as sulfur hosts prepared by an anion-exchange method are reported. The elaborate design of sulfur defects endows the NiCo2S4-x hollow spheres with significantly enhanced electronic conductivity and superior affinity for polysulfides as well as expedited sulfur conversion. Meanwhile, the unique yolk-shell NiCo2S4-x hollow sphere structure provides large cavities that not only increase sulfur storage but also relieve the electrode volume expansion during cycling. Combining these favorable features, the NiCo2S4-x-hosted sulfur cathode revealed enhanced cycling stability, corresponding to a negligible capacity fading rate of 0.0754% per cycle after 500 cycles at 1 C, and achieved an outstanding rate capability (628.9 mA-h g-1 up to 5 C).

ACS Applied Energy Materials published new progress about Carbon black Role: TEM (Technical or Engineered Material Use), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Veerabhadraswamy, B. N.; Bhat, Sachin A.; Hiremath, Uma S.; Yelamaggad, Channabasaveshwar V. published the artcile< Light-emitting chiral nematic dimers with anomalous odd-even effect>, Category: esters-buliding-blocks, the main research area is liquid crystal chiral oligomers microphase dimer Schiff base; chiral nematic phase; dimers; liquid crystals; odd-even effect; photoluminescence.

In this report, based on the results derived from the extensive study into the thermal and photophys. properties, an anomalous mesomorphic behavior of photoluminescent, chiral nematic (N*) liquid crystalline dimers, belonging to two different series has been revealed. They comprise cholesterol and fluorescent three-ring Schiff base or salicylaldimine core interlinked via an ω-oxyalkanoyloxy spacer of varying length and parity. The effect of mol. structure on the liquid crystal (LC) behavior and photophys. properties of both the series has been probed by varying the length of the terminal n-alkoxy tails for a fixed (odd or even) parity of the spacer. The detailed investigations using complementary techniques not only evidenced the existence of the N* phase in all the dimers synthesized but also the occurrence of an intriguing odd-even effect; blue phases (BPs) exist in all the dimers comprising even-membered spacer, which surprisingly remains totally absent in their odd-membered counterparts. While the results reported hitherto are exactly opposite to the aforesaid findings, this atypical behavior has been interpreted in terms of the over-all shape of the dimers rendered by the orientation of terminal tails. Photophys. studies carried out clearly revealed the intrinsic light emitting feature of the dimers not only in their dilute solutions but also in their three condensed states viz., solid, N* phase, and isotropic liquid state; the emission intensities of the N* phase varies with the change in temperature, as expected. CD spectra of the N* phase recorded as a function of temperature show bisignate CD band characteristically, signifying large chiral correlations in the mol. self-assembly, while the origin of bands from pos. to neg. region suggests a right-handed twist of the N* helix.

ChemPhysChem published new progress about Cholesteric liquid crystals. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yoshida, Shigeru; Unoki, Makoto published the artcile< Compounds allied to vitamin B1. I. Synthesis of 3-(2-methyl-4-amino-5-pyrimidylmethyl)-4-methyl-5-(2-hydroxyethylthio)-2-thiazolone>, Application of C19H34O2, the main research area is .

RCH2NH2.HCl (I, R = C(NH2):N.CMe:N.CH:C-) (2.1 g.) and 0.8 g. NaOH (II) in 10 ml. MeOH heated a while, filtered (to remove NaCl), mixed with 0.5 g. CS2, filtered, and washed with MeOH give 1.4 g. RCH2NHCS2NH3CH2R (III), needles, m. 235° (from hot water), less soluble in cold water, soluble in dilute acid, alkali hydroxide, and carbonate. AcCHCl(CH2)2OH (IV) prepared by boiling 0.7 g. α-aceto-α-chlorobutyrolactone (V) with 2.5 ml. 5% HCl for 1 hr., and neutralized with NaHCO3, added into 1.4 g. III in 6 ml. MeOH, heated 2-5 hrs. at 100°, filtered, washed with water, the filtrate treated with 0.21 g. Na2CO3 and 0.2 g. CS2 gives 1.2 g. VI, and the filtrate treated with IV prepared from 0.35 g. V gives 0.6 g. RCH2NHCS2-CHAc(CH2)2OH (VI), m. 255°; or treating 1.4 g. III and 0.42 g. Na2CO3 in 6 ml. water with aqueous IV (from 1.4 g. V) in 6 ml. MeOH and 0.4 g. CS2 on a water bath for several min., filtering, and washing with water give 2.4 g. VI, decompose 255°. III and AcCHCl(CH2)2OAc (VII) heated in the same way as in the preparation of VI give RCH2NHCS2-CHAc(CH2)2OAc (VIII), decompose 250°. VIII (1 g.) and 0.6 g. NaHSO4 or 0.2 g. AlCl3 heated on an oil bath 1 hr. at 140°, taken up with 5 ml. hot water, NaOH added in excess, and the product filtered and washed with water give 0.92 g. S.CS.N(CH2R).CMe:C(CH2)2OAc (IX), m. 169-70° (from dilute alc.), also prepared by refluxing the above mixture with 10 volumes dioxane. VI (1 g.) and 0.6 g. NaHSO4 or 0.2 g. AlCl3 fused on an oil bath or refluxed in dioxane give 0.8 g. S.CS.N(CH2R).CMe:C(CH2)2OH (X), m. 237-8° (from dilute alc.); hydrolysis of 1 g. IX with 0.2 g. NaOH in 13 ml. 60% alc. 10 min. on a water bath give X.

Yakugaku Zasshi published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jiang, Minbao; Yuan, Yong; Wang, Tao; Xiong, Yunkui; Li, Jun; Guo, Huijiao; Lei, Aiwen published the artcile< Exogenous-oxidant- and catalyst-free electrochemical deoxygenative C2 sulfonylation of quinoline N-oxides>, Electric Literature of 112-63-0, the main research area is sulfonylated quinoline regioselective green preparation; quinoline oxide sodium sulfinate electrochem deoxygenative sulfonylation.

An exogenous-oxidant- and catalyst-free electrochem. deoxygenative C2 sulfonylation reaction was achieved. By employing quinoline N-oxides with sodium sulfinates as the starting materials, the electrochem. C-H sulfonylation of electron-deficient quinolines was indirectly achieved at room temperature and a variety of sulfonylated quinoline derivatives I [R = Et, Ph, 4-ClC6H4, etc.; R1 = H, 3-Me, 6-Br, etc.] were synthesized in modest to high yield with excellent regioselectivity. Notably, this protocol was the first example for synthesizing sulfonylated electron-deficient heteroarenes/arenes through electrochem.

Chemical Communications (Cambridge, United Kingdom) published new progress about Amine oxides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Listowsky, Irving; Englard, Sasha; Avigad, Gad published the artcile< Conformational aspects of acidic sugars. Circular dichroism studies>, Synthetic Route of 617-55-0, the main research area is CD conformation sugar acid.

CD spectra were determined for 9 (S)-α-hydroxy acids, 7 (R)-aliphatic acids, and 6 monosaccharide acids. A rule was formulated which relates the sign of the observed ellipticity bands to the orientations of substituents relative to the carboxyl chromophore and explains the observed CD properties of the uronic and muramic acids.

Transactions of the New York Academy of Sciences published new progress about Circular dichroism. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Synthetic Route of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tenti, Giammarco; Cores, Angel; Ramos, Maria Teresa; Menendez, J. Carlos published the artcile< (E)-3-((2-fluorophenyl)(hydroxy)methylene)imidazo[1,2-a]pyridin-2(3H)-one>, Recommanded Product: Ethyl 3-oxo-3-phenylpropanoate, the main research area is imidazopyridinone methylene hydroxy fluorophenyl preparation diastereoselective; pyridyl bromine ketoamide domino bromination cyclization tautomerism.

Treatment of a 3-(2-fluorophenyl)-3-oxo-N-(pyridin-2-yl)propanamide precursor with bromine afforded the first example of the (E)-3-((2-fluorophenyl)(hydroxy)methylene)imidazo[1,2-a]pyridin-2(3H)-one framework. This transformation proceeded through a domino process comprising an initial bromination, cyclization via an intramol. SN reaction, and a final keto-enol tautomerism, and allows generation of the fused heterocyclic system and installation of the acyl substituent in a single operation.

Molbank published new progress about Bromination. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Recommanded Product: Ethyl 3-oxo-3-phenylpropanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics